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The Role of Micronutrients in DNA Synthesis and Maintenance

  • Robert A. Jacob
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 472)

Abstract

Recent research has indicated that the micronutrients, folate, niacin, and vitamin C may be important for various aspects of DNA and chromosome integrity. Folate is an essential cofactor for biosynthesis of deoxynucleotides and DNA methylation reactions. Niacin provides ADP-ribose units for proteins which are involved in DNA replication and repair. Vitamin C, a primary intracellular antioxidant, may provide protection against oxidative DNA base damage. Evidence for the importance of these micronutrients in DNA synthesis and repair is reviewed. The evidence is substantial for some of these nutrients and merely suggestive, even controversial, for others.

Keywords

Folate Deficiency Folate Depletion Thymine Glycol Uracil Misincorporation Lymphocyte Micronucleus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1999

Authors and Affiliations

  • Robert A. Jacob
    • 1
  1. 1.Western Human Nutrition Research Center U.S. Department of Agriculture Agricultural Research ServiceUniversity of CaliforniaDavisUSA

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