Introducing the Fundamental Concepts
Let us consider a system of m binding sites. Each site can be in one of two states: empty or occupied by a ligand L. First, we treat the case where the system contains a fixed number of ligands, n. In thermodynamic terms, we refer to such a system as a closed system with respect to the ligands. We are interested in asking probabilistic questions about this system. To this end we imagine a very large collection, an ensemble of such systems, all of which are identical in the sense that each has a fixed number of n ligands occupying n of the m sites (n ≤ m).
KeywordsCorrelation Function Partition Function Fundamental Concept Conformational State Final Configuration
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