Pathogenic Mechanisms of Urticaria

  • Allen P. Kaplan


Urticaria and angioedema are common disorders affecting approx 20% of the population at some time during their lifetime. Urticaria (hives) is an intensely pruritic rash that consists of a centrally raised blanched wheal surrounded by an erythematous flare that is generally circular but can vary greatly in size and shape depending on the particular type. It is caused by inflammation that is localized to the venular plexuses of the superficial dermis. Angioedema (except hereditary and vibratory angioedema) has the same causes and pathogenic mechanisms as does urticaria, but the reaction occurs in the deep dermis and subcutaneous tissue and has swelling as the prominent manifestation with a normal external appearance of the skin.


Histamine Release Allergy Clin Immunol Chronic Urticaria Systemic Mastocytosis Cold Urticaria 
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  • Allen P. Kaplan

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