Abstract
Lung cancer is a major cause of cancer incidence in the United States, accounting for an estimated 172,000 new cases in 1994 (Boring et al., 1994). Lung cancer incidence in males is second only to prostate cancer, and in females, it is second only to breast cancer (Miller et al., 1992a). Unfortunately, despite recent advances in oncologic therapy, survival from lung cancer remains poor, as indicated by an overall 5-yr relative survival rate of 13% (Miller et al., 1992a). As a result, lung cancer is the chief cause of cancer mortality in both men and women, accounting for an estimated 153,000 cancer deaths in 1994 (Boring et al., 1994). Further, lung cancer is likely to remain a leading cause of both cancer incidence and cancer mortality well into the next century (Gaffney et al., 1988).
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References
Barbacid, M. (1987), Annu. Rev. Biochem. 56, 799–827.
Bargmann, C. I., M. Hung, and R. A. Weinberg, (1986) Nature 319, 226–230.
Berger, M. S., W. J. Gullick, C. Greenfield, S. Evans, B. J. Addis, and M. D. Waterfield (1987), J. Pathol. 152, 297–307.
Biner, M. J. and J. D. Minna (1988), Semin. Oncol. 15, 759–767.
Biner, M. J. and J. D. Minna (1989), Annu. Rev. Med. 40, 305–317.
Bodner, S. M., J. D. Minna, S. M. Jensen, D. D’Amico, D. Carbone, T. Mitsudomi, J. Fedorko, D. L. Buchhagen, M. M. Nau, A. F. Gazdar, and R. I. Linnoila (1992), Onco gene 7, 743–749.
Boring C. C., T. S. Squires, T. Tong, and S. Montgomery (1994), CA Cancer J. Clin. 44, 7–26.
Brauch, H., B. Johnson, J. Hovis, T. Yano, A. Gazdar, O. S. Pettengill, S. Graziano, G. D. Sorenson, B. J. Poiesz, J. Minna, M. Linehan, and B. Zbar (1987), N. Engl. J. Med. 317, 1109–1113.
Brauch, H., T. Kalman, F. Kotler, A. F. Gazdar, O. S. Pettengill, B. Johnson, S. Graziano, T. Winton, C. H. C. M. Buys, G. D. Sorenson, B. J. Poiesz, J. D. Minna, and B. Zbar (1990), Genes Chromosomes Cancer 1, 240–246.
Brennan, J., T. O’Connor, R. W. Makuch, A. M. Simmons, E. Russell, R. I. Linnoila, R. M. Phelps, A. F. Gazdar, D. C. Ihde, and B. E. Johnson (1991), Cancer Res. 51, 1708–1712.
Broers, J. L. V., J. Viallet, S. M. Jensen, H. Pass, W. D. Travis, J. D. Minna, and R. I. Linnoila (1993), Am. J. Resp. Mol. Biol. 9, 33–43.
Carritt, B., K. Kok, A. van den Berg, J. Osinga, A. Pilz, R. M. W. Hofstra, M. B. Davis, A. Y. van der Veen, P. H. Rabbitts, K. Gulati, and C. H. C. M. Buys (1992), Cancer Res. 52, 1536–1541.
Cerny, T., D. M. Barnes, P. Hasleton, P. V. Barber, K. Healy, W. Gullik, and N. Thatcher (1986), Br. J. Cancer 54, 265–269.
Chiba, I., T. Takahashi, M. N. Nau, D. D’Amico, D. T. Curiel, T. Mitsudomi, D. L. Buchhagen, D. Carbone, S. Piantadosi, H. Koga, P. T. Reissman, D. J. Slamon, E. C. Holmes, and J. D. Minna (1990), Oncogene 5, 1603–1610.
Cline, M. J. and H. Battifora (1987), Cancer 60, 2669–2674.
Cole, M. D. (1986), Ann. Rev. Genet. 20, 361–384.
D’Amico, D., D. Carbone, T. Mitsudomi, M. Nau, J. Fedorko, E. Russell, B. Johnson, D. Buchhagen, S. Bodner, R. Phelps, A. Gazdar, and J. D. Minna (1992), Onco gene 7, 339–346.
DeGreve, J., J. Battey, J. Fedorko, M. Biner, G. Evan, F. Kaye, E. Sausville, and J. Minna (1988), Mol. Cell. Biol. 8, 4381–4388.
Downward, J., Y. Yarden, e. Mayes, G. Scrace, N. Totty, P. Stockwell, A. Ullrich, J. Schlessinger, and M. D. Waterfield (1984), Nature 307, 521–527.
El-Deiry, W. S., T. Tokino, V. E. Velculescu, D. B. Levy, R. Parsons, J. M. Trent, D. Lin, W. E. Mercer, K. W. Kinzler, and B. Vogelstein (1993), Cell 75, 817–825.
Eliyahu, D., A. Raz, P. Gruss, D. Givol, and M. Oren (1984), Nature 312, 646–649.
Fields, S. and S. K. Jang (1990), Science 249, 1046–1049.
Finlay, C. A., P. W. Hinds, and A. J. Levine (1989), Cell 57, 1083–1093.
Friend, S. H., R. Bernards, S. Rogelj, R. A. Weinberg, J. M. Rapaport, D. M. Albert, and T. P. Dryja (1986), Nature 323, 643–646.
Funa, K., L. Steinholtz, E. Nou, and J. Bergh (1987), Am. J. Clin. Pathol. 88, 216–220.
Gaffney, M. and B. Altshuler (1988), J. Natl. Cancer Inst. 80, 925–931.
Ginsberg, R. J., M. G. Kris, and J. G. Armstrong (1993), in Cancer: Principles and Practice of Oncology (DeVita, V. T., S. Hellman, and S. A. Rosenberg, eds.), J. B. Lippincott, Philadelphia, pp. 673–722.
Green, M. R. (1989), Cell 56, 1–3.
Harbour, J. W., S. Lai, J. Whang-Peng, A. F. Gazdar, J. D. Minna, and F. J. Kaye (1988), Science 241, 353–357.
Harper, J. W., G. R. Adami, N. Wei, K. Keyomarsi, and S. J. Elledge (1993), Cell 75, 805–816.
Hendler, F. J. and B. W. Ozanne (1984), J. Clin. Invest. 74, 647–651.
Hensel, C. H., R. H. Xiang, A. Y. Sakaguchi, and S. L. Naylor (1991), Oncogene 6, 1067–1071.
Hensel, C. H., C. Hsieh, A. F. Gazdar, B. E. Johnson, A. Y. Sakaguchi, S. L. Naylor, W. Lee, and E. Y. P. Lee (1990), Cancer Res. 50, 3067–3072.
Hibi, K., T. Takahashi, K. Yamakawa, R. Ueda, Y. Sekido, Y. Ariyoshi, M. Suyama, H. Takagi, Y. Nakamura, and T. Takahashi (1992), Oncogene 7, 445–449.
Hiyoshi, H., Y. Matsuno, H. Kato, Y. Shimosato, and S. Hirohashi (1992), Jpn. J. Cancer Res. 83, 101–106.
Horio, Y., T. Takahashi, T. Kuroishi, K. Hibi, M. Suyama, T. Niimi, K. Shimokata, K. Yamakawa, Y. Nakamura, R. Ueda, and T. Takahashi (1993), Cancer Res. 53, 1–4.
Horowitz, J. M., S. Park, E. Bogenmann, J. Cheng, D. W. Yandell, F. J. Kaye, J. D. Minna, T. P. Dryja, and R. A. Weinberg (1990), Proc. Natl. Acad. Sci. USA 87, 2775–2779.
Iggo, R., K. Gatter, J. Bartek, D. Lane, and A. L. Harris (1990), Lancet 335, 675–679.
Ihde, D. C., H. I. Pass, and E. J. Glatstein (1993), in Cancer: Principles and Practice of Oncology (DeVita, V. T., S. Hellman, and S. A. Rosenberg, eds.), J. B. Lippencott, Philadelphia, pp. 723–758.
Johnson, B. E., J. F. Brennan, D. C. Ihde, and A. F. Gazdar (1992), J. Natl. Cancer Inst. Monogr. 13, 39–43.
Johnson, B. E., A. Y. Sakaguchi, A. F. Gazdar, J. D. Minna, D. Burch, A. Marshall, and S. L. Naylor (1988), J. Clin. Invest. 82, 502–507.
Johnson, B. E., D. C. Ihde, R. W. Makuch, A. F. Gazdar, D. N. Carney, H. Oie, E. Russell, M. M. Nau, and J. D. Minna (1987), J. Clin. Invest. 79, 1629–1634.
Kaelin, W. G. Jr., D. C. Pallas, J. A. DeCaprio, F. J. Kaye, and D. M. Livingston (1991), Cell 64, 521–532.
Kashii, T., Y. Mizushima, K. Nakagawa, S. Monno, and S. Yano (1992), Anticancer Res. 12, 621–624.
Kaye, F. J., R. A. Kratzke, J. L. Gerster, and J. M. Horowitz (1990), Proc. Natl. Acad. Sci. USA 87, 6922–6926.
Kern, J. A., D. A. Schwartz, J. E. Nordberg, D. B. Weiner, M. I. Greene, L. Torney, and R. A. Robinson (1990), Cancer Res. 50, 5184–5191.
Kern, S. E., J. A. Pietenpol, S. Thiagalingam, A. Seymour, K. W. Kinzler, and B. Vogelstein (1992), Science 256, 827–830.
Kiefer, P. E., G. Bepler, M. Kubasch, and K. Havemann (1987), Cancer Res. 47, 6236–6242.
Kishimoto, Y., Y. Murakami, M. Shiraishi, K. Hayashi, and T. Sekiya (1992), Cancer Res. 52, 4799–4804.
Knudson, A. G. (1971), Proc. Natl. Acad. Sci. USA 68, 820–823.
Kobayashi, T., H. Tsuda, M. Noguchi, S. Hirohashi, Y. Shimosato, T. Goya, and Y. Hayata (1990), Cancer 66, 289–294.
Kohl, N. E., N. Kanda, R. R. Schreck, G. Bruns, S. A. Latt, F. Gilbert, and F. W. Alt (1983), Cell 35, 359–367.
Kok, K., J. Osinga, B. Carritt, M. B. Davis, A. H. van der Hout, A. Y. van der Veen, R. M. Landsvater, L. F. M. H. de Leij, H. H. Berendsen, P. E. Postmus, S. Poppema, and C. H. C. M. Buys (1987), Nature 330, 578–581.
Krystal, G., M. Birrer, J. Way, M. Nau, E. Sausville, C. Thompson, J. Minna, and J. Battey (1988), Mol. Cell. Biol. 8, 3373–3381.
Lane, D. P. and L. V. Crawford (1979), Nature 278, 261–263.
Lange-Carter, C. A., C. M. Pleiman, A. M. Gardner, K. J. Blurner, and G. L. Johnson (1993), Science 260, 315–319.
Lee, W., R. Bookstein, F. Hong, L. Young, J. Shew, and E. Y. P. Lee (1987a), Science 235, 1394–1399.
Lee, W., J. Shew, F. D. Hong, T. W. Sery, L. A. Donoso, L. Young, R. Bookstein, and E. Y. P. Lee (1987b), Nature 329, 642–645.
Li, N., A. Batzer, R. Daly, V. Yajnik, J. Skolnik, P. Chardin, D. Bar-Sagi, B. Margolis, and J. Schlessinger (1993), Nature 363, 85–88.
Lin, C. R., W. S. Chen, W. Kruiger, L. S. Stolarsky, W. Weber, R. M. Evans, I. M. Verma, G. N. Gill, and M. G. Rosenfeld (1984), Science 224, 843–848.
Linzer, D. I. H. and A. J. Levine (1979), Cell 17, 43–52.
Little, C., M. M. Nau, D. N. Carney, A. F. Gazdar, and J. D. Minna (1983), Nature 306, 194–196.
Lung, M. L., M. Wong, W. K. Lam, K. S. Lau, S. Kwan, K. Fu, H. Cheung, and W. W. Yew (1992), Cancer 70, 760–763.
McCormick, F. (1989), in Oncogenes and the Molecular Origins of Cancer (Weinberg, R. A., ed.), Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, pp. 125, 126.
Mellstrom, K., C. Bjelfman, U. Hammerling, and S. Pahlman (1987), Mol. Cell. Biol. 7, 4178–4184.
Miller, B. A., L. A. G. Ries, B. F. Hankey, C.L. Kosary, and B. K. Edwards (eds.) (1992a), Cancer Statistics Review: 1973–1989 National Cancer Institute, NIH Pub. No. 922–789, pp. xv.1, xv.5.
Miller, C. W., K. Simon, A. Aslo, K. Kok, J. Yokota, C. H. C. M. Buys, M. Terada, and H. P. Koeffler (1992b), Cancer Res. 52, 1695–1698.
Mitsudomi, T., J. Viallet, J. L. Mulshine, R. I. Linnoila, J. D. Minna, and A. F. Gazdar (1991a), Oncogene 6, 1353–1362.
Mitsudomi, T., S. M. Steinberg, H. K. Oie, J. L. Mulshine, R. Phelps, J. Viallet, H. Pass, J. D. Minna, and A. Gazdar (1991b), Cancer Res. 51, 4999–5002.
Mitsudomi, T., S. M. Steinberg, M. M. Nau, D. Carbone, D. D’Amico, S. Bodner, H. K. Oie, R. I. Linnoila, J. L. Mulshine, J. D. Minna, and A. F. Gazdar (1992), Oncogene 7, 171–180.
Nau, M. M., B. J. Brooks, J. Battey, E. Sausville, A. F. Gazdar, I. R. Kirsch, O. W. McBride, V. Bertness, G. F. Hollis, and J. D. Minna (1985), Nature 318, 69–73.
Nau, M. M., B. J. Brooks, D. N. Carney, A. F. Gazdar, J. F. Battey, E. A. Sausville, and J. D. Minna (1986), Proc. Natl. Acad. Sci. USA 83, 1092–1096.
Naylor S. L., B. E. Johnson, J. D. Minna, and A. Y. Sakaguchi (1987), Nature 329, 441–454.
O’Rourke, R. W., C. W. Miller, G. J. Kato, K. J. Simon, D. Chen, C. V. Dang, and H. P. Koeffler (1990), Oncogene 5, 1829–1832.
Quinlan, D. C., A. G. Davidson, C. L. Summers, H. E. Warden, and H. M. Doshi (1992), Cancer Res. 52, 4828–4831.
Raycroft, L., H. Wu, and G. Lozano (1990), Science 249, 1049–1051.
Rodenhuis, S. and R. J. C. Slebos (1992), Cancer Res. (suppl.) 52, 2665s - 2669s.
Rodenhuis, S., M. L. van de Wetering, W. J. Mooi, S. G. Evers, N. van Zandwijk, and J. L. Bos (1987), N. Engl. J. Med. 317, 929–935.
Rodenhuis, S., R. J. C. Slebos, A. J. M. Boot, S. G. Evers, W. J. Mooi, S. Sc. Wagenaar, P. Ch. van Bodegom, and J. L. Bos (1988), Cancer Res. 48, 5738–5741.
Sameshima, Y., Y. Matsuno, S. Hirohashi, Y. Shimosato, H. Mizoguchi, T. Sugimura, M. Terada, and J. Yokota (1992), Oncogene 7, 451–457.
Sanders, B. M., M. Jay, G. J. Draper, and E. M. Roberts (1989), Br. J. Cancer 60, 358–363.
Santos E., D. Martin-Zanca, E. P. Reddy, M. A. Pierotti, G. Della Porta, and M. Barbacid (1984), Science 223, 661–664.
Schechter, A. L., D. F. Stern, L. Vaidyanathan, S. J. Decker, J. A. Drebin, M. I. Greene, and R. A. Weinberg (1984), Nature 312, 513–516.
Schütte, J., M. Nau, M. Birrer, F. Thomas, A. Gazdar, and J. Minna (1988), Proc. Am. Assoc. Cancer Res. 29, 455.
Schwab, M., K. Alitalo, K. Klempnauer, H. E. Varmus, J. M. Bishop, F. Gilbert, G. Brodeur, M. Goldstein, and J. Trent (1983) Nature 305, 245–248.
Sheiness, D. and J. M. Bishop (1979), J. Virol. 31, 514–521.
Shih, C., L. C. Padhy, M. Murray, and R. A. Weinberg (1981), Nature 290, 261–264.
Shiraishi, M., M. Noguchi, Y. Shimosato, and T. Sekiya (1989), Cancer Res. 49, 6474–6479.
Slebos, R. J. C., and S. Rodenhuis (1992), J. Natl. Cancer Inst. Monogr. 13, 23–29.
Slebos, R. J. C., S. G. Evers, S. S. Wagenaar, and S. Rodenhuis (1989), Br. J. Cancer 59, 76–80.
Slebos, R. J. C., R. E. Kibbelaar, 0. Dalesio, A. Kooistra, J. Stam, C. J. L. M. Meijer, S. S. Wagenaar, R. G. J. R. A. Vanderschueren, N. van Zandwijk, W. J. Mooi, J. L. Bos, and S. Rodenhuis (1990), N. Engl. J. Med. 323, 561–565.
Sozzi, G., M. Miozzo, R. Donghi, S. Pilotti, C. T. Cariani, U. Pastorino, G. Della Porta, and M. Pierotti (1992), Cancer Res. 52, 6079–6082.
Sporn, M. B. and A. B. Roberts (1992), Ann. Intern. Med. 117, 408–414.
Stern, D. F., P. A. Heffernan, and R. A. Weinberg (1986), Mol. Cell. Biol. 6, 1729–1740.
Sugio, K., T. Ishida, H. Yokoyama, T. Inoue, K. Sugimachi, and T. Sasazuki (1992), Cancer Res. 52, 2903–2906.
Sundaresan, V., P. Ganly, P. Hasleton, R. Rudd, G. Sinha, N. M. Bleehen, and P. Rabbitts (1992), Oncogene 7, 1989–1997.
Suzuki, Y., M. Orita, M. Shiraishi, K. Hayashi, and T. Sekiya (1990), Oncogene 5, 1037–1043.
Suzuki, H., T. Takahashi, T. Kuroishi, M. Suyama, Y. Ariyoshi, T. Takahashi, and R. Ueda (1992), Cancer Res. 52, 734–736.
Takahashi, T., T. Takahashi, H. Suzuki, T. Hida, Y. Sekido, Y. Ariyoshi, and R. Ueda (1991), Oncogene 6, 1775–1778.
Takahashi, T., D. Carbone, T. Takahashi, M. M. Nau, T. Hida, I. Linnoila, R. Ueda, and J. D. Minna (1992), Cancer Res. 52, 2340–2343.
Trahey M. and F. McCormick (1987), Science 238, 542–545.
Ullrich, A., J; S. Hayflick, T. J. Dull, A. Gray, A. W. Tam, J. Lee, Y. Yarden, T. A. Libermann, J. Schlessinger, J. Downward, E. L. V. Mayes, N. Whittle, M. D. Waterfield, and P. H. Seeburg (1984), Nature 309, 418–425.
Veale, D., T. Ashcroft, C. Marsh, G. J. Gibson, and A. L. Harris (1987), Br. J. Cancer 55, 513–516.
Veillette, A., F. Foss, E. Sausville, J. Bolen, and N. Rosen (1987), Oncogene Res. 1, 357–374.
Vennstrom, B. and J. M. Bishop (1982), Cell 28, 135–143.
Vogelstein, B. and K. W. Kinzler (1992), Cell 70, 523–526.
Volm, M., T. Efferth, and J. Mattem (1992), Anticancer Res. 12, 11–20.
Weiner, D. B., J. Nordberg, R. Robinson, P. C. Nowell, A. Gazdar, M. I. Greene, W. V. Williams, J. A. Cohen, and J. A. Kern (1990), Cancer Res. 50, 421–425.
Weston, A., J. C. Willey, R. Modali, H. Sugimura, E. M. McDowell, J. Resau, B. Light, A. Haugen, D. L. Mann, B. F. Trump, and C. C. Harris (1989), Proc. Natl. Acad. Sci. USA 86, 5099–5103.
Westra, W. H., G. J. A. Offerhaus, S. N. Goodman, R. J. C. Slebos, M. Polak, I. O. Baas, S. Rodenhuis, and R. H. Hruban (1993), Am. J. Surg. Pathol. 17, 213–220.
Whang-Peng, J., C. S. Kao-Shan, E. C. Lee, P. A. Bunn, D. N. Carney, A. F. Gazdar, and J. D. Minna (1982a), Science 215, 181, 182.
Whang-Peng, J., P. A. Bunn, C. S. Kao-Shan, E. C. Lee, D. N. Carney, A. Gazdar, and J. D. Minna (1982b), Cancer Genet. Cytogenet. 6, 119–134.
Xu, H., S. Hu, P. T. Cagle, G. E. Moore, and W. F. Benedict (1991), Cancer Res. 51, 2735–2739.
Xu, Y., S. Ishii, A. J. L. Clark, M. Sullivan, R. K. Wilson, D. P. Ma, B. A. Roe, G. T. Merlino, and I. Pastan (1984), Nature 309, 806–810.
Yokota, J., M. Wada, Y. Shimosato, M. Terada, and T. Sugimura (1987), Proc. Natl. Acad. Sci. 84, 9252–9256.
Yokota, J., M. Wada, T. Yoshida, M. Noguchi, T. Terasaki, Y. Shimosato, T. Sugimura, and M. Terada (1988a), Oncogene 2, 607–611.
Yokota, J., T. Akiyama, Y. T. Fung, W. F. Benedict, Y. Namba, M. Hanaoka, M. Wada, T. Terasaki, Y. Shimosato, T. Sugimura, and M. Terada (1988b), Oncogene 3, 471–475.
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Lemon, S.J., Sabichi, A.L., Birrer, M.J. (1995). Genetic Alterations in Lung Cancer. In: Garrett, C.T., Sell, S. (eds) Cellular Cancer Markers. Contemporary Biomedicine, vol 12. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-4757-2381-6_8
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