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Radiologic Imaging and Staging of Primary and Metastatic Liver Tumors

  • Jonathan W. Berlin
  • Richard M. Gore
  • Vahid Yaghmai
  • F. Scott Pereles
  • Frank H. Miller
Part of the Cancer Treatment and Research book series (CTAR, volume 109)

Abstract

The radiologic imaging and staging of primary and metastatic liver tumors has been revolutionized by advances in ultrasonographic (US) imaging, computed tomography (CT), and magnetic resonance imaging (MRI). In spite of the improved sensitivity in the detection of hepatic malignancies, the ability to differentiate benign from malignant intrahepatic lesions often remains problematic due to extensive overlap in imaging appearances. Additionally, only several liver lesions have a pathognomonic appearance on cross-sectional imaging. As a result, tissue sampling performed with CT or ultrasound guidance is often required to better characterize a hepatic lesion (1–5).

Keywords

Hepatic Metastasis Compute Tomography Finding Portal Venous Phase Metastatic Liver Tumor Central Scar 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Baker, ME, Pelley R. Hepatic metastases: basic principles and implications for radiologists. Radiology 1995;197:329–337.PubMedGoogle Scholar
  2. 2.
    Meyers, MA (editor). Neoplasms of the Digestive Tract: Imaging, Staging and Management, Lippincott-Raven, 1998; pp361–395.Google Scholar
  3. 3.
    Mahfouz AE, Hamm B, Mathieu D. Imaging of metastases to the liver. Eur Radiol 1996; 6:607–614.CrossRefPubMedGoogle Scholar
  4. 4.
    Stark DD, Wittenberg J, Butch RJ et al. Hepatic metastases: randomized controlled comparison of detection with MR imaging and CT Radiology 1987;165:399–406.PubMedGoogle Scholar
  5. 5.
    Taylor HM, Ros PR, Hepatic Imaging: An Overview. Radiol Clin North Am, 1998;36:237–246.CrossRefPubMedGoogle Scholar
  6. 6.
    Couinaud C. Lefoie:etudes anatomiques et chirurgicales. Paris, France: Masson, 1957.Google Scholar
  7. 7.
    Soyer P, Elias D, Zeitoun G et al. surgical treatment of hepatic metastases: impact of intraoperative sonography. AJR 1993;160:511–514.CrossRefPubMedGoogle Scholar
  8. 8.
    Leen E, Anderson WJ, Wotherspoon H et al. Detection of colorectal liver metastases: comparison of laparotomy, CT, US, and Doppler perfusion index and evaluation of postoperative follow-up results. Radiology 1995;195:113–116.PubMedGoogle Scholar
  9. 9.
    Shuman WP. Liver metastases from colorectal carcinoma: detection with Doppler US-guided measurements of liver blood flow-past, present, future. Radiology 1995; 195:9–10.PubMedGoogle Scholar
  10. 10.
    Paley MR, Ros PR. Hepatic Metastates. Radiol Clin North Am 1998; 36:349–363.CrossRefPubMedGoogle Scholar
  11. 11.
    Vauthey JN. Liver Imaging: A Surgeon’s Perspective. Radiol Clin North Am 1998;36:445–457.CrossRefPubMedGoogle Scholar
  12. 12.
    Fernandez M, Redvanly RD. Primary hepatic Malignant Neoplasms, Radiol Clin North Am, 1998;36(2):333–348.CrossRefPubMedGoogle Scholar
  13. 13.
    Green B, Bree RL, Goldstein HM et al. Grey scale ultrasound evaluation of hepatic neoplasms: patterns and correlations. Radiology 1997;124:203–208.Google Scholar
  14. 14.
    Schieble W., Gosink BB, Leopold, GR. Gray scale echographic patterns of hepatic metastatic disease. AJR 1977;129:983–987.CrossRefGoogle Scholar
  15. 15.
    Marchal G, Tshibwabwa-Tumba E, Oyen R et al. Correlation of sonographic patterns in liver metastases with histology and microangiography. Invest Radiol 1985;20: 79–84.CrossRefPubMedGoogle Scholar
  16. 16.
    Marchal GJ, Pylyser K, Tshibwabwa Tumba EA et al. Anechoic halo in solid liver tumors: sonographic microangiographic, and histologic correlation. Radiology 1985;156:479–483.PubMedGoogle Scholar
  17. 17.
    Wernecke K, Henke L Vassallo P, Bick U et al. the distinction between benign and malignant liver tumors on sonography: value of a hypoechoic halo. AJR 1992;159:1005–1009.CrossRefPubMedGoogle Scholar
  18. 18.
    Jones EC, Chezmar JL, Nelson RC. The frequency and significance of small (<1.5cm)hepatic lesions detected by abdominal CT. AJR 1992;158:535–539.CrossRefPubMedGoogle Scholar
  19. 19.
    Kemmerer SR, Mortele KJ, Ros PR. CT Scan of the Liver. Radiol Clin North Am. 1998;36:247–261.CrossRefPubMedGoogle Scholar
  20. 20.
    Seigelman ES, outwater EK. MR Imaging of the Liver. Radiol Clin North Am. 1998;36:263–286.CrossRefGoogle Scholar
  21. 21.
    Hahn PF, Saini S. Liver-Specific MR Imaging Contrast Agents. 1998; 36:287–298.Google Scholar
  22. 22.
    Baron R, Oliver JH III, Dodd GD III, et al: Hepatocellular carcinoma: Evaluation with biphasic, contrast-enhanced, helical CT. Radiology 1996;199:505–51l.PubMedGoogle Scholar
  23. 23.
    Hodgson HJF. Primary hepatocellular carcinoma. In: Blumgart LH(ed), Surgery of the liver and biliarytract. Edinburgh: Churchill Livingstone, 1994;1341–1347.Google Scholar
  24. 24.
    Freeny P, Baron RL, Teefey SA: Hepatocellular carcinoma: Reduced frequency of typical findings with dynamic contrast-enhanced CT in a non-Asian population. Radiology 1992;182:143–148.PubMedGoogle Scholar
  25. 25.
    Heiken JP, Brink JA, Vannier, MW: Spiral (helical) CT. Radiology 1993;189:647–656.PubMedGoogle Scholar
  26. 26.
    Rummeny E, Weissleder R, Sironi S, et al. Primary liver tumors: diagnosis by MR imaging. AJR 1989;152:63–72.CrossRefPubMedGoogle Scholar
  27. 27.
    Earls JP, Theise ND, Weinreb JC, et al: Dysplastic nodules and hepatocellular carcinoma: Thin-section MR imaging of explanted cirrhotic livers with pathologic correlation. Radiology 1996;201: 207–214.PubMedGoogle Scholar
  28. 28.
    Kadoya M, Matsui O, Takashima T, et al. Hepatocellular carcinoma: Correlation of MR imaging and histopathologic findings. Radiology 1992;183:819–825.PubMedGoogle Scholar
  29. 29.
    Mathieu D, Guinet C, Bouklia-Hassane A et al. Hepatic vein involvement in hepatocellular carcinoma. Gastrointest Radiol 1988;13:55–60.CrossRefPubMedGoogle Scholar
  30. 30.
    Dodd, GD III, Miller WJ, Baron RL et al. Detection of malignant tumors in endstage cirrhotic livers: Efficacy of sonography as a screening technique AJR 1992;159:727–733.CrossRefPubMedGoogle Scholar
  31. 31.
    McLarney JK, Rucker PT, Bender GN. Fibrolamellar Carcinoma of the Liver: Radiologic-Pathologic Correlation. RadioGraphics 1999; 19:453–471.PubMedGoogle Scholar
  32. 32.
    Friedman AC, Lichtenstein JE, Goodman ZD, et al. Fibrolamellar hepatocellular carcinoma. Radiology 1985;157:583–587.PubMedGoogle Scholar
  33. 33.
    Brandt DJ, Johnson CD, Stephens DH et al. imaging of fibrolamellar hepatocellular carcinoma. AJR 1988; 151:295–299.CrossRefPubMedGoogle Scholar
  34. 34.
    Orsatti G, Hyritoglou P, Thung SN. Lamellar fibrosis in the fibrolamellar variant of hepatocellular carcinoma: a role for transforming growth factor beta. Liver 1997;12:152–156.Google Scholar
  35. 35.
    Bloom CM, Langer B, Wilson SR. Role of US in the detection, characterization, and staging of Cholangiocarcinoma. RadioGraphics 1999;19:1199–1218.PubMedGoogle Scholar
  36. 36.
    Honickman SP, Mueller PR, Wittenberg J et al. Ultrasound in obstructive jaundice: prospective evaluation of site and cause. Radiology 1983;147:511–515.PubMedGoogle Scholar
  37. 37.
    Robledo R, Avertano M, Prieto M. extrahepatic biliary ductal cancer. Radiology 1996;198:869–879.PubMedGoogle Scholar
  38. 38.
    Lacomis JM, Baron RL, Oliver JH III, et al. Cholangiocarcinoma: Delayed CT contrast enhancement patterns. Radiology 1997; 203:98–104.PubMedGoogle Scholar
  39. 39.
    Ros PR, Buck JL, Goodman ZD et al. Intrahepatic cholangiocarcinoma: radiologic-pathologic correlation. Radiology 1988;167:689–693.PubMedGoogle Scholar
  40. 40.
    Wibulpolprasert B, Dhiensiri T. Peripheral cholangiocarcinoma: sonographic evaluation. J Clin Ultrasound 1992;20:303–314.CrossRefPubMedGoogle Scholar
  41. 41.
    Soyer P, Bluemke DA, Reichle R et al. Imaging of intrahepatic cholangiocarcinoma, 1: peripheral cholangiocarcinoma. AJR 1995;165:1427–1431.CrossRefPubMedGoogle Scholar
  42. 42.
    Choi BI, Han JK, Shin YM et al. Peripheral cholangiocarcinoma: Comparison of MRI with CT. Abdom Imaging 1995;20:357–360.CrossRefPubMedGoogle Scholar
  43. 43.
    Choi BI, Lee JH, Han MC et al. Hilar cholangiocarcinoma: comparative study with sonography and CT. Radiology 1989;172:689–692.PubMedGoogle Scholar
  44. 44.
    McArdle CR. Ultrasonographic appearances of a hepatic hemangioma. J Clin Ultrasound 1978;6:124..Google Scholar
  45. 45.
    Nghiem H, Bogost G, Ryan J, Lund P, et al. Cavernous hemangiomas of the liver: enlargement over time. AJR 1997; 169:137–140.CrossRefPubMedGoogle Scholar
  46. 46.
    Quinn S, Benjamin G. Hepatic cavernous hemangiomas: simple diagnostic sign with dynamic bolus CT. Radiology 1992; 182:545–548.PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media Dordrecht 2001

Authors and Affiliations

  • Jonathan W. Berlin
    • 1
  • Richard M. Gore
    • 1
  • Vahid Yaghmai
    • 2
  • F. Scott Pereles
    • 2
  • Frank H. Miller
    • 2
  1. 1.Northwestern UniversityEvanstonUSA
  2. 2.Northwestern University Medical SchoolChicagoUSA

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