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Gene Regulation and Expression

  • Dennis W. Ross

Overview

A gene is a segment of DNA consisting of codons specifying the amino acids for a protein and of control sequences that regulate gene expression. When a cell divides, the entire human genome, that is, all the DNA stored within the nucleus, must be copied. In Figure 2.1 the replication of DNA is demonstrated. The regulation of a cell’s function is controlled by altering gene expression. The steps in gene expression are (1) transcription of the gene’s DNA to RNA, (2) RNA processing to produce a spliced mRNA, (3) translation of mRNA on a polyribosome to a polypeptide chain, and (4) final protein processing to the functional tertiary form. Figures 2.2 through 2.5 illustrate the steps in this process, which will be covered in more detail later in this chapter.

Keywords

Chronic Myeloid Leukemia Cystic Fibrosis Transmembrane Conductance Regulator Antisense Oligonucleotide Antisense Copy mRNA Molecule 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Bibliography

  1. Culotta E, Koshland DE Jr (1992) No news is good news. Science 258: 1862–1865.PubMedCrossRefGoogle Scholar
  2. Stein CA, Cheng YC (1993) Antisense oligonucleotides as therapeutic agents — is the bullet really magical? Science 261: 1004–1012.PubMedCrossRefGoogle Scholar
  3. Stein CA, Cohen JS (1989) Oligodeoxynucleotides as inhibitors of gene expression: a review. Cancer Res 48: 2659–2668.Google Scholar
  4. van der Krol AR, Mol JNM, Stuitje AR (1988) Modulation of eukaryotic gene expression by complementary RNA or DNA sequences. Biotechniques 6: 958–976.PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • Dennis W. Ross
    • 1
    • 2
  1. 1.The School of Medicine, Department of PathologyUniversity of North Carolina at Chapel HillChapel HillUSA
  2. 2.Department of PathologyForsyth Memorial HospitalWinston-SalemUSA

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