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Signaling Pathways Modulated by Dopamine Receptors

  • Rita M. Huff
Part of the The Receptors book series (REC)

Abstract

Knowledge of the intracellular signaling events altered by the binding of dopamine to its receptors is critical to the understanding of how dopamine and dopaminergic drugs elicit their actions. Activation of a signal transduction mechanism that can regulate ion channels and turn on second messenger systems is the first step toward a variety of responses in neurons, from immediate changes in neuron excitability to long-term modulatory processes. Dopamine is a neurotransmitter and, thus, affects the excitability of neurons, but it also regulates protein kinases and transcription factors through signal transduction cascades initiated by the receptors. The long-term adaptive responses resulting from dopamine receptor activation or blockade are undoubtedly important for the effects of psychotropic drugs (1). Characterization of the initial events triggered by activation of dopamine receptors at a molecular level can contribute to an understanding of how changes in ion channel actuation, protein phosphorylation, and the genetic programs of the cells can occur.

Keywords

Dopamine Receptor Adenylate Cyclase Pituitary Cell Pertussis Toxin Arachidonic Acid Release 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© Springer Science+Business Media New York 1997

Authors and Affiliations

  • Rita M. Huff

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