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Dopamine Receptor-Mediated Gene Regulation in the Pituitary

  • James L. Roberts
  • Stuart C. Sealfon
  • Jean Philippe Loeffler
Part of the The Receptors book series (REC)

Abstract

A common regulatory mechanism in the endocrine and neuroendocrine system is the coupling of secretion with the biosynthesis of a hormone. Factors that regulate hormone release also regulate its biosynthesis. This provides a cellular mechanism to ensure a ready supply of the protein or peptide. Thus, for any cell type in which secretion is regulated by dopamine via a dopamine receptor, it might be expected that dopamine would also have a significant effect on expression of the genes encoding the peptide/protein hormones themselves and/or those genes encoding the proteins involved in hormone production. Indeed, this linkage has been demonstrated in the first studies of regulation of prolactin and pro-opiomelanocortin (POMC) gene expression performed in model pituitary cell culture systems. Since these pituitary hormone-encoding genes were some of the first to be cloned in the early days of recombinant DNA technology, their regulation by dopamine has been well characterized but, surprisingly, some aspects of the underlying mechanisms have not been elucidated. In this chapter we discuss what is known about the expression of different dopamine receptor subtypes in the pituitary gland; their mechanisms of intracellular signaling; and processes by which the activation of these receptors interdicts the gene expression of two major pituitary peptide/protein hormone genes, prolactin and POMC.

Keywords

Dopamine Receptor Pituitary Cell Anterior Pituitary Cell Intermediate Lobe Receptor mRNA Level 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1997

Authors and Affiliations

  • James L. Roberts
  • Stuart C. Sealfon
  • Jean Philippe Loeffler

There are no affiliations available

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