Pharmacology in Sleep Medicine
In sleep disorders, as in all of medicine, the prescription of drugs is often an integral component of treatment. This chapter focuses on two general types of sleep medications: drugs that promote sleep and drugs that promote alertness. These have been generally labeled hypnotic-sedatives and central nervous system (CNS) stimulants, respectively. There are numerous classes of agents in each category, and often, numerous specific agents in each class. A few of them are described below, separated into those generally useful in insomnia and those generally useful in states of hypersomnolence such as narcolepsy. More detailed descriptions of the clinical conditions are available elsewhere in this volume, specifically in Chapters 2 and 5.
KeywordsObstructive Sleep Apnea Sleep Disturbance Sleep Disorder Sleep Latency Slow Wave Sleep
Unable to display preview. Download preview PDF.
- Berry RB, Kouchi K, Bower J, Prosise G, Light RW. Triazolam in patients with obstructive sleep apnea. AJRCCM 1995; 151: 450–454.Google Scholar
- Daly DD, Yoss RE. The treatment of narcolepsy with methyl phenylpiperidylacetate: a preliminary report. Proc Mayo Clin 1956; 31: 620–625.Google Scholar
- Mendelson WB. Clinical neuropharmacology of sleep. Clin Neuropharm 1990; 8: 153–160.Google Scholar
- Mendelson WB. Insomnia and related sleep disorders. Psych Clin NAm 1993; 16: 841–851.Google Scholar
- Mendelson WB. Adverse reactions to sedative/hypnotics: three years’ experience. Sleep 1997; 19: 702–706.Google Scholar
- Mendelson WB. Neuropharmacology of sleep induction by benzodiazepines. Crit Rev Neurobiol 1992; 16: 221–232.Google Scholar
- Mendelson WB. The use of sedative/hypnotic medication and its correlation with falling down in the hospital. Sleep 1997; 19: 698–701.Google Scholar
- Saletu B, Anderer P, Brandstatter N, et al. Insomnia in generalized anxiety disorder: polysomnographic, psychometric and clinical investigations before, during and after therapy with a long-vs a short-half-life benzodiazepine (quazepam versus triazolam). Neuropsychobiology 1994; 29: 69–90.PubMedCrossRefGoogle Scholar