Advertisement

Pathogenesis of Allergic Conjunctivitis

  • Sergio Bonini
  • Stefano Bonini
Chapter

Abstract

In recent years, tremendous progress in the understanding of allergic mechanisms has brought new insights into the pathophysiology and clinical aspects of several allergic diseases, as clearly documented by the previous chapters in this section of the book.

Keywords

Allergy Clin Immunol Allergen Challenge Eosinophil Cationic Protein Allergic Conjunctivitis Ocular Allergy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Allansmith MR (1982) The Eye and Immunology. Mosby, St. Louis.Google Scholar
  2. 2.
    Easty DL (1987) Allergy and the eye. In: Allergy-An International Textbook. ( Lessof, MH, Lee TH, Kemeny, DM eds) John Wiley, New York, pp. 513–528.Google Scholar
  3. 3.
    Bonini Se, Bonini St, Tomassini M (1992) Les allergies oculaires. In: Traite d’Allergologie ( Charpin J, Vervloet D, eds) Flammarion, Paris, Chapter 52.Google Scholar
  4. 4.
    Bielory L, Frohman L (1992) Allergic and immunologic disorders of the eye. J Allergy Clin Immunol 86: 1–20.CrossRefGoogle Scholar
  5. 5.
    Abelson MB, Schaefer K (1993) Conjunctivitis of allergic origin: immunologic mechanisms and current approaches to therapy. Sury Ophthalmol 38 (Suppl): 115–132.CrossRefGoogle Scholar
  6. 6.
    Friedlander MH (1993) Conjunctivitis of allergic origin: clinical presentation and differential diagnosis. Sury Ophthalmol 38 (Suppl): 105–114.CrossRefGoogle Scholar
  7. 7.
    Coombs RRA, Gell PGH (1975) Classification of allergic reactions responsible for clinical hypersensitivity and disease. In: Gell PGH, Coombs RRA, Lachmann PJ, Clinical aspects of immunology, third edn. Oxford: Blackwell, pp. 761–882.Google Scholar
  8. 8.
    Irani AM, Butrus SI, Tabbara KF, et al. (1990) Human conjunctival mast cells: distribution of MCT and MCTC in vernal conjunctivitis and giant papillary conjunctivitis. J Allergy Clin Immunol. 86: 34–40.PubMedCrossRefGoogle Scholar
  9. 9.
    Morgan SJ, Williams JH, Walls AF, et al. (1991) Mast cell numbers and staining characteristics in the normal and allergic human conjunctiva. J Allergy Clin Immunol 87: 111–116.PubMedCrossRefGoogle Scholar
  10. 10.
    Magrini L, Metz D, Bacon A, et al. (1993) Immunohistochemistry and inflammation of vernal keratoconjunctivitis. Invest Ophthalmol Vis Sci ARVO Suppl 34: 857.Google Scholar
  11. 11.
    Magrini L, Centofanti M, Schiavone M, et al. (1992) Increased tryptase tear levels in allergic conjunctivitis. In: XVth Europ. Congress Allergology and Clin. Immunol. Paris, p. 254.Google Scholar
  12. 12.
    Bonini St, Centofanti M, Schiavone M, et al. (1993) Passive transfer of the ocular late phase reaction. Ocular Immunol Inflamm 1: 323–325.CrossRefGoogle Scholar
  13. 13.
    Bonini Se, Trocme SD, Barney NP, et al. (1987) Late-phase reaction and tear fluid cytology in the rat ocular anaphylaxis. Curr Eye Res 6: 659–665.CrossRefGoogle Scholar
  14. 14.
    Bonini Se, Bonini St, Vecchione A, et al. (1988) Inflammatory changes in conjunctival scrapings after allergen provocation in humans. J Allergy Clin Immunol 82: 462–469.CrossRefGoogle Scholar
  15. 15.
    Bonini St, Bonini Se, Bucci MG, et al. (1990) Allergen dose response and late symptoms in a human model of ocular allergy. J Allergy Clin Immunol 86: 869–876.CrossRefGoogle Scholar
  16. 16.
    Bonini St, Centofanti M, Schiavone M, et al. (1994) The pattern of ocular late phase reaction induced by allergen challenge in hay fever conjunctivitis. Ocular Immunol Inflamm 2: 195–97.Google Scholar
  17. 17.
    Bonini Se, Bonini St, Berruto A, et al. (1989) Conjunctival provocation test as a model for the study of allergy and inflammation in humans. Int Arch Allergy Appl Immunol 88: 144–148.CrossRefGoogle Scholar
  18. 18.
    Bonini Se, Tomassini M, Bonini St, et al. (1992) The eosinophil has a pivotal role in allergic inflammation of the eye. Int Arch Allergy Appl Immunol 99: 354–358.CrossRefGoogle Scholar
  19. 19.
    Rutella S, Bonini St, Rumi C, et al. (1995) Flow cytometry of peripheral blood leucocytes in vernal keratoconjunctivitis. J Allergy Clin Immunol 95: 376 (abstract).Google Scholar
  20. 20.
    Tomassini M, Magrini L, Bonini St, et al. (1994) Increased serum levels of eosinophil cationic protein and eosinophil derived neurotoxin (protein X) in vernal keratoconjunctivitis. Ophthalmology 101: 1808–1811.PubMedGoogle Scholar
  21. 21.
    Bonini St, Bonini Se, Schiavone M, et al. (1992) Conjunctival hyperresponsiveness to ocular histamine challenge in patients with vernal conjunctivitis. J Allergy Clin Immunol 89: 103–107.CrossRefGoogle Scholar
  22. 22.
    Blumenthal M, Bonini S (1990) Immunogenetics of specific immune responses to allergens in twins and families. In: Marsh DG, Blumenthal M, eds. Genetic and Environmental Factors in Clinical Allergy. University of Minnesota Press, Minneapolis, pp. 132–142.Google Scholar
  23. 23.
    Bonini S, Rasi G, Trine) ME, et al. (1983) Atopy in twins. J Allergy Clin Immunol. pp. 71–100.Google Scholar
  24. 24.
    Bonini S, Trine, ME, Rasi G, et al. (1982) IgE and IgG serum levels in twins. In: Abs. XI Inter. Congress of Allergology and Clinical Immunology. London: Macmillan, p. 817.Google Scholar
  25. 25.
    Bonini Se, Bonini St (1987) Studies of allergic conjunctivitis. Chibret Int J 5: 12–22.Google Scholar
  26. 26.
    Marsh DG (1990) Immunogenetic and immunochemical factors determining imune responsiveness to allergens: studies in unrelated subjects. In: Marsh DG, Blumenthal M, eds. Genetics and environmental factors in clincal allergy. Minneapolis: University of Minnesota Press. pp. 97–122.Google Scholar
  27. 27.
    Bonini S, Adorno D, Piazza M, et al. (1980) Allergic diseases and HLA antigens. In: Oehling A et al., eds. Advances in allergology and clinical immunology. Oxford: Pergamon, p. 778.Google Scholar
  28. 28.
    Del Prete, G (1992) Human Thl and Th2 lymphocytes: their role in the pathophysiology of atopy. Allergy 47: 450–455.PubMedCrossRefGoogle Scholar
  29. 29.
    Bonini Se, Bonini St, and Lambiase A (1995) Vernal keratoconjunctivitis: a model of C5q cytokine gene cluster disease. Int Arch Allergy Appl Immunol. 107: 95–98.CrossRefGoogle Scholar
  30. 30.
    Trocme SD, Aldave AJ (1994) The eye and eosinophil. Sury Ophthalmol. 39: 251–252.Google Scholar
  31. 31.
    van Leeuwen Bh, Martinson ME, Webb CG, et al. (1989) Molecular organization of the cytokine gene cluster, involving the human IL-3, IL-4, IL-5 and GM-CSF genes on human chromosome 5. Blood. 73: 1142–1148.PubMedGoogle Scholar
  32. 32.
    Marshall JS, Stread RH, Macsciarri C, et al. (1990) The role of mast cell degranulation products in mast cell hyperplasia. 1. Mechanisms of action of nerve growth factor. J Immunol. 144: 1885–1892.Google Scholar
  33. 33.
    Foreman JC (1987) Neuropeptides and pathogenesis of allergy. Allergy 42: 1–11.PubMedCrossRefGoogle Scholar
  34. 34.
    Bonini Se, Bonini St, Lambiase A, et al. (1995) Immune, endocrine and neural aspects of allergic inflammation. In: Proceedings 1, XVI European Congress of Allergology and Clinical Immunology ( A. Basomba and J Sastre eds) Monduzzi, Bologna, pp. 475–480.Google Scholar
  35. 35.
    Bonini Se, Bonini St (1993) IgE and non-IgE mechanisms in ocular allergy. Ann Allergy. 71: 296–298.Google Scholar
  36. 36.
    Maggi E, Biswas P, Del Prete G, et al. (1991) Accumulation of Th2-like helper T cells in the conjunctiva of patients with vernal conjunctivitis. J Immunol 146: 1169–1174.PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1998

Authors and Affiliations

  • Sergio Bonini
  • Stefano Bonini

There are no affiliations available

Personalised recommendations