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Alcoholism: Acute Treatment

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Part of the book series: Critical Issues in Psychiatry ((CIPS))

Abstract

Alcohol is one of the most commonly misused substances, with abuse and dependence creating serious medical and psychological difficulties. This chapter presents an overview of emergency problems, and there is an extensive discussion of rehabilitation in chapter 15. A great deal of background material has already been put forth in chapter 3.

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References

  1. Substance Abuse and Mental Health Services Administration, Office of Applied Studies. National household survey on drug abuse: Population estimates 1997. Rockville, MD: U.S. Department of Health and Human Services, 1998.

    Google Scholar 

  2. Kessler, R. C., Crum, R. M., Warner, L. A., et al. Lifetime co-occurrence of DSM-III-R alcohol abuse and dependence with other psychiatric disorders in the National Comorbidity Survey. Archives of General Psychiatry 54:313–321, 1997.

    Article  PubMed  Google Scholar 

  3. Huseby, N.-E., Nilssen, O., & Kanitz, R-D. Evaluation of two biological markers combined as a parameter of alcohol dependency. Alcohol & Alcoholism 32:731–737, 1997.

    Article  Google Scholar 

  4. Daeppen, J.-B., Smith, T. L., & Schuckit, M. A. Influence of age and body mass index on γ-glutamyltrans-ferase activity: A 15-year follow-up evaluation in a community sample. Alcoholism: Clinical and Experimental Research 22:941–944, 1994.

    Google Scholar 

  5. Lichtenstein, M. J., Burger, M. C., Yarnell, J. W. G., et al. Derivation and validation of a prediction rule for identifying heavy consumers of alcohol. Alcoholism: Clinical and Experimental Research 13:626–630, 1989.

    Article  Google Scholar 

  6. American Psychiatric Association. The diagnostic and statistical manual of mental disorders (4th ed.). Washington, DC: American Psychiatric Press, 1994.

    Google Scholar 

  7. Cherpitel, C. J. Brief screening instruments for alcoholism. Alcohol Health & Research World 21:348–351, 1997.

    Google Scholar 

  8. Volk, R. J., Steinbauer, J. R., Cantor, S. B., & Holzer, C. E., III. The alcohol use disorders identification test (AUDIT) as a screen for at-risk drinking in primary care patients of different racial/ethnic backgrounds. Addiction 93:197–206, 1997.

    Article  Google Scholar 

  9. Bisson, J., Nadeau, L., & Demers, A. The validity of the CAGE scale to screen for heavy drinking and drinking problems in a general population survey. Addiction 94:715–722, 1999.

    Article  PubMed  Google Scholar 

  10. Schuckit, M. A. Educating yourself about alcohol and drugs. New York: Plenum Publishing Co., 1998.

    Google Scholar 

  11. Schuckit, M. A. Alcohol, anxiety, and depressive disorders. Alcohol Health & Research World 20:81–85, 1996.

    Google Scholar 

  12. Schuckit, M. A., Tipp, J. E., Bergman, M., et al. Comparison of induced and independent major depressive disorders in 2,945 alcoholics. American Journal of Psychiatry 154:948–957, 1997.

    PubMed  Google Scholar 

  13. Schuckit, M. A., Tipp, J. E., Smith, T L., & Bucholz, K. K. Periods of abstinence following the onset of alcohol dependence in 1,853 men and women. Journal of Studies on Alcohol 58:581–589, 1997.

    PubMed  Google Scholar 

  14. Schuckit, M. A., Tipp, J. E., Bucholz, K. K., et al. The life-time rates of three major mood disorders and four major anxiety disorders in alcoholics and controls. Addiction 92:1289–1304, 1997.

    Article  PubMed  Google Scholar 

  15. Raimo, E. B., & Schuckit, M. A. Alcohol dependence and mood disorders. Addictive Behaviors 23:933–946, 1998.

    Article  PubMed  Google Scholar 

  16. Soderstrom, C. A., Smith, G. S., Dischinger, P. C., et al. Psychoactive substance use disorders among seriously injured trauma center patients. Journal of the American Medical Association 277:1769–1774, 1997.

    Article  PubMed  Google Scholar 

  17. Hobbs, W. R., Rall, T. W., & Verdoorn, T. A. Hypnotics and sedatives: Ethanol. In J. G. Hardman, L. E. Limbird, P. B. Molinoff, et al. (Eds.), The pharmacological basis of therapeutics (9th ed.). New York: McGraw-Hill, 1995, pp. 361–396.

    Google Scholar 

  18. O’Brien, C. P. Drug addiction and drug abuse. In J. G. Hardman, L. E. Limbird, P. B. Molinoff, et al. (Eds.), The pharmacological basis of therapeutics (9th ed.). New York: McGraw-Hill, 1995, pp. 557–577.

    Google Scholar 

  19. Schuckit, M. A. Alcohol and alcoholism. In A. S. Fauci, E. Braunwald, K. J. Isselbacher, et al. (Eds.), Harrison’s principles of internal medicine (14th ed.). New York: McGraw-Hill, 1998, pp. 2503–2508.

    Google Scholar 

  20. Iber, F. L. Evaluation of an oral solution to accelerate alcoholism detoxification. Alcoholism: Clinical and Experimental Research 11:305–308, 1987.

    Article  Google Scholar 

  21. Valenzuela, C. F Alcohol and neurotransmitter interactions. Alcohol Health & Research World 21:144–148, 1997.

    Google Scholar 

  22. Stock, H., Ford, K., Biscardi, R., Wilson, M. A. Lack of sex differences in anxiety behaviors during precipitated benzodiazepine withdrawal in rats. Physiology and behavior 66:125–130, 1999.

    Article  PubMed  Google Scholar 

  23. Becker, H. C. Alcohol withdrawal: Neuroadaptation and sensitization. CNS Spectrums 4:38–65, 1999.

    Google Scholar 

  24. Schuckit, M. A., Tipp, J. E., Reich, T., et al. The histories of withdrawal convulsions and delirium tremens in 1648 alcohol dependent subjects. Addiction 90:1335–1347, 1995.

    Article  PubMed  Google Scholar 

  25. Goodwin, D. W., & Gabrielli, W. F. Alcohol: Clinical aspects. In J. H. Lowinson, P. Ruiz, R. B. Millman, & J. G. Langrod (Eds.), Substance abuse: A comprehensive textbook (3rd ed.). Baltimore, MD: Williams & Wilkins, 1996, pp. 142–148.

    Google Scholar 

  26. Tutus, A., Kugu, N., Sofuoglu, S., et al. Transient frontal hypoperfusion in Tc-99m hexamethylpropyleneami-neoxime single photon emission computed tomography imaging during alcohol withdrawal. Biological Psychiatry 43:923–928, 1998.

    Article  PubMed  Google Scholar 

  27. Thomas, J. D., Weinert, S. P., Sharif, S., & Riley, E. P. MK-801 administration during ethanol withdrawal in neonatal rat pups attenuates ethanol-induced behavioral deficits. Alcoholism: Clinical and Experimental Research 21:1218–1225, 1997.

    Article  Google Scholar 

  28. Tsai, G. E., Ragan, P., Chang, R., et al. Increased glutamatergic neurotransmission and oxidative stress after alcohol withdrawal. American Journal of Psychiatry 155:726–732, 1998.

    PubMed  Google Scholar 

  29. Seitz, H., & Poschl, G. Alcohol and gastrointestinal cancer: Pathogenic mechanisms. Addiction Biology 2:19–33, 1997.

    Article  Google Scholar 

  30. Sellers, E. M., Sullivan, J. T., Somer, K., & Sykora, K. Characterization of DSM-III-R criteria for uncomplicated alcohol withdrawal provides an empirical basis for DSM-IV. Archives of General Psychiatry 48:442–447, 1991.

    Article  PubMed  Google Scholar 

  31. Edwards, G. Withdrawal symptoms and alcohol dependence. British Journal of Addiction 85:1251–1254, 1990.

    Article  Google Scholar 

  32. King, A. C., Errico, A. L., Parsons, O. A., & Lovallo, W. R. Blood pressure dysregulation associated with alcohol withdrawal. Alcoholism: Clinical and Experimental Research 15:478–482, 1991.

    Article  Google Scholar 

  33. Mayo-Smith, M. F., et al. Pharmacological management of alcohol withdrawal: A meta-analysis and evidence-based practice guideline. Journal of the American Medical Association 278:144–151, 1997.

    Article  PubMed  Google Scholar 

  34. Pieninkeroinen, I. P., Telakivi, T. M., & Hillbom, M. E. Outcome in subjects with alcohol-provoked seizures. Alcoholism: Clinical and Experimental Research 16:955–959, 1992.

    Article  Google Scholar 

  35. Mayo-Smith, M. F., & Bernard, D. Late-onset seizures in alcohol withdrawal. Alcoholism: Clinical and Experimental Research 19:656–659, 1995.

    Article  Google Scholar 

  36. Becker, H. C., & Hale, R. L. Repeated episodes of ethanol withdrawal potentiate the severity of subsequent withdrawal seizures: An animal model of alcohol withdrawal “kindling.” Alcoholism: Clinical and Experimental Research 17:94–98, 1993.

    Article  Google Scholar 

  37. Wasilewski, D., Matsumoto, H., Kur, E., et al. Assessment of diazepam loading dose therapy of delirium tremens. Alcohol & Alcoholism 31:273–278, 1996.

    Article  Google Scholar 

  38. Wojnar, M., Bizon, Z., & Wasilewski, D. The role of somatic disorders and physical injury in the development and course of alcohol withdrawal delirium. Alcoholism: Clinical and Experimental Research 23:209–213, 1999.

    Article  Google Scholar 

  39. Slaby, A. E., & Martin, S. D. Drug and alcohol emergencies. In N. S. Miller (Ed.), Comprehensive handbook of drug and alcohol addiction. New York: Marcel Dekker, 1991, pp. 1003–1029.

    Google Scholar 

  40. Satel, S. L., Kosten, T. R., Schuckit, M. A., & Fischman, M. W. Should protracted withdrawal from drugs be included in DSM-IV? American Journal of Psychiatry 150:695–704, 1993.

    PubMed  Google Scholar 

  41. Trabert, W., Caspari, D., Bernhard, P., & Biro, G. Inappropriate ADH secretion in severe alcohol withdrawal. Acta Psychiatrica Scandinavica 85:376–379, 1992.

    Article  PubMed  Google Scholar 

  42. Adinoff, B., Risher-Flowers, D., De Jong, J., et al. Disturbances of hypothalamic-pituitary-adrenal axis functioning during ethanol withdrawal in six men. American Journal of Psychiatry 148:1023–1025, 1991.

    PubMed  Google Scholar 

  43. Denison, H., Jern, S., Jagenburg, R., et al. ST-segment changes and catecholamine-related myocardial enzyme release during alcohol withdrawal. Alcohol & Alcoholism 32:185–194, 1997.

    Article  Google Scholar 

  44. Knott, D. H., & Beard, J. D. A diuretic approach to acute withdrawal from alcohol. Southern Medical Journal 62:485–488, 1969.

    Article  PubMed  Google Scholar 

  45. Forsander, O. A. Dietary influences on alcohol intake: A review. Journal of Studies on Alcohol 59:26–31, 1998.

    PubMed  Google Scholar 

  46. Lieber, C. S. Hepatic and other medical disorders of alcoholism: From pathogenesis to treatment. Journal of Studies on Alcohol 59:9–25, 1998.

    PubMed  Google Scholar 

  47. Menzano, E., & Carlen, R L. Zinc deficiency and corticosteroids in the pathogenesis of alcoholic brain dysfunction—A review. Alcoholism: Clinical and Experimental Research 18:895–901, 1994.

    Article  Google Scholar 

  48. Gullestad, L., Dolva, L. O., Soyland, E., et al. Oral magnesium supplementation improves metabolic variables and muscle strength in alcoholics. Alcoholism: Clinical and Experimental Research 16:986–990, 1992.

    Article  Google Scholar 

  49. Naranjo, C. A., Sellers, E. M., Chater, K., et al. Nonpharmacologic intervention in acute alcohol withdrawal. Clinical Pharmacology and Therapeutics 34:214–219, 1983.

    Article  PubMed  Google Scholar 

  50. Saitz, R., Mayo-Smith, M. F., Roberts, M. S., et al. Individualized treatment for alcohol withdrawal: A randomized double-blind controlled trial. Journal of the American Medical Association 272:519–523, 1994.

    Article  PubMed  Google Scholar 

  51. Whitfield, C. L., Thompson, G., Lamb, A., et al. Detoxification of 1,024 alcoholic patients without psychoactive drugs. Journal of the American Medical Association 239:1409–1410, 1978.

    Article  PubMed  Google Scholar 

  52. Fuller, R. K., & Gordis, E. Refining the treatment of alcohol withdrawal. Journal of the American Medical Association 272:557–558, 1994.

    Article  PubMed  Google Scholar 

  53. Shaw, G. K. Detoxification: The use of benzodiazepines. Alcohol & Alcoholism 30:765–770, 1995.

    Google Scholar 

  54. Worner, T. M. Propanolol versus diazepam in the management of the alcohol withdrawal syndrome: Double-blind controlled trial. American Journal of Drug and Alcohol Abuse 20:115–124, 1994.

    Article  PubMed  Google Scholar 

  55. Zechnich, R. J. Beta blockers can obscure diagnosis of delirium tremens. Lancet 1:1071–1072. 1982.

    Article  PubMed  Google Scholar 

  56. Adinoff, B. Double-blind study of alprazolam, diazepam, Clonidine, and placebo in the alcohol withdrawal syndrome: preliminary findings. Alcoholism: Clinical and Experimental Research 18:873–878, 1995.

    Article  Google Scholar 

  57. Schuckit, M. A. Chlormethiazole (heminevrin). A drug for alcohol withdrawal? Vista Hill Foundation Drug Abuse & Alcoholism Newsletter, 19(1), 1990.

    Google Scholar 

  58. Addolorato, G., Castelli, E., Stefanini, G. F., et al. An open multicentric study evaluating 4-hydroxybutyric acid sodium salt in the medium-term treatment of 179 alcohol dependent subjects. Alcohol & Alcoholism 31:341–345, 1996.

    Article  Google Scholar 

  59. Stuppaeck, C. H., Deisenhammer, E. A., Kurz, M., et al. The irreversible γ-aminobutyrate transaminase inhibitor vigabatrin in the treatment of the alcohol withdrawal syndrome. Alcohol & Alcoholism 31:109–111, 1996.

    Article  Google Scholar 

  60. Dilts, D. L., Keleher, D. L., Hoge, G., & Haglund, B. Hydroxyzine in the treatment of alcohol withdrawal. American Journal of Psychiatry 134:92–93, 1977.

    PubMed  Google Scholar 

  61. Stuppaeck, C. H., Whitworth, A. B., & Fleischhacker, W. W. Abuse potential of carbamazepine. Journal of Nervous and Mental Disease 181:519–520, 1993.

    Article  PubMed  Google Scholar 

  62. Abbott, L., Nadler, J., & Rude, R. K. Magnesium deficiency in alcoholism: Possible contribution to osteoporosis and cardiovascular disease in alcoholics. Alcoholism: Clinical and Experimental Research 18:1076–1082, 1994.

    Article  Google Scholar 

  63. Hayashida, M., Alterman, A. I., McLellan, A. T., et al. Comparative effectiveness and costs of inpatient and outpatient detoxification of patients with mild to moderate alcohol withdrawal syndrome. New England Journal of Medicine 320:358–365, 1989.

    Article  PubMed  Google Scholar 

  64. Fleeman, N.D. Alcohol home detoxification: A literature review. Alcohol & Alcoholism. 32:649–656, 1997.

    Article  Google Scholar 

  65. Bennie, C. A comparison of home detoxification and minimal intervention strategies for problem drinkers. Alcohol & Alcoholism 33:157–163, 1998.

    Article  Google Scholar 

  66. Wojnar, M., Bizon, Z., & Wasilewski, D. Assessment of the role of kindling in the pathogenesis of alcohol withdrawal seizures and delirium tremens. Alcoholism: Clinical and Experimental Research 23:204–208, 1999.

    Article  Google Scholar 

  67. Kokavec, A., & Crowe, S. F. A comparison of cognitive performance in binge versus regular chronic alcohol misusers. Alcohol & Alcoholism 34:601–608, 1999.

    Article  Google Scholar 

  68. Emsley, R., Smith, R., Roberts, M., et al. Magnetic resonance imaging in alcoholic Korsakoff’s syndrome: Evidence for an association with alcoholic dementia. Alcohol & Alcoholism 31:479–486, 1996.

    Article  Google Scholar 

  69. Kaufman, M. J., Levin, J. M., Christensen, J. D., & Renshaw, P. F. Magnetic resonance studies of substance abuse. Seminars in Clinical Neuropsychiatry 1:61–75, 1996.

    PubMed  Google Scholar 

  70. Pfefferbaum, A., Lim, K. O., Desmond, J. E., & Sullivan, E. V. Thinning of the corpus callosum in older alcoholic men: A magnetic resonance imaging study. Alcoholism: Clinical and Experimental Research 20:752–757, 1996.

    Article  Google Scholar 

  71. Pfefferbaum, A., Sullivan, E. V., Rosenbloom, M. J., et al. A controlled study of cortical gray matter and ventricular changes in alcoholic men over a 5-year interval. Archives of General Psychiatry 55:905–912, 1998.

    Article  PubMed  Google Scholar 

  72. Wang, J. J.-L., Martin, P. R., & Singleton, C. K. A transketolase assembly defect in a Wernicke-Korsakoff syndrome patient. Alcoholism: Clinical and Experimental Research 21:576–580, 1997.

    Article  Google Scholar 

  73. Thomson, A. D., & Cook, C. C. H. Parenteral thiamine and Wernicke’s encephalopathy: The balance of risks and perception of concern. Alcohol & Alcoholism 32:207–209, 1997.

    Article  Google Scholar 

  74. Soyka, M. Pathophysiological mechanisms possibly involved in the development of alcohol hallucinosis. Addiction 90:289–294, 1995.

    Article  PubMed  Google Scholar 

  75. Soyka, M. Psychopathological characteristics in alcohol hallucinosis and paranoid schizophrenia. Acta Psychiatrica Scandinavica 81:225–259, 1990.

    Article  Google Scholar 

  76. Tsuang, J. W., Irwin, M. R., Smith, T. L., & Schuckit, M. A. Characteristics of men with alcoholic hallucinosis. Addiction 89:73–78, 1994.

    Article  PubMed  Google Scholar 

  77. Scribner, R., Cohen, D., Kaplan, S., & Allen, S. H. Alcohol availability and homicde in New Orleans: Conceptual considerations for small area analysis of the effect of alcohol outlet density. Journal of Studies on Alcohol 60:310–316, 1999.

    PubMed  Google Scholar 

  78. Rossow, I. Alcohol-related violence: The impact of drinking pattern and drinking context. Addiction 91:1651–1661, 1996.

    Article  PubMed  Google Scholar 

  79. Bellack, A. S., & Gearon, J. S. Substance abuse treatment for people with schizophrenia. Addictive Behaviors 23:749–766, 1998.

    Article  PubMed  Google Scholar 

  80. De Soto, C. B., O’Donnell, W. E., Allred, L. J., & Lopes, C. E. Symptomatology in alcoholics at various stages of abstinence. Alcoholism: Clinical and Experimental Research 9:505–512, 1985.

    Article  Google Scholar 

  81. Bjork, J. M., Dougherty, D. M., & Moeller, F. G. Symptomatology of depression and anxiety in female “social drinkers.” American Journal of Drug and Alcohol Abuse 25:173–182, 1999.

    Article  PubMed  Google Scholar 

  82. Markou, A., Kosten, T. R., & Koob, G. F. Neurobiological similarities in depression and drug dependence: A self-medication hypothesis. Neuropsychopharmacology 18:135–174, 1998.

    Article  PubMed  Google Scholar 

  83. Schuckit, M. A. Alcohol and depression: A clinical perspective. Acta Psychiatrica Scandinavica 377:28–32, 1994.

    Article  PubMed  Google Scholar 

  84. Murphy, G. E., Wetzel, R. D., Robins, E., & McEvoy, L. Multiple risk factors predict suicide in alcoholism. Archives of General Psychiatry 49:459–463, 1992.

    Article  PubMed  Google Scholar 

  85. Wetterling, T., Veltrup, C., Driessen, M., & John, U. Drinking pattern and alcohol-related medical disorders. Alcohol & Alcoholism 34:330–336, 1999.

    Article  Google Scholar 

  86. Abel, E. L. Maternal alcohol consumption and spontaneous abortion. Alcohol & Alcoholism 32:211–219, 1997.

    Article  Google Scholar 

  87. Mattson, S. N., & Riley, E. P. A review of the neurobehavioral deficits in children with fetal alcohol syndrome or prenatal exposure to alcohol. Alcoholism: Clinical and Experimental Research 22:279–294, 1998.

    Article  Google Scholar 

  88. Day, N. L., Zuo, Y., Richardson, G. A., et al. Prenatal alcohol use and offspring size at 10 years of age. Alcoholism: Clinical and Experimental Research 23:863–869, 1999.

    Article  Google Scholar 

  89. Thomas, S. E., Kelly, S. J., Mattson, S. N., & Riley, E. P. Comparison of social abilities of children with fetal alcohol syndrome to those of children with similar IQ scores and normal controls. Alcoholism: Clinical and Experimental Research 22:528–533, 1998.

    Article  Google Scholar 

  90. Roebuck, T. M., Mattson, S. N., & Riley, E. P. Behavioral and psychosocial profiles of alcohol-exposed children. Alcoholism: Clinical and Experimental Research 23:1070–1076, 1999.

    Article  Google Scholar 

  91. Larroque, B., & Kaminski, M. Prenatal alcohol exposure and development at preschool age: Main results of a French study. Alcoholism: Clinical and Experimental Research 22:295–303, 1998.

    Article  Google Scholar 

  92. Church, M. W., & Kaltenbach, J. A. Hearing, speech, language, and vestibular disorders in the fetal alcohol syndrome: A literature review. Alcoholism: Clinical and Experimental Research 21:495–512, 1997.

    Google Scholar 

  93. Church, M. W., Eldis, F., Blakley, B. W., & Bawle, E. V. Hearing, language, speech, vestibular, and dentofacial disorders in fetal alcohol syndrome. Alcoholism: Clinical and Experimental Research 21:237–277, 1997.

    Google Scholar 

  94. Goldschmidt, L., Richardson, G. A., Stoffer, D. S., et al. Prenatal alcohol exposure and academic achievement at age six: A nonlinear fit. Alcoholism: Clinical and Experimental Research 20:763–770, 1996.

    Article  Google Scholar 

  95. Yates, W. R., Cadoret, R. J., Troughton, E. P., et al. Effect of fetal alcohol exposure on adult symptoms of nicotine, alcohol, and drug dependence. Alcoholism: Clinical and Experimental Research 22:914–920, 1998.

    Article  Google Scholar 

  96. Famy, C., Streissguth, A. P., & Unis, A. S. Mental illness in adults with fetal alcohol syndrome. American Journal of Psychiatry 155:552–554, 1998.

    PubMed  Google Scholar 

  97. Kaufman, M. H. The teratogenic effects of alcohol following exposure during pregnancy, and its influence on the chromosome constitution of the pre-ovulatory egg. Alcohol & Alcoholism 32:113–128, 1997.

    Article  Google Scholar 

  98. Mennella, J. A., & Beauchamp, G. K. The transfer of alcohol to human milk. New England Journal of Medicine 325:981–985, 1991.

    Article  PubMed  Google Scholar 

  99. Abel, E. L., & Sokol, R. J. A revised conservative estimate of the incidence of FAS and its economic impact. Alcoholism: Clinical and Experimental Research 15:514–524, 1991.

    Article  Google Scholar 

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Schuckit, M.A. (2000). Alcoholism: Acute Treatment. In: Drug and Alcohol Abuse. Critical Issues in Psychiatry. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-3232-0_4

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