Irreversible Myocardial Ischemic Injury
Ischemia has many detrimental effects on the heart. Atherosclerosis, spasm of the epicardial or intramural branches of the coronary circulation, and alterations of the capillary network in an independent or combined fashion create varying degrees of ischemic injury. Its extent depends on the severity and duration of flow deprivation; ischemia will initiate a sequence of progressively more severe events which, unless halted by reperfusion, will eventually culminate in irreversible injury and cell death. The resulting clinical spectrum ranges from acute myocardial infarction to a chronic ischemic cardiomyopathy that develops years after the initial segmental loss of functional tissue (Anversa and Sonnenblick, 1990).
KeywordsInfarct Size Calcium Antagonist Cardiac Hypertrophy Ischemic Injury Calcium Overload
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