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Vitamin D and Bone Health in Adults and the Elderly

  • Chapter
Vitamin D

Part of the book series: Nutrition and Health ((NH))

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Abstract

Vitamin D is one of the principle hormonal regulators of calcium homeostasis in the body. Besides being critically important for calcium and phosphate absorption in the intestine, vitamin D is essential for normal mineralization of bone and has major regulatory effects on bone cells in the bone remodeling unit. In addition to distant skeletal and intestinal effects, the active form of vitamin D, 1,25-dihydroxyvitamin D3 [1,25(OH)2D3], also regulates its own synthesis in the kidney and parathyroid hormone (PTH) secretion in the parathyroid gland. These multisystem effects firmly establish the importance of this hormone in the maintenance of skeletal health. Moreover, perturbations in vitamin D synthesis, secretion, or action have been implicated as potential pathogenetic factors in the development of osteoporosis. For these reasons, there has been sustained interest in vitamin D and 1,25(OH)2D3 as therapeutic agents in several metabolic bone disorders. However, the relationship between active vitamin D and its metabolites and calcified tissue components is complex and redundant. Hence a thorough understanding of the role vitamin D plays in the bone remodeling process (either directly or indirectly) is extremely important. In turn, complete delineation of the physiologic role of vitamin D in mineral homeostasis illustrates why vitamin D deficiency, especially in the elderly, is now being recognized as a major public health issue.

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References

  1. Rosen CJ. Biochemical markers of bone turnover. In: Osteoporosis: Diagnostic and Therapeutic Principles. Rosen CJ, ed. Totowa, NJ: Humana, 1996; 129 - 141.

    Chapter  Google Scholar 

  2. Lian JB, Stein GS. Osteoblast biology. In: Osteoporosis. Marcus R, Feldman D, Kelsey J, eds. San Diego: Academic, 1996; 23 - 59.

    Google Scholar 

  3. Marks SC, Popoff SN. Bone cell biology: the regulation of development structure and function in the skeleton. Am J Anat 1988; 183: 1 - 44.

    Article  PubMed  Google Scholar 

  4. Lian JB, Stewart C, Puchacz E, Mackowiak S, Shalhoub V, Collart D, Sambetti G, Stein GS. Structure of the rat osteocalcin gene and regulation of vitamin D-dependent expression. Proc Natl Acad Sci USA 1989; 86: 1143 - 1147.

    Article  PubMed  CAS  Google Scholar 

  5. Glowacki J. The cellular and biochemical aspects of bone remodeling. In: Osteoporosis. Rosen CJ, ed. Totowa, NJ: Humana, 1996; 3 - 15.

    Chapter  Google Scholar 

  6. Menton DN, Simmons DJ, Chang SL, On BY. From bone lining cell to osteocyte-an SEM study. Anat Rec 1984; 209: 29 - 39.

    Article  PubMed  CAS  Google Scholar 

  7. Holtrop ME. The ultrastructure of bone. Ann Clin Lab Sci 1975; 5: 264 - 271.

    PubMed  CAS  Google Scholar 

  8. Teitelbaum SL, Tondravi MM, Ross FP. Osteoclast biology. In: Osteoporosis. Marcus R, Feldman D, Kelsey J, eds. San Diego: Academic, 1996; 61 - 94.

    Google Scholar 

  9. Blair HC, Teitelbaum SL, Grosso LE, Lacey DL, Tan H, McCort DW, Jeffrey JJ. Extracellular matrix degradation at acid pH: avian osteoclast acid collagenase isolation and characterization. Biochem J 1993; 290: 873 - 884.

    PubMed  CAS  Google Scholar 

  10. Kurihara N, Chenu C, Miller M, Civin C, Roodman GD. Identification of committed mononuclear precursors for osteoclast like cells formed in long term human marrow cultures. Endocrinology 1991; 126: 2733 - 2741.

    Article  Google Scholar 

  11. Miller PD. Guidelines for the clinical utilization of bone mass measurement in the adult population. Calcif Tiss Int 1995; 57: 251, 252.

    Google Scholar 

  12. Riggs BL. Overview of osteoporosis. West J Med 1991; 154: 63 - 77.

    PubMed  CAS  Google Scholar 

  13. Slemenda CW. Adult bone loss. In: Osteoporosis. Marcus R, ed. Boston: Blackwell Scientific, 1994; 107 - 124.

    Google Scholar 

  14. Parfitt AM. Osteomalacia and related disorders. In: Metabolic Bone Diseases and Clinically Related Disorders, vol. 2. Avioli L, Krane S, eds. Philadelphia: Saunders, 1990; 329 - 381.

    Google Scholar 

  15. Chen TL, Li JM, Van Ye T, Cone CM, Feldman D. Hormonal responses to 1,25 dihydroxyvitamin D3 in cultured mouse osteoblast like cells-modulation by changes in receptor level. J Cell Physiol 1986; 126: 21 - 28.

    Article  PubMed  CAS  Google Scholar 

  16. Noda M, Vogel RL, Craig AM, Prahl J, DeLuca HF, Denhardt DT. Identification of a DNA sequence responsible for binding of the 1,25 dihydroxyvitamin D3 receptor and 1,25dihydroxyvitamin D3 enhancement of mouse secreted phosphoprotein 1(osteopontin)gene expression. Proc Natl Acad Sci USA 1990; 87: 9995 - 9999.

    Article  PubMed  CAS  Google Scholar 

  17. Canalis E, Lian JB. 1,25 Dihydroxyvitamin D effects on collagen and DNA synthesis in periosteum and periosteum free cultures. Bone 1985; 6: 457 - 460.

    Article  PubMed  CAS  Google Scholar 

  18. Henthom PS, Raducha M, Fedde KN, Lafferty MA, Whyte MP. Different missense mutations at the tissue specific alkaline phosphatase gene locus in autosomal recessively inherited forms of mild and severe hypophosphatasia. Proc Natl Acad Sci USA 1992; 89: 9924 - 9928.

    Article  Google Scholar 

  19. Stein GS, Lian JB. Molecular mechanisms mediating developmental and hormone regulated expression of genes in osteoblasts. In: Cellular and Molecular Biology of Bone. Noda M, ed. San Diego: Academic, 1993; 47 - 95.

    Google Scholar 

  20. Desbois C, Bradley A, Karsenty G. Study of osteocalcin function in mouse by targeted disruption. J Bone Miner Res 1994; 9: S376.

    Google Scholar 

  21. Towler DA, Bennett CD, Rodan GA. Activity of the rat osteocalcin basal promoter in osteoblastic cells is dependent upon homeodomain and CP1 binding motifs. Mol Endocrinol 1994; 8: 614 - 624.

    Article  PubMed  CAS  Google Scholar 

  22. Hoffmann HM, Catron KM, van Wijnen AJ, McCabe LR, Lian JB, Stein GS, Stein JL. Transcriptional control of the tissue specific developmentally regulated osteocalcin gene requires a binding motif for the MSX family of homoeodomain proteins. Proc Natl Acad Sci USA 1994; 91: 1287 - 1291.

    Google Scholar 

  23. Raisz LG, Trummel CL, Holick MF, DeLuca HF. 1,25 Dihydroxycholecalciferol: a potent stimulator of bone resorption in tissue culture. Science 1972; 175: 768, 769.

    Google Scholar 

  24. Suda T, Tkahashi N, Martin TJ. Modulation of osteoclast differentiation. Endocr Rev 1992; 13: 66 - 80.

    PubMed  CAS  Google Scholar 

  25. Z-Bar-Shavit, Teitelbaum SL, Reitsma P, Hall A, Pegg LE, Trial J, Kahn AJ. Induction of monocyte differentiation and bone resorption by 1,25 dihydroxyvitamin D. Proc Natl Acad Sci USA 1983; 8: 5907 - 5911.

    Google Scholar 

  26. Feldman D, Malloy PJ, Gross C. Vitamin D: metabolism and action. In: Osteoporosis. Marcus R, Feldman D, Kelsey J, eds. San Diego: Academic, 1996; 205.

    Google Scholar 

  27. Perkins SL, Teitelbaum SL. 1,25 Dihydroxyvitamin D modulates colony stimulating factor-I receptor binding by murine bone marrow macrophage precursors. Endocrinology 1991; 128: 303 - 311.

    Article  PubMed  CAS  Google Scholar 

  28. Udagawa N, Takahashi N, Akatsu H, Tanaka H, Sasaki T, Hihihara T, Koga T. Origin of osteoclasts: mature monocytes and macrophages are cable of differentiating into osteoclasts under a suitable microenvironment prepared by bone marrow derived stromal cells. Proc Natl Acad Sci USA 1990; 87: 7260 - 7264.

    Article  PubMed  CAS  Google Scholar 

  29. Walling MW. Intestinal Ca and phosphate transport: differential response to vitamin D3 metabolites. Am J Physiol 1977; 253: E488 - E494.

    Google Scholar 

  30. Chan SD, Atkins D. The temporal distribution of the 1,25 dihydroxyvitamin D receptor in the rat jejunal vilus. Clin Sci 1984; 67: 285 - 290.

    PubMed  Google Scholar 

  31. Wasserman RH, Fullmer CS. On the molecular mechanism of intestinal calcium transport. Adv Exp Med Biol 1989; 249: 45 - 65.

    Article  PubMed  CAS  Google Scholar 

  32. Suda T, Shiniki T, Takahashi N. The role of vitamin D in bone and intestinal cell differentiation. Annu Rev Nutr 1990; 10: 195 - 211.

    Article  PubMed  CAS  Google Scholar 

  33. Johnson JA, Kumar R. Renal and intestinal calcium transport: roles of vitamin D and vitamin D-dependent calcium binding proteins. Semin Nephrol 1994; 14: 119 - 128.

    PubMed  CAS  Google Scholar 

  34. Holick MF, Matsuoka LY, Wortsman J. Age, vitamin D and solar ultraviolet radiation. Lancet 1989; 4: 1104 - 1105.

    Article  Google Scholar 

  35. Holick MF. Vitamin D. new horizons for the 21st century. Am J Clin Nutr 1994; 60: 619 - 630.

    PubMed  CAS  Google Scholar 

  36. Recihel H, Koeffler HP, Norman AW. The role of the vitamin D endocrine system in health and disease. N Engl J Med 1989; 320: 981 - 991.

    Google Scholar 

  37. Holick MF. Vitamin D photobiology, metabolism and clinical applications. In: Endocrinology, 3rd ed. DeGroot L, ed. Philadelphia: Saunders, 1995; 990 - 1013.

    Google Scholar 

  38. Antrobus SD, Walters MR. 1,25 Dihydroxyvitamin D effects in the kidney: induction of calmodulin binding proteins. Biochem Biophys Res Commun 1992; 185: 636 - 640.

    Article  PubMed  CAS  Google Scholar 

  39. Yamamaoto M, Kawanobe Y, Takahasi H, Shimazawa S, Kimura S, Ogata E. Vitamin D deficiency and renal calcium transport in the rat. J Clin Invest 1984; 74: 507 - 513.

    Article  Google Scholar 

  40. Bourdreau JE. Mechanism and regulation of calcium transport in the nephron. Semin Nephrol 1993; 13: 191 - 201.

    Google Scholar 

  41. Johnston CC, Miller JS, Slemenda CW, Reister TK, Hui S, Christian JC, Peacock M. Calcium supplementation increases bone mineral density in children. N Engl J Med 1992; 327: 82 - 87.

    Article  PubMed  Google Scholar 

  42. Lloyd T, Andon MB, Rolings N, Martel JK, Landis R, Demers LM, Eggli DF, Kieselhorst K, Kuhn HE. Calcium supplementation and bone mineral density in adolescent girls. JAMA 1993; 270: 841 - 844.

    Article  PubMed  CAS  Google Scholar 

  43. Dawson-Hughes B, Dallal GE, Krall EA, Sadowski L, Sahyoun N, Tannenbaum S. A controlled trial of the effect of calcium supplementation on bone density in postmenopausal women. N Engl J Med 1990; 323: 878 - 883.

    Article  PubMed  CAS  Google Scholar 

  44. Pocock NA, Eisman JA Hopper JL, Yeates MG, Sambrook PN, Ebert S. Genetic determinants of bone mass in adults: a twin study. J Clin Invest 1987; 80: 706 - 710.

    Article  PubMed  CAS  Google Scholar 

  45. Slemenda CW, Christian JC, Reed T, Resiter TK, Williams CJ, Johnston CC. Long term bone loss in men: effects of genetic and environmental factors. Ann Intern Med 1992; 117: 286 - 291.

    PubMed  CAS  Google Scholar 

  46. Hansen MA, Hassager C, Jensen SB, Christiansen C. Is heritability a risk factor for postmenopausal osteoporosis? J Bone Miner Res 1992; 9: 1037 - 1040.

    Google Scholar 

  47. Riggs BL, Hamstra A, DeLuca HF. Assessment of 25 hydroxyvitamin D 1 alpha hydroxylase reserve in postmenopausal osteoporosis by administration of PTH extract. J Clin Endocrinol Metab 1981; 53: 833 - 835.

    Article  PubMed  CAS  Google Scholar 

  48. Morrison NA, Qi JC, Tokita A, Kelly PJ, Crofts L, Nguyen TV, Sambrook PN, Eisman JA. Prediction of bone density from vitamin D receptor alleles. Nature 1994; 367: 284 - 287.

    Article  PubMed  CAS  Google Scholar 

  49. Fleet JC, Harris SS, Wood RW, Dawson-Hughes B. The BsmI vitamin D receptor restriction fragment length polymorphism predicts low bone density in premenopausal black and white women. J Bone Miner Res 1995; 10: 985 - 990.

    Article  PubMed  CAS  Google Scholar 

  50. Riggs BL, Nguyen TV, Melton L, Morrison NA, Fallon WM, Kelly P, Egan KS, Sambrook PN, Muhms JM, Eisman JA. The contribution of vitamin D receptor gene alleles to the determination of bone mineral density in normal and osteoporotic women. J Bone Miner Res 1995; 10: 991 - 996.

    Article  PubMed  CAS  Google Scholar 

  51. Hustmeyer FG, Peacock M, Huis S, Johnston CC, Christian J. BMD in relation to polymorphisms at the vitamin D receptor gene locus. J Clin Invest 1994; 94: 2130 - 2134.

    Article  Google Scholar 

  52. Garnero P, Borel O, Sornay-Rendu E, Delmas PD. Vitamin D Receptor gene polymorphisms do not predict bone turnover and bone mass in healthy premenopausal women. J Bone Miner Res 1995; 10: 1283 - 1288.

    Article  PubMed  CAS  Google Scholar 

  53. Krall EA, Parry P, Lichter JB, Dawson-Hughes B. Vitamin D receptor alleles and rates of bone loss: influences of years since menopause and calcium intake. J Bone Miner Res 1995; 10: 978 - 984.

    Article  PubMed  CAS  Google Scholar 

  54. Manolagas SC, Jilka RL. Bone marrow, cytokines and bone remodeling. N Engl J Med 1994; 332: 305 - 311.

    Google Scholar 

  55. Lund BJ, Sorensen OH, Lund BI, Agner E. Serum 1,25 dihydroxyvitamin D in normal subjects and in patients with postmenopausal osteopenia. Influence of age, renal function and estrogen therapy. Horm Metab Res 1982; 14: 271 - 274.

    Article  PubMed  CAS  Google Scholar 

  56. Sowers MR, Wallace RB, Hollis BW. The relationship of 1,25 dihydroxyvitamin D and radial bone mass. Bone Miner 1990; 10: 139 - 148.

    Article  PubMed  CAS  Google Scholar 

  57. Tsai KS, Heath H II, Kumar R, Riggs BL. Impaired vitamin D metabolism with aging in women. Possible role in pathogenesis of senile osteoporosis. J Clin Invest 1984; 73: 1668 - 1672.

    Article  PubMed  CAS  Google Scholar 

  58. Slovik DM, Adams JS, Neer RM, Holick MF, Potts JT. Deficient production of 1,25 dihydroxyvitamin D in elderly osteoporotic women. N Engl J Med 1981; 305: 372 - 374.

    Article  PubMed  CAS  Google Scholar 

  59. Martinex ME, Delcampo MJ, Sanchez-Calvezudo MJ. Relation between serum calcidiol levels and BMD in postmenopausal women with low bone density. Calcif Tiss Int 1994; 55: 253 - 256.

    Article  Google Scholar 

  60. Buring K, Hulth AG, Nilsson BE, Westlin E, Wiklund PE. Treatment of Osteoporosis with vitamin D. Acta Med Scand 1974; 195: 471, 472.

    Google Scholar 

  61. Nordin BEC, Horsman A, Crilly RG, Marchall DH, Simpson M. Treatment of spinal osteoporosis in postmenopausal women. BMJ 1980; 1: 451 - 454.

    Article  Google Scholar 

  62. Riggs BL, Seeman E, Hodgson SF, Taves DR, Oallon WM. Effect of the fluoride calcium regimen on vertebral fracture occurrence in postmenopausal osteoporosis. N Engl J Med 1982; 306: 444 - 450.

    Article  Google Scholar 

  63. Christiansen MS, Christiansen P, McNaire P. Prevention of early postmenopausal bone loss: controlled 2 year study in normal females. Eur J Clin Invest 1980; 10: 273 - 279.

    Article  PubMed  CAS  Google Scholar 

  64. Need AG, Horowitz M, Philcox JC, Nordin BEC. 1,25 Dihydroxyvitamin D and calcium therapy in osteoporosis with calcium malabsorption. Miner Electrolyte Metab 1985; 11: 35 - 40.

    PubMed  CAS  Google Scholar 

  65. Jiang YB, Wang YZ, Zhao K Marchal G, Wang X, Shen YL, Xing Z, Li RG, Baert AL. Bone remodeling in hypervitaminosis D: radiologic, microangiographic and pathologic correlations. Invest Radiol 1991; 26: 213 - 219.

    Article  PubMed  CAS  Google Scholar 

  66. Gallagher JC, Jerpbak CM, Jee SS, Johnson KA DeLuca HF, Riggs BL. 1,25 Dihydroxyvitamin D3: short and long term effects on bone and calcium metabolism in patients with postmenopausal osteoporosis. Proc Natl Acad Sci USA 1982; 79: 3325 - 3329.

    Article  PubMed  CAS  Google Scholar 

  67. Jensen GF, Christiansen C, Transbol I. Treatment of postmenopausal osteoporosis. A controlled therapeutic trial comparing oestrogen/gestagen, 1,25 dihydroxyvitamin D3 and calcium. Clin Endocrinol 1982; 16: 515 - 524.

    Article  CAS  Google Scholar 

  68. Jensen GF, Meinecke B, Boesen J, Transbol I. Does 1,25 dihydroxyvitaminD3 acclerate spinal bone loss? Clin Orthop 1985; 192: 215 - 221.

    PubMed  Google Scholar 

  69. Falch JA, Odegaard OR, Finnanger M, Matheson I. Postmenopausal osteoporosis: no effect of three years treatment with 1,25 dihydroxycholecalciferol. Acta Med Scand 1987; 221: 199 - 204.

    Article  PubMed  CAS  Google Scholar 

  70. Christiansen C, Christiansen MS, Rodboro P, Hagne C, Transbol I. Effect of 1,25 dihydroxyvitamin D3 in itself or combined with hormone treatment in preventing postmenopausal osteoporosis. Eur J Clin Invest 1981; 11: 305 - 309.

    Article  PubMed  CAS  Google Scholar 

  71. Aloia JF, Vaswani A, Yeh JK, Ellis K, Yasumura S, Cohn SH. Calcitriol in the treatment of postmenopausal osteoporosis. Am J Med 1988; 84: 401 - 408.

    Article  PubMed  CAS  Google Scholar 

  72. Gallagher JC, Riggs BL, Recker RR, Goldgar D. The effect of calcitriol on patients with postmenopausal ostoeporosis with special reference to fracture frequency. Proc Soc Exp Biol Med 1989 191: 287 - 291.

    PubMed  CAS  Google Scholar 

  73. Ott SM, Chestnut CH. Calcitriol treatment is not effective in postmenopausal osteoporosis. Ann Intern Med 1989; 110: 267 - 274.

    PubMed  CAS  Google Scholar 

  74. Ott SM, Chestnut CH. Tolerance to dose of calcitriol is associated with improved density in women with postmenopausal osteoporosis. J Bone Miner Res 1990; 5 (Suppl 2): s186.

    Google Scholar 

  75. Tilyard MW, Spears GFS, Thomson J, Dovey S. Calcitriol or calium for postmenopausal osteoporosis. N Engl J Med 1992; 327: 284 - 288.

    Google Scholar 

  76. Gallacher SJ, Cowan RA, Fraser WD, Logue FC, Jenkins A, Boyle IT. Acute effects of intravenous 1 alpha hydroxycholecalciferol on parathyroid hormone, osteocalcin and calcitriol in man. Eur J Endocrinol 1994; 130: 141 - 145.

    Article  PubMed  CAS  Google Scholar 

  77. Hoikka V, Alhava EM, Aaro A, Karjalainen P, Rehnberg V. Treatment of osteoporosis with 1 alphahydroxycholecalciferol and calcium. Acta Med Scand 1980; 23: 221 - 224.

    Google Scholar 

  78. Itami Y, Fujita T, Fujita T, Inoue E. Effect of alphacalcidol on osteoporosis. J Clin Exp Med 1982; 123; 958 - 973.

    Google Scholar 

  79. Sjiraki M, Orimo H, Ito H, Akiguchi I, Nakao J, Takahashi R, Ishizuka S. Long term trreatment of postmenopausal osteoporosis with active vitamin D3, 1 alpha hydroxycholecalciferol and 1,24 dihydroxycholicalciferol. Endocrinol J 1985; 32: 305 - 315.

    Google Scholar 

  80. Orimo H, Shirak M, Hayashi T, Nakamura T. Reduced occurrence of vertebral rush fractures in senile osteoporosis treated with 1 alpha OH vitamin D3. Bone Miner 1987; 3: 47 - 52.

    PubMed  CAS  Google Scholar 

  81. Fujita T,Orimo H, Inoue T. Double-blind mulitcenter comparative study of alphacalcidol with etidronate disodium in involutional osteoporosis. Clin Eval 1993; 6: 261 - 302.

    Google Scholar 

  82. Orimo, H, Shiraki M, Hayashi Y, Hohino T, Onaya T, Miyazaki S, Kuosawa H, Nakamura T, Ogawa N. Effects of 1 alpha hydroxyvitamin D3 on lumbar bone density and vertebral fractures in patients with postmenopausal osteoporosis. Calcif Tissue Int 1994; 54: 370 - 376.

    Article  PubMed  CAS  Google Scholar 

  83. Chapuy MC, Arlot ME, Delmas PD, Meunier PJ. Effect of calcium and cholecalciferol treatment for three years on hip fractures in elderly women. BMJ 1994; 308: 1081, 1082.

    Google Scholar 

  84. Recker RR, Kimmel DB, Hinders S, Davies KM. Anti fracture efficacy of calcium in elderly women. J Bone Miner Res 1994; 9 (Suppl 1): s154.

    Google Scholar 

  85. Reid IR, Ames RW, Evans MC, Gamble GD, Sharpe SJ. Long term effects of calcium supplementation on bone loss and fractures in postmenopausal women-a randomized controlled trial. Am J Med 1995; 98: 331 - 335.

    Article  PubMed  CAS  Google Scholar 

  86. Lips P, Van Ginkel CV, Jongen JM, Rubertus F, Van Der Vigh VWF. Netelenbos JC. Determinants of vitamin D status in patients with hip fracture and in elderly control subjects. Am J Clin Nutr 1987; 46: 1005 - 1010.

    PubMed  CAS  Google Scholar 

  87. Holick MF, Shao Q, Liu WW Chen TC. The vitamin D content of fortified milk and infant formula. N Engl J Med 1992; 326: 1178 - 1181.

    Article  PubMed  CAS  Google Scholar 

  88. Rosen CJ, Morrison A, Zhou H, Storm D, Hunter S, Musgrave KO, Chen T, Wen-Wei L, Holick MF. Elderly women in northern New England exhibit seasonal changes in bone mineral density and calciotropic hormones. Bone Miner 1994; 25: 83 - 92.

    Article  PubMed  CAS  Google Scholar 

  89. Rosen CJ, Hunter SJ, Vereault DO, Musgrave KO, Smith Porter EM, Chen T, Holick MF. Calcium supplementation prevents bone loss in elderly New England women in a dose dependent manner. J Bone Miner Res 1996; 11 (Suppl 1): 146.

    Google Scholar 

  90. Webb AR, Pilbeam C, Hanafin N, Holick MF. An evaluation of the relative contribution of exposure to sunlight and of diet to the circulating concentrations of 25 hydroxyvitamin D in an elderly nursing home population in Boston. Am J Clin Nutr 1990; 51: 1075 - 1081.

    PubMed  CAS  Google Scholar 

  91. Eberling PR, Sandren ME, DiMagno EP, Lane AW DeLuca HF, Riggs BL. Evidence of an age-related decrease in intestinal responsiveness to vitamin D: relationship between serum 1,25 dihydroxyvitamin D and intestinal vitamin D receptor concentration in normal women. J Clin Endocrinol Metab 1992; 75: 176 - 182.

    Article  Google Scholar 

  92. Heikinheimo RJ, Inkovaara JA, Harju EJ, Haavisto MV, Kaarela RH, Kataja JM, Kooko AM, Kolho LA, Rajala SA. Annual injection of vitamin D and fractures of aged bones. Calcif Tissue Int 1992; 51: 105 - 110.

    Article  PubMed  CAS  Google Scholar 

  93. Chapuy MC, Arlot ME, Duboeuf F, Brun J, Crouzet B, Arnaud S, Delmas PD, Meunier PJ. Vitamin D3 and calcium to prevent hip fractures in the elderly women. N Engl J Med 1992; 327: 1637 - 1642.

    Article  PubMed  CAS  Google Scholar 

  94. Holick MF, Krane S, Potts JR. Calcium phosphorus and bone metabolism: calcium regulating hormones. In: Harrions Principles of Internal Medicine, 13th ed. Isselbacher KJ, Braunwald E, Wilson JD, eds. New York: McGraw-Hill, 1994;:2137-2151.

    Google Scholar 

  95. Stamp TCB, Walker PG, PErry W, Jenkins MV. Nutritional osteomalacia and late rickets in greater London, 1974-1979: clinical and metabolic studies in 45 patients. Clin Endocrinol Metab 1980; 9: 81 - 105.

    Article  PubMed  CAS  Google Scholar 

  96. Parfitt AM, Chu HI. Pioneer clinical investigator of vitamin D deficiency and osteomalcia in China. Calcif Tissue Int 1985; 37: 335 - 339.

    Article  PubMed  CAS  Google Scholar 

  97. Schott GF, Wills MR. Muscle weakness in osteomalacia. Lancet 1976; 1: 626 - 629.

    Article  PubMed  CAS  Google Scholar 

  98. Parfitt AM. The clinical and radiographic manifestations of renal osteodystrophy. In: Perspectives in Hypertension and Nephrology: Calcium Metabolism in Renal Failure and Nephrolithiasis. David DJ, ed. New York: Wiley Sons, 1977; 145 - 195.

    Google Scholar 

  99. Steinbach HL, Noetzli M. Roentgen appearance of the skeleton in osteomalacia and rickets. AJR 1964; 91: 955 - 972.

    CAS  Google Scholar 

  100. Smith R, Dick M. Total urinary hydroxyproline in osteomalcia and the effect upon it of treatment with vitamin D. Clin Sci 1968; 34: 43 - 56.

    PubMed  CAS  Google Scholar 

  101. Peach H. A review of etiological and interventionals tides on rickets and osteomalacia in the United Kingdom. Community Med 1984; 6: 119 - 126.

    PubMed  CAS  Google Scholar 

  102. Henderson JB, Dunnigan MG, McIntosh WB. The importance of limited exposure to ultraviolet radiation and dietary factors in the etiology of Asian rickets. A risk model. Q J Med 1987; 241: 413 - 425.

    Google Scholar 

  103. Davies M, Mawer EB, Krawitt EL. Comparative absorption of vitamin D3 and 25 hydroxyvitamin D3 in intestinal disease. Gut 1980; 21: 287 - 292.

    Article  PubMed  CAS  Google Scholar 

  104. Meredith SC, Rosenberg IH. Gastrointestinal hepatic disorders and osteomalacia. Clin Endocrinol Metab 1980: 9: 131 - 150.

    Article  PubMed  CAS  Google Scholar 

  105. Harris OD, Warner M, Cooke WT. Serum alkaline phosphatase in adult celiac disease. Gut 1969; 10: 655 - 658.

    Article  PubMed  CAS  Google Scholar 

  106. Hajjar ET, Vincenti F, Salti CS. Gluten-induced enteropathy: osteomalacia as a principle manifestation. Arch Intern Med 1974; 134: 565, 566.

    Google Scholar 

  107. Kaplan MM. Metabolic bone disease associated with gastrointestinal disease. Viewpoints Dig Dis 1983; 15: 9 - 12.

    Google Scholar 

  108. Bikle DD, Genant HK, Cann C. Bone disease in alcohol abuse. Ann Intern Med 1985; 103: 42 - 48.

    PubMed  CAS  Google Scholar 

  109. Stellon AJ, Davies A, Compston J, Williams R. Osteoporosis in chronic cholestatic liver disease. Q J Med 1985; 223: 783 - 790.

    Google Scholar 

  110. Bouillon R, Reynaert J, Claes JH. The effect of anticonvulsant therapy on serum levels of 25 hydroxyvitamin D, calcium and PTH. J Clin Endocrinol Metab 1975; 41: 1130 - 1135.

    Article  PubMed  CAS  Google Scholar 

  111. Holick MF. Vitamin D and the kidney. Kidney Int 1987; 32: 919 - 929.

    Article  Google Scholar 

  112. Kumar R. Metabolism of 1,25 dihydroxyvitamin D. Physiol Rev 1984; 64: 478 - 504.

    PubMed  CAS  Google Scholar 

  113. Lopex-Hilker S, Rapp N, Martin K. On the mechanism of the prevention of secondary hyperparathyroidism by phosphate retention. Kidney Int 1986; 29: 164.

    Google Scholar 

  114. Korkor AB. Reduced binding of H-1,25 dihydroxyvitamin D in the parathyroid glands of patients with renal failure. N Engl J Med 1987; 316: 1573 - 1576.

    Article  PubMed  CAS  Google Scholar 

  115. Brown Em, Wilson RE, Easman RC, Pallotta J, Marynik S. Abnormal regulation of PTH release by calcium in secondary hyperparathyroidism due to chronic renal failure. J Clin Endocrinol Metab 1982; 54: 172 - 179.

    Article  Google Scholar 

  116. Sherrard DJ, Ott SM, Maloney NA, Andress DL, Coburn JW. Renal osteodystrophy. Semin Nephrol 1986; 6: 56 - 67.

    PubMed  CAS  Google Scholar 

  117. Mechs O. Renal osteodystrophy in children: etiology and clinical aspects. In: Endstage Renal Disease in Children. Fine RN, Gruskin AB, eds. Philadelphia: Saunders, 1984; 227 - 250.

    Google Scholar 

  118. Salusky IB, Fine RN, Kangarloo H, Gold R, Paunier L, Goodman WG, Brill JE, Gilli G, Slatopolsky E, Coburn JW. High dose calcitriol for control of renal osteodystrophy in children on CAPD. Kidney Int 1987; 32: 89 - 95.

    Article  PubMed  CAS  Google Scholar 

  119. Chesney RW, Moorthy AV, Eisman JA, Tax DK, Mazess RB, DeLuca HG. Increased growth after long term oral 1,25 dihydroxyvitamin D3 in childhood renaly osteodystrophy. N Engl J Med 1978; 298: 238 - 242.

    Article  PubMed  CAS  Google Scholar 

  120. Baker LR, Muir JW, Sharman VL, Abrams SM, Greenwood RN, Cattell WR, Goodwin FJ, Marsh FP, Adami S, Hately W, Hattersly LA, Morgan AG, Papapoulous SE, Revell PA, Tucker AK, Chaput de Saintonge DM, Riordan JLH. Controlled trial of calcitriol in hemodilaysis patients. Clin Nephrol 1986; 26: 185 - 191.

    PubMed  CAS  Google Scholar 

  121. Berl T, Berns AS, Huffer WE, Hammill K, Alfrey AC, Arnaud CD. Schrier RW. 12,5 Dihydroxycholecalciferol effects in chronic dialysis. A double blind controlled study. Ann Intern Med 1978; 88: 774 - 780.

    PubMed  CAS  Google Scholar 

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Authors
  1. Clifford J. Rosen
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Editors and Affiliations

  1. Boston University Medical Center, Boston, MA, USA

    Michael F. Holick PhD, MD

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© 1999 Springer Science+Business Media New York

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Rosen, C.J. (1999). Vitamin D and Bone Health in Adults and the Elderly. In: Holick, M.F. (eds) Vitamin D. Nutrition and Health. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-4757-2861-3_17

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  • DOI: https://doi.org/10.1007/978-1-4757-2861-3_17

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-4757-2863-7

  • Online ISBN: 978-1-4757-2861-3

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