Molecular Mechanisms of Isotype Switching to IgE

  • Donata Vercelli


During an immune response, B-lymphocytes express different immunoglobulin (Ig) heavy-chain isotypes sharing the same variable region. This phenomenon (isotype switching) allows a single B-cell clone to produce antibodies with the same fine specificity, but different effector functions. In order to switch to a particular isotype, a B-cell needs to receive two signals: signal 1 is cytokine-dependent, results in the activation of transcription at a specific region of the Ig locus, and determines isotype specificity. Signal 2 activates the recombination machinery, and leads to DNA switch recombination.


Class Switch Recombination Isotype Switching CD40 Engagement Nonhistone Chromosomal Protein Germline Transcript 
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© Springer Science+Business Media New York 1998

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  • Donata Vercelli

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