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Developmental Origins of Hematopoietic Stem Cells

  • Elaine Dzierzak
  • Alexander Medvinsky
Chapter
Part of the Contemporary Immunology book series (CONTIM)

Abstract

The hemato/lymphopoietic system is a dynamic continuum of differentiating cells leading to the production of numerous lineages of blood effector cells. In the adult, only a few immature undifferentiated hematopoietic stem cells are required to yield the enormous number of intermediate progenitors and effector cells produced daily. Although these founder cells of the adult mammalian blood system have been extensively studied, the developmental origins of definitive hematopoietic stem cells are controversial, and the subject of much current research. In this article, the authors review studies that explore the ontogeny of the hemato/lymphopoietic system and present current models of initiation, migration, lineage potential, and molecular programming of the cells involved in establishing the complex network in the adult. The combined results of studies on the origin and function suggest distinct embryonic and adult hierarchies on the cellular levels, whereas molecular studies suggest some, but not complete, overlap in the genetic programming of embryonic and adult hematopoietic cells.

Keywords

Hematopoietic Stem Cell Hematopoietic Cell Fetal Liver Hematopoietic Progenitor Adult Bone Marrow 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© Springer Science+Business Media New York 1998

Authors and Affiliations

  • Elaine Dzierzak
  • Alexander Medvinsky

There are no affiliations available

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