Abstract
The hematologic malignancies are a diverse group of disorders that are frequently considered together because they consist of clonal expansions of hematopoietic cells. The cell of origin of many of the hematologic malignancies is known. The stage of differentiation of the transformed cell essentially determines the phenotype of the disorder. Before considering the types of hematologic malignancies, we will review the normal differentiation pathway of hematopoietic cells.
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References
Preti A, Kantarjian HM. Management of adult acute lym- 20. phocytic leukemia: present issues and key challenges. J Clin Oncol. 1994; 12: 1312–1322.
Hoelzer DF. Therapy of the newly diagnosed adult with acute lymphoblastic leukemia. Hematol Oncol Clin North 21. Am. 1993; 7: 139–160.
Harousseau J-L. Is intensive treatment beneficial to elderly 22. patients with ANLL? Hematol Oncol. 1993; 11: 4–8.
Foon KA, Zighelboim J, Yale C, et al. Intensive chemotherapy is the treatment of choice for elderly patients with 23. acute myelogenous leukemia. Blood. 1981; 58: 467–470.
Tallman MS, Rowe JM. Acute promyelocytic leukemia: a paradigm for differentiation therapy with retinoic acid. Blood Rev. 1994; 8: 70–78. 24.
Kourdes PA, Bennett JM. Morphology and classification of myelodysplastic syndromes. Hematol Oncol Clin North 25. Am. 1992; 6: 485–500.
Mufti GJ. A guide to risk assessment in the primary 26. myelodysplastic syndrome. Hematol Oncol Clin North Am. 1992; 6: 587–606.
Noel P, Solberg LA. Myelodysplastic syndromes. Crit Rev 27. Oncol Hematol. 1992; 12: 193–215.
Kantarjian HM, Deisseroth A, Kurzrock R, et al. Chronic myelogenous leukemia: a concise update. Blood. 1993; 28. 82: 691–703.
Tura S, Baccarani M, Zuffa E, et al. Interferon alfa-2a as compared with conventional chemotherapy for the treatment of chronic myeloid leukemia. N Engl J Med. 29. 1994; 330: 820–825.
Miller JS, McGlave PB. Therapy for chronic myelogenous leukemia with marrow transplantation. Curr Opin Oncol. 1993; 5: 262–269.
Prchal JT, Prchal JF. Evolving understanding of the cellular defect in polycythemia vera: applications for its clinical diagnosis and molecular pathophysiology. Blood. 1994; 83: 1–4.
Tura S. The management of elderly patients with myeloproliferative disorders. Hematol Oncol. 1993; 11: 39–41.
Silver RT. Interferon-a2b: a new treatment for polycythemia vera. Ann Intern Med. 1993; 119: 1091–1092.
Benbassat J, Gilon D, Penchas S. The choice between splenectomy and medical treatment in patients with advanced agnogenic myeloid metaplasia. Am J Hematol. 1990; 33: 128–135.
Oscier DG. Cytogenetic and molecular abnormalities in chronic lymphocytic leukaemia. Blood Rev. 1994; 8: 88–97.
Rozman C, Montserrat E, Rodriquez-Fernandez JM, et al. Bone marrow histologic pattern, the best single prognostic parameter in chronic lymphocytic leukemia: a multivariate survival analysis of 329 cases. Blood. 1984; 64: 642.
Keating MJ, McLaughlin P, Plunkett W, et al. Fludarabine-present status and future developments in chronic lymphocytic leukemia and lymphoma. Ann Oncol. 1994; 5 (suppl 2): 79–83.
Cooperative Group for the Study of Immunoglobulin in Chronic Lymphocytic Leukemia. Intravenous immunoglobulin for the prevention of infection in chronic lymphocytic leukemia. A randomized controlled clinical trial. N Engl J Med. 1988; 319: 902.
Smalley RV, Connors J, Tuttle RL, et al. Splenectomy vs alpha interferon: a randomized study in patients with previously untreated hairy cell leukemia. Am J Hematol. 1992; 41: 13–18.
Saven A, Piro L. Newer purine analogues for the treatment of hairy-cell leukemia. N Engl J Med. 1994; 330: 691–697.
Crawford J, Eye MK, Cohen HJ. Evaluation of monoclonal gammopathies in the “well” elderly. Am J Med. 1987; 82: 39–45.
Kyle RA. Plasma cell proliferative disorders. In: Hoffman R, Benz EJ, Shattil SJ, Furie B, et al., eds. Hematology Basic Principles and Practice. New York: Churchill-Livingstone; 1991: 1021–1038.
Kyle RA. Current concepts on monoclonal gammopathies. Aust NZ J Med. 1992; 22: 291–302.
Gautier M, Cohen HJ. Multiple myeloma in the elderly. J Am Geriatr Soc. 1994; 42: 653–664.
Paquette RL, Berenson J, Lichtenstein A, et al. Oncogenes in multiple myeloma: point mutation of N-ras. Oncogene. 1990; 5: 1659–1663.
Bataille R, Chappard D, Klein B. Mechanisms of bone lesions in multiple myeloma. Hematol Oncol Clin North Am. 1992; 6: 285–295.
Gregory WM, Richards MA, Malpas JS. Combination chemotherapy versus melphalan and prednisolone in the treatment of multiple myeloma: an overview of published trials. J Clin Oncol. 1992; 10: 334–342.
Buzaid AC, Durie BGM. Management of refractory myeloma: a review. J Clin Oncol. 1988; 6: 889–905.
Sonneveld P, Durie BGM, Lokhorst HM, et al. Modulation of multidrug-resistant multiple myeloma by cyclosporin. Lancet. 1992; 340: 255–259.
Mandelli F, Avvisati G, Amadori S, et al. Maintenance treatment with recombinant interferon alfa-2b in patients with multiple myeloma responding to conventional induction chemotherapy. N Engl J Med. 1990; 322: 1430–1434.
Klein B, Wijdenes J, Zhang XG, et al. Murine anti-interleukin-6 monoclonal antibody therapy for apatient with plasma cell leukemia. Blood. 1991; 78: 1198 1204.
Ludwig H, Fritz E, Kotzmann H, et al. Erythropoietin treat ment of anemia associated with multiple myeloma. N Engl J Med. 1990; 322: 1693–1699.
Crawford J, Cox EB, Cohen HJ. Evaluation of hyperviscosity in monoclonal gammopathies. Am J Med. 1985; 79: 13.
Gertz MA, Kyle RA, Greipp PR. Response rates and sur vival in primary systemic amyloidosis. Blood. 1991; 77: 257–262.
Weisenburger DD. Epidemiology of non-Hodgkin’s lymphoma: recent findings regarding an emerging epidemic. Ann Oncol. 1994; 5 (suppl 1): 19–24.
Gaidano G, Dalla-Favera R. Biologic and molecular char acterization of non-Hodgkin’s lymphoma. Curr Opin Oncol. 1993; 5: 776–784.
Young RC, Longo DL, Glatstein E, et al. The treatment of indolent lymphomas: watchful waiting. V. Aggressive com bined modality treatment. Semin Hematol. 1988; 25: 11.
Shipp MA. Prognostic factors in aggressive non-Hodgkin’s lymphoma: who has “high-risk” disease? Blood. 1994; 83: 1165–1173.
Dixon DO, Neilan B, Jones SE, et al. Effect of age ontherapeutic outcome in advanced diffuse histiocytic lymphoma: The Southwest Oncology Group experience. J Clin Oncol. 1986; 4: 295–305.
Vose JM, Armitage JO, Weisenburger DD, et al. The im portance of age in survival of patients treated with chemotherapy for aggressive non-Hodgkin’s lymphoma. J Clin Oncol. 1988; 6: 1838–1844.
Mauch PM, Kalish LA, Kadin M, et al. Patterns of presentation of Hodgkin disease: implications for etiology and pathogenesis. Cancer. 1993; 71: 2062–2071.
Kaufman D, Lungo DL. Hodgkin’s disease. Clin Rev Oncol/Hematol. 1992; 13: 135–187.
Mauch PM. Controversies in the management of early stage Hodgkin’s disease. Blood. 1994; 83: 318–329.
DeVita VT, Hubbard SM. Drug therapy: Hodgkin’s dis ease. N Engl J Med. 1993; 328: 560–565.
Canellos GP, Anderson JR, Propert KJ, et al. Chemotherapy of advanced Hodgkin’s disease with MOPP, ABVD, or MOPP alternating with ABVD. N Engl J Med. 1992; 327: 1478–1484.
Prosnitz LR, Roberts KB. Combined chemotherapy and radiotherapy for Hodgkin’s disease. Oncology. 1992;6: 113–137.
Mir R, Anderson J, Strauchen J, et al. Hodgkin disease in patients 60 years of age or older. Cancer. 1993; 71: 1857–1866.
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Gautier, M., Cohen, H.J. (1997). Hematologic Malignancies. In: Cassel, C.K., et al. Geriatric Medicine. Springer, New York, NY. https://doi.org/10.1007/978-1-4757-2705-0_25
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DOI: https://doi.org/10.1007/978-1-4757-2705-0_25
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