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The Role of Free Radicals in NMDA and Glutamate Excitotoxicity

  • A. S. Yalçın
  • Goncagül Haklar
  • Belgin Küçükkaya
  • Meral Yüksel
  • Hale Saybaşılı
Chapter
Part of the NATO ASI Series book series (NSSA, volume 296)

Abstract

The central nervous system is particularly vulnerable to oxidative stress. Neuronal membranes contain high levels of polyunsaturated fatty acids which are susceptible to free radical attack (Grisham, 1992). Normally, reactive oxygen species (ROS) generated as byproducts of cellular metabolism are maintained at very low, non-toxic levels with the aid of free radical scavengers and antioxidants (Sies, 1993). However, in recent years it has been established that oxidative stress is an important causal factor in the pathogenesis of several neurological disorders such as stroke, trauma, seizures and chronic neurodegenerative diseases (Dawson and Dawson, 1996; Simonian and Coyle, 1996).

Keywords

Nitric Oxide NMDA Receptor Hippocampal Slice Free Radical Attack Important Causal Factor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Ballyk, B.A., and Goh, J.W., 1992, Elevation of extracellular potassium facilitates the induction of hippocampal long-term potentiation, J. Neurosci. Res. 33: 596–604.CrossRefGoogle Scholar
  2. Bradford, H.F., 1986, The synaptosome, an in vitro model for the synapse, in: Chemical Neurobiology, pp. 311–352, Freeman Press, New York.Google Scholar
  3. Coyle, J.T., and Putfarcken, P., 1993, Oxidative stress, glutamate, and neurodegenerative disorders, Science 262: 689–695.CrossRefGoogle Scholar
  4. Dawson, V.L., and Dawson, T.M., 1996, Free radicals and neuronal cell death, Death and Differentiation 3: 71–78.Google Scholar
  5. Garthwaite, J., 1994, NMDA receptors, neuronal development, and neurodegeneration, in: The NMDA Receptor, ( G.L. Collingridge and J.C. Watkins, eds.) pp. 428–456, Oxford University Press, New York.Google Scholar
  6. Grisham, M.B., 1992, Reactive Metabolies of Oxygen and Nitrogen in Biology and Medicine,pp. 65–66Google Scholar
  7. R.G. Landes Company, Austin. ladecola, C., 1997, Bright and dark sides of nitric oxide in ischemic brain injury, TINS 20: 132–139.Google Scholar
  8. Kikuchi, K., Nagano, T., Hayakawa, H., Hirata, Y., and Hirobe, M., 1993, Detection of nitric oxide production from a perfused organ by a luminol-H2O2 system, Anal. Chem. 65: 1794–1799.CrossRefGoogle Scholar
  9. Küçükkaya, B., Haklar, G., and Yalçrn, A.S., 1996, NMDA excitotoxicity and free radical generation in rat brain homogenates: application of a chemiluminescence assay, Neurochem. Res. 21: 1533–1536.CrossRefGoogle Scholar
  10. Lipton, S.A., and Rosenberg, P.A., 1994, Excitatory amino acids as a final common pathway for neurologic disor ders, Mech. Dis. 330: 613–622.Google Scholar
  11. Nicholls, D.G., 1993, The glutamatergic nerve terminal, Eur. J. Biochem. 212: 613–631.CrossRefGoogle Scholar
  12. Sies, H., 1993, Strategies of antioxidant defence, Eur. J. Biochem. 215: 213–219.CrossRefGoogle Scholar
  13. Simonian, N.A., and Coyle, J.T., 1996, Oxidative stress in neurodegenerative diseases, Annu. Rev. Pharmacol. Toxicol. 36: 83–106.CrossRefGoogle Scholar
  14. Sucher, N.J., and Lipton, A., 1991, Redox modulatory site of the NMDA receptor channel complex: regulation by oxidized glutathione, J. Neurosci. Res. 30: 582–591.CrossRefGoogle Scholar
  15. Tang, L.H., and Aizenman, E., 1993, Long-lasting modification of the N-Methyl-D-Aspartate receptor channel by a voltage-dependent sulfhydryl redox process, Molec. Pharmacol. 44: 473–478.Google Scholar

Copyright information

© Springer Science+Business Media New York 1998

Authors and Affiliations

  • A. S. Yalçın
    • 1
  • Goncagül Haklar
    • 1
  • Belgin Küçükkaya
    • 1
  • Meral Yüksel
    • 1
  • Hale Saybaşılı
    • 2
  1. 1.Department of BiochemistryFaculty of Medicine Marmara UniversityTurkey
  2. 2.Institute of Biomedical EngineeringBoğaziçi UniversityIstanbulTurkey

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