Subclinical Saccadic Adduction Slowing in Patients with Monosymptomatic Unilateral Optic Neuritis Predicts the Development of Multiple Sclerosis
Many patients with acute unilateral optic neuritis (ON) develop later multiple sclerosis (MS), the risk varying widely between 35% and 75% (McDonald 1983). Many MS and ON patients are subject to abnormalities of eye movements (Reulen et al 1983). Saccadic disturbances are the commonest among them, which in many cases cannot easily be detected clinically (Meienberg et al 1986). Using electro-oculography, it was concluded that the ratio of abduction vs. adduction peak velocities represents a sensitive index of subclinical abnormality (Ventre et al 1991). However, the pathological significance of subtle abnormalities revealed by quantitative testing of eye movements remains unclear.
KeywordsMultiple Sclerosis Peak Velocity Optic Neuritis Multiple Scle Lower Normal Limit
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