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Biological Response to Particulate Debris from Nonmetallic Orthopedic Implants

  • Michael A. Pappas
  • Christopher C. Schmidt
  • Arun S. Shanbhag
  • Theresa A. Whiteside
  • Harry E. Rubash
  • James H. Herndon
Chapter

Abstract

Since their introduction in the 1960s, nonmetallic biomaterials, such as silicone rubber and polyethylene, have been used extensively in orthopedic surgery. Alfred Swanson introduced silicone rubber for small flexible joints, and John Charnley pioneered the use of polyethylene as the articulating surface for large, weight-bearing joint replacements. In spite of their recent association with failed breast implants and osteolysis in total joint arthroplasty, respectively, these materials have provided excellent service and improved the quality of life for many patients and for extended periods. Both of these materials in bulk form are biocompatible and essentially noninflammatory. However, the degradation products of these materials, i.e., wear particles, have been found to initiate and propagate a foreign-body response that leads to osteolysis and arthroplasty failure. In this chapter, we will discuss current concepts regarding the biological response to silicone rubber and polyethylene.

Keywords

Aseptic Loosening Wear Debris Total Joint Arthroplasty Particulate Debris Silicone Implant 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Abbas AK, Lichtman AH, and Pober JS. Cytokines, in Cellular and Molecular Immunology 1991; (Wonsiewicz MJ, ed), Saunders, Philadelphia, pp 226–242.Google Scholar
  2. 2.
    Swanson AB. Silicone rubber implants for replacement of arthritic or destroyed joints of the hand. Surg Clin North Am 1968; 48: 1113–1127.Google Scholar
  3. 3.
    Swanson AB. Silicone rubber implants for the replacement of the carpal scaphoid and lunate bones. Orth Clin North Am 1970; 1: 299–308.Google Scholar
  4. 4.
    Swanson AB. Flexible implant arthroplasty for arthritic disabilities of the radiocarpal joint. Orth Clin North Am 1973; 4: 383–394.Google Scholar
  5. 5.
    Swanson AB and Herndon JH. Flexible (silicone) implant arthroplasty of the metacarpophalangeal joint of the thumb. J Bone Joint Surg 1977; 59-A: 362–368.Google Scholar
  6. 6.
    Swanson AB, Lumsden RM, and Swanson GD. Implant arthroplasty of the great toe. Clin Orthop 1979; 142: 30–43.Google Scholar
  7. 7.
    Lichtman DM, Mack GR, MacDonald RI, and Gunther SF. Kienbock’s disease: the role of silicone replacement arthroplasty. J Bone Joint Surg 1977; 59-A: 899–908.Google Scholar
  8. 8.
    Roca J, Beltran JE, and Fairen MF. Treatment of Kienbock’s disease using a silicone rubber implant. J Bone Joint Surg 1976; 58-A: 373–376.Google Scholar
  9. 9.
    Stark HH, Zemel NP, and Ashworth CR. Use of hand-carved silicone-rubber spacers for advanced Kienbock’s disease. J Bone Joint Surg 1981; 63-A: 1359–1370.Google Scholar
  10. 10.
    Swanson AB, Swanson GD, and Watermeier JJ. Trapezium implant arthroplasty. J Hand Surg 1981; 6: 125–141.Google Scholar
  11. 11.
    Swanson AB. Flexible implant resection arthroplasty. Hand 1972; 2: 119–134.Google Scholar
  12. 12.
    Kossovsky N, Zeidler M, Chun G, and Papsasian N. Surface dependent antigens identified by high binding avidity of serum antibodies in a subpopulation of patients with breast prosthesis. JAppl Biomat 1993; 4: 281–288.CrossRefGoogle Scholar
  13. 13.
    Eiken O, Ekerot L, Lindstrom C, and Jonsson K. Silicone carpal implants: risk or benefit? Scand J Plast Reconstr Surg 1985; 19: 295–304.CrossRefGoogle Scholar
  14. 14.
    Fatti JF, Palmer AK, Greenky S, and Moseher JF. The long-term results of Swanson interpositional wrist arthroplasty. J Hand Surg 1986; 11-A: 166–175.Google Scholar
  15. 15.
    Herndon JH. Trapeziometacarpal arthroplasty. Clin Orthop 1987; 220: 99–105.Google Scholar
  16. 16.
    Karlsson MK, Necking L-E, and Redlund-Johnell I. Foreign body reaction after modified silicone rubber arthroplasty of the first carpometacarpal joint. Scand J Plast Reconstr Surg 1992; 26: 101–103.CrossRefGoogle Scholar
  17. 17.
    Smith RJ, Atkinson RE, and Jupiter JB. Silicone synovitis of the wrist. JHand Surg 1985; 10-A: 47–60.Google Scholar
  18. 18.
    Verhaar J, Vermeulen A, Bulstra S, and Walenkamp G. Bone reaction to silicone metatarsophalangeai joint-1 hemiprosthesis. Clin Orthop 1989; 245: 228–232.Google Scholar
  19. 19.
    Carter PR, Benton LJ, and Dysert PA. Silicone rubber carpal implants: a study of the incidence of late osseous complications. JHand Surg 1986: 11-A: 639–644.Google Scholar
  20. 20.
    Lemon RA, Engber WD, and McBeath AA. A complication of silastic hemiarthroplasty in bunion surgery. Foot and Ankle 1984; 4: 262–266.Google Scholar
  21. 21.
    Peimer CA. Long-term complication oftrapeziometacarpal silicone arthroplasty. Clin Orthop 1987; 220: 86–98.Google Scholar
  22. 22.
    Peimer CA, Medige J, Eckert BS, and Wright JR. Reactive synovitis after silicone arthroplasty. J Hand Surg 1986; 11-A: 624–638.Google Scholar
  23. 23.
    Peimer CA, Taleisnik J, and Sherwin FS. Pathologic factures: complication ofmicroparticulate synovitis. JHand Surg 1991; 16-A: 835–843.Google Scholar
  24. 24.
    Schneider HJ, Weiss MA, and Stern PJ. Silicone-induced erosive arthritis. Am JRheum 1987; 148: 923–925.Google Scholar
  25. 25.
    Wanivenhaus A, Lintner F, Wurnig C, and Missaghi-Schinzl M. Long-term reaction of the osseous bed around silicone implants. Arch Orthop Trauma Surg 1991; 110: 146–150.CrossRefGoogle Scholar
  26. 26.
    Worsing RA Jr, Engber WD, and Lange TA. Reactive synovitis from particulate silastic. J Bone Joint Surg 1982; 64-A: 581–585.Google Scholar
  27. 27.
    Germain BF. Silicone breast implants and rheumatic disease. Bull Rheum Dis 1991; 41: 1–5.Google Scholar
  28. 28.
    Gordon M and Bullough PG. Synovial and osseous inflammation in failed silicone-rubber prosthesis. J Bone Joint Surg 1983; 65-A: 574–580.Google Scholar
  29. 29.
    Heggers JP, Kossovsky N, Parsons RW, and Pelley RP. Biocompatibility of silicone implants. Ann Plast Surg 1983; 11: 38–45.CrossRefGoogle Scholar
  30. 30.
    Swanson AB, Meester WD, Swanson GD, and Ranagaswamy L. Durability of silicone implants-an in vivo study. Orth Clin North Am 1973; 4: 1097–1112.Google Scholar
  31. 31.
    Sergott TJ, Limoli JP, Baldwin CM Jr, and Laub DR. Human adjuvant disease, possible autoimmune disease after silicone implantation: a review of the literature, case studies and speculation for the future. Plast Reconstr Surg 1986; 78 (1): 104–114.CrossRefGoogle Scholar
  32. 32.
    Swanson AB and Swanson GD. Reconstruction of the thumb basal joints. Clin Orthop 1987; 220: 68–85.Google Scholar
  33. 33.
    Brase DW and Millender LH. Failure of silicone rubber wrist arthroplasty in rheumatoid arthritis. J Hand Surg 1986; 11-A: 175–183.Google Scholar
  34. 34.
    Ferlic DC, Clayton ML, and Holloway M. Complications of silicone implant surgery in the metacarpophalangeal joint. J Bone Joint Surg 1975; 11-A: 991–994.Google Scholar
  35. 35.
    Jolly SL, Ferlic DC, Clayton ML, and Dennis DA. Swanson silicone arthroplasty of wrist. J Hand Surg 1992; 17-A: 142–179.Google Scholar
  36. 36.
    Lundkvist L and Barfred T. Total wrist arthroplasty. Scand J Plast Reconstr Surg 1992; 26: 97–100.CrossRefGoogle Scholar
  37. 37.
    Pellegrini V and Burton R. Surgical management of basal joint arthritis of the thumb. Part 1. Long-term results of silicone implant arthroplasty. JHand Surg 1986; 11-A: 309–323.Google Scholar
  38. 38.
    Aptekar RG, Davie JM, and Cattell HS. Foreign body reaction to silicone rubber. Clin Orthop 1974; 98: 231, 232.Google Scholar
  39. 39.
    Lagier R. Case report 719. Skeletal Radiol 1992; 21: 137–139.CrossRefGoogle Scholar
  40. 40.
    Rosenthal DI, Rosenberg AE, Schiller AL, and Smith RJ. Destructive arthritis due to silicone: a foreign-body reaction. Radiology 1983; 149: 69–72.Google Scholar
  41. 41.
    Smith DJ Jr, Sazy JA, Crissman JD, and Niu X-T. Immunogenic potential of carpal implants. JSurg Res 1990; 48: 13–20.CrossRefGoogle Scholar
  42. 42.
    Alexander AH, Turner MA, Alexander CE, and Lichtman DM. Lunate silicone replacement arthroplasty in Kienbock’s disease: a long-term followup. JHand Surg 1990; 15-A: 401–407.Google Scholar
  43. 43.
    Christie AJ and Levitan J. Silicone synovitis. Semin Arthr Rheum 1989; 19: 166–171.CrossRefGoogle Scholar
  44. 44.
    Schmidt C, Whiteside T, and Herndon JH. Current concepts: the biocompatibility of silicone. Pittsburgh Orthop J 1994; 5: 63–66.Google Scholar
  45. 45.
    Christie AJ, Weinberger KA, and Dietrich M. Silicone lymphadenopathy and synovitis: complications of silicone elastomer finger joint prosthesis. JAMA 1977; 237: 1463, 1464.Google Scholar
  46. 46.
    Corrin B. Silicone lymphadenopathy. J Clin Pathol 1982; 35: 901, 902.Google Scholar
  47. 47.
    Groff GD, Schned AR, and Taylor TH. Silicone-induced adenopathy eight years after metacarpophalangeal arthroplasty. Arthritis Rheum 1981; 24: 1578–1581.CrossRefGoogle Scholar
  48. 48.
    Kircher T. Silicone lymphadenopathy: a complication of silicone elastomer finger joint prostheses. Hum Pathol 1980; 11: 240–244.CrossRefGoogle Scholar
  49. 49.
    Paplanus SH and Payne CM. Axillary lymphadenopathy 17 years after digital silicone implants: study with x-ray microanalysis. J Hand Surg 1988; 13-A: 399,400.Google Scholar
  50. 50.
    Roggers LA, Longtine JA, Garnick MB, and Pinkus GS. Silicone lympadenopathy in a long distance runner: complication of a silastic prosthesis. Hum Pathol 1988; 19: 1237–1239.CrossRefGoogle Scholar
  51. 51.
    Lazaro MA, Morteo DG, DeBenyacar MA, and Paira SO. Lymphadenopathy secondary to silicone hand joint prostheses. Clin Exptl Rheum 1990; 8: 17–22.Google Scholar
  52. 52.
    Boomer J, Ritz E, and Walderr R. Silicone-induced splenomegaly. NEngl JMed 1981; 305: 1077–1079.CrossRefGoogle Scholar
  53. 53.
    Goldring SR, Schiller AL, Roelke M, Rourke CM, O’Neill DA, and Harris WH. The synovial-like membrane at the bone-cement interface in loose total hip replacements and its proposed role in bone lysis. JBone Joint Surg 1983; 65A: 575–584.Google Scholar
  54. 54.
    Das SK, Johnson M, Ellsaesser C, and Brantley SK. Macrophage interleukin-1 response to injected silicone in a rat model. Ann Plast Surg 1992; 28: 535–537.Google Scholar
  55. 55.
    Goldblum RM, Relley RP, O’Donell AA, and Pyron D. Antibodies to silicone elastomers and reactions to ventriculoperitoneal shunts. Lancet 1992; 340: 510–513.CrossRefGoogle Scholar
  56. 56.
    Kossovsky N, Heggers JP, and Roboson MC. Experimental demonstration of the immunogenicity of silicone-protein complexes. J Biomed Mater Res 1987; 21: 1125–1133.CrossRefGoogle Scholar
  57. 57.
    Koeger AC and Bourgeous P. Systemic manifestations after silicone breast implants. Revue Du Rhumatisme 1993; 2: 120–126.Google Scholar
  58. 58.
    Baldwin CM Jr and Kaplan EN. Silicone-induced human adjuvant disease? Ann Plas Surg 1983; 10: 270–273.CrossRefGoogle Scholar
  59. 59.
    Brozena SJ, Fenske NA, Cruse CW, and Espinoza CG. Human adjuvant disease following augmentation mammoplasty. Arch Dermatol 1988; 124: 1383–1386.CrossRefGoogle Scholar
  60. 60.
    Van Nunen SA, Gatenby PA, and Basten A. Postmammoplasty connective tissue disease. Arthritis Rheum 1982; 25: 694–697.CrossRefGoogle Scholar
  61. 61.
    Chang Y-H. Adjuvanticity and arthritogenicity of silicone. Plast Reconstr Surg 1993; 92: 469–475.CrossRefGoogle Scholar
  62. 62.
    Kumagai Y, Shiokawa Y, Medsger J, and Rodman GP. Clinical spectrum of connective tissue disease after cosmetic surgery. Arthritis Rheum 1984; 27: 1–12.CrossRefGoogle Scholar
  63. 63.
    Shons AR and Schubert W. Silicone breast implants and immune disease. Ann Plast Surg 1992; 28: 491–501.CrossRefGoogle Scholar
  64. 64.
    Spiera H. Scleroderma after silicone augmentation mammoplasty. JAMA 1988; 260: 236–238.CrossRefGoogle Scholar
  65. 65.
    Varga J, Schumacher HR, and Jimenez SA. Systemic sclerosis after augmentation mammoplasty with silicone implants. Ann Intern Med 1989; 111: 377–383.Google Scholar
  66. 66.
    Press RI, Peebles CL, Kumagai Y, and Ochs RL. Antinuclear autoantibodies in women with silicone breast implants. Lancet 1992; 28: 1304–1307.CrossRefGoogle Scholar
  67. 67.
    Weisman MH, Vecchione TR, Albert D, and Moore LT. Connective-tissue disease following breast augmentation: a preliminary test of human adjuvant disease hypothesis. Plast Reconstr Surg 1988; 82: 626–630.CrossRefGoogle Scholar
  68. 68.
    Rodrigo JJ and Gershwin ME. Management of the arthritic joint; in Operative Orthopaedics 1993; (Chapman MW, ed), Lippincott, Philadelphia, pp 1795–1809.Google Scholar
  69. 69.
    Herbert P, Ahnfelt L, Malcham H, Stromberg C, and Andersson GBJ. Multicenter clinical trials and their value in assessing total joint arthroplasty. Clin Orthop 1989; 249: 48–55.Google Scholar
  70. 70.
    Wilson PD Jr, Amstutz HC, Czerniecki A, Salvati EA, and Mendes DG. Total hip replacement with fixation by acrylic cement. J Bone Joint Surg 1972; 54-A: 207–236.Google Scholar
  71. 71.
    Charnley J. Postoperative infection after total hip replacement with special reference to air contamination in the operating room. Clin Orthop 1972; 87: 167–187.CrossRefGoogle Scholar
  72. 72.
    Charnley J and Eftekhar NS. Postoperative infection in total prosthetic replacement arthroplasty of the hip joint. Br J Surg 1969; 56: 641–649.CrossRefGoogle Scholar
  73. 73.
    Beckenbaugh RD and Ilstrup DM. Total hip arthroplasty. JBone Joint Surg 1978; 60-A: 306–313.Google Scholar
  74. 74.
    Black J. Orthopaedic Biomaterials in Research and Practice 1988; Churchill Livingstone, New York.Google Scholar
  75. 75.
    Kavanagh BF, Dewitz MA, Ilstrup DM, Stauffer RN, and Coventry MB. Charnley total hip arthroplasty with cement. J Bone Joint Surg 1989; 71-A: 1496–1503.Google Scholar
  76. 76.
    Salvati EA, Wilson PD Jr, Jolley MN, Vakili F, Aglietti P, and Brown GC. A ten-year follow-up study of our first one hundred consecutive Charnley total hip replacements. J Bone Joint Surg 1981; 63-A: 753–767.Google Scholar
  77. 77.
    Kunkel SL, Chensue SW, and Phan SH. Prostaglandins as endogenous mediators of endogenous mediators of interleukin 1 production. Jlmmunol 1986; 136: 186–192.Google Scholar
  78. 78.
    Lennox DW, Schofield BH, McDonald DF, and Riley LH Jr. A histologic comparison ofaseptic loosening of cemented, press-fit, and biologic ingrowth prostheses. Clin Orthop 1987; 225: 171–191.Google Scholar
  79. 79.
    Ahlberg A and Linden B. The radiolucent zone in arthroplasty of the knee. Acta Orthop Scand 1977; 48: 687–690.CrossRefGoogle Scholar
  80. 80.
    Cameron HU and McNeice GM. A correlation of radiographic “Modes of Failure” with clinical failure of cemented stem-type femoral components. Clin Orthop 1980; 150: 154–158.Google Scholar
  81. 81.
    Gruen TA, McNeice GM, and Amstutz HC. “Modes of failure” of cemented stem-type femoral components. Clin Orthop 1979; 17–27.Google Scholar
  82. 82.
    Harris WH and McGann WA. Loosening of the femoral component after use of the medullary-plug cementing technique. J Bone Joint Surg 1986; 68-A: 1064–1066.Google Scholar
  83. 83.
    O’Neill DA and Harris WH. Failed total hip replacement: assessment by plain radiographs, arthrograms, and aspiration of the hip joint. J Bone Joint Surg 1986; 66-A: 540–546.Google Scholar
  84. 84.
    Charosky CB, Bullough PG, and Wilson PD Jr. Total hip replacement failures. A histological evaluation. JBone Joint Surg 1973; 55A: 49–58.Google Scholar
  85. 85.
    Ferguson GM and Evans CH. The possible role of implant materials in promoting the aseptic loosening of prosthetic joints, in Interaction of Cells with Natural and Foreign Surfaces 1986; (Crawford N and Taylor DEM, eds), Plenum, New York, pp 279–286.Google Scholar
  86. 86.
    Landegren U. Measurement of cell numbers by means of the endogenous enzyme hexosaminidase. Applications to detection of lymphokines and cell sulface antigens. Jlmmunol Meth 1984; 67: 379–388.CrossRefGoogle Scholar
  87. 87.
    Harris WH, Schiller AL, Scholler J-M, Freiberg RA, and Scott R. Extensive localized bone resorption in the femur following total hip replacement. JBone Joint Surg 1976; 58A: 612–618.Google Scholar
  88. 88.
    Tanzer M, Maloney WJ, Jasty MJ, and Harris WH. The progression of femoral cortical osteolysis in association with total hip arthroplasty without cement. JBone Joint Surg 1992; 74-A: 404–410.Google Scholar
  89. 89.
    Charnley J. Anchorage of the femoral head prosthesis to the shaft of the femur. JBone Joint Surg 1960; 42-B: 28–30.Google Scholar
  90. 90.
    Charnley J. Arthroplasty of the hip. Lancet 1961; 1129–1132.Google Scholar
  91. 91.
    Charnley J. The bonding of prostheses to bone by cement. JBone Joint Surg 1964; 46-B: 518–529.Google Scholar
  92. 92.
    Charnley J, Follacci FM, and Hammond BT. The long-term reaction of bone to self-curing acrylic cement. JBone Joint Surg 1968; 50-B: 822–829.Google Scholar
  93. 93.
    Charnley J. Tissue reaction to implanted plastics, in Acrylic Cement in Orthopedic Surgery 1970; (Charnley J, ed), Livingstone, Edinburgh, pp 1–9.Google Scholar
  94. 94.
    Wroblewski BM. Charnley low-friction arthroplasty, review of past, present status and prospects for the future. Clin Orthop 1986; 210: 37–42.Google Scholar
  95. 95.
    Mina JM, Amstutz HC, Matos M, and Gold R. The pathology of the joint tissues and its clinical relevance in prosthesis failure. Clin Orthop 1976; 117: 221–240.Google Scholar
  96. 96.
    Mina JM, Marder RA, and Amstutz HC. The pathology of failed total joint arthroplasty. Clin Orthop 1982; 170: 175–183.Google Scholar
  97. 97.
    Bullough PG, DiCarlo EF, Hansraj KK, and Neves MC. Pathologic studies of total joint replacement. Orth Clin NA 1988; 19: 611–625.Google Scholar
  98. 98.
    Willert HG and Semlitsch M. Tissue reactions to plastic and metallic wear products of joint endoprostheses, in Total Hip Prosthesis 1976; (Gschwend N and Debrunner HU, eds), Williams and Wilkins, Baltimore, pp 205–239.Google Scholar
  99. 99.
    Willert HG and Semlitsch M. Reactions of the articular capsule to wear products of artificial joint prostheses. J Biomed Mater Res 1977; 11: 157–164.CrossRefGoogle Scholar
  100. 100.
    Kim KJ, Chiba J, and Rubash HE. In vivo and in vitro analysis of membranes from hip prostheses inserted without cement. JBone Joint Surg 1994; 76-A: 172–180.Google Scholar
  101. 101.
    Kim KJ, Greis P, Wilson SC, D’Antonio JA, McClain EJ, and Rubash HE. Histological and biochemical comparison of membranes from titanium, cobalt-chromium and non polyethylene hip prostheses. Trans Orthop Res Soc 1991; 16: 191.Google Scholar
  102. 102.
    Kim KJ, Rubash HE, Wilson SE, D’Antonio JA, and McClain EJ. A histological and biochemical comparison of the interface tissues in cementless and cemented hip prosthesis. Clin Orthop 1993; 286: 142–152.Google Scholar
  103. 103.
    Chiba J, Iwaki Y, Kim KJ, and Rubash HE. The role of cytokines in femoral osteolysis after cementless total hip arthroplasty. Trans Orthop Res Soc 1992; 17: 350.Google Scholar
  104. 104.
    Chiba J, Rubash HE, Kim KJ, and Iwaki Y. The characterization of cytokines in the interface tissue obtained from failed cementless total hip arthroplasty with and without femoral osteolysis. Clin Orthop 1994; 300: 304–312.Google Scholar
  105. 105.
    Murray DW, Rae T, and Rushton N. The influence of the surface energy and roughness of implants on bone resorption. J Bone Joint Surg 1989; 71-B: 632–637.Google Scholar
  106. 106.
    Willert HG, Bertram H, and Buchhorn GH. Osteolysis in alloarthroplasty of the hip. The role of bone cement fragmentation. Clin Orthop 1990; 258: 108–121.Google Scholar
  107. 107.
    Jasty MJ, Floyd WE, Schiller AL, Goldring SR, and Harris WH. Localized osteolysis in stable, non-septic total hip replacement. J Bone Joint Surg 1986: 68A: 912–919.Google Scholar
  108. 108.
    Friedman RJ, Black J, Galante JO, Jacobs JJ, and Skinner HB. Current concepts in orthopaedic biomaterials and implant fixation. J Bone Joint Surg 1993; 75-A: 1086–1109.Google Scholar
  109. 109.
    Jasty MJ. Clinical reviews: particulate debris and failure of total hip replacements. J App! Biomat 1993; 4: 273–276.CrossRefGoogle Scholar
  110. 110.
    Jasty MJ, Maloney WJ, Bragdon CR, O’Connor DO, Haire T, and Harris WH. The initiation of failure in cemented femoral components of hip arthroplasties. JBone Joint Surg 1991; 73-B: 551–558.Google Scholar
  111. 111.
    Jones LC and Hungerford DS. Cement disease. Clin Orthop 1987; 225: 192–206.Google Scholar
  112. 112.
    Huddleston HD. Femoral lysis after cemented THA. JArthroplasty 1988; 3: 285–297.CrossRefGoogle Scholar
  113. 113.
    Mulroy RD Jr and Harris WH. The effect of improved cementing techniques on component loosening in total hip replacement. J Bone Joint Surg 1990; 72-B: 757–760.Google Scholar
  114. 114.
    Rubash HE and Harris WH. Revision ofnonseptic, loose, cemented femoral components using modern cementing techniques. JArthroplasty 1988; 3: 241–248.CrossRefGoogle Scholar
  115. 115.
    Burke DW, Gates EI, and Harris WH. Centrifugation as a method of improving tensile and fatigue properties of acrylic bone cement. JBone Joint Surg 1984; 66-A: 1265–1273.Google Scholar
  116. 116.
    Harris WH and Davies JP. Modern use of modern cement for total hip replacement. Orth Clin NA 1988; 19: 581–589.Google Scholar
  117. 117.
    Park JB. Method of orthopedic implantation and implant product. US Patent 1985; No. 4, 491, 987.Google Scholar
  118. 118.
    Park JB, Von Recum AF, and Gratzick GE. Pre-coated orthopedic implants with bone cement. Biomat Med Dev Art Org 1979; 7: 41–53.Google Scholar
  119. 119.
    Maloney WJ, Jasty MJ, Harris WH, Galante JO, and Callaghan JJ. Endosteal erosion in association with stable uncemented femoral components. JBone Joint Surg 1990; 72-A: 1025–1034.Google Scholar
  120. 120.
    Maloney WJ, Engh CA, and Chandler H. Severe osteolysis of the pelvis in association with acetabular replacement without cement. J Bone Joint Surg 1993; 75-A: 1627–1635.Google Scholar
  121. 121.
    Jacobs JJ, Urban RM, Schajowicz F, et al. Particulate-associated endosteal osteolysis in titanium-base alloy cementless total hip replacement, in Particulate Debris from Medical Implants: Mechanisms ofFormation and Biological Consequences, ASTM STP 1144 1992; (St John KR, ed), American Society for Testing and Materials, Philadelphia, pp 52–60.Google Scholar
  122. 122.
    Willert HG, Bertram H, and Buchhorn GH. Osteolysis in alloarthroplasty of the hip. The role of ultra-high molecular weight polyethylene wear particles. Clin Orthop 1992; 258: 95–107.Google Scholar
  123. 123.
    Galante JO. Clinical results with the HGP cement-less total hip prosthesis, in Non-Cemented Total Hip Arthroplasty 1988; (Fitzgerald R Jr, ed), Raven, New York, pp 427–431.Google Scholar
  124. 124.
    Brown IW and Ring PA. Osteolytic changes in the upper femoral shaft following porous-coated hip replacement. J Bone Joint Surg 1985; 67-B: 218–221.Google Scholar
  125. 125.
    Maloney WJ, Smith RL, Castro F, and Schurman DJ. Fibroblast response to metallic debris in vitro. Enzyme induction, cell proliferation, and toxicity. J Bone Joint Surg 1993; 75-A: 835–844.Google Scholar
  126. 126.
    Santavirta S, Konttinen YT, Bergroth V, Eskola A, Tallroth K, and Lindholm TS. Aggressive granulomatous lesions associated with hip arthroplasty. J Bone Joint Surg 1990; 72-A: 252–258.Google Scholar
  127. 127.
    Shanbhag AS and Rubash HE. Wear: The basis of particle disease in total hip arthroplasty. Tech Orthop 1993; 8 (4): 269–274.CrossRefGoogle Scholar
  128. 128.
    Shanbhag AS, Jacobs JJ, Black J, Galante JO, and Giant TT. Macrophage/particle interactions: effect of size, composition and surface area. J Biomed Mater Res 1994; 28: 81–90.CrossRefGoogle Scholar
  129. 129.
    Giant TT, Jacobs JJ, Molnâr G, Shanbhag AS, Valyon M, and Galante JO. Bone resorption activity ofparticulate-stimulated macrophages. J Bone Miner Res 1993; 8: 1071–1079.Google Scholar
  130. 130.
    Evans EM, Freeman MAR, Miller AJ, and Vernon- Roberts B. Metal sensitivity as a cause of bone necrosis and loosening of the prosthesis in total joint replacement. J Bone Joint Surg 1974; 56B: 626–642.Google Scholar
  131. 131.
    Goodman SB and Chin RC. Prostaglandin E2 levels in the membrane surrounding bulk and particulate polymethylmethacrylate in the rabbit tibia. Clin Orthop 1990; 257: 305–309.Google Scholar
  132. 132.
    Kozinn SC, Johanson NA, and Bullough PG. The biologic interface between bone and cementless femoral endoprostheses. JArthroplasty 1986; 1: 249–259.CrossRefGoogle Scholar
  133. 133.
    Horowitz SM, Doty SB, Lane JM, and Burstein AH. Studies of the mechanism by which the mechanical failure of polymethylmethacrylate leads to bone resorption. JBone Joint Surg 1993; 75-A: 802–813.Google Scholar
  134. 134.
    Horikoshi M, Dowd J, Maloney WJ, Crossett L, and Rubash HE. Activation of human fibroblasts and macrophages by particulate wear debris from failed total hip and total knee arthroplasty. Trans Orthop Res Soc 1994; 19: 199.Google Scholar
  135. 135.
    Dowd J, Schwendeman L, Doyle S, et al. Aseptic loosening: a histologic and biochemical analysis in a canine model. Trans Orthop Res Soc 1994: 19: 805.Google Scholar
  136. 136.
    Goldring SR, Jasty MJ, Roelke MS, Rourke CM, Bringhurst FR, and Harris WH. Formation of a synovial-like membrane at the bone-cement interface. Its role in bone resorption and implant loosening after total hip replacement. Arthritis Rheum 1986; 29: 836–841.CrossRefGoogle Scholar
  137. 137.
    Goldring SR, Flannery MS, Petrison KK, Evins AE, and Jasty MJ. Evaluation of connective tissue cell responses to orthopaedic implant materials. Connect Tissue Res 1990; 24: 77–81.CrossRefGoogle Scholar
  138. 138.
    Horowitz SM, Frondoza CG, and Lennox DW. Effects of polymethylmethacrylate exposure upon macrophages. J Orthop Res 1988; 6: 827–832.CrossRefGoogle Scholar
  139. 139.
    Shanbhag AS, Glant TT, Jacobs JJ, and Black J. Macrophage release of inflammatory mediators is affected by size, composition and surface area of phagocytosable particles. Orthop Trans 1992; 16(2): 487,488.Google Scholar
  140. 140.
    Shanbhag AS, Black J, Jacobs JJ, Galante JO, and Glant TT. Human monocyte response to submicron fabricated and retrieved polyethylene, Ti-A1–4V and Ti particles. Trans Orthop Res Soc 1994; 19: 849.Google Scholar
  141. 141.
    Shanbhag AS, Jacobs JJ, Glant TT, Talbert LF, Leigh HD, and Black J. Submicron particulate polyethylene and titanium-alloy stimulated bone resorptive and fibroblast stimulatory activity. Trans Soc for Biomater 1994; 17: 242.Google Scholar
  142. 142.
    Remes A and Williams DF. Chemotaxis and the inhibition of chemotaxis of human neutrophils in response to metal ions. J Mater Sci Mater Med 1990; 1: 26–32.CrossRefGoogle Scholar
  143. 143.
    Vernon-Roberts B and Freeman MAR. Morphological and analytical studies of the tissues adjacent to joint prostheses: investigations into the causes of loosening prostheses, in Advances in Artificial Hip and Knee Joint Technology 1976; (Schaldach M and Hohmann D, eds), Springer-Verlag, Berlin, pp 148–186.Google Scholar
  144. 144.
    di Carlo EF and Bullough PG. The biologic responses to orthopedic implants and their wear debris. Clin Mater 1992; 9: 235–260.CrossRefGoogle Scholar
  145. 145.
    Forest M, Carlioz A, Vacher Lavenu MC, et al. Histological patterns of bone and articular tissues after orthopaedic reconstructive surgery (artificial joint implants). Path Res Pract 1991; 187: 963–977.CrossRefGoogle Scholar
  146. 146.
    Howie DW. Tissue response in relation to type of wear particles around failed hip arthroplasties. J Arthroplasty 1990; 5: 337–348.CrossRefGoogle Scholar
  147. 147.
    Horowitz SH, Doty SB, Lane JM, and Burstein AH. Mechanism by which cement failure leads to bone resorption in aseptic loosening. Orthop Trans 1991; 15: 540, 541.Google Scholar
  148. 148.
    Schmalzried TP, Jasty MJ, Rosenberg A, and Harris WH. Histologic identification ofpolyethylene wear debris using oil red O stain. J Appl Biomat 1993; 4: 119–125.CrossRefGoogle Scholar
  149. 149.
    Lee J-M, Salvati EA, Betts F, DiCarlo EF, Doty SB, and Bullough PG. Size of metallic and polyethylene debris in failed cemented total hip replacements. J Bone Joint Surg 1992; 74-B: 380–384.Google Scholar
  150. 150.
    Shanbhag AS, Jacobs JJ, Giant TT, Gilbert JL, Black J, and Galante JO. Characterization of wear particles retrieved from failed uncemented total hip arthroplasty. Transactions of the Implant Retrieval Symposium of the Sociery for Biomaterials 1992; 15: 29.Google Scholar
  151. 151.
    Shanbhag AS, Jacobs JJ, Glant TT, Gilbert JL, Black J, and Galante JO. Composition and morphology of wear debris in failed uncemented total hip replacement arthroplasty. J Bone Joint Surg 1994; 76-B: 60–67.Google Scholar
  152. 152.
    Maloney WJ, Smith RL, Huene D, and Rubash HE. Particulate wear debris: characterization and quantitation from membranes around failed cementless femoral replacements. Trans Orthop Res Soc 1993; 18: 294.Google Scholar
  153. 153.
    Benz EB, Federman M, Godleski JJ, et al. Ultra-structure of cells that have phagocytosed polyethylene particles in peri-implant tissue from revision arthroplasty. Trans Orthop Res Soc 1994; 19: 200.Google Scholar
  154. 154.
    Campbell P, McKellop H, Yeom B, Grigoris P, Salovey R, and Amstutz HC. Isolation and characterization of UHMWPE particles from periprosthetic tissues. Trans Soc Biomater 1994; 17: 391.Google Scholar
  155. 155.
    Shanbhag AS, Glant TT, Gilbert JL, Black J, and Galante JO. Chemical and morphological characterization of wear debris in failed uncemented total hip replacement. Trans Orthop Res Soc 1993; 18: 296.Google Scholar
  156. 156.
    Campbell P, McKellop H, Belcher G, Ma S, and Schmalzried T. Automated particle sizing following digestion of periprosthetic tissues: what are we measuring? Trans Soc Biomater 1993; 16: 241.Google Scholar
  157. 157.
    Howie DW, Vernon-Roberts B, Oakeshott R, and Manthey B. A rat model of resorption of bone at the cement-bone interface in the presence of polyethylene wear particles. JBone Joint Surg 1988; 70-A: 257–263.Google Scholar
  158. 158.
    Goodman SB, Fornasier VL, and Kei J. The effects of bulk versus particulate ultra-high-molecularweight polyethylene on bone. J Arthroplasty 1988; October Supplement: S41—S46.Google Scholar
  159. 159.
    Goodman SB, Fornasier VL, and Kei J. The effects of bulk versus particulate polymethylmethacrylate on bone. Clin Orthop 1988; 232: 255–262.Google Scholar
  160. 160.
    Goodman SB, Chin RC, Chiou SS, and Lee J. Modulation of the membrane surrounding particulate polymethylmethacrylate in the rabbit tibia. Trans Soc Biomater 1990; 13: 289.Google Scholar
  161. 161.
    Goodman SB, Chin RC, Chiou SS, et al. Prostaglandin E2 synthesis by the tissue surrounding ultrahigh molecular weight polyethylene in different physical forms, in Particulate Debris from Medical Implants: Mechanisms of Formation and Biological Consequences, ASTMSTP 1144 1992; (St John KR, ed), American Society for Testing and Materials, Philadelphia, pp 111–117.Google Scholar
  162. 162.
    Thornhill TS, Ozuna RM, Shortkroff S, Keller K, Sledge CB, and Spector M. Biochemical and histological evaluation of the synovial-like tissue around failed (loose) total joint replacement prostheses in human subjects and a canine model. Biomaterials 1990; 11: 69–72.Google Scholar
  163. 163.
    Dorr LD, Bloebaum R, Emmanual J, and Meldrum R. Histologic, biochemical and ion analysis of tissue and fluids retrieved during total hip arthroplasty. Clin Orthop 1990; 261: 82–95.Google Scholar
  164. 164.
    Shanbhag AS, Jacobs JJ, Black J, Galante JO, and Giant TT. Inflammatory mediators secreted by cells of interfacial membranes from revision total hip replacements. Orthop Trans 19931994; 17: 796.Google Scholar
  165. 165.
    Haynes DR, Rogers SD, Hay S, App B, Pearcy MJ, and Howie DW. The differences in toxicity and release of bone-resorbing mediators induced by titanium and cobalt-chromium-alloy wear particles. JBone Joint Surg 1993; 75-A: 825–834.Google Scholar
  166. 166.
    Shanbhag AS, Black J, Jacobs JJ, Galante JO, and Giant TT. Surface area ratio as a parameter to study macrophage response to particulate biomaterials. Trans Soc Biomater 1993; 16: 190.Google Scholar
  167. 167.
    Gelb H, Schumacher HR, Cuckler J, and Baker DG. In vivo inflammatory response to polymethylmethacrylate particulate debris: effect of size, morphology, and surface area. J Orthop Res 1994; 12: 83–92.CrossRefGoogle Scholar
  168. 168.
    Vernon-Roberts B and Freeman MAR. The tissue response to total joint replacement prostheses, in The Scientific Basis of Joint Replacement 1977; (Swanson SAV and Freeman MAR, eds), Wiley, New York, pp 86–129.Google Scholar
  169. 169.
    Stauffer RN. Ten-year follow-up study of total hip replacement. JBone Joint Surg 1982; 64-A: 983–990.Google Scholar
  170. 170.
    Brown GC, Lockshin MD, Salvati EA, and Bullough PG. Sensitivity to metal as a possible cause of sterile loosening after cobalt-chromium total hip-replacement arthroplasty. J Bone Joint Surg 1977; 59-A: 164–168.Google Scholar
  171. 171.
    Carando S, Cannas M, Rossi P, and PortigliattiBarbos M. The lymphocytic transformation test (L.T.T.) in the evaluation of intolerance in prosthetic implants. Ital J Orthop Traumatol 1985; 11: 475–481.Google Scholar
  172. 172.
    DiCarlo EF and Bullough PG. The biologic responses to orthopedic implants and their wear debris. Clin Mater 1992; 9: 235–260.CrossRefGoogle Scholar
  173. 173.
    Hayashi T and Inoue H. Tissue reaction around loosened prostheses: a histological, x-ray micro-analytic and immunological study. Acta Med Okayama 1986; 40: 229–241.Google Scholar
  174. 174.
    Merritt K and Brown SA. Hypersensitivity to metallic biomaterials, in Systemic Aspects of Biocompatibility, vol. II 1981; (Williams DF, ed), CRC, Boca Raton, FL, pp 33–48.Google Scholar
  175. 175.
    Rooker GD and Wilkinson JD. Metal sensitivity in patients undergoing hip replacement. J Bone Joint Surg 1980; 62-B: 502–505.Google Scholar
  176. 176.
    Al-Saffar N, Revell PA, and Sachs JA. Assessment of osteolysis in relation to inflammatory cellular response and underlying joint disease. Trans Soc Biomater 1993; 16: 193 (Abstract).Google Scholar
  177. 177.
    Goodman SB, Huie P, Doshi A, et al. The mechanism of cell recruitment and osteolysis in arthroplasty loosening: analysis of thepseudomembrane using immunohistochemistry and in situ hybridization. Trans Soc Biomater 1993; 16: 192.Google Scholar
  178. 178.
    Lalor PA, Freeman MAR, and Revell PA. Immunological studies of the bone-implant interface. Trans Soc Biomater 1990; 13: 203 (Abstract).Google Scholar
  179. 179.
    Lalor PA, Revell PA, Gray AB, Wright S, Railton GT, and Freeman MAR. Sensitivity to titanium (A cause of implant failure?) J Bone Joint Surg 1991; 73-B: 25–28.Google Scholar
  180. 180.
    Santavirta S, Konttinen YT, Hoikka V, and Eskola A Immunopathological response to loose cementless acetabular components. J Bone Joint Surg 1991; 73-B: 38–42.Google Scholar
  181. 181.
    Collier JP, Suprenant VA, Jensen RA, Mayor MB, and Suprenant HP. Corrosion between the components of modular femoral hip prostheses. J Bone Joint Surg 1992; 74-B: 511–517.Google Scholar
  182. 182.
    Collier JP, Surprenant VA, Jensen RE, and Mayor MB. Corrosion at the interface of colbalt alloy heads on titanium alloy stems. Trans Soc Biomater 1991; 14: 292.Google Scholar
  183. 183.
    Gilbert JL, Buckley CA, and Jacobs JJ. In vivo corrosion of modular hip prosthesis components in similar metal combinations. The effect of crevice, stress, motion and alloy coupling. J Biomed Mater Res 1993; 27: 1533–1544.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • Michael A. Pappas
  • Christopher C. Schmidt
  • Arun S. Shanbhag
  • Theresa A. Whiteside
  • Harry E. Rubash
  • James H. Herndon

There are no affiliations available

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