Epstein-Barr Virus Infection and Infectious Mononucleosis
First detected in African Burkitt’s lymphoma cells in 1964,1 the Epstein-Barr virus (EBV) was identified as the cause of infectious mononucleosis (IM) in 19682 when a laboratory worker developed antibodies to the virus during an episode of IM. Large-scale seroepidemiologic studies subsequently confirmed the role of EBV in IM. EBV has also been implicated as an etiologic factor in undifferentiated nasopharyngeal carcinoma, B cell lymphomas in immunocompromised individuals, and oral hairy leukoplakia.
KeywordsInfectious Mononucleosis Cold Agglutinin Slide Test Viral Capsid Antigen Heterophile Antibody
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- 6.Hoagland RJ. Clinical manifestations. In: Infectious mononucleosis. Orlando, FL: Grune & Stratton, 1967:52–60.Google Scholar
- 8.Hoagland RJ. General features of infectious mononucleosis. In: Glade PR, editor. Infectious mononucleosis. Philadelphia: Lippincott, 1973:3–4.Google Scholar