Advertisement

Multiphasic or “Pulsatile” Controlled Release System for the Delivery of Vaccines

  • Otute Akiti
  • A. Ganiyu Jimoh
  • Donald L. Wise
  • Gilda A. Barabino
  • Debra J. Trantolo
  • Joseph D. Gresser
Chapter

Abstract

Controlled drug release refers to the technique of drug administration whereby a reservoir delivers drug to a host. Such a system releases the required drug at some rate for a predetermined period of time. The origins of controlled drug release can be traced as far back as 1000 yr ago. Rhazes (850–923) recommended mucilage coating of pills using an extract ofpsyllium, and Avicenna (980–1037) recommended silvering and gilding pills (1). The silvering and gilding technology found its way to Europe, where the nobility enjoyed the luxury of pills coated with silver or gold. Although the coatings served primarily to mask the taste of the bitter tasting agents, they nevertheless altered the release kinetics of the drugs they enveloped.

Keywords

Membrane Thickness Delivery Device Malaria Vaccine Control Drug Release Insulin Delivery 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Sonnedecker G and Griffenhagen G. Sugarcoating the pill: a historical perspective. Pharm Tech 1980; 4: 77.Google Scholar
  2. 2.
    Langer RS and Wise DL. Medical Applications ofControlled Release, vol 1, 1984; CRC, Boca Raton, FL.Google Scholar
  3. 3.
    Cowser DR. Introduction to Controlled Release. Southern Research, Birmingham, AL.Google Scholar
  4. 4.
    Hsieh DS. Controlled Release Systems: Fabrication Technology, vol 2, 1988; CRC, Boca Raton, FL.Google Scholar
  5. 5.
    Miller RA, Brady JM, and Cutright DE. Degradation rates of oral resorbable implants (polylactates and polyglycolates): rate modification and changes in PLA/PGA copolymer ratios. J Biomed Mater Res 1977; 11: 711.CrossRefGoogle Scholar
  6. 6.
    Gurny R, Junginger HE, and Peppas NA. Pulsatile Drug Delivery Current Applications and Future Trends, 1993; Wissenschaftliche Verlagsgesellschaft mBH, Germany.Google Scholar
  7. 7.
    Wise DL. Biopolymeric Controlled Release Systems, vol 1, 1984; CRC, Boca Raton, FL.Google Scholar
  8. 8.
    Ferencik M. Handbook oflmmunochemistry,1993; Chapman and Hall, London, p 117.Google Scholar
  9. 9.
    Kimball JW. Introduction to Immunology,2nd ed, 1986; MacMillan, New York.Google Scholar
  10. 10.
    Schmidt-GallwitzerM. LH-RHandltsAnaloguesFertility and Antifertility Aspects,1985; Walter de Gruyter, pp 2–3.Google Scholar
  11. 11.
    Jimoh AG, Wise DL, Gresser JD, Foote RH, Rhodes RC, and Trantolo DJ. Pulsatile release of follicle stimulating hormone. J Controlled Rel.Google Scholar
  12. 12.
    Jimoh AG, Wise DL, Gresser JD, Foote RH, Rhodes RC, and Trantolo DJ. Pulsatile release of FSH for cattle reproduction management. Theriogenology, 1995; 43: 645–656.CrossRefGoogle Scholar
  13. 13.
    Greene L, Phan LX, Schmitt EE, and Muhr JM. Side-chain crystallizable polymers for temperature-activated controlled release, in Polymeric Delivery Systems: Properties and Applications, 1993; (Al-Nokaly MA, Charpentier BA, and Piatt DM, eds ), ACS Symposium Series 520.Google Scholar
  14. 14.
    Theeuwes F. Elementary osmotic pump. JPharma Sci 1975; 64: 12.Google Scholar
  15. 15.
    Ueda et al. US Patent 4,871,549, October 3, 1989.Google Scholar
  16. 16.
    Cohen S, Yoshioka T, Luconelli M, Hwang LH, and Langer RS. Controlled delivery systems for proteins based on poly(lactic/glycolic) acid micro-spheres. Pharm Res 1991; 8: 6.CrossRefGoogle Scholar
  17. 17.
    Heller J. Chemically self-regulated drug delivery systems. J Controlled Rel 1988; 8: 111–125.CrossRefGoogle Scholar
  18. 18.
    Brownlee M and Cerami A. A glucose-controlled insulin-delivery system: semisynthetic insulin bound to lectin. Science 1979; 206: 1190, 1191.Google Scholar
  19. 19.
    Brownlee M and Cerami A. Glycosylated insulin compound to Concanvalin A. Biochemical basis for a closed-loop insulin delivery system. Diabetes 1983; 32: 499–504.CrossRefGoogle Scholar
  20. 20.
    Heller J, Pangburn SH, and Penhale DWH. Use of bioerodible polymers in self-regulated systems, in Controlled Release Technology, 1987; (Lee PI and Good WR, eds), ACS Symposium Series, No. 348, American Chemical Society, Washington DC, pp 172–187.Google Scholar
  21. 21.
    Heller J, Penhale DWH, and Pangburn SH. Chemically self-regulated drug delivery systems, in Polymers in Medicine, 1988; (Migliaresi C, Nicolais L, Giusti P, and Chiellini E, eds), Elsevier, Amsterdam, pp 175–188.Google Scholar
  22. 22.
    Herbert TA, Kost J, and Ratner BD. Swelling behaviour of glucose sensitive membranes, in Polymers as Biomaterials, 1984; (Shelaby SW, Hoffman AS, Ratner BD, and Herbert TA, eds), Plenum, New York, pp 193–207.Google Scholar
  23. 23.
    Ishihara K, Kobayashi M, and Shionohara I. Control of insulin permeation through a polymer membrane with responsive function for glucose, 1983; Makromol Chem 1983; 4: 327–331.Google Scholar
  24. 24.
    Ishihara K, Kobayashi M, and Shinihara I. Insulin permeation through amphihilic polymer membranes having 2-hydroxyethyl methacrylate moiety. Polym J 1984; 16: 647–651.CrossRefGoogle Scholar
  25. 25.
    Miyazaki S, How W-M, and Takeda M. Controlled release by ultrasound irradiation. Chem Pharm Bull 1985; 33 (1): 428–431.CrossRefGoogle Scholar
  26. 26.
    Edelman EK, Kost J, Bobeck H, and Langer RS. Regulation of drug release from polymer matrices by oscillating magnetic fields I. JBiomed Res 1985; 19: 67–83.CrossRefGoogle Scholar
  27. 27.
    Kwan IC, Bae YH, and Kim SW. Heparin release from polymer complex. JControlled Rel 1994; 30: 155–159.CrossRefGoogle Scholar
  28. 28.
    Ansel HC. Introduction to Pharmaceutical Dosage Forms 1985; Lea and Febiger, Philadelphia.Google Scholar
  29. 29.
    Brown P. Malaria vacccine passes key test. New Sci 1994; 7.Google Scholar
  30. 30.
    Redfern M. First trials for malaria vaccine. New Sci 1988.Google Scholar
  31. 31.
    TDR News. UNDP/World Bank/Who Special Program for Research and Training in Tropical Diseases (TDR), no 41, 1992.Google Scholar
  32. 32.
    TDR News. UNDP/World Bank/Who Special Program for Research and Training in Tropical Diseases (TDR), no 42, 1993Google Scholar
  33. 33.
    Strategic Plan forApplied Field Research in Tropical Diseases. UNDP/World Bank/Who Special Program for Research and Training in Tropical Diseases (TDR) and Division for Control of Tropical Diseases, World Health Organization (WHO).Google Scholar
  34. 34.
    Press release, WHO/13, Feb 13, 1994.Google Scholar
  35. 35.
    Kenley RA, Lee MO, Mahoney R, and Sanders LM. Poly(lactide-co-glycolide) decomposition kinetics in vivo and invitro.Macromolecules 1987; 20:2398–2408.Google Scholar
  36. 36.
    Baker R. Controlled Release of Bioactive Agents, 1980; Academic, New York.Google Scholar
  37. 37.
    Kuethe KO, Augustein DC, Gresser JD, and Wise DL. Design of capsules that burst at predetermined times by dialysis. JControlled Rel 1992; 18: 159–164.CrossRefGoogle Scholar
  38. 38.
    Ross TF. Applied Stress Analysis,1987; Halstad Press.Google Scholar
  39. 39.
    Perry JH. Chemical Engineer ‘s Handbook, 1950; Mc Graw-Hill, New York.Google Scholar

Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • Otute Akiti
  • A. Ganiyu Jimoh
  • Donald L. Wise
  • Gilda A. Barabino
  • Debra J. Trantolo
  • Joseph D. Gresser

There are no affiliations available

Personalised recommendations