Pancreatic Endocrine Tumors

  • James Zasuly


Pancreatic endocrine tumors are derived from amine precursor uptake and decarboxylation (APUD) cells found within the islet cells of the pancreas. These tumors are rare, incidences range from one case per one million to one case per twenty million persons per year. These tumors include glucagonoma, VIPoma (Verner-Morrison syndrome), somatostatinoma, pancreatic polypeptidoma, insulinoma and gastrinoma; the latter two are discussed in separate chapters. In general, tumors producing primarily entopic (normally produced by that cell) hormones carry a lower malignancy rate (10–15%) than those excreting ectopic (normally produced elsewhere) hormones (60–90%) and all have a variable association with MEN-I (10–50%).


Anemia Diarrhea Glucagon Atropine Octreotide 


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© Springer Science+Business Media New York 1998

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  • James Zasuly

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