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Distribution of Dopamine Receptors

  • Marjorie A. Ariano
Part of the The Receptors book series (REC)

Abstract

Dopamine neurotransmission has a very broad clinical relevance because of its alteration in several prevalent psychomotor disturbances (see Chapter 15 for more details). The most frequently occurring dopaminergic dysfunction is associated with Parkinson’s disease, caused by the progressive loss of the dopaminergic neurons of the substantia nigra (1). Although the etiology of affective psychoses, addictions to cocaine or alcohol, and hypertension are less well understood, a large body of clinical and experimental observations document that changes occur in dopamine mechanisms in these disorders (2,3). One of the prevalent treatments for dopaminergic dysfunctions is the use of exogenous dopamine replacement/attenuation therapies in modern neurology and psychiatry to activate/block dopamine receptors. This type of intervention is prescribed whether or not the dopaminergic system has a direct etiology for the disorder, for example, Huntington’s disease (4), schizophrenia (5), addiction (6), and stress (7) in addition to the well-established regimen of L-DOPA precursor treatment for amelioration of the symptoms associated with Parkinson’s disease.

Keywords

Dopamine Receptor Nucleus Accumbens Olfactory Tubercle Receptor Subfamily Dopamine Receptor Subtype 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Ehringer, J. and Hornykiewicz, 0. (1960) Verteilung von adrenalin und dopamin (3-hydroxytyramin)im gtehirn des menschen und i hr verhalten bei erkran-kungen des extrapyramidalen systems. Wien Klin. Wschr. 38, 1236–1239.CrossRefGoogle Scholar
  2. 2.
    Carlsson, A. (1987) Perspectives on the discovery of central monoaminergic neurotransmission. Annu. Rev. Neurosci. 10, 19–40.PubMedCrossRefGoogle Scholar
  3. 3.
    Kalivas, P. and Nemeroff, C. R. (1988) The mesocorticolimbic system. Ann. NY Acad. Sci. 537, 1–537.CrossRefGoogle Scholar
  4. 4.
    DeLong, M. (1990) Primate models of involvement disorders of basal ganglia origin. TINS 13, 281–285.Google Scholar
  5. 5.
    Reynolds, G. P. (1992) Developments in the drug treatment of schizophrenia. TIPS 13, 116–121.Google Scholar
  6. 6.
    Rossetti, Z. L., Honaiden, Y., and Gessa, G. L. (1992) Marked inhibition of mesolimbic dopamine release: a common feature of ethanol, morphine, cocaine and amphetamine abstinence in rats. Eur. J. Pharmacol. 221, 227–234.Google Scholar
  7. 7.
    Cenci, M. A., Kalén, P., Mandel, R. J., and Bjorklund, A. (1992) Regional differences in the regulation of dopamine and noradrenaline release in medial frontal cortex, nucleus accumbens and caudate-putamen: a microdialysis study in the rat. Brain Res. 581, 217–228.Google Scholar
  8. 8.
    Kebabian, J. W. and Calne, D. B. (1979) Multiple receptors for dopamine. Nature 277 93–96.Google Scholar
  9. 9.
    Ariano, M. A., Briggs, C. A., and McAfee, D. A. (1982) Cellular localization of cyclic nucleotide changes in rat superior cervical ganglion. Cell Mol. Neurobiol. 2, 143–156.CrossRefGoogle Scholar
  10. 10.
    Ariano, M. A. and Adinolfi, A. M. (1977) Cyclic nucleotide phosphodiesterase: subcellular localization in caudate following selective interruption of striatal afferents. Exp. Neurol. 57, 426 ‘133.Google Scholar
  11. 11.
    Ariano, M. A., Butcher, L. L., and Appleman, M. M. (1980) Cyclic nucleotides in rat caudate-putamen complex: histochemical characterization and effects of deafferentation and kainic acid infusion. Neuroscience 5, 1269–1276.PubMedCrossRefGoogle Scholar
  12. 12.
    Spano, P. F., Trabucchi, M., and DiChiara, G. (1977) Localization of nigral dopamine-sensitive adenylate cyclase on neurons originating from the corpus striatum. Science 196, 1343–1345.PubMedCrossRefGoogle Scholar
  13. 13.
    Briggs, C. A., Whiting, C., Ariano, M. A., and McAfee, D. A. (1982) Cyclic nucleotide metabolism in the sympathetic ganglion. Cell Mol. Neurobiol. 2, 129–142.CrossRefGoogle Scholar
  14. 14.
    Ariano, M. A. and Ufkes, S. K. (1983) Cyclic nucleotide distribution within rat striatonigral neurons. Neuroscience 9, 23–29.PubMedCrossRefGoogle Scholar
  15. 15.
    Ariano, M. A. and Kenny, S. L. (1 985) Neurotransmitter receptor autoradiography in immunohistochemically identified neurons. J. Neurosci. Methods 15, 49–61.Google Scholar
  16. 16.
    Billard, W., Ruperto, V., Crosby, G., Iorio, L. C., and Barnett, A. (1984) Characterization of the binding of3H-SCH 23390, a selective D-1 receptor antagonist ligand, in rat striatum. Life Sci. 35, 1885–1893.PubMedCrossRefGoogle Scholar
  17. 17.
    Iorio, L. C., Barnett, A., Leitz, F. H., Houser, V. P., and Korduba, C. (1983) SCH 23390, a potential benzazepine antipsychotic with unique interactions on dopamine systems. J. Pharmacol. Exp. Ther. 226, 462–468.PubMedGoogle Scholar
  18. 18.
    Scatton, B. and Dubois, A. (1985) Autoradiographic localization of D dopamine receptors in the rat brain with 3H-SKF 38393. Eur. J. Pharmacol. 111, 145, 146.Google Scholar
  19. 19.
    Jastrow, T. R., Richfield, E., and Gnegy, M. E. (1984) Quantitative autoradiography of 3H-sulpiride binding sites in rat brain. Neurosci. Lett. 51, 47–53.PubMedCrossRefGoogle Scholar
  20. 20.
    Drukarch, B. and Stoof, J. C. (1990) Dz dopamine autoreceptor selective drugs: do they really exist? Life Sci. 47, 361–376.PubMedCrossRefGoogle Scholar
  21. 21.
    Plantje, J. F., Hansen, H. A., Daus, F. J., and Stoof, J. C. (1984) The effects of SCH 23390, YM 09151–2, (+)- and (—)-3-PPP and some classical neuroleptics on D-1 and D-2 receptors in rat neostriatum in vitro. Eur. J. Pharmacol. 105, 73–83.PubMedCrossRefGoogle Scholar
  22. 22.
    Wolf, M. E. and Roth, R. H. (1987) Dopamine autoreceptors, in Receptor Biochemistry and Methodology ( Venter, J. C. and Harrison, L. C., eds.), Wiley, New York, pp. 45–96.Google Scholar
  23. 23.
    Wolf, M. E. and Roth, R. H. (1990) Autoreceptor regulation of dopamine synthesis. Ann. N.Y Acad. Sci. 604, 323–343.PubMedCrossRefGoogle Scholar
  24. 24.
    Skirboll, L. R., Grace, A. A., and Bunney, B. S. (1979) Dopamine auto-and postsynaptic receptors: electrophysiological evidence for differential sensitivity to dopamine agonists. Science 206, 80–82.PubMedCrossRefGoogle Scholar
  25. 25.
    Bunzow, J. R., Van Tol, H. H. M., Grandy, D. K., Albert, P., Salon, J., Christy, M., Machida, C. A., Neve, K., and Civelli, O. (1988) Cloning and expression of a rat D2 dopamine receptor cDNA. Nature 336, 22–29.Google Scholar
  26. 26.
    O’Malley, K. L., Harmon, S., Tang, L., and Todd, R. D. (1992) The rat dopamine D4 receptor: sequence, gene structure, and demonstration of expression in the cardiovascular system. N. Biol. 4, 137–146.Google Scholar
  27. 27.
    Sokoloff, P., Giros, B., Martres, M.-P., Bouthenet, M.-L., and Schwartz, J.-C. (1990) Molecular cloning and characterization of a novel dopamine receptor (D3) as a target for neuroleptics. Nature 347, 146–151.PubMedCrossRefGoogle Scholar
  28. 28.
    Sunahara, R. K., Guan, H.-C., O’Dowd, B. F., Seeman, P., Laurier, L. G., Ng, G., George, S. R., Torchia, J., Van Tol, H. H. M., and Niznik, H. B. (1991) Human dopamine D1 receptor encoded by an intronless gene on chromosome 5. Nature 350, 614–619.Google Scholar
  29. 29.
    Tiberi, M., Jarvie, K. R., Silvia, C., Falardeau, P., Gingrich, J. A., Godinot, N., Bertrand, L., Yang-Feng, T. L., Fremeau, R. P., Jr., and Caron, M. G. (1991) Cloning, molecular characterization, and chromosomal assignment of a gene encoding a second DI dopamine receptor subtype: differential expression pattern in rat brain compared with the DIA receptor. Proc. Natl. Acad. Sci. USA 88, 7491–7495.Google Scholar
  30. 30.
    Van Tol, H. H. M., Bunzow, J. R., Guan, H.-C., Sunahara, R. K., Seeman, P., Niznik, H. B., and Civelli, 0. (1991) Cloning of the gene for a human D4 receptor with high affinity for the antipsychotic clozapine. Nature 350, 610–614.Google Scholar
  31. 31.
    Andersen, P. H. Gingrich, J. A., Bates, M. D., Dearry, A., Falardeau, P., Senogles, S. E., and Caron, M. G. (1990) Dopamine receptor subtypes: beyond the Di /D, classification. Trends Pharmacol. Sci. 11 231–236.Google Scholar
  32. 32.
    Sibley, D. R. and Monsma, F. J., Jr. (1992) Molecular biology of dopamine receptors. TIPS 13, 61–69.Google Scholar
  33. 33.
    Monsma, F. J., Jr., Mahan, L. C., McVittie, L. D., Gerfen, C. R., and Sibley, D. R. (1990) Molecular cloning and expression of a D, dopamine receptor linked to adenylyl cyclase activation. Proc. Natl. Acad. Sci. USA 87, 6723–6727.PubMedCrossRefGoogle Scholar
  34. 34.
    Fishburn, C. S., Belleli, D., David, C., Carmon, S., and Fuchs, S. (1993) A novel short isoform of the D3 receptor generated by alternative splicing in the third cytoplasmic loop. J. Biol. Chem. 268, 5872–5878.PubMedGoogle Scholar
  35. 35.
    Monsma, F. J., Jr., McVittie, L. D., Gerfen, C. R., Mahan, L. C., and Sibley, D. R. (1989) Multiple D2 dopamine receptors produced by alternative RNA splicing. Nature 342, 926–929.Google Scholar
  36. 36.
    Altar, C. A. and Marien, M. R. (1986) Picomolar affinity of 125I-SCH23982 for D, receptors in brain demonstrated with digital subtraction autoradiography. J. Neurosci. 7, 213–222.Google Scholar
  37. 37.
    Ariano, M. A., Kang, H. C., Haugland, R. P., and Sibley, D. R. (1991) Multiple fluorescent ligands for dopamine receptors. II. Visualization in neural tissues. Brain Res. 547, 208–222.PubMedCrossRefGoogle Scholar
  38. 38.
    Bouthenet, M.-L., Martres, M.-P., Sales, N., and Schwartz, J.-C. (1987) A detailed mapping of dopamine D-2 receptors in rat central nervous system by autoradiography with 125I-iodosulpride. Neuroscience 20, 117–155.PubMedCrossRefGoogle Scholar
  39. 39.
    Boyson, S. J., McGonigle, P., and Molinoff, P. (1986) Quantitative autoradio-graphic localization of the D-1 and D-2 subtypes of dopamine receptors in rat brain. J. Neurosci. 6, 3177–3188.PubMedGoogle Scholar
  40. 40.
    Larson, E. R. and Ariano, M. A. (1995) D3 and D2 dopamine receptors: visualization of cellular expression patterns in motor and limbic structures. Synapse 20, 325–337.PubMedCrossRefGoogle Scholar
  41. 41.
    Vincent, S. L., Khan, Y., and Benes, F. M. (1993) Cellular distribution of dopamine D, and D2 receptors in rat medial prefrontal cortex. J. Neurosci. 13, 2557–2564.Google Scholar
  42. 42.
    Bouthenet, M. L., Souil, M.-P., Sokoloff, P., Giros, B., and Schwartz, J.-C. (1991) Localization of dopamine D3 receptor mRNA in the rat brain using in situ hybridization histochemistry: comparison with D2 receptor mRNA. Brain Res. 564, 203–219.PubMedCrossRefGoogle Scholar
  43. 43.
    Fremeau, R. T., Jr., Duncan, G. E., Fornaretto, M.-G., Dearry, A., Gingrich, J. A., Breese, G. R., and Caron, M. G. (1991) Localization of D, dopamine receptor mRNA in brain supports a role in cognitive, affective, and neuroendocrine aspects of dopaminergic neurotransmission. Proc. Natl. Acad. Sci. USA 88, 3772–3776.Google Scholar
  44. 44.
    Le Moine, C. and Bloch, B. (1991) Rat striatal and mesencephalic neurons contain the long form of the D2 receptor mRNA. Mol. Brain Res. 10, 283–289.PubMedCrossRefGoogle Scholar
  45. 45.
    Meador-Woodruff, J. H., Mansour, A., Grandy, D. K., Damask, S. P., Civelli, 0., and Watson, S. J., Jr. (1992) Distribution of D5 receptor mRNA in rat brain. Neurosci. Lett. 145, 209–212.Google Scholar
  46. 46.
    Meador-Woodruff, J. H., Mansour, A., Van Tol, H. H. M., Watson, S. J., Jr., and Civelli, 0. (1989) Distribution of D2 dopamine receptor mRNA in rat brain. Proc. Natl. Acad. Sci. USA 86, 7625–7628.PubMedCrossRefGoogle Scholar
  47. 47.
    Large, C. H. and Stubbs, C. M. (1994) The dopamine D3 receptor: Chinese hamsters or Chinese whispers? TIPS 15, 46, 47.Google Scholar
  48. 48.
    Liu, J.-C., Cox, R. F., Greif, G. J., Freedman, J. E., and Waszczak, B. L. (1994) The putative dopamine D3 receptor agonist 7-OH-DPAT: lack of mesolimbic selectivity. Eur. J. Pharmacol. 264, 265–269.CrossRefGoogle Scholar
  49. 49.
    Mansour, A., Meador-Woodruff, J., Bunzow, J. R., Civelli, O., Akil, H., and Watson, S. J., Jr. (1990) Localization of dopamine D2 receptor mRNA and DI and D2 receptor binding in the rat brain and pituitary: an in situ hybridization-receptor autoradiographic analysis. J. Neurosci. 10, 2587–2600.Google Scholar
  50. 50.
    Mansour, A., Meador-Woodruff, J., Zhou, Q., Civelli, O., Akil, H., and Watson, S. J., Jr. (1991) A comparison of Di receptor binding and mRNA in rat brain using receptor autoradiography and in situ hybridization histochemistry techniques. Neuroscience 45, 359–377.Google Scholar
  51. 51.
    Qin, Z. H., Chen, J. F., and Weiss, B. (1994) Lesions of mouse striatum induced by 6-hydroxydopamine differentially alter the density, rate of synthesis, and level of gene expression of DI and D2 dopamine receptors. J. Neurochem. 62, 411–420.PubMedCrossRefGoogle Scholar
  52. 52.
    Noblett, K. L. and Ariano, M. A. (1996) Co-expression of receptor mRNA and protein: striatal dopamine and excitatory amino acid subtypes. J. Neurosci. Methods 66, 61–66.PubMedCrossRefGoogle Scholar
  53. 53.
    Ariano, M. A. and Sibley, D. R. (1994) Dopamine receptor distribution in the rat CNS: elucidation using anti-peptide antisera directed against DIA and D3 subtypes. Brain Res. 648, 95–110.CrossRefGoogle Scholar
  54. 54.
    David, C., Ewert, M., Seeburg, P. H., and Fuchs, S. (1991) Antipeptide antibodies differentiate between long and short isoforms of the D2 receptor. Biochem. Biophys. Res. Commun. 179, 824–829.PubMedCrossRefGoogle Scholar
  55. Huang, Q., Zhou, D. Chase, K., Gusella, J. F., Aronin, N., and DiFiglia, M. (1992) Immunohistochemical localization of the DI dopamine receptor in rat brain reveals its axonal transport, pre-and postsynaptic localization, and prevalence in the basal ganglia, limbic system, and thalamic reticular nucleus. Proc. Natl. Acad. Sci. USA 89 11,988–11,992.Google Scholar
  56. 56.
    Levey, A. I., Hersch, S. M., Rye, D. B., Sunahara, R. K., Niznik, H. B., Kitt, C. A., Price, D. L., Maggio, R., Brann, M. R., and Ciliax, B. J. (1993) Localization of DI and D2 dopamine receptors in brain with subtype-specific antibodies. Proc. Natl. Acad. Sci. USA 90, 8861–8865.Google Scholar
  57. 57.
    McVittie, L. D., Ariano, M. A., and Sibley, D. R. (1991) Immunocytochemical localization of the D2 dopamine receptor in the rat striatum using anti-peptide antibodies. Proc. Natl. Acad. Sci. USA 88, 1441–1445.PubMedCrossRefGoogle Scholar
  58. 58.
    Sesack, S. R., Aoki, C. J., and Pickel, V. M. (1994) Ultrastructural localization of D2 receptor-like immunoreactivity in midbrain dopamine neurons and their striatal targets. J. Neurosci. 14, 88–108.PubMedGoogle Scholar
  59. 59.
    Ariano, M. A., Fisher, R. S., Smyk-Randall, E., Sibley, D. R., and Levine, M. S. (1993) D2 dopamine receptor distribution in the CNS using subtype specific anti-peptide antisera. Brain Res. 609, 71–80.PubMedCrossRefGoogle Scholar
  60. 60.
    Fisher, R. S., Levine, M. S., Sibley, D. R., and Ariano, M. A. (1994) D2 dopamine receptor protein location: Golgi impregnation gold toned and ultrastructural analysis of the rat neostriatum. J. Neurosci. Res. 38, 551–564.PubMedCrossRefGoogle Scholar
  61. 61.
    Ariano, M. A., Larson, E. R., and Noblett, K. L. (1995) Cellular dopamine receptor subtype localization, in Cellular and Molecular Mechanisms of Striatal Function ( Ariano, M. A. and Surmeier, D. J., eds.), Landes, Austin, TX, pp. 59–70.Google Scholar
  62. 62.
    Ariano, M. A. (1987) Comparison of dopamine binding sites in the rat superior cervical ganglion and caudate nucleus. Brain Res. 421, 245–254.PubMedCrossRefGoogle Scholar
  63. 63.
    Ariano, M. A. (1988) Striatal D, dopamine receptor distribution following chemical lesion of the nigrostriatal pathway. Brain Res. 443, 204–214.PubMedCrossRefGoogle Scholar
  64. 64.
    Arian, M. A. (1989) Long-term changes in striatal D, dopamine receptor distribution after dopaminergic deafferentation. Neuroscience 32, 203–212.CrossRefGoogle Scholar
  65. 65.
    Tecotte, L. H., Barchas, J. D., and Eberwine, J. H. (1988) In situ transcription: specific synthesis of complementary DNA in fixed tissue sections. Science 240, 1661–1664.CrossRefGoogle Scholar
  66. 66.
    Lidow, M. S., Goldman-Rakic, P. S., Gallager, D. W., and Rakic, P. (1991) Distribution of dopamine receptors in the primate cerebral cortex: quantitative autoradiographic analysis using 3H-raclopride, 3H-spiperone, and 3H-SCH-23390. Neuroscience 40, 657–671.PubMedCrossRefGoogle Scholar
  67. 67.
    Richfield, E. K., Young, A. B., and Penney, J. B. (1987) Comparative distribution of dopamine D, and D2 receptors in the basal ganglia of turtles, pigeons, rats, cats and monkeys. J. Comp. Neurol. 262, 446–463.PubMedCrossRefGoogle Scholar
  68. 68.
    Dearry, A., Edelman, J., Miller, S., and Burnside, B. (1990) Dopamine induces light-adaptive retinomotor movements in bullfrog cones via D2 receptors and in retinal pigment epithelium via D, receptors. J. Neurochem. 54, 1367–1378.PubMedCrossRefGoogle Scholar
  69. 69.
    Makman, M. H. and Dvorkin, B. (1986) Binding sites of3H-SCH-23390 in retina: properties and possible relationship to dopamine D, receptor mediating stimulation of adenylate cyclase. Mol. Brain Res. 1, 261–270.CrossRefGoogle Scholar
  70. 70.
    Chronwall, B. M., Dickerson, D. S., Huerter, B. S., Sibley, D. R., and Millington, W. R. (1994) Regulation of heterogeneity in D2 dopamine receptor gene expression among individual melanotropes in the rat pituitary intermediate lobe. Mol. Cell. Neurosci. 5, 35–45.PubMedCrossRefGoogle Scholar
  71. 71.
    De Sousa, E. B. (1986) Serotonin and dopamine receptors in the rat pituitary gland: autoradiographic identification, characterization, and localization. Endocrinology 119, 1534–1542.CrossRefGoogle Scholar
  72. 72.
    Levant, B., Grigoriadis, D. E., and DeSouza, E. B. (1993) 3H-Quinpirole binding to putative D2 and D3 dopamine receptors in rat brain and pituitary gland: a quantitative autoradiographic study. J. Pharmacol. Exp. Ther. 264, 991–1001.Google Scholar
  73. 73.
    Alkadhi, K. A., Sabouni, M. J., Ansar, A. F., and Lokhandwala, M. F. (1986) Activation of DA, receptors by dopamine or fenoldopam increases cyclic AMP levels in the renal artery but not in the superior cervical ganglion of the rat. J. Pharmacol. Exp. Ther. 238, 547–553.PubMedGoogle Scholar
  74. 74.
    Lokhandwala, M. F. and Steenberg, M. L. (1984) Evaluation of the effects of SKF 82526 and LY 17155 on presynaptic (DA2) and postsynaptic (DA,) dopamine receptors in rat kidney. J. Auton. Pharmacol. 4, 273–277.PubMedCrossRefGoogle Scholar
  75. 75.
    O’Connell, D. P., Botkin, S. J., Ramos, S. I., Sibley, D. R., Ariano, M. A., Felder, R. A., and Carey, R. M. (1995) Localization of the D receptor protein in the rat kidney. Am. J. Physiol. 268, F1185–F1197. IAGoogle Scholar
  76. 76.
    De Keyser, J., Claeys, A., De Backer, J. P., Ebinger, G., Rocis, F., and Vauquelin, G. (1988) Autoradiographic localization of D, and D2 dopamine receptors in the human brain. Neurosci. Lett. 91, 142–147.PubMedCrossRefGoogle Scholar
  77. 77.
    Seeman, P. (1987) Dopamine receptors in human brain diseases, in Dopamine Receptors ( Creese, I. and Fraser, C. M., eds.), Liss, New York, pp. 233–245.Google Scholar
  78. 78.
    Artalejo, C. R., Garcia, A. G., Montiel, C., and Sanchez, G. P. (1985) A dopaminergic receptor modulates catecholamine release from the cat adrenal gland. J. Physiol. 362, 359–368.PubMedGoogle Scholar
  79. 79.
    Brann, M. R. and Young, W. S., III (1986) Dopamine receptors are located on rods in bovine retina. Neurosci. Lett. 69, 221–226.PubMedCrossRefGoogle Scholar
  80. 80.
    Wagner, H.-J., Luo, B. G., Ariano, M. A., Sibley, D. R., and Stell, W. K. (1993) Localization of D2 dopamine receptors in vertebrate retinae with anti-peptide antibodies. J. Comp. Neurol. 331, 469–481.PubMedCrossRefGoogle Scholar
  81. 81.
    Dearry, A., Gingrich, J. A., Falardeau, P., Fremeau, R. T., Jr., Bates, M. D., and Caron, M. G. (1990) Molecular cloning and expression of the gene for a human D, dopamine receptor. Nature 347, 72–76.Google Scholar
  82. 82.
    Meador-Woodruff, J. H., Mansour, A., Healy, D. J., Kuehnt R., Zhou, Q.-Y., Bunzow, J. R., Akil, H., Civelli, O., and Watson, S. J., Jr. (1991) Comparisons of the distributions of D, and D2 dopamine receptor mRNAs in rat brain. Neuropsychopharmacology 5, 231–242.Google Scholar
  83. 83.
    Le Moine, C., Normand, E., and Bloch, B. (1991) Phenotypical characterization of the rat striatal neuron expression the D1 dopamine receptor gene. Proc. Natl. Acad. Sci. USA 88, 4205–4209.PubMedCrossRefGoogle Scholar
  84. 84.
    Lester, J., Fink, J. S., Aronin, N., and DiFiglia, M. (1992) Co-localization of dopamine D, and D2 receptor mRNAs in striatal neurons. Brain Res. 621, 106–110.CrossRefGoogle Scholar
  85. 85.
    Rappoport, M. S., Sealfon, S. C., Prikhozhan, A., Huntley. G. N., and Morrison, J. H. (1993) Heterogeneous distribution of D,, D2, and D5 receptor mRNAs in monkey striatum. Brain Res 616, 242–250.Google Scholar
  86. 86.
    Surmeier, D. J., Eberwine, J. H., Wilson, C. J., Stefani, A., and Kitai, S. T. (1992) Dopamine receptor subtypes co-localize in rat: striatonigral neurons. Proc. Natl. Acad. Sci. USA 89, 10,178–10, 182.Google Scholar
  87. 87.
    Ariano, M. A., Monsma, F. J., Jr., Barton, A. C., Kang, H. C., Haugland, R. P., and Sibley, D. R. (1989) Direct visualization and cellular localization of D, and D2 dopamine receptors in rat forebrain by use of fluorescent ligands. Proc. Natl. Acad. Sci. USA 86, 9570–9575.CrossRefGoogle Scholar
  88. 88.
    Monsma, F. J., Jr., Barton, A. C., Kang, H. C., Brassard, D. L., Haugland, R. P., and Sibley, D. R. (1989) Molecular characterization of novel fluorescent ligands with high affinity for D, and D2 dopaminergic receptors. J. Neurochem. 52, 1641–1644.Google Scholar
  89. 89.
    Barton, A. C., Kang, H. C., Rinaudo, M. S., Monsma, F. J., Jr., Stewart-Fram, R. M., Macinko, J. A., Jr., Haugland, R. P., Ariano, M. A., and Sibley, D. R. (1991) Multiple fluorescent ligands for dopamine receptors. I. Pharmacological characterization and receptor selectivity. Brain Res. 547, 199–207.Google Scholar
  90. 90.
    Madras, B. K., Canfield, D. R., Pfaelzer, C., Vittimberga, F. J., Jr., DiFiglia, M., Aronin, N., Bakthavachalam, V., Baindur, N., and Neumeyer, J. L. (1990) Fluorescent and biotin probes for dopamine receptors: D, and D2 receptor affinity and selectivity. Mol. Pharmacol. 37, 833–839.PubMedGoogle Scholar
  91. 91.
    Larson, E. R. and Ariano, M. A. (1994) Dopamine receptor binding on identified striatonigral neurons. Neurosci. Lett. 172, 101–106.PubMedCrossRefGoogle Scholar
  92. 92.
    Mathiasen, J. R., Larson, E. R., Ariano, M. A., and Sladek, C. D. (1996) Neurophysin expression is stimulated by dopamine D, agonist in dispersed hypothalamic cultures. Am. J. Physiol. 39, R404 — R412.Google Scholar
  93. 93.
    Rayport, S. and Sulzer, D. (1995) Visualization of antipsychotic drug binding to living mesolimbic neurons reveals DZ receptor, acidotropic and lipophilic components. J. Neurochem. 65, 691–703.PubMedCrossRefGoogle Scholar
  94. 94.
    Artalejo, C. R., Ariano, M. A., Perlman, R. L., and Fox, A. P. (1990) Activation of facilitation calcium channels in chromaffin cells by DI dopamine receptors through a cAMP/protein kinase A-dependent mechanism. Nature 348, 239–242.PubMedCrossRefGoogle Scholar
  95. 95.
    Gerfen, C. R. (1992) The neostriatal mosaic: multiple levels of compartmental organization. TINS 15, 133–139.Google Scholar

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  • Marjorie A. Ariano

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