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Preparation of Dextran-Based Macromolecular Chelates for Magnetic Resonance Angiography

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Biorelated Polymers

Abstract

The preparation of macromolecular conjugates of dextran, which could be used in the design of in perfusion contrast agents for Magnetic Resonance Angiography (MRA), is described. In a first step, an amino group was introduced in the diethylenetriamine pentaacetic acid (DTPA) structure, in order to obtain a complex with one linking group. The derivatized DTPA was characterized by NMR, and subsequently covalently linked to dextran using carbonyldiimidazole (CDI) as an activating agent. The degree of substitution of macromolecular conjugates of dextran can be tuned by the molar ratio of CDI/dextran applied.

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Author information

Authors and Affiliations

  1. Department of Biochemistry, University of Coimbra, Portugal

    Maria G. Duarte & Carlos F. G. C. Geraldes

  2. Laboratory of Applied Organic Chemistry and Catalysis, Delft University of Technology, The Netherlands

    Joop A. Peters

  3. Department of Chemical Engineering, University of Coimbra, Portugal

    Maria H. Gil

Authors
  1. Maria G. Duarte
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  2. Carlos F. G. C. Geraldes
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  3. Joop A. Peters
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  4. Maria H. Gil
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Editor information

Editors and Affiliations

  1. University of Pisa, Pisa, Italy

    Emo Chiellini

  2. University of Coimbra, Coimbra, Portugal

    Helena Gil

  3. Technical University of Graz, Graz, Austria

    Gerhart Braunegg

  4. VTT Biotechnology, Espoo, Finland

    Johanna Buchert

  5. Chalmers University of Technology, Göteborg, Sweden

    Paul Gatenholm

  6. ATO B.V., Wageningen, The Netherlands

    Maarten van der Zee

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© 2001 Springer Science+Business Media New York

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Duarte, M.G., Geraldes, C.F.G.C., Peters, J.A., Gil, M.H. (2001). Preparation of Dextran-Based Macromolecular Chelates for Magnetic Resonance Angiography. In: Chiellini, E., Gil, H., Braunegg, G., Buchert, J., Gatenholm, P., van der Zee, M. (eds) Biorelated Polymers. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-3374-7_19

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  • DOI: https://doi.org/10.1007/978-1-4757-3374-7_19

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4419-3369-0

  • Online ISBN: 978-1-4757-3374-7

  • eBook Packages: Springer Book Archive

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