Glues, Inhalants, and Aerosols

  • Marc A. Schuckit
Part of the Critical Issues in Psychiatry book series (CIPS)


This short chapter describes a heterogeneous group of industrial substances that share the ability to produce generalized CNS depression and signs of confusion through disturbances in physiological functioning within neurons.1–4 Although labeled as glues, solvents, and aerosols in prior editions of this text, in deference to the DSM-IV system, this update uses the more generic term of inhalants,5 reflecting the ability of these substances to be administered through inhalation via the lungs. Some other drugs are also inhaled, including tobacco and several agents discussed with the hallucinogens (e. g., amyl and butyl nitrite and nitrous oxide), but the clinical and biological effects of these other drugs make it more appropriate that they be discussed in chapters 8 and 12.


Alcohol Dependence Hippuric Acid Renal Tubular Acidosis Methyl Chloride Ethyl Chloride 
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  1. 1.
    Crowley, T. J. Inhalant-related disorders. In H. I. Kaplan & B. J. Sadock (Eds.), Comprehensive textbook of psychiatry (6th ed.). Baltimore, MD: Williams & Wilkins, 1995, pp. 838–842.Google Scholar
  2. 2.
    Klaassen, C. D. Nonmetallic environmental toxicants. In J. G. Hardman, L. E. Limbird, P. B. Molinoff, et al. (Eds.), The pharmacological basis of therapeutics (9th ed.). New York: McGraw-Hill, 1995, pp. 1673–1684.Google Scholar
  3. 3.
    Sharp, C. W., & Rosenberg, N. L. Inhalants. In J. H. Lowinson, P. Ruiz, R. B. Millman, & J. G. Langrod (Eds.), Substance abuse: A comprehensive textbook (3rd ed.). Baltimore, MD: Williams & Wilkins, 1996, pp. 246–264.Google Scholar
  4. 4.
    Giannini, A. J. The volatile agents. In N. S. Miller (Ed.), Comprehensive handbook of drug and alcohol addiction. New York: Marcel Dekker, 1991, pp. 125–130.Google Scholar
  5. 5.
    American Psychiatric Association. The diagnostic and statistical manual of mental diseases (4th ed.). Washington, DC: American Psychiatric Press, 1994.Google Scholar
  6. 6.
    Dinwiddie, S. The pharmacology of inhalants. In A. W. Graham, T. K. Schultz, & B. B. Wilford (Eds.), Principles of addiction medicine (2nd ed.). Chevy Chase, MD: American Society of Addiction Medicine, 1998, pp. 187–193.Google Scholar
  7. 7.
    Balster, R. L., Bowen, S. E., Evans, E. B., & Tokarz, M. E. Evaluation of the acute behavioral effects and abuse potential of a C8-C9 isoparaffin solvent. Drug and Alcohol Dependence 46:125–135, 1997.PubMedCrossRefGoogle Scholar
  8. 8.
    Richardson, H. Volatile substance abuse: Evaluation and treatment. Human Toxicology 8:319–322, 1989.PubMedCrossRefGoogle Scholar
  9. 9.
    O’Brien, C. P. Drug addiction and drug abuse. In J. G. Hardman, L. E. Limbird, P. B. Molinoff, et al. (Eds.), The pharmacological basis of therapeutics (9th ed.). New York: McGraw-Hill, 1995, pp. 557–577.Google Scholar
  10. 10.
    Balster, R. L. Neural basis of inhalant abuse. Drug and Alcohol Dependence 51:207–214, 1998.PubMedCrossRefGoogle Scholar
  11. 11.
    Riegel, A. C., & French, E. D. Acute toluene induces biphasic changes in rat spontaneous locomotor activity which are blocked by remoxipride. Pharmacology, Biochemistry and behavior 62:399–402, 1999.CrossRefGoogle Scholar
  12. 12.
    Dinwiddie, S. H. Volatile substances. In H. Rommelspocher & M. Schuckit (Eds.), Bailliere’s clinical psychiatry: Drugs of abuse. London: Bailliere Tindall, 1996, pp. 501–517.Google Scholar
  13. 13.
    Esmail, A., Warburton, B., Bland, J. M., Anderson, H. R., & Ramsey, J. Regional variations in deaths from volatile solvent abuse in Great Britain. Addiction 97:1765–1771, 1997.CrossRefGoogle Scholar
  14. 14.
    Brady, M. Heavy metal: The social meaning of petrol sniffing in Australia. Canberra: Aboriginal Studies Press, 1992.Google Scholar
  15. 15.
    Zebrowski, P. L., & Gregory, R. J. Inhalant use patterns among Eskimo school children in western Alaska. Journal of Addictive Diseases 15:67–77, 1996.PubMedCrossRefGoogle Scholar
  16. 16.
    Howard, M. O., & Jenson, J. M. Inhalant use among antisocial youth: prevalence and correlates. Addictive Behaviors 24:59–74, 1999.PubMedCrossRefGoogle Scholar
  17. 17.
    Substance Abuse and Mental Health Services Administration, Office of Applied Studies. National Household Survey on drug abuse: Population estimates 1997. Rockville, MD: U.S. Department of Health and Human Services, 1998.Google Scholar
  18. 18.
    Johnston, L. D., O’Malley, P. M., & Bachman, J. G. National survey results on drug use from the Monitoring the Future Study, 1975–1997, Vol. I, Secondary School Students. Rockville, MD: National Institute on Drug Abuse, U.S. Department of Health and Human Services, 1998.Google Scholar
  19. 19.
    Mora, M. E., Villatoro, J., & Rojas, E. Drug use among students in Mexico’s northern border states. In Department of Health and Human Services, Epidemiologic trends in drug abuse. Washington, DC: U.S. Government Printing Office, 1996, pp. 367–375.Google Scholar
  20. 20.
    Royo-Bordonada, M. A., Cid-Ruzafa, J., Martin-Morena, J. M., & Guallar, E. Drug and alcohol use in Spain: Consumption habits, attitudes and opinions. Public Health 111:277–284, 1997.PubMedGoogle Scholar
  21. 21.
    Howard, M. O., Walker, R. D., Silk Walker, P., et al. Inhalant use among urban Anerican Indian youth. Addiction 94:83–95, 1999.PubMedCrossRefGoogle Scholar
  22. 22.
    Forster, L. M., Tannhauser, M., & Barros, H. M. Drug use among street children in southern Brazil. Drug and Alcohol Dependence 43:57–62, 1996.PubMedCrossRefGoogle Scholar
  23. 23.
    Lerner, R., & Ferrando, D. Inhalants in Peru. NIDA Research Monograph 148:191–204, 1995.PubMedGoogle Scholar
  24. 24.
    Mackesy-Amiti, M. E., & Fendrich, M. Inhalant use and delinquent behavior among adolescents: a comparison of inhalant users and other drug users. Addiction 94:555–564, 1999.PubMedCrossRefGoogle Scholar
  25. 25.
    Taylor, J. C., Norman, C. L., Bland, J. M., Ramsey, J. D., & Anderson, A. R. Trends in deaths associated with abuse of volatile substances 1971–1995. (10th annual report) London: St George’s Hospital, 1997.Google Scholar
  26. 26.
    Bowen, S. E., Daniel, J., & Balster, R. L. Deaths associatd with inhalant abuse in Virginia from 1987 to 1996. Drug and Alcohol Dependence 53:239–245, 1999.PubMedCrossRefGoogle Scholar
  27. 27.
    Spiller, H. A., & Krenzelok, E. P. Epidemiology of inhalant abuse reported to two regional poison centers. Journal of Toxicology 35:167–173, 1997.PubMedGoogle Scholar
  28. 28.
    Johns, A. Volatile solvent abuse and 963 deaths. British Journal of Addiction 86:1053–1056, 1991.PubMedCrossRefGoogle Scholar
  29. 29.
    Miyashita, H., Saito, T., Sasaki, et al. A case of volatile solvents psychosis accompanied with multiple neurological and psychological symptoms. Japanese Journal of Alcohol and Drug Dependence 31:146–154, 1996.Google Scholar
  30. 30.
    Hernandez-Avila, C. A., Ortega-Soto, H. A., Jasso, A., et al. Treatment of inhalant-induced psychotic disorder with carbamazepine versus haloperidol. Psychiatric Services 49:812–815, 1998.PubMedGoogle Scholar
  31. 31.
    Chadwick, O., Anderson, R., Bland, M., & Ramsey, J. Neuropsychological consequences of volatile substance abuse: A population-based study of secondary school pupils. British Medical Journal 298:1679–1684, 1989.PubMedCrossRefGoogle Scholar
  32. 32.
    Yamanouchi, N., Okada, S., Kodama, K., et al. Effects of MRI abnormalities on WAIS-R performance in solvent abusers. Acta Neurologica Scandinavica 96:34–39, 1997.PubMedCrossRefGoogle Scholar
  33. 33.
    Yamanouchi, N., Okada, S., Kodama, K., et al. White matter changes caused by chronic solvent abuse. American Journal of Neuroradiology 16:1643–1649, 1995.PubMedGoogle Scholar
  34. 34.
    Goodwin, D. W., & Guze, S. B., Psychiatric diagnosis (5th ed.). New York: Oxford University Press, 1996.Google Scholar
  35. 35.
    Dinwiddie, S. H., Reich, T., & Cloninger, C. R. Solvent use and psychiatric comorbidity. British Journal of Addiction 85:1647–1656, 1990.PubMedCrossRefGoogle Scholar
  36. 36.
    Dinwiddie, S. H., Zorumski, C. F., & Rubin, E. H. Psychiatric correlates of chronic solvent abuse. Journal of Clinical Psychiatry 48:334–337, 1987.PubMedGoogle Scholar
  37. 37.
    Hersh, R. Abuse of ethyl chloride. American Journal of Psychiatry 148:270–271, 1991.PubMedGoogle Scholar
  38. 38.
    Meadows, R., & Verghese, A. Medical complications of glue sniffing. Southern Medical Journal 89:455–462, 1996.PubMedCrossRefGoogle Scholar
  39. 39.
    Erramouspe, J., Galvez, R., & Fischel, D. R. Newborn renal tubular acidosis associated with prenatal maternal toluene sniffing. Journal of Psychoactive Drugs 28:201–204, 1996.PubMedCrossRefGoogle Scholar
  40. 40.
    Schikler, K. N., Lane, E. E., Seitz, K., & Colins, W. M. Solvent abuse associated with pulmonary abnormalities. Advances in Alcohol and Substance Abuse 3:75–81, 1984.PubMedCrossRefGoogle Scholar
  41. 41.
    Tenebein, M., de Groot, W., & Rajani, K. R. Peripheral neuropathy following intentional inhalation of naphtha fumes. Canadian Medical Association Journal 131:1077–1079, 1984.Google Scholar
  42. 42.
    Gospe, S. M., Jr., Zhou, S. S. Toluene abuse embryopathy: longitudinal neurodevelopmental effects of prenatal exposure to toluene in rats. Reproductive Toxicology 12:119–126, 1998.PubMedCrossRefGoogle Scholar
  43. 43.
    Jones, H. E., & Balster, R. L. Inhalant abuse in pregnancy. Obstetrics and Gynecology Clinics of North America 25:153–167, 1998.PubMedCrossRefGoogle Scholar
  44. 44.
    Schwartz, B. S., Ford, D. P., Bolla, K. L., et al. Solvent-associated olfactory dysfunction: Not a predictor of deficits in learning and memory. American Journal of Psychiatry 148:751–756, 1991.PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2000

Authors and Affiliations

  • Marc A. Schuckit
    • 1
  1. 1.University of California Medical School and Veterans Affairs San Diego Healthcare SystemSan DiegoUSA

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