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Role of CD8+ T-Cells in the Regulation of Immunoglobulin E

  • Paul A. MacAry
  • David M. Kemeny
Chapter

Abstract

Asthma and other allergic diseases have become increasingly common in the latter part of the 20th century. Allergic reactions in the airways are triggered by immunoglobulin E (IgE) sensitized mast cells and T-helper 2 (Th2) CD4+ T-cells, whose activation leads to the infiltration of other inflammatory cells, which contribute to tissue damage. One-third of all circulating T-cells are CD8+/CD4. These cells are found at all immune sites and are particularly prominent in mucosal tissues, where they provide a first line of defense fulfilling an immunological gatekeeper function (1,2). CD8+ T-cells recognize intracellular antigens presented via major histocompatibility complex (MHC) class I and are more cytolytic than CD4+ T-cells, producing perforin and degradative enzymes such as granzyme B. CD8+ T-cells can kill MHC class-I peptide-bearing target cells via the Fas-dependent “kiss-of-death” pathway. In this chapter we will review the role of CD8+ T-cells in IgE regulation.

Keywords

Major Histocompatibility Complex Major Histocompatibility Complex Class Castor Bean Tuberculoid Leprosy Sensitize Mast Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© Springer Science+Business Media New York 1998

Authors and Affiliations

  • Paul A. MacAry
  • David M. Kemeny

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