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Vitamin D pp 57-84 | Cite as

Metabolism and Catabolism of Vitamin D, Its Metabolites, and Clinically Relevant Analogs

  • Glenville Jones
Chapter
Part of the Nutrition and Health book series (NH)

Abstract

The elucidation of the metabolism of vitamin D3 is arguably one of the most important developments in nutritional sciences over the latter half of the 20th century. An appreciation that vitamin D3 represents a precursor to the functionally active form and that two steps of activation are necessary to produce the hormone 1α,25-dihydroxyvitamin D3 [1α,25(OH)2D3] constitute historical landmarks in modern vitamin research (1). These developments spawned not only detailed studies of the biologic properties of vitamin D metabolites produced and the regulation of cytochrome P450-containing enzymes involved in their production but also provided the stimulus for the chemical synthesis of a plethora of vitamin D analogs (approx 300 at last count). Furthermore, it appears that susceptibility to vitamin D catabolic pathways and other important parameters such as binding to the vitamin D receptor (VDR) functional complex and binding to the vitamin D binding protein (DBP) are probably key elements in dictating the differences in the actions of so-called calcemic and noncalcemic vitamin D analogs. Therefore, from the perspective of its historical significance and relevance, it seems entirely logical to consider the metabolism of vitamin D and its analogs together at this stage of a general text on vitamin D.

Keywords

Cerebrotendinous Xanthomatosis Cytochrome P450 Species 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© Springer Science+Business Media New York 1999

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  • Glenville Jones

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