The degree of ischemic injury depends not only on the intensity and duration of the ischemic stimulus but also on the level of cardiac tolerance to oxygen deprivation (Fig. 25). It is, therefore, not surprising that the interest of many experimental and clinical cardiologists during the past 35 years has been focused on the question of how cardiac tolerance to oxygen deprivation might be increased. The relatively short history of this endeavour represents a good example of the mutual inspiration and collaboration between experimental and clinical cardiologists.
KeywordsInfarct Size Ischemic Precondition Cardioprotective Effect Chronic Hypoxia Oxygen Deprivation
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