Case Study in Cox Regression

  • Frank E. HarrellJr.
Part of the Springer Series in Statistics book series (SSS)


Consider the randomized trial of estrogen for treatment of prostate cancer60 described in Chapter 8. Let us now develop a model for time until death (of any cause). There are 354 deaths among the 502 patients. If we only wanted to test for a drug effect on survival time, a simple rank-based analysis would suffice. To be able to test for differential treatment effect or to estimate prognosis or expected absolute treatment benefit for individual patients, however, we need a multivariable survival model.


Placebo Estrogen Shrinkage Stratification Cali 


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Copyright information

© Springer Science+Business Media New York 2001

Authors and Affiliations

  • Frank E. HarrellJr.
    • 1
  1. 1.Department of BiostatisticsVanderbilt University School of MedicineNashvilleUSA

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