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Vitamin D pp 101-107 | Cite as

The Vitamin D Binding Protein and Its Clinical Significance

  • John G. Haddad
Chapter
Part of the Nutrition and Health book series (NH)

Abstract

The plasma protein that transports vitamin D and its metabolites [vitamin D binding protein (DBP)] was first recognized as a postalbumin component of human sera during electrophoretic analyses (1). Subsequently, the identity of this group-specific component (Gc-globulin) and plasma DBP was discovered (2) and confirmed (3). The protein is synthesized in the liver and displays features homologous with albumin and α-fetoprotein (4). Neither of the latter proteins binds vitamin D sterols with high affinity, however. DBP is 122 amino acids shorter than albumin and α-fetoprotein, and the genes of all three of these proteins map to human chromosome 4g11–22 (4).

Keywords

Total Sterol Actin Monomer Macrophage Activate Factor Cellular Access Free Hormone Hypothesis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1999

Authors and Affiliations

  • John G. Haddad

There are no affiliations available

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