Slow Release of an LHRH Analog to Reduce Serum Testosterone

  • Debra J. Trantolo
  • Joseph D. Gresser
  • A. Ganiyu Jimoh
  • Donald L. Wise
  • Richard C. RhodesIII
  • Janet E. Hall


During the last several decades, research into neuroendocrine control by LHRH and other hypothalamic hormones has been an area of high activity. Since Schally and Guillemin’s Nobel Prize winning work of the early 1970s, the isolation, determination of structure, and synthesis of hypothalamic peptide hormones, as well as the synthesis of their analogs, have revealed radically new approaches to diagnosis and treatment of endocrine and nonendocrine disorders (1–10). Clinical applications of the hypothalamic hormones include: differentiation between hypothalamic and pituitary lesion, stimulation of fertility, birth control, and treatment of precocious puberty, endometriosis, cryptochidism, diabetes mellitus, acromegaly, and acute pancreatitis. The uses of analogs of hypothalamic hormones for hormone-sensitive tumors is relatively more recent, but of major current clinical value and significance, as evidenced by the quick transfer of basic research results to FDA approvals. LHRH agonist analogs are now used for the treatment of endometriosis and precocious puberty, as well as many of the endocrine-dependent tumors found in prostate cancer, breast cancer, and ovarian cancer.


Polylactic Acid Serum Testosterone Glycolic Acid Precocious Puberty LHRH Agonist 


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Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • Debra J. Trantolo
  • Joseph D. Gresser
  • A. Ganiyu Jimoh
  • Donald L. Wise
  • Richard C. RhodesIII
  • Janet E. Hall

There are no affiliations available

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