Theories of Circular Dichroism for Nucleic Acids
Two kinds of theories for the circular dichroism of nucleic acids are currently in use: a fundamental theory derived from quantum mechanics, and a phenomenological theory based on classical electrodynamics. The quantum approach is preferable from a strict theoretical point of view, but is hard to implement in real calculations on molecules as large and complex as the nucleic acids. The classical theory is easier to implement, but has less theoretical justification. It turns out that with the approximations needed to make the quantum theory tractable, the two approaches are almost equivalent.
KeywordsCircular Dichroism Quantum Theory Classical Theory Transition Dipole Magnetic Transition Dipole
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