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Hormonal Regulation of Liver Cytochrome P450 Enzymes

  • David J. Waxman
  • Thomas K. H. Chang
Chapter

Abstract

Endogenous steroids and other naturally occurring lipophilic substances serve as important substrates for cytochrome P450 (CYP) enzymes found in liver and other tissues,1,2 including the primary steroidogenic tissues (Kagawa and Waterman, this volume). Steroid hormones are metabolized by liver P450 enzymes with a higher degree of regio-and stereoselectivity than many foreign compound substrates,3 suggesting that these endogenous lipophiles serve as physiological P450 substrates. Eight of the twelve mammalian P450 gene families described as of 19934 encode enzymes that catalyze steroid hydroxylations. Two of these gene families (CYP2 and CYP3) encode liver P450 enzymes required for the hydroxylation of steroid hormones and bile acids, and two encode P450s that participate in the conversion of cholesterol to bile acids in the liver, where they contribute in a major way to cholesterol homeostasis (CYP7, CYP27).5

Keywords

Growth Hormone Thyroid Hormone Growth Hormone Secretion P450 Reductase Growth Hormone Pulse 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • David J. Waxman
    • 1
  • Thomas K. H. Chang
    • 2
  1. 1.Division of Cell and Molecular Biology, Department of BiologyBoston UniversityBostonUSA
  2. 2.Division of Pharmacology and Toxicology, Faculty of Pharmaceutical SciencesThe University of British ColumbiaVancouverCanada

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