Apolipoprotein E Oxidation Through Enzymes Localized into the Brain
The cerebral tissue is highly susceptible to oxidative damage as it essentially contains lipids and proteins, which are potential targets for free radicals. Oxidation of proteins results as an increase of carbonyl groups through the formation of aldehydes and ketones (Stadtman and Oliver, 1991) and accumulation of oxidized proteins has been observed in Alzheimer’s disease (AD) brains (Smith et al., 1991).
KeywordsMethionine Residue Cerebral Microvessels HPLC Elution Profile Cyanogen Bromide Cleavage High Apparent Molecular Weight
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