The Science of Neoplasia

  • William B. Ershler


Cancer is a geriatric disease. Over 50% of all cancers occur in the 13% of the population over 65 years old and this population sustains over 60% of all cancer deaths. Neoplastic transformation at the cellular level involves many of the same genetic and molecular pathways as normal cellular senescence. Cell immortalization and senescence reflect contrasting outcomes that involve similar metabolic and molecular pathways. This chapter discusses certain of these common, clinically relevant principles relating cancer and aging. Additionally, an extension of these principles to the topics of cancer prevention and management is presented.


Breast Cancer Familial Adenomatous Polyposis Antigenic Tumor Beta Carotene Natl Cancer Inst 


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© Springer Science+Business Media New York 1997

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  • William B. Ershler

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