The Role of Free Radicals in NMDA and Glutamate Excitotoxicity
The central nervous system is particularly vulnerable to oxidative stress. Neuronal membranes contain high levels of polyunsaturated fatty acids which are susceptible to free radical attack (Grisham, 1992). Normally, reactive oxygen species (ROS) generated as byproducts of cellular metabolism are maintained at very low, non-toxic levels with the aid of free radical scavengers and antioxidants (Sies, 1993). However, in recent years it has been established that oxidative stress is an important causal factor in the pathogenesis of several neurological disorders such as stroke, trauma, seizures and chronic neurodegenerative diseases (Dawson and Dawson, 1996; Simonian and Coyle, 1996).
KeywordsNitric Oxide NMDA Receptor Hippocampal Slice Free Radical Attack Important Causal Factor
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