Ulcerative Colitis

Abstract

Ulcerative colitis is initially treated non-surgically and most patients respond favorably. A variety of medications are used including steroids, anti-inflammatory drugs, and immunosuppressive medications. Bowel rest and hyperalimentation are occasionally needed for patients presenting with an acute exacerbation. Steroids are used primarily to control acute flare-ups and once the disease has been brought under control, every attempt should be made to gradually wean the steroids. There is no benefit in long-term steroid therapy. In contrast, anti-inflammatory medications such as sulfasalazine or the aminosalicylate preparations can be used for long-term therapy to keep the disease in remission. Immunosuppressive medications include azathioprim, 6-mercaptopurine, and cyclosporin, and their main benefit comes from their ability to lower the dose of prednisone needed to control the disease.