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Potential Effects of Dietary Vitamin E in Laboratory Animal Diets on Results Obtained in Models of Disease

  • Hans-Anton Lehr
  • Peter Vajkoczy
  • Michael D. Menger
Chapter
Part of the NATO ASI Series book series (NSSA, volume 296)

Abstract

This chapter will demonstrate the importance of vitamin E dietary supplements on cell functions, on different biomedical systems, and on diverse pathophysiological conditions, with special emphasis being placed on cardiovascular pathophysiology. These effects are presented as a rationale for the use of vitamin E supplements in diets of farm animals, pets, and also of laboratory animals. The latter point gives reason for considerable problems, which are discussed in the last chapter of this article.

Keywords

Intermittent Claudication Dietary Vitamin Animal Diet Microvascular Network Microvascular Endothelium 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Abadie, C., Ben Baouali, A., Maupoil, V., and Rochette, L., 1993, An alpha-tocopherol analogue with antioxidant activity improves myocardial function during ischemia reperfusion in isolated working rat hearts, Free Radic. Biol. Med. 15: 209–215.CrossRefGoogle Scholar
  2. Amatuni, V.G., Matevosian, R. S., Sisakian, S. A., and Arakelian, I. G., 1989, The effect of alphatocopherol and intal on heart capillary bed and lipid peroxide oxidation in experimental necrosis of the rat myocardium, Cor Vasa 31: 500–507.Google Scholar
  3. Andersson-T. L., Matz, J., Ferns, G. A., and Anggard, F. F., 1994, Vitamin E reverses cholesterol-induced endothelial dysfunction in the rabbit coronary circulation, Atherosclerosis 111: 39–45.Google Scholar
  4. Arnold, R. N., Arp, S. C., Scheller, K. K., Williams, S. N., and Schaefer, D. M., 1993, Tissue equilibration and subcellular distribution of vitamin E relative to myoglobin and lipid oxidation in displayed beef, J. Anim. Sci. 71: 105–118.Google Scholar
  5. Arnold, R. N., Scheller, K. K., Arp, S. C., Williams, S. N., Buege, D.R., Schaefer, D. M., 1992, Effect of long or short term feeding of a-tocopherol acetate to Holstein and crossbred beef steers on performance, carcass characteristics and beef color stability, J. Anim. Sci. 70: 3055–3065Google Scholar
  6. Asadian, A., Mezes, M., and Mirhadi, S. A., 1996, Effect of vitamins A and E on blood plasma vitamin status and daily body mass gain of different fat-tailed sheep breeds, Acta. Vet. Hung. 44: 99–109.Google Scholar
  7. Asghar, A., Gray, J. A., Booren, A. M., Gomaa, E. A., Abouzied, M. M., and Miller, E. F., 1991, Effect of supranutritional dietary vitamin E levels on subcellular deposition of alpha-tocopherol in the muscle and on pork quality, J. Sci. Food. Agric. 57: 31–41.CrossRefGoogle Scholar
  8. Augustin, C., and Freudenreich, P., 1996, Vitamin E-Einsatz in der Rindermast. Mitteilungsblatt der BAFF Kulmbach 132: 149–155.Google Scholar
  9. Axford-Gately, R. A., and Wilson, G. J., 1993, Myocardial infarct size reduction by single high dose or repeated low dose vitamin E supplementataion in rabbits, Can. J. Cardiol. 9: 94–98.Google Scholar
  10. Axford-Gatley, R. A., and Wilson, G. J., 1991, Reduction of experimental myocardial infarct size by oral administration of alpha-tocopherol, Cardiovasc. Res. 25: 89–92.CrossRefGoogle Scholar
  11. Bai, S. C., and Gatli, D. M., 1993, Dietary vitamin E concentration and duration of feeding affect tissue atocopherol concentrations of channel catfish (ictalurus punctatus), Aquaculture 113: 129–35.CrossRefGoogle Scholar
  12. Balla, J., Belcher, J. D., Balla, G, Jacob, H. S., and Vercellotti, G. M., 1993, Oxidized low-density lipoproteins and endothelium: oral vitamin E supplementation prevents oxidized low-density lipoprotein-mediated vascular injury, Trans. Assoc. Am. Physicians. 106: 128–33.Google Scholar
  13. Bartov, I., and Bornstein, S., 1977, Stability of abdominal fat and meat of broilers:the interrelationship between the effects of dietary fat and vitamin E supplements, Brit. Poultry Sci. 18: 47–57.CrossRefGoogle Scholar
  14. Bartov, I., and Frigg, M., 1992, Effect of high concentrations of dietary vitamin E during various age periods on performance, plasma vitamin E and meat stability of broiler chicks at 7 weeks of age, Br. Poultry Sci. 33: 393–402.Google Scholar
  15. Bieri, J.G., and Fvarts, R. P., 1974, Vitamin E activity of gamma-tocopherol in the rat, chick and hamster, J. Nutr. 104: 850–857.Google Scholar
  16. Block, F. R.,1991, Hydrogen peroxide alters the physical state and function of the plasma membrane of pulmonary artery endothelial cells, J. Cell. Physiol. 146: 362–9.Google Scholar
  17. Blum, J. C., Tourraille, C., Salichon, M. R., Richard, F. H., and Frigg, M., 1992, Effect of dietary vitamin E supplies in broilers. 2. Male and female growth rate, viability, immune response, fat content and meat flavour variations during storage, Arch. Geflügelkunde 56: 37–42.Google Scholar
  18. Boggio, S. M., Hardy, R. W., Babbitt, J. K., and Brannon, F. L., 1985, The influence of dietary lipid source and alpha-tocopheryl acetate level on product quality of rainbow trout (Salmo gairdnei), Aquaculture 51: 13–24.CrossRefGoogle Scholar
  19. Boogaerts, M. A., Van de Broeck, J., Deckmyn, H., Roelant, C., Vermylen, J., and Verwilghen R. L., 1984, Protective effect of vitamin E on immune-triggered, granulocyte mediated endothelial injury, Thromb. Haemostas. 51: 89–92.Google Scholar
  20. Buckley, D. J., Morrissey, P. A., and Gray, J. I., 1995, Influence of dietary vitamin E on the oxidative stability and quality of pig meat, J. Anim. Sci. 73: 3122–30.Google Scholar
  21. Cannon, J. F., Morgan, J. B., Schmidt, G. R., Tatum, J. D., Sofos, J. N., Smith, G. C., Delmore, R. J., and Williams, S. N., 1996, Growth and fresh meat quality characteristics of pigs supplemented with Vitamin E, J. Amin. Sci. 74: 98–105.Google Scholar
  22. Cavarocchi, N. C., Fngland, M. D., O’Brien, J. F., Solis, F., Russo, P, Schaff, H. V., Orszulak, T. A., Pluth, J. R., Kaye, M. P., 1986, Superoxide generation during cardiopulmonary bypass: Is there a role for Vitamin E?, J. Surg. Res. 40: 519–527.CrossRefGoogle Scholar
  23. Chan, A. C., and Leith, M. K., 1981, Decreased prostacyclin synthesis in vitamin E-deficient rabbit aorta, Am. J. Clin. Nutr. 34: 2341–2347.Google Scholar
  24. Chan, A. C., Tran, K., Pyke, D. D., and Powell, W. S., 1989, Effects of dietary vitamin E on the biosynthesis of 5lipoxygenase products by rat polymorphonuclear leukocytes (PMNL), Biochem. Biophys. Acta 1005: 265–269.CrossRefGoogle Scholar
  25. Chen, H.W., Hendrich, S., and Cook, L. R., 1994, Vitamin E deficiency increases serum thromboxane A2, platelet arachidonate and lipid peroxidation in male Sprague-Dawley rats, Prostagladins. Leukot. Essent. Fatty. Acids. 51: 11–17.CrossRefGoogle Scholar
  26. Colnago, G. L., Jensen, L. S., and Long, P. L., 1984, Effect of selenium and vitamin E on the development of immunity to coccidiosis in chickens, Poultry Sci. 63: 1136CrossRefGoogle Scholar
  27. Cox, A. C., Rao, G. H., Gerrard, J. M., and White, J. G., 1980, The influence of vitamin E quinone on platelet structure, function, and biochemistry, Blood 55: 907–914.Google Scholar
  28. Davidge, S. T., Hubel, C. A., and McLaughlin, M. K., 1993, Cyclooxygenase-dependent vasoconstrictor alters vascular function in the vitamin E-deprived rat, Circ. Res. 73: 79–88.CrossRefGoogle Scholar
  29. de Lorgeril, M., Boissonnat, P., Salen, P., Monjaud, I., Monnez, C., Guidollet, J., Ferrera, R., Dureau, G., Ninet, J., and Renaud, S., 1994, The beneficial effect of dietary antioxidant supplementation on platelet aggregation and cylosporine treatment in heart transplant recipients, Trans. 58: 193–195.Google Scholar
  30. Defraigne, J. O., Pincemail, J., Detry, O., Franssen, C., Meurisse, M., and Limet, R., 1994, Preservation of cortical microcirculation after kidney ischemia-reperfusion: value of an iron chelator, Ann. Vase. Surg. 9: 227–228.Google Scholar
  31. Demirbas, A., Bozoklu, S., Ozdemir, A., Bilgin, N., and Haberal, M., 1993, Effect of alpha tocopherol on the prevention of reperfusion injury caused by free oxygen radicals in the canine kidney autotranspantation model, Transplant. Proc. 25: 2274Google Scholar
  32. Devaraj, S.,Li, D., and Jialal, I,. 1996, The effects of alpha tocopherol supplementation on monocyte function. Decreased lipid oxidation, interleukin 1 beta secretion, and monocyte adhesion to endothelium, J. Clin. Invest. 98: 756–63.CrossRefGoogle Scholar
  33. Dieber-Rotheneder, M., Puhl, H., Waeg, G., Striegl, G., and Fsterbauer, H., 1991, Effect of oral supplementation with D-alpha-tocopherol on the vitamin E content of human low density lipoproteins and resistance to oxidation, J. Lipid Res. 32: 1325–1332.Google Scholar
  34. Divers, T. J., Mohammed, H. O., Cummings, J. F., Valentine, B. A., De-Lahunta, A., Jackson, C. A., and Summers, B. A., 1994, Equine motor neuron disease: findings in 28 horses and proposal of a pathophysiological mechanism for the disease, Equine. Vet. J. 26: 409–15CrossRefGoogle Scholar
  35. Ellis, R. P., and Vorhies, M. W., 1976, Effect of supplemental dietary vitamin E on the serologic response of swine to an Escherichia coli bacterin, J. Am. Vet. Med. Assoc. 168: 231–232.Google Scholar
  36. Engibarian, A. A., and Agaian, K. A., 1989, Changes of the necrotic area and functional indices of the myocardial microcirculatory bed during the treatment of experimental myocardial infarct with nitroglycerin, alphatocopherol and sodium nucleinate, Patol. Fiziol. Eksp. Ter. 5: 24–26.Google Scholar
  37. Esterbauer, H., Gebicki, J., Puhl, H., and Jurgens, I., 1992, The role of lipid peroxidation and antioxidants in the oxidative modification of LDKL, Free Radic. Biol. Med. 13: 341–390.CrossRefGoogle Scholar
  38. Faruqi, R., Motte, C., and DiCorleto, P. 1994. Alpha tocopherol inhibits agonist-induced monocytic cell adhesion and protein kinase C activity in vascular smooth muscle cells. J. Clin. Invest. 94: 592–600.CrossRefGoogle Scholar
  39. Faustman, C., Cassens, R. G., Schaefer, D. M., Buege, D. R., Williams, S. N., and Scheller, K. K., 1989, Improvement of pigment and lipid stability in Holstein steer beef by dietary supplementation with vitamin E, J. Food. Sci. 54: 858–862.CrossRefGoogle Scholar
  40. Flachowsky, G., Richter, G. H., Wendemuth, H., Möckel, R, Graf, H., Jahreis, G., and Lubbe, F., 1994, Einfluss von Rapssamen in der Mastrinderernährung auf Fettsäurenmuster, Vitamin-E-Gehalt and oxidative Stabilität des Körperfettes, 7. Ernährungswiss. 33: 277–285.CrossRefGoogle Scholar
  41. Fox, R R., Trautwein, F. A., Hayes, K. C., Bond, B, R., Sisson, D. D., and Moise, N. S., 1993, Comparison of taurine, alpha-tocopherol, retinol, selenium, and total triglycerides and cholesterol concentrations in cats with cardiac disease and in healthy cats, Am. J. Vet. Res. 54: 563–9.Google Scholar
  42. Frigg, M., Buckley, D. J., Morrissey, R M., 1993, Influence of alpha tocopherol acetate supplementation on the susceptibility of chicken or pork tissues to lipid oxidation, Mh. Vet. Med. 48: 79–83.Google Scholar
  43. Frigg, M., Prabucki, A. L., and Ruhdel, F. U., 1990, Effect of dietary vitamin E levels on oxidative stability of trout fillets, Aquaculture 84: 145–158.CrossRefGoogle Scholar
  44. Fuhrmann, H., and Sallmann, H. R, 1995, The influence of dietary fatty acids and vitamin E on plasma prostanoids and liver microsomal alkane production in broiler chickens with regard to nutritional encephalomalacia, J. Nutt-. Sci. Vitaminol. Tokyo. 41: 553–61.Google Scholar
  45. Fujimoto, S., Mizoi, K., Yoshiumoto, T., and Suzuki, J., 1984, The protective effect of vitamin E on cerebral ischemia, Surg. Neurol. 22: 449–454.CrossRefGoogle Scholar
  46. Furones, M. D., Alderman, D. J., Bucke, D., Fletcher, T. C., Knox, D., and White, A., 1992, Dietary vitamin E and the response of rainbow trout, oncorhynchus mykiss (Walbaum), to infection with yersinia ruckeri, J. Fish. Biol. 41: 1037–41.CrossRefGoogle Scholar
  47. Galley, H.F., Richardson, N., Howdle, Walker, B.F., and Webster N.R., 1995, Total antioxidant capacity and lipid peroxidation during liver transplantation, Clin. Sci. 89: 329–331.Google Scholar
  48. Gatlin, D. M., Ill, Bai, S. C., and Frrickson, M. C:; 1992, Effects of dietary vitamin E and synthetic antioxidants on composition and storage quality of channel catfish, Icta lurus punctatus, Aquacualture 106: 323–332.Google Scholar
  49. Gauduel, Y., and Duvelleroy, M. A., 1984, Role of oxygen radicals in cardiac injury due to reoxygenation, J. Mol. Cell. Cardiol. 16: 459–470.CrossRefGoogle Scholar
  50. Gerster, H., 1993, Prevention of platelet dysfunction by vitamin E in diabetic atherosclerosis, Z. Ernährungswiss. 32: 243–261.CrossRefGoogle Scholar
  51. Gey, K. F., 1993, Prospects for the prevention of free radical disease, regarding cancer and cardiovascular disease, Br. Med. Bull. 49: 679–99.Google Scholar
  52. Giardino, I., Edelstein, D., and Brownlee, M., 1996, BCL-2 expression or antioxidants prevent hyperglycemia-induced formation of intracellular advanced glycation endproducts in bovine endothelial cells, J. Clin. Invest. 97: 1422–1428.CrossRefGoogle Scholar
  53. Gill, D. R., Smith, R. A., Hicks, R. B., and Ball, R. L., 1986, The effect of vitamin E supplementation on health and performance of newly arrived stocker cattle, Research Rep. MP-I 18, Stillwater. 10: 240–243.Google Scholar
  54. Gilligan, D. M., Sack, M. N., Guetta, V., Casino, P. R., Quyyumi, A. A., Rader, D. J., Panza, J. A., and CannonR.O. 3rd., 1994, Effect of antioxidant vitamins on low density lipoprotein oxidation and impaired endothelium-dependent vasodilation in patients with hypercholesterolemia, J. Am. Coll. Cardiol. 24: 1611–1617.CrossRefGoogle Scholar
  55. Giugliano, D., Marfella, R., Verrazzo, G., Acampora, R., Donzella, C., Quatraro, A., Coppola, L., and D’Onofrio, F., 1995, Abnormal rheologic effects of glyceryl trinitrate in patients with non-insulin-dependent diabetes mellitus and reversal by antioxidants, Ann. Intem. Med. 123: 338–43.CrossRefGoogle Scholar
  56. Goering, H. K., Gordon, C. H., Wrenn, T. R., Bitman, L., King, R. L., and Douglas, F. W., 1976, Effect of feeding protected safflower oil on yield, composition, flavor and oxidative stability of milk, J. Dairy. Sci. 59: 416–425.CrossRefGoogle Scholar
  57. Goode, H.F., Webster, N.R., Howdle, Leek, J.P., Lodge, J.P., Sadek, S.A., and Walker, B.F., 1994, Reperfusion injury, antioxidants and hemodynamics during orthotopic liver transplantation, Hepatology 19: 354–359CrossRefGoogle Scholar
  58. Haeger, K., 1973, Walking distance and arterial flow during long term treatment of intermittent claudication with d-alpha tocopherol, Vasa 2: 280–287.Google Scholar
  59. Haeger, K.,1982, Long term study of alpha tocopherol in intermittent claudication, Ann. N. Y. Acad. Sci. 393: 369–375.Google Scholar
  60. Hall, F. D., and Yonkers, P. A., 1989, Mechanisms of neuronal degeneration secondary to central nervous system trauma or ischemia, J. Neurotrauma 6: 227–228.CrossRefGoogle Scholar
  61. Halliwell, B., 1993, The role of oxygen radicals in human disease, with particular reference to the vascular system, Haemostasis 23: 118–126.Google Scholar
  62. Hamelin, St.- J. S., and Chan, A. C., 1983, A carrier-mediated transport for folate in basolateral membrane vesicles of rat small intestine, Lipids 18: 267–269.CrossRefGoogle Scholar
  63. Haramaki, N., Packer, L., Assadnazari, H., and Zimmer, G., 1993, Cardiac recovery during post-ischemic reperfusion is improved by combination of vitamin E with dihydrolipoic acid, Biochem. Biophys. Res. Commun. 196: 1101–7.CrossRefGoogle Scholar
  64. He, H., and Lawrence, A. L., 1993, Vitamin E requirement of penaeus vannamel, Aquaculture 118: 245–55.Google Scholar
  65. Heinzerling, R. H., Nockels, C. F., Quarles, C. L., and Tengerdy, R. R, 1974, Protection of chicks against E. coli infection by dietary supplementation with vitamin E, Proc. Soc. Exp. Biol. Med. 146: 279–283.Google Scholar
  66. Heizerling, R. H., Tengerdy, R. P., Wick, L. L., and Leuker, C., 1974, Vitamin E protects mice against diplococcus pneumoniae Type I infection, Infect. Immun. 10: 1292–1295.Google Scholar
  67. Hennig, B., Boissonneault, G. A., Chow, C. K., Wang, Y., Matulionis, D. H., and Glauert, H. P., 1990, Effect of vitamin E in linoleic acid-mediated induction of peroxisomal enzymes in cultured porcine endothelial cells, J. Nutr. 120: 331–7.Google Scholar
  68. Hennig, B., Toborek, M., Joshi-Barve, S., Barger, S. W., Barve, S., Mattson, M. P., and McClain, C. J., 1996, Linoleic acid activates nuclear transcription factor-kappa B (NF-kappa B) and induces NF-kappa B-dependent transcription in cultured endothelial cells, Am. J. Clin. Nutr. 63: 322–8.Google Scholar
  69. Herbaczynska-Cedro, K., Wartanowicz, M., Panczenko-Kresowska, B., Cedro, K., Klosiewicz-Wasek, B., and Wasek, W., 1994, Inhibitory effect of vitamins C and E on the oxygen free radical production in human polymorphonuclear leucocytes, Eur. J. Clin. Invest. 24: 316–9.Google Scholar
  70. Hicks, R. B., 1985, Effect of nutrition, medical treatments and management practices on health and performance of newly-received stocker cattle, Stillwater. 10: 21–37.Google Scholar
  71. Hill, G. L., and Williams, S. F., 1993, Vitamin E in beef nutrition and meat quality, Proc. Nutr. Conf. Bloomington 197–211.Google Scholar
  72. Hogan, J. S., Weiss, W. P., and Smith, K. L., 1993, Role of vitamin E and selenium in host defense against mastitis, J. Dairy. Sci. 76: 2795–2803.CrossRefGoogle Scholar
  73. Hosoi, Y., Yamamoto, M., Ono, T., and Sakamoto, K., 1993, Prostacyclin production in cultured endothelial cells is highly sensitive to low doses of ionizing radiation, Int. J. Radiat. Biol. 63: 631–8.CrossRefGoogle Scholar
  74. Hutcheson, D. P., and Cole, N. A., 1985, Vitamin E and selenium for yearling feedlot cattle. Fed. Proc. 44: 549Google Scholar
  75. Ikeda, M., Sumimoto K., Urushihara, T., Fukuda, Y., Dohi, K., and Kawasaki, T., 1994, Prevention of ischemic damage in rat pancreatic transplantation by pretreatment with alpha tocopherol, Transplant. Proc. 26: 561–562.Google Scholar
  76. Ikezawa, T., 1989, An experimental study of tissue injury associated with reperfusion in ischemic limbs, J. Jap. Surg. Soc. 90: 1799–1805.Google Scholar
  77. Jacobson, J. M., Michael, J. R., Jafri, M. H., Jr., and Gurtner, G. H., 1990, Antioxidants and antioxidant enzymes protect against pulmonary oxygen toxicity in the rabbit, J. Appl. Physiol. 68: 1252–9.CrossRefGoogle Scholar
  78. Jahreis, G., Steinhart, H., Pfalzgraf, A., Flachowsky, G., and Schone, F., 1996, Zur Wirkung von Rapso-Ifutterung an Milchkuhe auf das Fettsaurenspektrum des Butterfettes, Z. Ernahrungswiss. 35: 185–190.CrossRefGoogle Scholar
  79. Jandak, J., Steiner, M., and Richardson, P. D., 1988, Reduction of platelet adhesiveness by vitamin E supplementation in humans, Thromb. Res. 49: 393–404.CrossRefGoogle Scholar
  80. Jialal, I., and Grundy, S. M., 1993, Effect of combined supplementation with alpha-tocopherol, ascorbate, and beta-carotene on low-density lipoprotein oxidation, Circulation 88: 2780–6.CrossRefGoogle Scholar
  81. Kaneko, T., Nakano, S. I., and Matsuo M., 1991, Protective Effect of Vitamin E on Linoleic Acid Hydroperoxide-Induced Injury to Human Endothelial Cells, Lipids 26: 345–348.CrossRefGoogle Scholar
  82. Karpen, C., Pritchard, K. A., Arnold, J.H, Cornwell, D.G., Panganamala, R.V., 1982, Restoration of prostacyclin/thromboxane A2 balance in the diabetic rat—influence of dietary vitamin E, Diabetes 31: 947–951.Google Scholar
  83. Kashiwado, I., Hattori, Y., and Qiao-Y., 1994, Functional and morphological changes in the cochlea of cholesterol fed guinea pigs, Nippon. Ika. Daigaku. Zasshi. 61: 321–329.Google Scholar
  84. Keaney, J. F. Jr., Gaziano, J. M., Xu, A., Frei, B., Curran-Celentano, J., Shwaery, G. T., Loscalzo, J., and Vita, J. A., 1993, Dietary antioxidants preserve endothelium-dependent vessel relaxation in cholesterol-fed rabbits, Proc. Natl. Acad. Sci. USA 90: 11880–11884.CrossRefGoogle Scholar
  85. Keegan, A., Walbank, H., Cotter, M. A., and Cameron, N. F., 1995, Chronic vitamin E treatment prevents defective endothelium-dependent relaxation in diabetic rat aorta, 1995, Diabetologia. 38: 1475–1478.CrossRefGoogle Scholar
  86. Kilinc, C., Ozcan, O., Karaoz, F., Sunguroglu, K., Kutluay, T., and Karaca L., 1993, Reducing effect of vitamin E on bleomycin-induced lung fibrosis in mice: Biochemical and histological evidence, Turk. J. Med. Sci. 17: 275–85.Google Scholar
  87. Kiser, M. L., Williams, S. F., Hill, G. M., and Williams, S. N., 1993, Interrelationship of dietary vitamin E and postmortem storage on visual and oxidative properties of loin steaks and ground beef, Proc. Recprocal Meat Conf. 174A.Google Scholar
  88. Klein, D. R., Novilla, M. N., and Watkins, K. L., 1994, Nutritional encephalomalacia in turkeys: diagnostic and growth performance, Avian. Dis. 38: 653–659.CrossRefGoogle Scholar
  89. Kolb, F., and Grün, F., 1995, Die Bedeutung des Vitamin E and des Selens für das Immunsystem des Rindes, insbesondere für die Eutergesundheit. Der Praktische Tierarzt 9: 794–756.Google Scholar
  90. Korpela, H., 1990, Increased myocardial and hepatic iron concentration in pigs with microangiopathy (mulberry heart disease) as a risk factor of oxidative damage, Ann. Nutr. Metab. 34: 193–7.CrossRefGoogle Scholar
  91. Kunisaki, M., Bursell, S. F., Clermont, A. C., Ishii, H., Ballas, L. M., Jirousek, M. R., Umeda, F., Nawata, H., and King, G. L., 1995, Vitamin E prevents diabetes-induced abnormal retinal blood flow via the diacylglycerolprotein kinase C pathway, Am. J. Physiol. 269: E239–246.Google Scholar
  92. Kurose, I., Fukumura, D., Miura, S., Suematsu, M., Suzuki, M., Sekizuka, F., Nagata, H., Morishita, T., and Tsuchiya, M., 1993, Fluorographic study on the oxidative stress in the process of gastric mucosal injury: Attenuating effect of vitamin E, J. Gastroenterol. Hepatol. 8: 254–258.CrossRefGoogle Scholar
  93. Kuzuya, M., Naito, M., Funaki, C., Hayashi, T., Asai, K., and Kuzuya, F., 1991, Probucol prevents oxidative injury to endothelial cells, J. Lipid. Res. 32: 197–204.Google Scholar
  94. Lafuze, J. F., Weisman, S. J., Al pert, L. A., and Baehner, R. L., 1984, Vitamin E attenuates the effect of FMLP on rabbit circulating granulocytes, Pediatr. Res. 18: 536–540.CrossRefGoogle Scholar
  95. Lanari, M. C., Cassens, R. G., Schaefer, D. M., and Scheller, K. K., 1993, Dietary vitamin E enhances color and display life of frozen beef from Holstein steers, J. Food. Sci. 58: 701–4.CrossRefGoogle Scholar
  96. Lee, K. C., Hamel, D. W., and Kunbel, S., 1993, Rodent model of renal ischemia and reperfusion injury: influence of body temperature, seasonal variation, tumor necrosis factor, endogenous and exogenous antioxidants, Methods. Find. Exp. Clin. Pharmacol. 15: 153–9.Google Scholar
  97. Lee, R. W., Stuart, R. L., Perryman, K. R., and Ridenour, K. W., 1995, Effect of vitamin supplementation on the performance of stressed beef calves, J. Anim. Sci. 61: 425Google Scholar
  98. Lee, S. M., and Clemens, M. G., 1992, Effect of alpha-tocopherol on hepatic mixed function oxidases in hepatic ischemia/reperfusion, Hepatology 15: 276–281.CrossRefGoogle Scholar
  99. Lehr, H. A., Guhlmann, A., Nolte, D., Keppler, D., and Messmer, K., 1991a, Leukotrienes as mediators in is- chemia-reperfusion injury in a microcirculation model in the hamster, J. Clin. Invest. 87: 2036–2041.CrossRefGoogle Scholar
  100. Lehr, H.A., Hubner, C., Nolte, D., Kohlschutter, A., Messmer, K., 199 lb, Dietary fish oil blocks the microcirculatory manifestations of ischemia-reperfusion injury in striated muscle in hamsters. Proc. Natl. Acad. Sci. USA 88: 6726–2730.Google Scholar
  101. Lehr, H.A., and Messmer, K., 1996, Rationale for the use of antioxidant vitamins in clinical organ transplantation. Transplantation 62: 1197–1199.CrossRefGoogle Scholar
  102. Lin, C.F., Gray, J.I., Ashgar, A., Buckley, D.J., Booren, A.M., Flegel, C.J., 1989, Effects of dietary oils and a-tocopherol supplementation on lipid composition and stability of broiler meats, J. Food. Sci. 54: 1457–1460.CrossRefGoogle Scholar
  103. Liu, Q., Scheller, K. K., Arp, S. C., Schaefer, D. M., and Frigg, M., 1996, Color coordinates for assessment of dietary vitamin E effects on beef color stability, J. Anim. Sci. 74: 106–16.Google Scholar
  104. Lu, L. J., 1993, Ultrastructural changes in endothelial cells in rabbits with multiple organ failure (MOF), Chung. Hua. Ping. Li. Hsueh. Tsa. Chih. 22: 169–71.Google Scholar
  105. Luostarinen, R., Siegbahn, A., and Saldeen, T., 1991, Effects of dietary supplementation with vitamin E on human neutrophil chemotaxis and generation of LTB4, Upsala J. Med. Sci. 96: 103–111.CrossRefGoogle Scholar
  106. Mahan, D. C., 1994, Effects of dietary vitamin E on sow reproductive performance over a five-parity period, J. Anim. Sci. 72: 2870–9.Google Scholar
  107. Mahoney, C. W., and Azzi, A., 1988, Vitamin E inhibits protein kinase C activity, Biochem. Biophys. Res. Cornmun. 154: 694–697.CrossRefGoogle Scholar
  108. Marubayashi, S., Dohi, K., Ochi, K., and Kawasaki, T., 1986, Role of free radicals in ischemic rat liver cell injury: Prevention of damage by alpha-tocopherol administration, Surgery 99: 184–192.Google Scholar
  109. Marusisch, W. L., deRitter, E., Ogrinz, E. F., Keating, J., Mitrovic, M., and Bunnel, R. H., 1975, Effect of supplemental vitamin E in control of rancidity in poultry meat, Poultry. Sci. 54: 831–844.CrossRefGoogle Scholar
  110. Massey, K.D., and Burton, K. P., 1989, Alpha-tocopherol attenuates myocardial membrane-related alterations resulting from ischemia and reperfusion, Am. J. Physiol. 256:H1192–HI199.Google Scholar
  111. Menger, M. D., Pelikan, S., Steiner, D., and Messmer, K., 1992a, Microvascular ischemia-reperfusion injury in striated muscle: significance of“reflow paradox”, Am. J. Physiol. 263: H1901 - H1906.Google Scholar
  112. Menger, M. D., Steiner, D., and Messmer, K., 1992b, Microvascular ischemia-reperfusion injury in striated muscle: significance of “no reflow”, Am. J. Physiol. 263: H1892 - H1900.Google Scholar
  113. Meydani, M., 1992, Modulation of the platelet thromboxane A2 and aortic prostacyclin synthesis by dietary selenium and vitamin E, Biol. Trace. Flem. Res. 33: 79–86.CrossRefGoogle Scholar
  114. Michiels, C., Toussaint, 0., and Remade, J.,1990, Comparative study of oxygen toxicity in human fibroblasts and endothelial cells, J. Cell. Physiol. 144: 295–302.Google Scholar
  115. Mitsumoto, M., Arnold, R. N., Schaefer, D. M., and Cassens R. G., 1993, Dietary versus postmortem supplementation of vitamin E on pigment and lipid stability in ground beef, J. Anim. Sc. 71: 1812–16.Google Scholar
  116. National Institutes of Health, 1982, NIH Rodents, 1980 Catalogue: strains and stocks of laboratory rodents provided by the NIH genetic resource. NIH Publication 83–606. Bethesda, MD.: U.S. Public Health Service.Google Scholar
  117. Nemec, M., Butler, G., Hidiroglou, M., Famworth, E. R., and Nielsen, K., 1994, Effect of supplementing gilts’ diets with different levels of vitanin E and different fats on the humoral and cellular immunity of gilts and their progeny, J. Anim. Sci. 72: 665–76.Google Scholar
  118. Ochi, H., Morita, I., and Murota, S., 1992, Mechanism for endothelial cell injury induced by 15-hydroperoxyeicosatetraenoic acid, an arachidonate lipoxygenase product, Biochim. Biophys. Acta. 1136: 247–52.CrossRefGoogle Scholar
  119. Oda, T., Nakai, I., Mituo, M., Yamagishi, H., Oka, T., and Yoshikawa, T.,1992, Role of oxygen radicals and synergistic effect of superoxide dismutase and catalase on ischemia-reperfusion injury of the rat pancreas, Transplant. Proc. 24: 797–798Google Scholar
  120. Patterson, R. L., and Stevenson, M. H., 1995, Irradiation-induced off-odour in chicken and its possible control, Br. Poult. Sci. 36: 425–41.CrossRefGoogle Scholar
  121. Peet, R.L., and Dickson, J., 1988, Rhabdomyolysis in housed, fine-woolled merino sheep, associated with low plasma alpha-tocopherol concentrations, Aust. Yet. J. 65: 398–399.CrossRefGoogle Scholar
  122. Pentland, A. P., Morrison, A. R., Jacobs, S. C., Hruza, L. L., Hebert, J. S., and Packer, L., 1992, Tocopherol analogs suppress arachidonic acid metabolism via phospholipase inhibition, J. Biol. Chem. 267: 15578–15584.Google Scholar
  123. Peplowski, M. A., Mahan, D. C., Murray, F. A., Moxon, A. L., Cantor, A. H., and Ekstrom, K. F., 1980, Effect of dietaray and injectable vitamin E and selenium in weaning swine antigenically challenged with sheep red blood cells, J. Animal Sci. 51: 344–351.Google Scholar
  124. Polette, A., and Blache, D., 1992, Effect of vitamin E on acute iron load-potentiated aggregation, secretion, calcium uptake and thromboxane biosynthesis in rat platelets, Atherosclerosis 96: 171–9.CrossRefGoogle Scholar
  125. Politis, I., Hidiroglou, N., White, J. H., Gilmore, J. A., Williams, S. N., Schert’, H., and Frigg, M., 1996, Effects of vitamin E on mammary and blood leukocyte function, with emphasis on chemotaxis, in periparturient dairy cows, Am. J. Vet. Res. 57: 468–471.Google Scholar
  126. Pruitt, S. P., Morrill, J. L., Blecha, F., Reddy, P. G., Higgins, J., and Anderson, N. V., 1989, Effect of supplemental vitamin C and E in milk replacer on lymphocyte and neutrophil function in bull calves, J. Anim. Sci. 67: 243AGoogle Scholar
  127. Pyke, D. D., and Chan, A. C., 1990, Effects of vitamin E on prostacyclin release and lipid composition of theischemic rat heart, Arch. Biochem. Biophys. 277: 429–433.CrossRefGoogle Scholar
  128. Rabi, H., Khoschsorur, G., Colombo, T., Petritsch, P., Rauchenwald, M., Kotringer, P., Tatzber, F., and Esterbauer, H., 1993, A multivitamin infusion prevents lipid peroxidation and improves transplantation performance, Kidney Int. 43: 912–917.CrossRefGoogle Scholar
  129. Rao, P.N., Walsh, T.R., Makowka, L., Liu, T., Demetris, A.J., Rubin, R.S., Snyder, J.T., Mischinger, H.J., and Stazl, T.F., 1990, Inhibition of free radical generation and improved survival by protection of the hepatic microvascular endothelium by targeted erythrocytes in orthotopic liver transplantation, Transplantation 49: 1055–1059.CrossRefGoogle Scholar
  130. Reddy, P. G., Morrill, J. L., Minocha, H. C., Monili, M. B., Dayton, A. D., and Frey, R. A., 1986, Effect of supplemental vitamin E on the immune system of calves, J. Dairy Sci. 69: 164–170.CrossRefGoogle Scholar
  131. Reddy, P. G., Morrill, J. L., Minocha, H. C., Stevenson, J. S., 1987, Vitamin E is immunostimulatory in calves, J. Dairy Sci. 70: 993–999.Google Scholar
  132. Rethwill, C. F., Bruin, T. K., Waibel, P. F., Addis, P. B., 1981, Influence of dietary fat source and vitamin E on market stability of turkeys, Poultry. Sci. 60: 2466–2474.CrossRefGoogle Scholar
  133. Rojas, C., Cadenas, S., Lopez-Torres, M., Perez-Campo, R., and Barja, G. 1997, Increase in heart glutathione redox ratio and total antioxidant capacity and decrease in lipid peroxidation after vitamin E dietary supplementation in guinea pigs. Free Radic. Biol. Med. 21: 907–918.CrossRefGoogle Scholar
  134. Rösen, P., Ballhausen, T., Bloch, W., and Addicks, K., 1995, Endothelial relaxation is disturbed by oxidative stress in the diabetic rat heart: influence of tocopherol as antioxidant, Diabetologia. 38: 1157–1168.CrossRefGoogle Scholar
  135. Rubino, A., and Burnstock, G., 1994, Recovery after dietary vitamin E supplementation of impaired endothelial function in vitamin E-deficient rats, Br. J. Pharmacol. 112: 515–518.CrossRefGoogle Scholar
  136. Sakamoto, W., Fujie, K., Handa, H., Ogihara, T., and Mino, M., 1990, In vivo inhibition of superoxide production and protein kinase C activity in macrophages from vitamin E-treated rats, Int. J. Nutr. Res. 60: 338–342.Google Scholar
  137. Salonen, J. T., Salonen, R., Seppanen, K., Rinta-Kiikka, S., Kuukka, M., Korpela, H., Alfthan, G., Kantola, M., and Schalch, W., 1991, Effects of antioxidant supplementation on platelet function: A randomized pair-matched, placebo-controlled double-blind trial in men with low antioxidant status, Am. J. Clin. Nutr. 53: 1222–1229.Google Scholar
  138. Schaeffer, D. M., Scheller, K. K., Arp., S. C., Buege, D. R., and Lane, S. F., 1989, Growth of Holstein steers and beef color as affected by dietary vitamin E supplementation, J. Anim., Sci. 68: 190A.Google Scholar
  139. Schwarz, F., 1996, Influence of dietary fatty acid composition and vitamin E on fatty acids and alpha-tocopherol in carp (Cyprinus caprio L.) Arch. Anim. Nutr. 49: 63–71.Google Scholar
  140. Sheehy R. J., Morrissey, P. A., and Flynn, A., 1991, Influence of dietary alpha-tocopherol on tocopherol concentration in chick tissues. Brit. Poultry Sci. 32: 391–397.CrossRefGoogle Scholar
  141. Shirahata, A., 1993, Clinical application of fat soluble vitamins to retinopathy of prematurity and intracranial hemorrhage, Nippon. Rinsho. 51: 1029–1036.Google Scholar
  142. Smith, G. C., Morgan, J. B., Sofos, J. N., Tatun, J. D., 1996, Supplemental vitamin E in beef cattle diets to improve shelf-life of beef, Anim. Feed. Sci. Technol. 59: 207–214.CrossRefGoogle Scholar
  143. St. Laurent, A., Hidiroglou, M., Snoddon, M., and Nichlson, J. W. G., 1990, Response to dietary vitamin E in the dairy cow and its effect on spontaneous oxidized flavor in milk. Can. J. Anim. Sci. 70: 561–570.Google Scholar
  144. Steiner, M., and Mower, R., 1982, Mechanism of action of vitamin E on platelet function, Ann. NY Acad. Sci. 393: 289–299.CrossRefGoogle Scholar
  145. Strivastava, K. C., 1986, Vitamin E experts antiaggregatory effects without inhibiting the enzymes of the arachidonic acid cascade in platelets, Prostagland. Leukotr. Medicine 21: 177–185.CrossRefGoogle Scholar
  146. Suntres, Z.F., Herworth, S.R., and Shek, P.N., 1992, Protective effect of liposome-associated alpha-tocopherol against paraquat-induced acute lung toxicity, Biochem. Pharmacol. 9: 1811–1818.CrossRefGoogle Scholar
  147. Suzuki, Y.J., Packer, L. 1993. Inhibition of NFkB activation by vitamin E derivatives. Biochem. Biophys. Res. Commun. 193: 277–283.CrossRefGoogle Scholar
  148. Takenaka, M., Tatsukawa, Y., Dohi, K., Ezaki, H., Matsukawa, K., and Kawasaki, T., 1981, Protective effects of alpha-tocopherol and coenzyme Q10 on warm ischemic dangers of the rat kidney, Transplantation 32: 137–141.CrossRefGoogle Scholar
  149. Tanabe, M., Kito, G. 1989. Effects of CV-361 1, a new free radical scavenger, on ischemic heart failure in conscious dogs. Jap. J. Pharmacol. 50: 467–476.CrossRefGoogle Scholar
  150. Tanaka, T., Fujiwara, H., and Torisu, M., 1979, Vitamin E and immune response: I. Enhancement of helper T cell activity by dietary supplementation of vitamin E in mice, Immunology 38: 727–734Google Scholar
  151. Taoka, Y., Ikata, T., and Fukuzawa, K., 1990, Influence of dietary vitamin E deficiency on compression injury of rat spinal cord, J. Nutr. Sci. Vitaminol. 36: 217–226.CrossRefGoogle Scholar
  152. Tengerdy, R. P., Heinzerling, R. H., and Nockels, C. F., 1972, Effect of vitamin E on the immune response of hypoxic and normal chicken, Infect. Immun. 5: 987–989.Google Scholar
  153. Teoh, M. K., Chong, M. K., and Jamaludin, M., 1992, Effects of tocotrienol-rich vitamin E on patients with peripheral vascular disease, Lipid-Soluble Antoxid. 606–21.Google Scholar
  154. Toborek, M., Barger, S. W., Mattson, M. R, Barve, S., McClain, C. J., and Hennig, B., 1996, Linoleic acid and TNF-alpha cross-amplify oxidative injury and dysfunction of endothelial cells, J. Lipid. Res. 37: 123–35.Google Scholar
  155. Tran, K., Proulx, P.R., and Chan, A. C., 1994, Vitamin E suppresses diacylglycerol (DAG) level in thrombin-stimulated endothelial cells through an increase of DAG kinase activity, Biochim. Biophys. Acta. 1212: 193–202.CrossRefGoogle Scholar
  156. Umeda, F., Kunisaki, M., Inoguchi, T., and Nawata, H., 1990, Vitamin E enhances prostacyclin production by cultured aortic endothelial cells, J. Clin. Biochem. Nutr. 8: 175–183.CrossRefGoogle Scholar
  157. Vajkoczy, P., Lehr, H.A., Hubner, C., Arfors, K.E., and Menger, M.D., 1997, Prevention of pancreatic islet xenograft rejection by dietary vitamin E. Am. J. Pathol. 150: 1487–1495.Google Scholar
  158. Van Jaarsveld, H., Kuyl, J. M., and Alberts, D. W., 1992, Antioxdant vitamin supplementation of smoke-exposed rats partially protects against myocardial ischemic/reperfusion injury, Free Radic. Res. Commun. 17: 263–269.CrossRefGoogle Scholar
  159. Verlhac, V., N’Doye, A., Gabaudan, J., Troutaud, D., and Deschaux, P., 1993, vitamin nutrition and fish immunity: influence of antioxidant vitamins (C and E) on immune response of rainbow trout, Colloq. INRA. 61: 167–77.Google Scholar
  160. Villa, S., Lorico, A., Morazzoni, G., de Gaetano, G., and Sameraro, N., 1986, Vitamin E and vitamin C inhibit arachi- donate-induced aggregation of human peripheral blood leukocytes in vitro, Agents Actions 19: 127–131.CrossRefGoogle Scholar
  161. Waagboe, R., Sandnes, K., Torrissen, O. J., Sandvin, A., and Lie, 0., 1993, Chemical and sensory evaluation of fillets from atlantic salmon (salmo salar) fed three levels of N-3 polyunsaturated fatty acids at two levels of vitamin E, Food. Chem. 46: 361–6.CrossRefGoogle Scholar
  162. Walsh, D. M., Kennedy, D. G., Goodall, F. A., and Kennedy, S., 1993, Antioxidant enzyme activity in the muscles of calves depleted of vitamin E or selenium or both, Br. J. Nutr. 70: 621–30.CrossRefGoogle Scholar
  163. Wang, X., Feuerstein, G. Z., Gu, J. L., Lysko, P. G., and Yue, T. L., 1995. IL-1 beta induces expression of adhesion molecules in human vascular smooth muscle cells and enhances adhesion of leukocytes to smooth muscle cells. Atherosclerosis 115: 89–98.CrossRefGoogle Scholar
  164. Washio, M., Nanishi, F., Okuda, S., Onoyama, K., and Fujishima, M., 1994, Alpha-tocopherol improves focal glomerulosclerosis in rats with adriamycin-induced progressive renal failure, Nephron. 68: 347–352.CrossRefGoogle Scholar
  165. Weiss, W. P., Hogan, J. S., Smith, K. L., and Hoblet, K. H., 1990, Relationships among selenium, vitamin E and mammary gland health in commercial dairy herds, J. Dairy. Sci. 73: 381–390.CrossRefGoogle Scholar
  166. Williams, G. M., Frye, T. M., Frigg, M., Schaefer, D. M., Scheller, K. L., and Liu, Q., 1992, Vitamin E, Meat. Int. 3: 22.Google Scholar
  167. Willy, C., Thiery, J., Menger, M.D., Messmer, K., Arfors, K.F., and Lehr, H.A. 1995, Impact of vitamin E supplements in standard laboratory animal diet on microvascular manifestations of ischemia/reperfusion injury. Free Radic. Biol. Med. 19: 919–926.Google Scholar
  168. Wolf, H. R. D., and Seeger, H. W., 1982, Experimental and clinical results in shock lung treatment with vitamin F, Ann. NYAcad. Sci. 393: 392–410.Google Scholar
  169. Wolfram, D., and Flachowsky, G., 1991, Hohe Vitamin-F-Gaben in der Milchkuhfutterung, Proc. 3. Symp. “Vìtamine and weitere Zusatzstoffe bei Mensch and Tier”, Stadtroda. 196–199.Google Scholar
  170. Wulf, D. M., Morgan, J. B., Sanders, S. K., Tatum, J. D., Smith, G, C., and Williams, S., 1995, Effects of dietary sup- plementation of vitamin E on storage and caselife properties of lamb retail cuts, J. Anim. Sci. 73: 399–405.Google Scholar
  171. Yamamoto, M., Shima, T., Uozumi, T., Sogabe, T., Yamada, K., and Kawasaki, T., 1983, A possible role of lipid peroxidation in cellular damages caused by cerebral ischemia and the protective effect of alphatocopherol administration, Stroke 14: 977–982.CrossRefGoogle Scholar
  172. Yoshikawa, T., Yasuda, M., Ueda, S., Naito, Y., Tanigawa, T., Oyamada, H., and Kondo, M., 1991, Vitamin E in Gastric Mucosal Injury Induced by Ischemia-reperfusion, Am. J. Clin. Nutr. 53: 2105–214S.Google Scholar
  173. Zadkova, G. F., Avakian, T. T., and Markov, K. h. M., 1993, Effect of alpha-tocopherol on the development of diabetic angiopathy, platelet aggregation, and status of the prostacyclin-thromboxane system in rats with streptozotocin diabetes, Probl. Endokrinol. Mosk. 39: 40–3.Google Scholar

Copyright information

© Springer Science+Business Media New York 1998

Authors and Affiliations

  • Hans-Anton Lehr
    • 1
  • Peter Vajkoczy
    • 2
  • Michael D. Menger
    • 3
  1. 1.Institute of PathologyUniversity of MainzGermany
  2. 2.Neurosurgical ClinicUniversity of Heidelberg at MannheimGermany
  3. 3.Institute for Clinical Experimental SurgeryUniversity of Homburg/SaarGermany

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