Non-Specific Protein-Membrane Interactions: Adsorption and Fouling
One of the major factors limiting the development and application of biofunctional membranes is membrane fouling, the irreversible alteration in the membrane caused by specific physical and/or chemical interactions with various components present in the process stream. Fouling can cause dramatic changes in the rate of solute transport through the membrane, potentially destroying the membrane’s ability to function in the particular biomedical device, biosensor, or bioreactor.
KeywordsProtein Adsorption Hydraulic Resistance Ultrafiltration Membrane Membrane Fouling Flux Decline
A.D. Marshall, P.A. Munro, and G. Tragardh, The effect of protein fouling in microfiltration and ultrafiltration on permeate flux, protein retention and selectivity: a literature review, Desalination
91:65 (1993).CrossRefGoogle Scholar
B.C. Robertson and A.L. Zydney, Protein adsorption in asymmetric ultrafiltration membranes with highly constricted pores, J. Colloid Inteiface Sci.
134:563 (1990).CrossRefGoogle Scholar
J.M. Sheldon, I.M. Reed, and C.R. Hawes, The fine-structure of ultrafiltration membranes. II. Protein fouled membranes, J. Membrane Sci.
62:87 (1991).CrossRefGoogle Scholar
G. Belfort, R.H. Davis, and A.L. Zydney, The behavior of suspensions and macromolecular solutions in crossflow microfiltration, J. Membrane Sci.
96:1 (1994).CrossRefGoogle Scholar
W.R. Bowen and D.T. Hughes, Properties of microfiltration membranes. Adsorption of bovine serum albumin at aluminum oxide membranes, J. Membrane Sci.
51:189 (1990).CrossRefGoogle Scholar
W.S. Opong and A.L. Zydney, Hydraulic permeability of deposited protein layers formed during ultrafiltration, J. Colloid Interface Sci.
142:41 (1991).CrossRefGoogle Scholar
S. Mochizuki and A.L. Zydney, Effect of protein adsorption on the transport characteristics of asymmetric ultrafiltration membranes, Biotech. Prog.
8:553 (1992).CrossRefGoogle Scholar
R. Boyd, L.J. Langsdorf, and A.L. Zydney, A two-layer model for the effects of blood contact on membrane transport in artificial organs, Trans. Am. Soc. Artif. Intern. Organs
40:M864 (1994).CrossRefGoogle Scholar
L.J. Langsdorf and A.L. Zydney, Effect of blood contact on the transport properties of hemodialysis membranes: a two-layer membrane model, Blood Purification
S.T. Kelly and A.L. Zydney, Effect of thiol-disulfide interchange reactions on albumin fouling during membrane microfiltration, Biotech. Bioeng.
44:972 (1994).CrossRefGoogle Scholar
D.N. Lee and R.L. Merson, Examination of cottage cheese whey by scanning electron microscopy: relationship to membrane fouling during ultrafiltration, J. Dairy Sci.
58:1423 (1974).CrossRefGoogle Scholar
S.P. Palecek and A.L. Zydney, Hydraulic permeability of protein deposits formed during microfiltration: effect of solution pH and ionic strength, J. Membrane Sci.
95:71 (1994).CrossRefGoogle Scholar
S. Mochizuki and A.L. Zydney, Sieving characteristics of albumin deposits formed during microfiltration, J. Colloid Interface Sci.
159:136 (1993).CrossRefGoogle Scholar
S.T. Kelly, W.S. Opong, and A.L. Zydney, The influence of protein aggregates on the fouling of microfiltration membranes during stirred cell filtration, J. Membrane Sci.
80:175 (1993).CrossRefGoogle Scholar
S.T. Kelly and A.L. Zydney, Fouling mechanisms during BSA microfiltration, J. Membrane Sci.
© Springer Science+Business Media New York 1996