Characterization of Lymphotoxin-α-Deficient Mice
The tumor necrosis factor (TNF) family of proteins consists of a rapidly growing collection of ligands and receptors, many of which appear to be critically involved in the regulation of the immune system. To date, a large number of studies have focused on the structural and functional relationships of three cytokines in particular, tumor necrosis factor-α (TNFα), lymphotoxin-α (LTα), and lymphotoxin-β (LTβ). Whereas TNFα and LTα were one of the first members of the TNF family to be studied at the genetic level (1), the organization of the LTβ locus has only recently been defined (2). All three genes are located in close proximity to one another in the major histocompatibility complex (MHC) class III region of human chromosome 6 and murine chromosome 17 (1).
KeywordsMajor Histocompatibility Complex Mutant Mouse SCID Mouse Tumor Necrosis Factor Family Tumor Necrosis Factor Signal
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