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The Molecular Mechanism of Interaction of H2O2 with Metmyoglobin

  • Dimitrios Galaris
  • Stelianos Kokkoris
  • Ioannis Toumpoulis
  • Panagiotis Korantzopoulos
Chapter
Part of the NATO ASI Series book series (NSSA, volume 296)

Abstract

Slight changes in the intacellular redox equilibrium is a physiological situation utilized by nature to regulate many important cell functions (Sundaresan et al., 1995). However, when the level of the oxidizing substances produced exceeds a certain threshold it becomes deleterious for the cells (Halliwell and Gutteridge, 1989). The main source of oxidizing agents is the monovalent reduction of oxygen to superoxide anion and the subsequent formation of reactive oxygen intermediates (ROI) (Figure 1).

Keywords

Ascorbic Acid Electron Spin Resonance Peroxyl Radical Reactive Oxygen Intermediate Oxidizable Amino Acid 
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Copyright information

© Springer Science+Business Media New York 1998

Authors and Affiliations

  • Dimitrios Galaris
    • 1
  • Stelianos Kokkoris
    • 1
  • Ioannis Toumpoulis
    • 1
  • Panagiotis Korantzopoulos
    • 1
  1. 1.Laboratory of Biological ChemistryUniversity of Ioannina Medical SchoolIoanninaGreece

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