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Ocular Motor Disorders Associated with Inborn Chiasmal Crossing Defects

Multi-Planar Eye Movement Recordings in See-Saw and Congenital Nystagmus
  • P. Apkarian
  • L. J. Bour
  • J. van der Steen
  • H. Collewijn
Chapter

Abstract

The present study briefly reviews the accompanying ocular motor function and dysfunction in two major inborn conditions of naturally occurring aberrant optic pathway projections, i.e., albinism and non-decussating retinal-fugal fibre syndrome (Apkarian et al. 1994; 1995; Apkarian 1996). The latter is a rare, isolated achiasmatic condition in which nasal retinal projections and concomitant visuotopic and retinotopic mapping misroute due to the inborn and isolated absence of the optic chiasm. The achiasmatic ocular motor profile is compared with that of albinos who also present with optic pathway misrouting but in opposite form from that of the achiasmatic condition. In albinism there is a preponderance of erroneously decussating temporal retinal-fugal fibres whilst in achiasmatic syndrome there is a complete absence of decussating nasal retinal-fugal fibres. The simplified sketches of Figure 1, adapted from Polyak (1957), emphasize the normal organisation of retinal-fugal projections compared to the relative majority of contralateral projections pathognomonic to albinism and the nonextant contralateral projections characteristic of the achiasmatic condition.

Keywords

Visual Pathway Target Fixation Ocular Motor Torsional Component Oculocutaneous Albinism 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Abadi RV, Pascal E (1995) Eye movement behaviour in human albinos. In: Findlay JM, Walker R, Kentridge RW (eds) Eye Movement Research. Mechanisms, Processes and Applications. Elsevier, Amsterdam, pp 255–268CrossRefGoogle Scholar
  2. Abel LA (1989) Ocular oscillations. Congenital and acquired. Bull Soc Belge Ophtalmol 237: 163–189PubMedGoogle Scholar
  3. Alvord EC Jr, Lofton S (1988) Gliomas of the optic nerve or chiasm. J Neurosurg 68: 85–98PubMedCrossRefGoogle Scholar
  4. Apkarian P (1996) Chiasmal crossing defects in disorders of binocular vision. Eye 10: 222–232PubMedCrossRefGoogle Scholar
  5. Apkarian P, Bour L, Barth PG (1994) A unique achiasmatic anomaly detected in non-albinos with misrouted reti-nal-fugal projections. Eur J Neurosci 6: 501–507PubMedCrossRefGoogle Scholar
  6. Apkarian P, Bour LJ, Barth PG, Wenniger-Prick L, Verbeeten B. Jr (1995) Non-decussating retinal-fugal fibre syndrome. An inborn achiasmatic malformation associated with visuotopic misrouting, visual evoked potential ipsilateral asymmetry and nystagmus. Brain 118: 1195–1216PubMedCrossRefGoogle Scholar
  7. Apkarian P, Bour LJ, van der Steen J, de Faber JTHN (1996) Chiasmal crossing defects in disorders of ocular motor function: three dimensional eye movement recordings in albinism and non-decussating retinal fugal fibre syndrome. Invest Ophthalmol Vis Sci 37 (suppl.): 228Google Scholar
  8. Apkarian P, Shallo-Hoffmann J (1991) VEP projections in congenital nystagmus; VEP asymmetry in albinism: a comparison study. Invest Ophthalmol Vis Sci 32: 2653–2661PubMedGoogle Scholar
  9. Apkarian P, Spekreijse H, Collewijn H (1983) Oculomotor behavior in human albinos. Doc Ophthalmol 37: 361–372Google Scholar
  10. Bataini JP, Delanian S, Ponvert D (1991) Chiasmal gliomas: results of irradiation management in 57 patients and review of literature. Int J Radiation Oncology Biol Phys 21: 615–623CrossRefGoogle Scholar
  11. Bedell HE, White JM, Abplanalp PL (1989) Variability of foveations in congenital nystagmus. Clinical Vision Sci 4: 247–252Google Scholar
  12. Bergin DJ, Halpern J (1986) Congenital see-saw nystagmus associated with retinitis pigmentosa. Ann Ophthalmol 18:346–349PubMedGoogle Scholar
  13. Chung STL, Bedell HE (1996) Velocity criteria for “foveation periods” determined from image motions simulating congenital nystagmus. Optometry & Vision Sci 73: 92–103CrossRefGoogle Scholar
  14. Collewijn H, Apkarian P, Spekreijse H (1985) The oculomotor behaviour of human albinos. Brain 108: 1–28PubMedCrossRefGoogle Scholar
  15. Crawford JD, Cadera W, Vilis T (1991) Generation of torsional and vertical eye position signals by the interstitial nucleus of Cajal. Science 252: 1551–1553PubMedCrossRefGoogle Scholar
  16. Daroff RB (1965) See-saw nystagmus. Neurology 15: 874–877PubMedCrossRefGoogle Scholar
  17. Daroff RB, Troost BT, Dell’Osso LF (1978) Nystagmus and related ocular oscillations. In: Glaser JS (ed) Neurophthalmology. Harper and Row, Hagerstown, pp 219–240.Google Scholar
  18. Druckman R, Ellis P, Kleinfeld J, Waldman M (1966) Seesaw nystagmus. Arch Ophthalmol 76: 668–675PubMedCrossRefGoogle Scholar
  19. Dutton JJ (1994) Gliomas of the anterior visual pathway. Survey of Ophthalmol 38: 427–452CrossRefGoogle Scholar
  20. Elekessy EI, Campion JE, Henry GH (1973) Differences between the visual fields of Siamese and common cats. Vision Res 13: 2533–2543PubMedCrossRefGoogle Scholar
  21. Ferman L, Collewijn H, Jansen TC, van den Berg AV (1987) Human gaze stability in the horizontal, vertical and torsional direction during voluntary head movements, evaluated with a three-dimensional scleral induction coil technique. Vision Res 27: 811–828PubMedCrossRefGoogle Scholar
  22. Fisher NF, Jampolsky A, Scott AB (1968) Traumatic bitemporal hemianopsia. Part I. Diagnosis of macular splitting. Amer J Ophthalmol 65: 237–242Google Scholar
  23. Guillery RW (1990) Normal and abnormal visual field maps in albinos: central effects of non-matching maps. Ophthalmic Paediat & Genetics 3: 177–183CrossRefGoogle Scholar
  24. Guillery RW (1996) Why do albinos and other hypopigmented mutants lack normal binocular vision, and what else is abnormal in their central visual pathways? Eye 10: 217–221PubMedCrossRefGoogle Scholar
  25. Guillery RW, Casagrande VA (1977) Studies of the modifiability of the visual pathways in Midwestern Siamese cats. J. Comp Neurol 174: 15–46PubMedCrossRefGoogle Scholar
  26. Halmagyi GM, Aw ST, Dehaene I, Curthoys IS, Todd MJ (1994) Jerk-waveform see-saw nystagmus due to unilat eral meso-diencephalic lesion. Brain 117: 789–803PubMedCrossRefGoogle Scholar
  27. Haustein W (1989) Considerations on Listing’s law and the primary position by means of a matrix description of eye position control. Biol. Cybern 60: 411–420PubMedCrossRefGoogle Scholar
  28. Hess BJM, van Opstal AJ, Straumann D, Hepp K (1992) Calibration of three-dimensional eye position using search coil signals in rhesus monkey. Vision Res 32: 1647–1654PubMedCrossRefGoogle Scholar
  29. Iraci G, Gerosa M, Tomazzoli L, Pardatscher K, Fiore DL, Javicoli R, Secchi AG (1981) Gliomas of the optic nerve and chiasm. A clinical review. Child’s Brain 8: 326–349PubMedGoogle Scholar
  30. Leigh RJ, Zee DS (1991) The Neurology of Eye Movements. Edition 2. FA Davis Co, PhiladelphiaGoogle Scholar
  31. MacCarty CS, Boyd AS Jr, Childs DS Jr (1970) Tumors of the optic nerve and optic chiasm. J. Neurosurg 33: 439–444PubMedCrossRefGoogle Scholar
  32. Maddox EE (1914) See-saw nystagmus with bitemporal hemianopia. Proc Royal Soc Med 7: 12–13Google Scholar
  33. Nakada T, Kwee IL (1992) Role of visuo-vestibular interaction in pathological ocular oscillation: new model and control system analysis. Medical Hypotheses 38: 261–269PubMedCrossRefGoogle Scholar
  34. Optican LM, Zee DS (1984) A hypothetical explanation of congenital nystagmus. Biol Cybern 50: 119–134PubMedCrossRefGoogle Scholar
  35. Polyak S (1957) The vertebrate visual system. University of Chicago Press, ChicagoGoogle Scholar
  36. Robinson DA (1963) A method of measuring eye movement using a scleral search coil in a magnetic field. IEEE Transactions on Biomedical Electronics BME-10: 137–145Google Scholar
  37. Samkoff LM, Smith CR (1994) See-saw nystagmus in a patient with clinically definite MS. Eur Neurol 34: 228–229PubMedCrossRefGoogle Scholar
  38. Schmidt D, Kommerell G (1974) Congenitaler Schaukelnystagmus (Seesaw Nystagmus). Graefes Archs Klin Exp Ophthal 191:265–272CrossRefGoogle Scholar
  39. Traquair HM, Dott NM, Russell WR (1935) Traumatic lesions of the optic chiasma. Brain 58: 398–411CrossRefGoogle Scholar
  40. Tweed, D, Cadera W, Vilis T (1990) Computing three-dimensional eye position quaternions and eye velocity from search coil signals. Vision Res 30: 97–110PubMedCrossRefGoogle Scholar
  41. Yee RD, Wong EK, Baloh RW, Honrubia V (1976) A study of congenital nystagmus: waveforms. Neurology 26: 326–333PubMedCrossRefGoogle Scholar
  42. Zauberman H, Magora A (1969) Congenital “see-saw” movement. A rare anomaly of ocular motility. Br J Ophthal 53:418–421CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1999

Authors and Affiliations

  • P. Apkarian
    • 1
  • L. J. Bour
    • 2
  • J. van der Steen
    • 1
  • H. Collewijn
    • 1
  1. 1.Department of Physiology, Faculty of Medicine and Health Sciences ErasmusUniversity RotterdamRotterdamThe Netherlands
  2. 2.Department of Neurology, Clinical NeurophysiologyAcademic Medical CentreAmsterdamThe Netherlands

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