In the previous chapter it was pointed out that biological cells are enclosed by a plasma membrane. This membrane consists of a lipid bilayer and, as seen in Fig. 3.1, the hydrophilic polar heads are oriented facing the intracellular and extracellular water-containing media while the hydrophobic tails, on the other hand, are internal to the membrane. The biophysical consequence of the lipid is a membrane with the high dielectric constant of oil and the high resistivity of that material. We have noted a membrane capacitance of C m = 1 μf/cm2; the lipid membrane specific resistance is 109 Ω cm2.
KeywordsPotassium Channel Open Channel Patch Clamp Closed Channel Excitable Membrane
Unable to display preview. Download preview PDF.
- 1.B. Hille, Ion Channels of Excitable Membranes, 2nd edn., Sinauer Associates, Sunderland, MA, 1992.Google Scholar
- 2.L. J. De Felice, Electrical Properties of Cells, Plenum Press, New York, 1997.Google Scholar
- 3.B. Sakmann and E. Neher, eds., Single Channel Recording, 2nd edn., Plenum Press, New York, 1995.Google Scholar
- 4.H. Lodish, J. E Darnell, and J, Edwin, Molecular Cell Biology, 3rd edn., Scientific American Books, New York, 1995.Google Scholar