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Mutations and Mutagenesis

  • Edward A. Birge

Abstract

The first problem facing early bacterial geneticists was to prove that bacteria did have inherited traits. The earliest presumption was that bacteria and other microorganisms were too small to have any phenotypic traits that could be studied. That concept was disabused by the work of George Beadle and Edward Tatum, who demonstrated that biochemical reactions could be used as phenotypic traits and then developed the famous “one gene—one enzyme” hypothesis. There was, however, one remaining area of uncertainty regarding bacterial genetics. Many workers thought that the hypothesis of Lamarck regarding inheritance of acquired traits was true for bacteria even though it had already been disproved for animals and plants. The first task of the fledgling science of bacterial genetics was to prove that the same processes of mutation that had already been shown to occur in eukaryotes also occurred in prokaryotes. Recently, this controversy has arisen again in a new and particularly interesting form.

Keywords

Mutation Rate Genetic Code Mutant Cell Frameshift Mutation Adaptive Mutation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

General

  1. Andersson, D.I., Slechta, E.S., Roth, J.R (1998). Evidence that gene amplification underlies adaptive mutability of the bacterial lac operon. Science 282: 1133–1135.PubMedCrossRefGoogle Scholar
  2. Foster, P.L. (1998). Adaptive mutation: Has the unicorn landed? Genetics 148: 1453–1459.PubMedGoogle Scholar
  3. Rosenberg, S.M., Thulin, C., Harris, R.S. (1998). Transient and heritable mutators in adaptive evolution in the lab and in nature. Genetics 148: 1559–1566. (This paper presents a model for adaptive evolution.)PubMedGoogle Scholar

Specialized

  1. Drake, J.W., Charlesworth, B., Charlesworth, D., Crow, J.F. (1998). Rates of spontaneous mutation. Genetics 148: 1667–1686.PubMedGoogle Scholar
  2. Jayaram, B. (1997). Beyond the wobble: The rule of conjugates. Journal of Molecular Evolution 45: 704–705.PubMedCrossRefGoogle Scholar
  3. Reddy, M., Gowrishankar, J. (1997). A genetic strategy to demonstrate the occurrence of spontaneous mutations in nondividing cells within colonies of Escherichia coli. Genetics 147: 991–1001.PubMedGoogle Scholar
  4. Rossi, J.J., Berg, C.M. (1971). Differential recovery of auxotrophs after penicillin enrichment in E. coli. Journal of Bacteriology 106: 297–300.PubMedGoogle Scholar
  5. Taddel, F., Radman, M., Maynard-Smith, J., Toupance, B., Gouyon, P.H., Godelle (1997). Role of mutator alleles in adaptive evolution. Nature 387: 700–702. (Mathematical models and simulations of adaptive evolution.)CrossRefGoogle Scholar
  6. Torkelson, J., Harris, R.S., Lombardo, M.-J., Nagendran, J., Thulin, C. (1997) Genome-wide hypermutation in a subpopulation of stationary-phase cells underlies recombination-dependent adaptive mutation. EMBO Journal 16: 3303–3311.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2000

Authors and Affiliations

  • Edward A. Birge
    • 1
  1. 1.Department of MicrobiologyArizona State UniversityTempeUSA

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