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Multiphasic or “Pulsatile” Controlled Release System for the Delivery of Vaccines

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Human Biomaterials Applications

Abstract

Controlled drug release refers to the technique of drug administration whereby a reservoir delivers drug to a host. Such a system releases the required drug at some rate for a predetermined period of time. The origins of controlled drug release can be traced as far back as 1000 yr ago. Rhazes (850–923) recommended mucilage coating of pills using an extract ofpsyllium, and Avicenna (980–1037) recommended silvering and gilding pills (1). The silvering and gilding technology found its way to Europe, where the nobility enjoyed the luxury of pills coated with silver or gold. Although the coatings served primarily to mask the taste of the bitter tasting agents, they nevertheless altered the release kinetics of the drugs they enveloped.

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Authors
  1. Otute Akiti
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  2. A. Ganiyu Jimoh
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  3. Donald L. Wise
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  4. Gilda A. Barabino
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  5. Debra J. Trantolo
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  6. Joseph D. Gresser
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Editor information

Editors and Affiliations

  1. Northeastern University, Boston, MA, USA

    Donald L. Wise PhD

  2. Cambridge Scientific, Inc., Belmont, MA, USA

    Debra J. Trantolo PhD  & Joseph D. Gresser PhD  & 

  3. Harvard School of Dental Medicine, Boston, MA, USA

    David E. Altobelli DMD, MD

  4. USAF Medical Center, Lackland AFB, TX, USA

    Michael J. Yaszemski MD, PhD

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© 1996 Springer Science+Business Media New York

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Akiti, O., Jimoh, A.G., Wise, D.L., Barabino, G.A., Trantolo, D.J., Gresser, J.D. (1996). Multiphasic or “Pulsatile” Controlled Release System for the Delivery of Vaccines. In: Wise, D.L., Trantolo, D.J., Altobelli, D.E., Yaszemski, M.J., Gresser, J.D. (eds) Human Biomaterials Applications. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-4757-2487-5_14

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  • DOI: https://doi.org/10.1007/978-1-4757-2487-5_14

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-61737-012-0

  • Online ISBN: 978-1-4757-2487-5

  • eBook Packages: Springer Book Archive

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