Cooperation Between the TNF Receptors Demonstrated by TNF Receptor Knockout Mice
Tumor necrosis factor (TNF) is a potent cytokine that mediates many biological events, including proliferation of fibroblasts and T-cells, induction of NF-κB, cytotoxicity, tumor necrosis as well as antiviral, inflammatory, and immunoregulatory responses. TNF has been implicated as a central mediator of septic shock as well as graft-vs-host disease, arthritis, and several autoimmune disorders. There are two related TNF molecules, TNFα (tumor necrosis factor or cachectin) and TNFβ (lymphotoxin). TNFα is produced mainly by T-cells, macrophages, and mast cells, whereas TNFß is produced by activated lymphocytes. TNFα and β mediate their actions by binding to two distinct cell surface receptors, TNF-R1 (55 kDa also known as TNFRβ and TNF-R55) and TNF-R2 (75 kDa, also known as TNFRα, and TNFR-75). Both receptors are found on most cell types.
KeywordsDeficient Mouse Cytoplasmic Domain Tumor Necrosis Factor Receptor Follicular Dendritic Cell Thymocyte Development
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