Genetic Alterations in Colon Cancer

  • Suhail Nasim
  • Carleton T. Garrett
Part of the Contemporary Biomedicine book series (CB, volume 12)


Human colon cancer has proven to be an excellent model system for studying the development of malignant disease in humans. Based on clinical and pathological findings, colon cancer is observed to develop through a variety of stages involving premalignant adenomatous polyps followed by localized invasive malignant carcinoma and subsequently disseminated malignant tumor (Muto et al., 1975; O’Brien et al., 1992). Premalignant lesions vary from small relatively well-differentiated hyperplastic lesions to larger less-well-differentiated tubular adenomas and subsequently to lesions that demonstrate still greater size, and reduced cytologic differentiation called villus adenomas (Muto et al., 1975; Jass et al., 1986; O’Brien et al., 1992). This process occurs over a period of years and is believed to involve the occurrence of four to six separate genetic changes (Fearon and Vogelstein, 1990).


Colon Cancer Focal Adhesion Kinase Familial Adenomatous Polyposis Adenomatous Polyposis Coli Allelic Loss 


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  1. Aaltonen, L. A., P. Peltomaki, F. S. Leach, P. Sistonen, L. Pylkkanen, J.-P. Mecklin, H Jarvinen, S. M. Powell, J. Jen, S. R. Hamilton, G. M. Petersen, K. W. Kinzler, B. Vogelstein, and A. de la Chapelle (1993), Science 260 812–816.Google Scholar
  2. Aaltonen, L. A., P. Peltomaki, J.-P. Mecklin, H. Jarvinen, J. Jass, J. Green, H. T. Lynch,P. Watson, G. Tallqvist, M. Juhola, P. Sistonen, S. R. Hamilton, K. W. Kinzler, B.Vogelstein, and A. de la Chapelle (1994), Cancer Res. 54, 1645–1648. Adany R. and R. V. Iozzo (1991), Biochem. J 276, 301–306.Google Scholar
  3. Albini, A., A. Melchioi, L. Santi, L. A. Liotta, P. D. Brown, and W. G. Stetler-Stevenson (1991), J. Natl. Cancer Inst 83, 775–779.PubMedCrossRefGoogle Scholar
  4. Alexander, R. J., J. N. Buxbaum, and R. F. Raicht (1991), Am. J. Med. Sci. 301, 238–245. Alitalo, K., M. Schwab, C. C. Lin, H. E. Varmus, and J. M. Bishop (1983), Proc. Natl. Acad. Sci. USA 80, 1707–1711.Google Scholar
  5. Amati, B., T. D. Littlewood. G. I Evan, and H. Land (1993), EMBO J 12 5083–5087. Aneskievich, B. J., B. Haimovich, and D. Boettiger (1991) Oncogene 6 1381–1390. Aoyama, N., T. Nagase, T. Sawazaki, G. Mizuouchi, H. Nakagoshi, J. I. Fujisawa, M.Yoshida, and S. Ishji (1992), Proc. Natl. Acad. Sci. USA 89 5403–5407.Google Scholar
  6. Arnemann, J., N. K. Spurr, A. I. Magee, and R. S. Buxton (1992), Genomics 13, 48486. Askew, D. S., R. A. Ashmun, B. C. Simmons, and J. L. Cleveland (1991), Oncogene 6, 1915–1922.Google Scholar
  7. Augenlicht, L. H., C. Augeron, G. Yander, and C. Laboisse (1987), Cancer Res. 47, 3763–3765. Ayer, D. E. and R. N. Eisenman (1993), Genes 7, 2110–2119.Google Scholar
  8. Azzam, H S., G. Arand, M. E. Lippman, and E. W. Thompson (1993), J. Natl. Cancer Inst 85, 1758–1764.PubMedCrossRefGoogle Scholar
  9. Baker, S. J., E. R. Fearon, J. M. Nigro, S. R. Hamilton, A. C. Preisinger, J. M. Jessup, P. van Turinen, D. H. Ledbetter, D. F. Barker, Y. Nakamura, R. White, and B. Vogelstein (1989), Science 244, 217–221.PubMedCrossRefGoogle Scholar
  10. Baker, S. J., S. Markowitz, E. R. Fearon, J. K. V. Willson, and B. Vogelstein (1990), Science 249, 912–915.PubMedCrossRefGoogle Scholar
  11. Baker, S. J., et al. (1990), Cancer Res. 50, 7717.PubMedGoogle Scholar
  12. Barbarcid, M. (1987), Annu. Rev. Biochem 56, 799–827.Google Scholar
  13. Barnes, D. M., A. M. Hanby, C. E. Gillett, S. Mohammed, S. Hodgson, L. G. Bobrow, I. M. Leigh, T. Purkis, C. MacGeoch, N. K. Spurr, J. Bartek, B Vojtesek, S. M. Picksley, and D. P. Lane (1992), Lancet 340(8814) 259–263.Google Scholar
  14. Bauer, E. A., T. W. Cooper, J. S. Huang, J. Altman, and T. F. Deuel (1985), Proc. Natl. Acad. Sci. USA 82, 4132–4136.PubMedCrossRefGoogle Scholar
  15. Baylin, R. A. and B. Casero, Jr. (1992), J. Biol. Chem. 267, 15,092–15,096. Baylin, S. B. (1992), AIDS Res. Hum. Retroviruses 8, 811–820.Google Scholar
  16. Behrens, J., L. Vakaet, R. Friis, E. Winterhager, F. Van Roy, M. M. Mareel, and W. Birchmeier (1993), J. Cell Biol 120, 757–766.PubMedCrossRefGoogle Scholar
  17. Bell, S. M., N. Scott, D. Cross, P. Sagar, F. A. Lewis, G. E. Blair, G. R. Taylor, M. F. Dixon, and P. Quirke (1993), Gastroenterology 104, 57–64.PubMedGoogle Scholar
  18. Benedict, W. F., A. L. Murphree, A. Banerjee, C. A. Spina, M. C. Sparkes, and R. S. Sparkes (1983) Science 219, 973–975.PubMedCrossRefGoogle Scholar
  19. Bertrand, R., M. Sarang, J. Jenkin, D. Kerrigan, and Y. Pommier (1991), Cancer Res. 51 (23 Pt. 1), 6280–6285.PubMedGoogle Scholar
  20. Bevilacqua, G., M. E. Sobel, L. A. Liotte, and P. S. Steeg (1989), Cancer Res. 49, 5185–5190.PubMedGoogle Scholar
  21. Biggs, J., E. Hersperger, P. S. Steeg, L. A. Liotta, and A. A. Shearn (1990), Cell 63, 933–940.PubMedCrossRefGoogle Scholar
  22. Bischoff, J.R., D. Casso, and D. Beach (1992), Mol. Cell. Biol. 12(4), 1405–1411. Bissonnette, R. P., F. Echeverri, A. Mahboubi, and D. R. Green (1992), Nature 359, 552–554.Google Scholar
  23. Blackwood, E. M. and R. N. Eisenman (1991), Science 251, 1211–1217.PubMedCrossRefGoogle Scholar
  24. Bodmer, W. F., C. J. Bailey, J. Bodmer, H. J. R. Bussey, A. Ellis, P. Gorman, F. C. Lucibello, V. A. Murday, S. H. Rider, P. Scambler, D. Sheer, E. Solomon, and N. K. Spurr (1987), Nature 328, 614–616.PubMedCrossRefGoogle Scholar
  25. Bolen, J. B., A. Veillette, A. M. Schwartz, V. Deseau, and N. Rosen (1987), Oncogene. Res 1 (2), 149–168.PubMedGoogle Scholar
  26. Bosch, K. V. D., I. Becker, I. Savelyeva, S. Bruderlein, P. Schlag, and M. Schwab (1992), Genes Chromosomes Cancer 5, 91–95.PubMedCrossRefGoogle Scholar
  27. Botwell, D., P. Fu, M. Simon, and P. Senior (1992), Proc. Natl. Acad. Sci. USA 89, 6511–6515.CrossRefGoogle Scholar
  28. Bouchet, C., F. Spyratos, P. M. Martin, K. Hacene, A. Gentile, and J. Oglobine (1994), Br. J. Cancer 69, 398–405.PubMedCrossRefGoogle Scholar
  29. Bova, G S., B S. Carter, M J. Bussemakers, M. Emi, Y. Fujiwara, N. Kyprianou, S C. Jacobs, J C. Robinson, J. I.L Epstein, and P. C. Walsh (1993), Cancer Res 53 3869–3873.Google Scholar
  30. Boyes, J. A. and A. Bird (1991), Cell 64, 1123–1134.PubMedCrossRefGoogle Scholar
  31. Boynton, R. F., P. L. Blount, J. Yin, V. L. Brown, Y. Huang, Y. Tong, T. McDaniel, C. Newkirk, J. H. Resau, W. H Raskind, R. C. Haggitt, B. J. Reid, and S. J. Meltzer (1992), Proc. Natl. Acad. Sci. USA 89(8) 3385–3388.Google Scholar
  32. Bronner, C. E., S. M. Baker, P. T. Morrison, G. Warren, L. G. Smith, M. K. Lescoe, M. Kane, C. Earabino, J. Lipford, A. Lindblom, P. Tannergard, R. J. Bollag, A. R. Godwin, D. C. Ward, M. Nordenskjold, R. Fishel, R. Kolodner, and R. M. Liskay (1994), Nature 368, 258–261.PubMedCrossRefGoogle Scholar
  33. Brown, P. D., R. E. Bloxidge, N. S. A. Stuart, K. C. Gatter, and J. Carmichael (1993), J. Natl. Cancer Inst 85, 574–578.PubMedCrossRefGoogle Scholar
  34. Burks, R T., T. D. Kessis, K. R. Cho, and L. Hedrick (1994), Oncogene 9, 1163–1166. Burmer, G. C., D. S. Levine, B. G. Kulander, R. C. Haggitt, C. E. Rubin, and P. S. Rabinovitch (1990), Gastroenterology 99 (2), 416–420.Google Scholar
  35. Burns, J. S., J. P. Blaydes, P. A. Wright, L. Lemoine, J. A. Bond, E. D. Williams, and D. Wynford-Thomas (1992), Mol. Carcinog 6 (2), 129–139.PubMedCrossRefGoogle Scholar
  36. Burt, R. W., D. T. Bishop, H. T. Lynch, P. Roen, and S. J. Winawer (1990), Bull. World. Health. Organ 68 (5), 655–665.PubMedGoogle Scholar
  37. Busiek, D. F., F. P. Ross, S. McDonnell, G. Murphy, L. M. Matrisian, and H. G. Welgus (1992), J. Biol. Chem 267, 9087–9092.PubMedGoogle Scholar
  38. Campo, E., O. D. L. Calle-Martin, R. Miguel, A. Palacin, M. Romero, V. Fabregat, J. Vives, A. Cardesa, and J. Yague (1991), Cancer Res. 51, 4436–4442.PubMedGoogle Scholar
  39. Cantley, L. C., K. R. Auger, C. Carpenter, B. Duckworth, A. Granziani, R. Kapeller, and S. Soltoff (1991), Cell 64, 281–302.PubMedCrossRefGoogle Scholar
  40. Cartwright, C. A., A. I. Meisler, and W. Eckhart (1990), Proc. Natl. Acad. Sci. USA 87 (2), 558–562.PubMedCrossRefGoogle Scholar
  41. Cartwright, C. A., C. A. Coad, and B. M. Egbert (1994), J. Clin. Invest 93, 509–515.PubMedCrossRefGoogle Scholar
  42. Celano, P., C. M. Berchtold, D. L. Kizer, A. Weeraratna, B. D. Nelkin, S. B. Baylin, and R. A. Casero, Jr. (1992), J. Biol. Chem 267 15,092–15,096.Google Scholar
  43. Celano, P., C. M. Berchtold, M. Mabry, M. Carroll, D. Sidransky, R. A. Casero, Jr., and R. Lupu (1993), Cell Growth Differ. 4, 341–347.PubMedGoogle Scholar
  44. Chen, L. C., A. Neubauer, W. Kurisu, F. M. Waldman, B. M. Ljung, W. W. Goodson, E. S. Goldman, D. Moore, M. Balazs, E. Liu, B. H. Mayall, and H. S. Smith (1991), Proc. Natl. Acad. Sci. USA 88 (9), 3847–3851.PubMedCrossRefGoogle Scholar
  45. Chen, P. L., Y. Chen, R. Bookstein, and W. H. Lee (1990), Science 250, 1576–1580.PubMedCrossRefGoogle Scholar
  46. Chenevix-Trench, G. J. Leary, J. Kerr, J. Michel, R. Kefford, T. Hurst, P. G. Parsons, M. Friedlander, and S. K. Khoo (1992), Oncogene 7, 1059–1065.PubMedGoogle Scholar
  47. Chin, K. V., K. Ueda, I. Pastan, and M. M. Gottesman (1992), Science 255, 459–462.PubMedCrossRefGoogle Scholar
  48. Chuang, L. Y., W. C. Hung, C. C. Chang, and J H. Tsai (1994), Anticancer Res. 14, 147–152.PubMedGoogle Scholar
  49. Clark, E. A. and J. S. Brugge (1993), Mol Cell. Biol 13, 1863–1871.PubMedGoogle Scholar
  50. Cohn, K. H., F. Wang, F. DeSoto-LaPain, W. B. Solomon, L. G. Patterson, M. R. Arnold, J. Weimar, J G. Feldman, A. T. Levy, A. Leone, and P. S. Steeg (1991), Lancet 338 722–724.Google Scholar
  51. Coulier, F., R. Kumar, M. Ernst, R. Klein, D. Martin-Zanca, and M. Barbacid (1990), Mol. Cell. Biol 10 (8), 4202–4210.PubMedGoogle Scholar
  52. Crawford, L. V., D. C. Pim, E. G. Gurney, P. Goodfellow, and J. Taylor-Papadimitriou (1981), Proc. Natl. Acad. Sci. USA 78, 41–45.PubMedCrossRefGoogle Scholar
  53. Crowley, C. W., R. L. Cohen, B. K. Lucas, G. Liu, M. A. Shuman, and A. D. Levinson (1993), Proc. Natl. Acad. Sci. USA 90, 5021–5025.PubMedCrossRefGoogle Scholar
  54. Czerniak, B., F. Herz, L. G. Koss, and J. Schlom (1987), Cancer 60, 2432–2436. D’Amico, D, D. P. Carbone, B. E. Johnson, S. J. Meltzer, and J. D. Minna (1992), Cancer Res 52 (7), 1996–1999.Google Scholar
  55. D’Emilia, J. C., B. Mathey-Prevot, K. Jaros, B. Wolf, G. Steele, Jr., and I. C. Summerhayes (1991), Oncogene 6 (2), 303–309.PubMedGoogle Scholar
  56. D’Emilia, J., K. Bulovas, K. D’Erole, B. Wolf, G. Steele, and I C. Summerhayes (1989), Oncogene 4 1233–1239.Google Scholar
  57. D’Errico, A., S. Garbisa, L A. Liotta, V. Castronovo, W. G. Stetler-Stevenson, and W. F. Grigioni (1991), Mod. Pathol 4, 239–246.PubMedGoogle Scholar
  58. Daar, I., A. R. Nebreda, N. Yew, P. Sass, R. Paules, E. Santos, M. Wigler, and G. F. Vande-Woude (1991), Science 253, 74–76.PubMedCrossRefGoogle Scholar
  59. Daidone, M. G., R. Silvestrini, A. D’Errico, G. Di Fronzo, E. Benini, A. M. Mancini, S. Garbisa, L. A. Liotta, and W. F. Grigioni (1991), Int. l. Cancer 48, 529–532.CrossRefGoogle Scholar
  60. Dejana, E., I. Martin-Padura, D. Lauri, S. Bernasconi, M. R. Bani, A. Garofalo, R. Giavazzi, J. Magnani, A. Mantovani, and S. Menard (1992), Lab. Invest 66, 324–330.PubMedGoogle Scholar
  61. Delattre, P., S. Olschwang, D. J. Law, T. Melot, Y. Remvikos, R. J. Salmon, X. Sastre, P. Validire, A. P. Feinberg, and G. Thomas (1989), Lancet 2, 353–356.PubMedCrossRefGoogle Scholar
  62. DeSeau, V., N. Rosen, and J. B. Bolen (1987), J. Cell. Biochem 35 (2), 113–128.PubMedCrossRefGoogle Scholar
  63. Devilee, P., M. van-Vliet, N. Kuipers-Dijkshoorn, P. L. Pearson, and C. J. Cornelisse (1991), Oncogene 6 (2), 311–315.PubMedGoogle Scholar
  64. Dickson, B., F. Sprenger, D. Morrison, and E. Hafen (1992), Nature 360, 600–603.PubMedCrossRefGoogle Scholar
  65. Dietrich, W. F., E. S. Lander, J. S. Smith, A. R. Moser, K. A. Gould, C. Luongo, N. Borenstein, and W. Dove (1993), Cell 75, 631–639.PubMedCrossRefGoogle Scholar
  66. Diller, L., J. Kassel, C. E. Nelson, M. A. Gryka, G. Litwak, M. Gebhardt, B. Bressac, M. Ozturk, S. J. Baker, B. Vogelstein, and S. H. Friend (1990), Mol. Cell. Biol 10, 5772–5781.PubMedGoogle Scholar
  67. Douglass, E. C., M. Valentine, A. A. Green, F. A. Hayes, and E. I. Thomson (1986), J. Natl. Cancer Inst 77, 1211–1215.PubMedGoogle Scholar
  68. Dracopoli, N.C., P. Harnett, S. J. Bale, B. Z. Stanger, M. A. Tucker, D. E. Housman, and R. F. Kefford (1989), Proc. Natl. Acad. Sci. USA 86, 4614–4618.PubMedCrossRefGoogle Scholar
  69. Edelhoff, S., D. E. Ayer, A. S. Zervos, E. Steingrimsson, N. A. Jenkins, N. G. Copeland, R. N. Eisenman, R. Brent, and C. M. Disteche (1994), Oncogene 9, 665–668.PubMedGoogle Scholar
  70. Edelman, G. M. (1988), Biochemistry 27, 3533–3543.PubMedCrossRefGoogle Scholar
  71. El-Deiry, W. S., T. Tokino, V. E. Velculescu, D. B. Levy, R. Parsons, J. M. Trent, D. Lin, W. E. Mercer, K. W. Kinzler, and B. Vogelstein (1993), Cell 75, 817–825.PubMedCrossRefGoogle Scholar
  72. Eliyahu, D., A. Raz, P. Gruss, D. Givol, and M. Oren (1984), Nature (Lund.) 312, 646–49.CrossRefGoogle Scholar
  73. Eliyahu, D., D. Michalovitz, and M. Oren (1985), Nature (Lund.) 316, 158–160.CrossRefGoogle Scholar
  74. Eliyahu, D., N. Goldfinger, O. Pinhasi-Kimhi, G. Shaulsky, Y. Skumik, N. Arai, V. Rotter, and M. Oren (1988), Oncogene 3, 313–321.PubMedGoogle Scholar
  75. Erisman, M. D., J. K. Scott, and S. M. Astrin (1989), Proc. Natl. Acad. Sci. USA 86 (11), 4264–4268.PubMedCrossRefGoogle Scholar
  76. Erisman, M.D., S. Litwin, R. D. Keidan, R. L. Comis, and S. M. Astrin (1988), Cancer Res. 48 (5), 1350–1355.PubMedGoogle Scholar
  77. Evan, G. I A. H. Wyllie, C. S. Gilbert, T. D. Littlewood, H. Land, M. Brooks, C. M. Waters, L. Z. Penn, and D. C. Hancock (1992), Cell 63 119–125.Google Scholar
  78. Fanidi, A., E. A. Harrington, and G. I. Evan (1992), Nature 35, 554–556.CrossRefGoogle Scholar
  79. Fearon, E. R. and B. Vogelstein (1990), Cell 61, 759–767.PubMedCrossRefGoogle Scholar
  80. Fearon, E. R., K. R. Cho, J. M. Nigro, S. E. Kern, J. W. Simons, J. M. Ruppert, S. R. Hamilton, A. C. Preisinger, G. Thomas, K. W. Kinler, and B. Vogelstein (1990), Science 247, 49–56.PubMedCrossRefGoogle Scholar
  81. Feinberg, A. P C. W. Gehrke, K. C. Kuo, and M. Ehrlich (1988), Cancer Res 48 1159–1161.Google Scholar
  82. Fernandez, P. L., M. J. Melino, F. F. Nogales, A. S. Charonis, W. Stetler-Stevenson, and L. Liotta (1992), Lab. Invest 66, 572–579.PubMedGoogle Scholar
  83. Filhol, O., J. Baudier, C. Delphin, P. Loue-Mackenbach, E. M. Chambaz, and C. Cochet (1992), J. Biol. Chem 267(29) 20,577–20,583.Google Scholar
  84. Finlay, C. A., P. W. Hinds, and A. J. Levine (1989), Cell 57, 1083–1093.PubMedCrossRefGoogle Scholar
  85. Finlay, C. A., P. W. Hinds, T.-H. Tan, D. Eliyahu, M. Oren, and A. J. Levine (1988), Mol. Cell. Biol 8, 531–539.PubMedGoogle Scholar
  86. Finley, G. G., N. T. Schulz, S. A. Hill, J. R. Geiser, J. M. Pipas, and A. I. Meisler (1989), Oncogene 4 (8), 963–971.PubMedGoogle Scholar
  87. Fisher, F., D. H. Crouch, P. S. Jayaraman, W. Clark, D. A. Gillespie, and C. R. Goding (1993), EMBO J. 12, 5075–5082.PubMedGoogle Scholar
  88. Flejter, W. L., F. P. Li, K. H. Antman, and J. R. Testa (1989), Genes Chromosomes Cancer 1, 148–154.PubMedCrossRefGoogle Scholar
  89. Florenes, V. A., S. Aamdal, O. Myklebost, G. M. Maelandsmo, 0. S. Bruland, and 0. Fodstad (1992), Cancer Res. 52, 6088–6091.PubMedGoogle Scholar
  90. Foekens, J. A., M. Schmitt, W. L. van Putten, H. A. Peters, M. Bontenbal, F. Janicke, and J. G. Klijn (1992), Cancer Res. 52, 6101–6105.PubMedGoogle Scholar
  91. Forrester, K., C. Almoguera, K. Han, W. E. Grizzle, and M. Perucho (1987), Nature 327, 298–303.PubMedCrossRefGoogle Scholar
  92. Foss, F. M., A. Veillette, O. Sarto, N. Rosen, and J. B. Bolen (1989), Oncogene. Res 5 (1), 13–23.PubMedGoogle Scholar
  93. Francis, B., J. Overmeyer, W. John, E. Marshall, and B. Haley (1989), Carcinog. 2 (3), 168–178.CrossRefGoogle Scholar
  94. Fujiwara, Y., M. Emi, H. Ohata, Y. Kato, T. Nakajima, T. Mori, and Y. Nakamura (1993), Cancer Res. 53, 1172–1174.PubMedGoogle Scholar
  95. Furth, M. E., L. J. Davis, B. Fleurdelys, and E. M Scolnick (1982), 43, 294–304.Google Scholar
  96. Gaire, M. Z. Magbanua, S. McDonnell, L. McNeil, D H. Lovett, and L. M. Matrisian (1994), J. Biol. Chem 269, 2032–2040.PubMedGoogle Scholar
  97. Gannon, J. V. and D. P. Lane (1991), Nature 349, 802–806.PubMedCrossRefGoogle Scholar
  98. Garbisa, S., G. Scagliotti, L. Masiero, C. Di Francesco, C. Caenazzo, M. Onisto, M. Micela, W. G. Stetler-Stevenson, and L A. Liotta (1992), Cancer Res. 52, 4548–4549.PubMedGoogle Scholar
  99. Garcia, R., N. U. Parikh, H. Saya, and G. E. Gallick (1991), Oncogene 6(11), 1983–1989.Google Scholar
  100. Garrett, C. T. (1986), Clin. Chim. Acta 156, 1–40.PubMedCrossRefGoogle Scholar
  101. Gastl, G. A., J. S. Abrams, D. M. Nanus, R. Oosterkamp, J. Silver, F. Liu, M. Chen, A. P. Albino, and N. H. Bander (1993), Int. J. Cancer 55, 96–101.PubMedCrossRefGoogle Scholar
  102. Genuardi, M., H. Tsihira, D. E. Anderson, and G. F. Saunders (1989), Am. J. Hum. Genet 45, 73–82.Google Scholar
  103. Gerwin, B. I E. Spillare, K. Forrestier, T. A. Lehman, J. Kispert, J. A. Welsh, A. M. A. Pfeifer, J. F. Lechner, S. J. Baker, B. Vogelstein, and C. C. Harris (1992), Proc. Natl. Acad. Sci. USA 89 2759–2763.Google Scholar
  104. Gilles, A. M., E. Presecan, A. Vonica, and I. Lascu (1991), J. Biol. Chem. 266, 8784–8789. Giovannucci, E., G. A. Colditz, and M. J. Stampfer (1993), Gastroenterology 105, 130–141.Google Scholar
  105. Goelz, S. E., B. Vogelstein, S. R. Hamilton, and A. P Feinberg (1985), Science 228,187–190. Golden, A., M. Benedict, A. Shearn, N. Kimura, A. Leone, L. A. Liotta, and P. S. Steeg (1992), Cancer Treat. Res 63, 345–358.Google Scholar
  106. Goustin A. S., E. B. Leof, G. D. Shipley, and H. L. Moses (1986), Cancer Res. 46,1015–1029. Goyette, M. C., K. Cho, C. L. Fasching, D. B. Levy, K. W. Kinzler, C. Paraskeva, B. Vogelstein, E. J. Stanbridge E J. (1992), Mol. Cell Biol 12, 1387–1395.Google Scholar
  107. Graffner, H., G. Singh, I. Chaudry, and J. W. Milsom (1992), Dig. Dis. Sci 37, 485–9.PubMedCrossRefGoogle Scholar
  108. Greenwald, B. D., N. Harpaz, J. Yin, Y. Huang, Y. Tong, V. L. Brown, T. McDaniel, C. Newkirk, J. H. Resau, and S. J. Meltzer (1992), Cancer Res. 52, 741–745.PubMedGoogle Scholar
  109. Gregoire, M., L. Garrigue, H. M. Blottiere, M. G. Denis, and K. Meflah (1992), Invasion Metastasis 12, 185–96.PubMedGoogle Scholar
  110. Groden, J A. Thliveris, W. Samowitz, M. Carlson, L. Gelbert, H. Albertsen, G. Joslyn, J. Stevens, L. Spirio, M. Robertson, L. Sargeant, K. Krapcho, E. Wolff, R. Burt, J. P. Hughes, J. Warrington, J. McPherson, J Wasmuth, D. L. Paslier, H. Abderrahim, D. Cohen, M. Leppert, and R. White (1991), Cell 66 589–600.Google Scholar
  111. Grondahl-Hansen, J., E. Ralfkiaer, L. T. Kirkeby, P. Kristensen, L. R. Lund, and K. Dano (1991), Am. J. Pathol 138, 111–117.PubMedGoogle Scholar
  112. Gu, W., K. Bhatia, I. T. Magrath, C. V. Dang, R. and Dalla-Favera R. (1994), Science 264, 251–254.PubMedCrossRefGoogle Scholar
  113. Gu, W., K. Cechova, V. Tassi, and R. Dalla-Favera (1993), Proc. Natl. Acad. Sci. USA 90, 2935–2939.PubMedCrossRefGoogle Scholar
  114. Guan, J. L. and D. Shalloway (1992) Nature 358, 690–692.PubMedCrossRefGoogle Scholar
  115. Guillem, J. G., M. F. Levy, L. L. Hsieh, M. D. Johnson, P. LoGerfo, K. A. Forde, and I. B. Weinstein (1990), Mol. Carcinog 3, 68–74.PubMedCrossRefGoogle Scholar
  116. Hafez, M. M., D. Infante, S. Winawer, and E. Friedman (1990), Cell Growth Diff 1, 617–626.PubMedGoogle Scholar
  117. Hague, A., A. M. Manning, J. W. van der Stappen, and C. Paraskeva (1993), Cancer Metastasis Rev. 12, 227–237.PubMedCrossRefGoogle Scholar
  118. Hakala, T., J. P. Mecklin, M. Forss, H. Jarvinen, and P. Lehtovirta (1991), Cancer 68, 1656–1659.PubMedCrossRefGoogle Scholar
  119. Halevy, O., D. Michalovitz, and M. Oren (1990), Science 250, 113–116.PubMedCrossRefGoogle Scholar
  120. Haliotis, T., W. Trimble, S. Chow, S. Bull, G. Mills, P. Girard, J. F. Kuo, and N. Hozumi (1990), Int. J. Cancer 45, 1177–1183.PubMedCrossRefGoogle Scholar
  121. Hamilton, S. R. (1992), Cancer 70, 1216–1221.PubMedCrossRefGoogle Scholar
  122. Han, H.-J., A. Yanagisawa, Y. Kato, J.-G. Park, and Y. Nakamura (1993), Cancer Res. 53, 5100–5103.Google Scholar
  123. Han, K. A. and M. F. Kulesz-Martin (1992), Cancer Res. 52, 749–753.PubMedGoogle Scholar
  124. Hand, P. H., V. Vilasi, A. Thor, N. Ohuchi, and J. Schlom (1987), J. Natl. Cancer Inst 79, 59–65.PubMedGoogle Scholar
  125. Haut, M., P. S. Steeg, J. K. V. Willson, and S. D. Markowitz (1991), J. Natl. Cancer Inst 83, 712–716.PubMedCrossRefGoogle Scholar
  126. Hennessy, C., J. A. Henry, F. E. B. May, B. R. Westley, B. Angus, and T. W. J Lennard (1991), J. Natl. Cancer Inst 83 281–285.Google Scholar
  127. Hinds, P. W., C. A. Finlay, R. S. Quartin, S. J. Baker, E. R. Fearon, B. Vogelstein, and A. J Levine (1990), Cell Growth Diff. 1,571–580.Google Scholar
  128. Hoffman, S. and G. M. Edelman (1983), Proc. Natl. Acad. Sci. USA 80, 5762–5766.PubMedCrossRefGoogle Scholar
  129. Hohne, M. W., M. E. Halatsch, G. F. Kahl, and R. J. Weinel (1992), Cancer Res. 52 (9), 2616–2619.PubMedGoogle Scholar
  130. Hollstein, M., D. Sidransky, B. Vogelstein, and C. C. Harris (1991), Science 253, 49–53.PubMedCrossRefGoogle Scholar
  131. Holzmann, K., C. Welter, V. Klein, G. Pistorius, G. Seitz, and N. Blin (1992), Anticancer Res. 12, 1013–1018.PubMedGoogle Scholar
  132. Hori, A., S. Nakatsuru, S. Ichii, H Nagase, and Y. Nakamura (1993), Hum. Mol. Genet 2 283–287.Google Scholar
  133. Hori, A., S. Nakatsuru, Y. Miyoshi, S. Ichii, H. Nagase, H. Ando, A. Yanagisawa, E.Google Scholar
  134. Tsuchiya, Y. Kato, and Y. Nakamura (1992), Cancer Res. 52, 6698–8. Hotz-Wagenblatt, A. and D. Shalloway (1993), Crit. Rev. Oncog 4, 541–558.Google Scholar
  135. Houlston, R S., A. Collins, J. Slack, and N. E. Morton (1992), Ann. Hum. Genet 56 (Pt 2), 99–103.PubMedCrossRefGoogle Scholar
  136. Hoyhtya, M., R. Fridman, D. Komarek, K. Porter-Jordan, W. G. Stetler-Stevenson, L. A. Liotta, and C. M. Liang (1994), Int. J. Cancer 56, 500–505.PubMedCrossRefGoogle Scholar
  137. Ichii, S., A. Horii, S. Nakatsuru, J. Furuyama, J. Utsunomiya, and Y. Nakamura (1992), Hum. Mol. Gent 1, 387–390.CrossRefGoogle Scholar
  138. Iguchi-Ariga, S. M. M., T. Okazaki, T. Itano, M. Ogata, Y. Sato, and H. Ariga (1988), EMBO J. 7, 3135–3142.PubMedGoogle Scholar
  139. Imamura, T., T. Arima, H. Kato, S. Miyamoto, T. Sasazuki, and N. Wake (1992), Int. J. Cancer 51 (1), 47–52.PubMedCrossRefGoogle Scholar
  140. Ingvarsson, S., C. Asker, H. Axelson, G. Klein, and J. Sumegi (1988), Mol. Cell. Biol 8, 3168–3174.PubMedGoogle Scholar
  141. Ionov, Y., M. A. Peinado, S. Malkhosyan, D. Shibata, and M. Perucho (1993), Nature 363, 558–561.PubMedCrossRefGoogle Scholar
  142. Iozzo, R V. and Cohen I. (1994), EXS 7, 199–214.Google Scholar
  143. Issa, J. P., P. M. Vertino, J. Wu, S. Sazawal, P. Celano, B. D. Nelkin, S. R. Hamilton, and S. B. Baylin (1993), J. Natl. Cancer Inst 85, 1235–1240.PubMedCrossRefGoogle Scholar
  144. Ito, K., K. Watanabe, S. Nasim, H. Sasano, S. Sato, A. Yajima, S. G. Silverberg, and C. T. Garrett (1994), manuscript in preparation.Google Scholar
  145. Izquierdo, M., J. Downward, J D. Graves, and D. A. Cantrell (1992), Mol. Cell. Biol 12 3305–3312.Google Scholar
  146. Jacoby, R. F., R. J. Alexander, R. F. Raicht, and T. A. Brasitus (1992), Carcinogenesis 13, 45–49.PubMedCrossRefGoogle Scholar
  147. Janicke, F., L. Pache, M. Schmitt, K. Ulm, C. Thomssen, A. Prechtl, and H. Graeff (1994), Cancer Res. 54, 2527–2530.PubMedGoogle Scholar
  148. Jansson, D. A., J. A. Radosevich, W. P. Carney, S. T. Rosen, J. Schlom, and E. D. Staren (1990), Cancer 65, 1329–1337.PubMedCrossRefGoogle Scholar
  149. Jass, J. R. and S M. Stewart (1992), Gut 33, 783–786.PubMedCrossRefGoogle Scholar
  150. Jass, J. R., W. S. Atkin, J. Cuzick, H. J R. Bussey, B C. Morson, J. M. A. Northover, and I. P. Todd (1986), Histopathology 10 437–459.Google Scholar
  151. Jenkins, J. R., K. Rudge, and C. A. Currie (1984), Nature (Lond.) 312, 651–654.CrossRefGoogle Scholar
  152. Jenkins, J. R., K. Rudge, P. Chumakow, and G. A. Currie (1985), Nature (Lond.) 317, 816–818.CrossRefGoogle Scholar
  153. Joslyn, G., M. Carlson, A. Thliveis, H. Albertsen, L. Gelbert, W. Samowitz, J. Groden, J. Stevens, L. Spirio, M. Robertson, K. Krapcho, L. Sargeant, E. Wolff, R. Burt, J. P. Hughes, J. Warrington, J. McPherson, J. Wasmuth, D. Le Paslier, H. Abderrahim, D. Cohen, M. Leppert, and R. White (1991), Cell 66, 589–600.PubMedCrossRefGoogle Scholar
  154. Kastan, M. B., A. I. Radin, S. J. Kuerbitz, O. Onyekwere, C. A. Wolkow, C. I. Civin, K. D. Stone, T. Woo, Y. Ravindranath, and R. W. Craig (1991a), Cancer Res. 51, 4279–4286.PubMedGoogle Scholar
  155. Kastan, M. B., O. Onyekwere, D. Sidransky, B. Vogelstein, and R. W. Craig (1991b), Cancer Res. 51, 6304–6311.PubMedGoogle Scholar
  156. Katsuyama, J., P. R. Papenhausen, F. Herz, P. Gazivoda, A. Hirano, and L. G. Koss (1986), Cancer Genet. Cytogent 22, 63–68.CrossRefGoogle Scholar
  157. Kee, F. and B. J.Collins (1991), Gut 32, 509–512.PubMedCrossRefGoogle Scholar
  158. Kellie, S., A. R. Horvath, G. Felice, R. Anand, C. Murphy, and J. Westwick (1993), Symp. Soc. Exp. Biol 47, 267–282.PubMedGoogle Scholar
  159. Kern, S. E., E. R. Fearon, K. W. F. Tersmette, J. P. Enterline, M. Leppert, Y. Nakamura,R. White, B. Vogelstein, and S. R. Hamilton (1989), JAMA 261, 3099–3103.PubMedCrossRefGoogle Scholar
  160. Kern, S., J. A. Pietenpol, S. Thiagalingam, A. Seymour, K. W. Kinzler, and B. VogelsteinGoogle Scholar
  161. (1992).
    Science 256 827–830.Google Scholar
  162. Kerr, I. B., F. D. Lee, M. Quintanilla, and A. Balmain (1985), Br. J. Cancer 52, 695–700. Khokha, R. and D. T. Denhardt (1989), Invasion Metastasis 9, 391–405.Google Scholar
  163. Kikuchi-Yanoshita, R., M. Konishi, H. Fukunari, K. Tanaka, and M. Miyaki (1992), Cancer Res. 52 (13), 3801–3803.PubMedGoogle Scholar
  164. Kinzler, K. W., M. C. Nilbert, B. Vogelstein, T. M. Bryan, D. B. Levy, K. J. Smith, A. C. Preisinger, S. R. Hamilton, P. Hedge, A. Markham, M. Carlson, G. Joslyn, J. Groden, R. White, Y. Miki, Y. Miyoshi, I. Nishisho, and Y. Nakamura (1991a), Science 251, 1366–1370.PubMedCrossRefGoogle Scholar
  165. Kinzler, K. W., M. C. Nilbert, L.-K. Su, B. Vogelstein, T. M. Bryan, D. B. Levy, K. J. Smith, A. C. Preisinger, P. Hedge, D. McKechnie, R. Finniear, A. Markham, J. Groffen, M. S. Boguski, S. F. Altschul, A. Horii, H. Ando, Y. Miyoshi, Y. Miki, I. Nishisho, and Y. Nakamura (199 lb), Science 253 661–665.Google Scholar
  166. Knudson, A. G. (1985), Cancer Res. 45, 1437–1443.PubMedGoogle Scholar
  167. Knyazev, P. G., E. N. Imyanitov, O. I. Chernitca, I. F. Nikiforova, and K. P. Hanson (1992), Oncology 49, 162–165.PubMedCrossRefGoogle Scholar
  168. Kolch, W., G. Heidecker, P. Lloyd, and U. R. Rapp (1991), Nature 349, 426–428. Krone, W. and I. Hoegemann (1986), Hum. Genet 74, 453–455.Google Scholar
  169. Krook, A., M. J. Rapoport, S. Anderson, H. Pross, Y. C. Zhou, D. T. Denhardt, T. L. Delovitch, and T. Haliotis (1993), Mol. Cell. Biol 13, 1471–1479.PubMedGoogle Scholar
  170. Kuerbitz, S. J., B. S. Plunkett, V. W. Walsh, and M. B. Kastan (1992), Proc. Natl. Acad. Sci. USA 89, 7491–7495.PubMedCrossRefGoogle Scholar
  171. Lacal, J. C., T. P. Fleming, B. S. Warren, P. M. Blumberg, and S. A. Aaronson (1987), Mol. Cell. Biol 7, 4146–4149.PubMedGoogle Scholar
  172. Land, H., L. F. Parada, R. A. Weinberg (1983), Science 222, 771–778.PubMedCrossRefGoogle Scholar
  173. Lane, D. P. (1992), Nature (Lond.) 358, 15–16.CrossRefGoogle Scholar
  174. Lane, D. P. and S. Benchimol (1990), Genes Dev. 4, 1–8.PubMedCrossRefGoogle Scholar
  175. Lange-Carter, C. A., C. M. Pleiman, A. M. Gardner, K. J. Blumer, and G. L. Johnson (1993), Science 260, 315–319.PubMedCrossRefGoogle Scholar
  176. Langer, S. J., D. M. Bortner, M. F. Roussel, C. J. Sherr, and M. C. Ostrowski (1992), Mol Cell. Biol 5355–5362.Google Scholar
  177. Larsson, L G., M. Pettersson, F. Oberg, K. Nilsson, and B. Luscher (1994), Oncogene 9, 1247–1252.PubMedGoogle Scholar
  178. Lawlor, K. G., and R. Narayanan (1992), Cell Growth Diff. 3 (9), 609–616PubMedGoogle Scholar
  179. Leach, F. S., N. C. Nicolaides, N. Papadopoulos, B. Liu, J. Jen, R. Sistonen, L. A. Aaltonen, M. Nystrom-Lahti, X.-Y. Guan, J. Zhang, P. S. Meltzer, J.-W. Yu, F.-T. Kao, D. J. Chen, K M. Cerosaletti, R. E. K. Fournier, S. Todd, T. Lewis, R. J. Leach, S. L. Naylor, J. Weissenbach, J.-P. Mecklin, H. Jarvinen, G. M. Petersen, S. R. Hamilton, J. Green, J. Jass, P. Watson, H. T. Lynch, J. M. Trent, A. de la Chapelle, K. W. Kinzler, and B. Vogelstein (1993), Cell 75, 1215–1225.Google Scholar
  180. Leevers, S. J., F. F. Paterson, and C. J. Marshall (1994), Nature 369, 411–414.PubMedCrossRefGoogle Scholar
  181. Leister, I., A. Weith, S. Bruderlein, C. Cziepluch, D. Kangwanpong, P. Schlag, and M. Schwab (1990), Cancer Res. 50, 7232–7235.PubMedGoogle Scholar
  182. Leone, A., O. W. McBride, A. Weston, M. G. Wang, P. Anglard, C. S. Cropp, J. R. Goepel, R. Lidereau, R. Callahan, M. Linehan, R. C. Rees, C. C. Harris, L. A. Liotta, and P. S. Steeg (1991), Cancer Res. 51, 2490–2493.PubMedGoogle Scholar
  183. Leone, A., R. C. Seeger, C. M. Hong, Y. Y. Hu, M. J. Arboleda, G. M. Brodeuo, D. Stram, D. J. Slamon, and P. S. Steeg (1993), Oncogene 8, 855–865.PubMedGoogle Scholar
  184. Leonhardt, H., A. W. Page, H. Weier, and T. H. Bestor (1992), Cell 71, 865–873.PubMedCrossRefGoogle Scholar
  185. Leppert, M., M. Dobbs, P. Scambler, P. O’Connell, Y. Nakamura, D. Stauffer, S. Woodward, R. Burt, J. Hughes, E. Gardner, M. Lathrop, J. Wasmuth, J.-M. Lalouel, R. White (1987), Science 238, 1411–1413.PubMedCrossRefGoogle Scholar
  186. Levine, A. J., J. Momand, and C. A. Finlay (1991b), Nature (Lond.) 351, 453–456. Levine, A., G. L. Cantoni, and A. Razin (1991a), Proc. Natl. Acad. Sci. USA 88, 6515–6518.Google Scholar
  187. Levy, A T., V. Cioce, M. E. Sobel, S. Garbisa, W. F. Grigioni, L. A. Liotta, and W. G. Stetler-Stevenson (1991), Cancer Res. 51, 439–444.PubMedGoogle Scholar
  188. Liotta, L. A. (1986), Cancer Res. 46, 1–7.PubMedCrossRefGoogle Scholar
  189. Liotta, L. A., P. S. Steeg, and W. G. Stetler-Stevenson (1991), Cell 64, 327–336.PubMedCrossRefGoogle Scholar
  190. List, H. J., V. Patzel, U. Zeidler, A. Schopen, G. Ruhl, J. Stollwerk, and G. Klock (1994), J. Biol. Chem 269 11,902–11,911.Google Scholar
  191. Lloyd, A. C., H. F. Paterson, J. D. H. Morris, A. Hall, and C. J. Marshall (1989), EMBO J. 8, 1099–1104.PubMedGoogle Scholar
  192. Luscher, B. and R. N. Eisenman (1990), Genes Del,4 2025–2035.Google Scholar
  193. Lynch, H T., S. Lanspa, T. Smyrk, B. Boman, P. Watson, and J. Lynch (1991), Cancer Genet. Cytogenet 53, 143–160.PubMedCrossRefGoogle Scholar
  194. Lynch, H. T., P. Watson, T. C. Smyrk, S. J. Lanspa, B. M. Boman, C. R. Boland, J. F. Lynch, R. J. Cavalieri, M. Leppert, R. White, D. Sidransky, and B. Vogelstein (1992), Cancer 70, 1306–1312.Google Scholar
  195. Mackay, J., C M. Steel, P A. Elder, A P. Forrest, and H J. Evans (1988), Lancet 2, 1384–1385.PubMedCrossRefGoogle Scholar
  196. Macpherson, A. J., K. A. Chester, L. Robson, I. Bjarnason, A. D. Malcolm, and T. J. Peters (1992), Gut 33, 651–656.PubMedCrossRefGoogle Scholar
  197. Makos, M.B. D. Nelkin, M. I. Lerman, F. Latif, B. Zbar, and S. B. Baylin (1992), Proc. Natl. Acad. Sci. USA 89, 1929–1933.PubMedCrossRefGoogle Scholar
  198. Malkin, D., F. P. Li, L. C. Strong, J. F. Fraumeni, Jr., C. E. Nelson, D. H. Kim, J. Kassel, M. A. Gryka, F. Z. Bischoff, M. A. Tainsky, and S. H. Friend (1990), Science 250, 1233–1238.PubMedCrossRefGoogle Scholar
  199. Malkin, D., K. W. Jolly, N. Barbier, A. T. Look, S. H. Friend, M. C. Gebhardt, T. I. Andersen, A. L. Borrensen, F. P. Li, J. Garber, and L. C. Strong (1992), N. Engl. J. Med 326, 1350–1352.CrossRefGoogle Scholar
  200. Maness, P. F. (1992), Dell. Neurosci 14, 257–270.CrossRefGoogle Scholar
  201. Manning, A. M., A. C. Williams, S. M. Game, and C. Paraskeva (1991), Oncogene 6, 1471–1476.PubMedGoogle Scholar
  202. Martegani, E., M. Vanoni, R. Zippel, P. Coccetti, R. Brambilla, C. Ferrari, E. Sturani, and L. Alberghina (1992), EMBO J. 6, 2151–2157.Google Scholar
  203. Martinez, J., I. Georgoff, J. Martinez, and A. J. Levine (1991), Genes 5, 151–159. Matrisian, L. M. (1992), BioEssays 14, 455–463Google Scholar
  204. Matrisian, L. M., G. L. Ganser, L. D. Kerr, R. W. Pelton, and L. D. Wood (1992), Mol. Reprod. Del 32, 111–120.Google Scholar
  205. Matsushita, Y., K. R. Cleary, D. M. Ota, S. D. Hoff, and T. Irimura (1990), Lab. Invest 63, 780–791.PubMedGoogle Scholar
  206. McCann, A., P. A. Dervan, P. A. Johnston, W. J. Gullick, and D. N. Carney (1990), Cancer 65, 88–92.PubMedCrossRefGoogle Scholar
  207. McDonnell, S., M. Navre, R. J. Coffey, Jr., and L. M. Matrisian (1991), Mol. Carcinog 4, 527–533.PubMedCrossRefGoogle Scholar
  208. McGlade, J., A. Cheng, G. Pelicci, P. G. Pelicci, and T. Pawson (1992), Proc. Natl. Acad. Sci. USA 89, 8869–8873.PubMedCrossRefGoogle Scholar
  209. Mecklin, J. P. and H. Jarvinen (1991), Cancer 68, 1109–1112PubMedCrossRefGoogle Scholar
  210. Mecklin, J. P. and H. Jarvinen (1993), Dis. Colon Rectum 36, 927–992.PubMedCrossRefGoogle Scholar
  211. Meltzer, S. J., D. J. Ahnen, H. Battifora, J. Yokota, and M. J. Cline (1987), Gastroenterology 92, 1174–1180.PubMedGoogle Scholar
  212. Mercer, W. E., M. T. Shields, M. Amin, M. G. J. Sauve, E. Apella, J. W. Romano, and S. J. Ullrich (1990), Proc. Natl. Acad. Sci. USA 87, 6166–6170.PubMedCrossRefGoogle Scholar
  213. Michalovitz, D., O. Halevy, and M. Oren (1990), Cell 62, 671–680.PubMedCrossRefGoogle Scholar
  214. Michelassi, F., F. Erroi, M. Roncella, and G. E. Block (1989), Dis. Colon Rectum 32, 665–668.PubMedCrossRefGoogle Scholar
  215. Milner, J. and E. A. Medcalf (1991), Cell 65, 765–774.PubMedCrossRefGoogle Scholar
  216. Mitra, G., D. Martin-Zanca, and M. Barbacid (1987), Proc. Natl. Acad. Sci. USA 84, 6707–6711.PubMedCrossRefGoogle Scholar
  217. Mitsudomi, T., S. M. Steinberg, H. K. Oie, J. L. Mulshine, R. Phelps, J. Viallet, H. Pass, J. D. Minna, and A. F. Gazdar (1991), Cancer Res 51 4999=5002.Google Scholar
  218. Miyaki, M., M. Seki, M. Okamoto, A. Yamanaka, Y. Maeda, K. Tanaka, R. Kikuchi, T. Iwama, T. Ikeuchi, A. Tonomura, Y. Nakamura, R. White, Y. Miki, J. Utsunomiya, and M. Koike (1990), Cancer Res. 50, 7166–7173.PubMedGoogle Scholar
  219. Miyoshi, Y., H. Ando, H. Nagase, I. Nishisho, A. Horii, Y. Miki, T. Mori, J. Utsunomiya, S. Baba, G. Petersen, S. R. Hamilton, K. W. Kinzler, B. Vogelstein, and Y. Nakamura (1992a), Proc. Natl. Acad. Sci. USA 89, 4452–4456.PubMedCrossRefGoogle Scholar
  220. Miyoshi, Y., H. Nagase, H. Ando, A. Horii, S. Ichii, S. Nakatsuru, T. Aoki, Y. Miki, T. Mori, and Y. Nakamura (1992b), Hum. Mol. Genet 1, 229–233.PubMedCrossRefGoogle Scholar
  221. Mizuuchi, H., S. Nasim, R. Kudo, S. G. Silverberg, S. Greenhouse, and C. T. Garrett (1992), Cancer Res. 52, 2777–2781PubMedGoogle Scholar
  222. Moerkerk, P., J. W. Arends, M. van Driel, A. de Bruine, A. de Goeij, and J. ten Kate (1994), Cancer Res. 54, 3325–3643.Google Scholar
  223. Moll, U. M., G. Riou, and A. J. Levine (1992), Proc. Natl. Acad. Sci. USA 89, 7262–7266.PubMedCrossRefGoogle Scholar
  224. Morimoto, H., T. Monden, Y. Miyoshi, Y. Kawasaki, H. Nakanishi, T. Shimano, and T. Mori (1991), Nippon-Geka-Gakkai-Zasshi 92, 1094–1097.PubMedGoogle Scholar
  225. Morris, J. D. H., B. Price, A. C. Lloyd, A. J. Self, C. J. Marshall, and A. Hall (1989), Oncogene 4, 27–31.PubMedGoogle Scholar
  226. Mulder, K. M. (1991), Cancer Res. 51, 2256–2262.PubMedGoogle Scholar
  227. Mulder, K. M. and M. G. Brattain (1988), Intl. J. Cancer 42, 64–70.CrossRefGoogle Scholar
  228. Mulder, K. M. and S. L. Morris (1992), J. Biol. Chem 267, 5029–5031.PubMedGoogle Scholar
  229. Muleris, M., R. J. Salmon, and B. Dutrillaun (1986), Int. J. Cancer 38, 167–172.PubMedCrossRefGoogle Scholar
  230. Muleris, M., R. J. Salmon, B. Zafrani, J. Girodet, and B. Dutrillaux (1985), Ann. Genet 28, 206–213.PubMedGoogle Scholar
  231. Muto, T., H. J. R. Bussey, and B. C. Morson (1975), Cancer 36, 2251–2270.PubMedCrossRefGoogle Scholar
  232. Myers, R. M. and T. Maniatis (1986), Cold Spring Harbor Symp. Quant. Biol 51, 275–284.PubMedCrossRefGoogle Scholar
  233. Nakai, H., S. Misawa, J. Toguchida, D. W. Yandell, and K. Ishizaki (1992), Cancer Res. 52, 6588–6593.PubMedGoogle Scholar
  234. Narayanan, R., K. G. Lawlor, R. Q. Schaapveld, K. R. Cho, B. Vogelstein, P. Buj-Vinh-Tran, M. P. Osborne, and N. T. Telang (1992) Oncogene 7, 553–561.PubMedGoogle Scholar
  235. Nasim, S., J. Ahlgren, M. Radel, S. G. Silverberg, A. Schwartz, G. Wampler, and C. T. Garrett (1993), Proc. Am. Assoc. Cancer Res 34, 3086.Google Scholar
  236. Natali, P. G., M. R. Nicotra, A. Bigotti, I. Venturo, D. J. Slamon, B. M. Fendly, and A. Ullrich (1990), Int. J. Cancer 45, 457–461.PubMedCrossRefGoogle Scholar
  237. Nekarda, H., M. Schmitt, K. Ulm, A. Wenninger, H. Vogelsang, K. Becker, J. D. Roder, U. Fink, and J. R. Siewert (1994), Cancer Res. 54, 2900–2907.PubMedGoogle Scholar
  238. Nickerson, J. A. and W. W. Wells (1984), J. Biol. Chem 259 11,297–11,304.Google Scholar
  239. Nigro, J. M., S. J. Baker, A. C. Preisinger, J. M. Jessup, R. Hostetter, K. Cleary, S. H. Bigner, N. Davidson, S. Baylin, P. Devilee, T. Glover, F. S. Collins, A. Weston, R. Modali, C. C. Harris, and B. Vogelstein (1989), Nature 342, 705–707.PubMedCrossRefGoogle Scholar
  240. Nishisho, I Y. Nakamura, Y. Miyoshi, Y. Miki, H. Ando, A. Horii, K. Koyama, J. Utsunomiy, S. Baba, P. Hedge, A. Markham, A. J. Krush, G. Petersen, S. R. Hamilton, M. C. Nilbert, D. B. Levy, T. M. Bryan, A. C. Preisinger, K. J. Smith, L.-K. Su, K. W. Kinzler, and B. Vogerstein (1991), Science 253 665–669.Google Scholar
  241. Novotny-Smith, C. L. and G. E. Gallick (1992), J. Immunother 11, 159–168.PubMedCrossRefGoogle Scholar
  242. O’Brien, M. J., J. C. O’Keane, A. Zauber, L. S. Gottlieb, and S. J. Winawer (1992), Cancer 70, 1318–1327.Google Scholar
  243. Oberhammer, F. J W. Wilson, C. Dive, I D. Morris, J. A. Hickman, A. E. Wakeling, P. R.Walker, and M. Sikorska (1993), EMBO J 12 3679–3684.Google Scholar
  244. Offerhaus, G. J. A., E. P. De eyter, C. J. Comelisse, K. W. F. Tersmette, J. Floyd, S. E. Kern, B. Vogelstein, and S. R. Hamilton (1992), Gastroenterology 102, 1612–1619.PubMedGoogle Scholar
  245. Okabe-Kado, J., T. Kasukabe, Y. Honma, M. Hayashi, W. J. Henzel, and M. Hozumi (1992), Biochem. Biophys. Res. Commun 182, 987–994.PubMedCrossRefGoogle Scholar
  246. Okamoto, M., M. Sasaki, K. Sugio, C. Sato, T. Iwama, T. Ikeuchi, A. Tonomura, T. Sasazuki, and M. Miyaki (1988), Nature 331, 273–277.PubMedCrossRefGoogle Scholar
  247. Oliner, J. D., K. W. Kinzler, P. S. Meltzer, D. L. George, and B. Vogelstein (1992), Nature 358, 80–83.PubMedCrossRefGoogle Scholar
  248. Onisto, M., S. Garbisa, C. Caenazzo, M P. Freda, C. Di Francesco, D. Nitti, L. A. Liotta, and W. G. Stetler-Stevenson (1993), Diagn. Mol. Pathol 2, 74–80.PubMedGoogle Scholar
  249. Ossowski, L., G. Clunie, M. T. Masucci, and F. Blasi (1991), J. Cell. Biol. 115, 1107–1112. Oudejans, J. J., R. J. Slebos, F. A. Zoetmulder, W. J. Mooi, and S. Rodenhuis (1991), Int. J. Cancer 49, 875–879.Google Scholar
  250. Papadopoulos, N., N. C. Nicolaides, Y.-F. Wei, S. M. Ruben, K. C. Carter, C. A. Rosen, W. A. Haseltine, R. D. Fleischmann, C. M. Fraser, M. D. Adams, J. C. Ventter, S. R. Hamilton, G. M. Petersen, P. Watson, H. T. Lynch, P. Peltomaki, J.-P. Mecklin, A. de la Chapelle, K. W. Kinzler, and B. Vogelstein (1994), Science 263, 1625–1629.PubMedCrossRefGoogle Scholar
  251. Parada, L. F., H. Land, R. A. Weinberg, D. Wolf, and V. Rotter (1984), Nature 312, 649–651. Pavelic, Z. P., L. Pavelic, R. Kuvelkar, and S. R. Gapany (1992), Anticancer Res 12 (1), 171–175.Google Scholar
  252. Pedersen, H., J. Grondahl-Hansen, D. Francis, K. Osterlind, H H. Hansen, K. Dano, and N. Brunner (1994), Cancer Res. 54, 120–123.PubMedGoogle Scholar
  253. Peifer, M. (1993), Science 262, 1667–1668.PubMedCrossRefGoogle Scholar
  254. Peltomaki, Paivi, L. A. Aaltonen, P. Sistonen, L Pylkkanen, J.-P. Mecklin, H. Jarvinen, J. S. Green, J. R. Jass, J. L. Weber, F. S. Leach, G. M. Petersen, S. R. Hamilton, A. de la Chapelle, and B. Vogelstein (1993), Science 260 810–812.Google Scholar
  255. Pena, A., C. D. Reddy, S. Wu, N. J. Hickok, E. P. Reddy, G. Yumet, D. R. Soprano, and K. J. Soprano (1993), J. Biol. Chem 268 27,277–27,285.Google Scholar
  256. Pines, J. (1994), Science 369, 520, 521.Google Scholar
  257. Polyak, K., M.-H. Lee, H. Erdjument-Bromage, A. Koff, J. M. Roberts, P. Ternpst, and J. Massague (1994), Cell 78, 59–66.PubMedCrossRefGoogle Scholar
  258. Pories, S., K. Jaros, G. Steele, Jr., A. Pauley, and I. C. Summerhayes, (1992), Oncogene 7, 885–893.PubMedGoogle Scholar
  259. Powell, S. M., G. M. Petersen, A. J. Krush, S. Booker, J. Jen, F. M. Giardiello, S. R. Hamilton, B. Vogelstein, and K. W. Kinzler (1993), NEJM 329, 1982–1987.PubMedCrossRefGoogle Scholar
  260. Powell, S. M., N. Zilz, Y. Beazer-Barclay, T. M. Bryan, S. R. Hamilton, S. N. Thibodeau, B. Vogelstein, and K. W. Kinzler (1992), Nature 359, 235–237.PubMedCrossRefGoogle Scholar
  261. Preiss, J., C. R. Loomis, W. R. Bishop, R. Stein, J. E. Neidel, and R. M. Bell (1986), J. Biol. Chem 261, 8597–8600.PubMedGoogle Scholar
  262. Prendergast, G. C. and M. D. Cole (1989), Mol. Cell. Biol 9, 124–134.PubMedGoogle Scholar
  263. Pretlow, T. P., T. A. Brasitus, N. C. Fulton, C. Cheyer, and E. L. Kaplan (1993), J. Natl. Cancer Inst 85, 2004–2007.PubMedCrossRefGoogle Scholar
  264. Pulverer, B J., C. Fisher, K. Vousden, T. Littlewood, G. Evan, and J. R. Woodgett (1994), Onco gene 9, 59–70.Google Scholar
  265. Pulverer, B. J., J. M. Kyriakis, J. Avruch, E. Nikolakaki, and J. R. Woodgett (1991), Nature 353670–674.Google Scholar
  266. Pyke, C., E. Ralfkiaer, E. Ronne, G. Hoyer-Hansen, L. Kirkeby, and K. Dano (1994), Histopathology 24, 131–138.PubMedCrossRefGoogle Scholar
  267. Pyke, C., E. Ralfkiaer, K. Tryggvason, and K. Dan (1993), Am. J. Pathol 142, 359–365.PubMedGoogle Scholar
  268. Pyke, C., P. Kriistensen, E. Ralfkiaer, J. Eriksen, and K. Dano (1991a), Cancer Res. 51, 4067–4071.PubMedGoogle Scholar
  269. Pyke, C., P. Kristensen, E. Ralfkiaer, J. Grondahl-Hansen, J. Eriksen, F. Blasi, and K. Dano (1991b), Am. J. Pathol 138, 1059–1067.Google Scholar
  270. Radulovic, S., G. Miller, and A. V. Schally (1991), Cancer Res 51, 6006–6009.PubMedGoogle Scholar
  271. Randazzo, P. A., J. K. Northup, and R. A. Kahn (1992), J. Biol. Chem 267 18,182–18,189.Google Scholar
  272. Rapp, U. R. (1991), Oncogene 6, 495–500.PubMedGoogle Scholar
  273. Reed, J. C., S. Haldar, C. M. Croce, and M. P.Cuddy (1990), Mol. Cell Biol 10, 4370–4374.PubMedGoogle Scholar
  274. Reichmann, A., P. Martin, and B. Levin (1981), Int. J. Cancer 28, 431–440.PubMedCrossRefGoogle Scholar
  275. Reiss, M., V. F. Vellucci, and Z.-L. Zhou (1993), Cancer Res. 53, 899–904.PubMedGoogle Scholar
  276. Resar, L. M. S., C. Dolde, J. F. Barrett, and C. V. Dang (1993), Mol. Cell. Biol 13, 1130–1136.PubMedGoogle Scholar
  277. Reznikoff, C. A., D. W. Brankow, and C. Heidelberger (1973), Cancer Res. 33, 3231–3238.PubMedGoogle Scholar
  278. Rideout, W. M., 3rd, G. A. Coetzee, A. F. Olumi, C. H. Spruck, and P. A. Jones (1991) Princess Takamatsu Symp. 22, 207–219.PubMedGoogle Scholar
  279. Risinger, J. I., A. Berchuck, M. F. Kohler, P. Watson, H. T. Lynch, and J. Boyd (1993), Cancer Res. 53, 5100–5103.PubMedGoogle Scholar
  280. Roberton, A. M. (1993), Mutat. Res 290, 71–78.PubMedCrossRefGoogle Scholar
  281. Roberts, T. M. (1992), Nature 360, 534.PubMedCrossRefGoogle Scholar
  282. Rodgers, W. H., K. G. Osteen, L. M. Matrisian, M. Navre, L. C. Giudice, and F. Gorstein (1993), Am. J. Obstet. Gynecol 168, 253–260.Google Scholar
  283. Rodrigues, N. R., A. Rowan, M. E. F. Smith, I B. Kerr, W. F. Bodmer, J. V. Gannon, and D. P. Lane (1990), Proc. Natl. Acad. Sci. USA 87 7555–7559.Google Scholar
  284. Rodriguez-Alfageme, C., E. J. Stanbridge, and S. M. Astrin (1992), Proc. Natl. Acad. Sci. USA 89, 1482–1486.PubMedCrossRefGoogle Scholar
  285. Rosengard, A. M., H. C. Krutzsch, A. Shearn, J. R. Biggs, E. Barker, I M. K. Margulies, C. R. King, L. A. Liotta, and P. S. Steeg (1989), Nature (Lond.) 342 177–180.Google Scholar
  286. Rothberg, P. G. (1987), Semin. Surg. Oncol 3, 152–158.PubMedCrossRefGoogle Scholar
  287. Rothberg, P. G., H. M. Spandorfer, M. D. Erisman, R. N. Staroscik, H. F. Sears, R. O. Peterson, and S. M. Astrin (1985), Br. J. Cancer 52, 629–632.PubMedCrossRefGoogle Scholar
  288. Rovinski, B. and S. Benchimol (1988), Oncogene 2, 445–451.PubMedGoogle Scholar
  289. Rozakis-Adcock, M., J. McGlade, G. Mbamalu, G. Pelicci, R. Daly, W. Li, A. Batzer, S. Thomas, J. Brugge, P. G. Pelicci, J. Schlessinger, and T. Pawson (1992), Nature 360, 689–692.PubMedCrossRefGoogle Scholar
  290. Rubinfeld, B., B. Souza, I. Albert, O. Muller, S. H. Chamberlain, F. R. Masiarz, S. Munemitsu, and P. Polakis (1993), Science 262, 1731–1734.PubMedCrossRefGoogle Scholar
  291. Sabe, H A. Hata, M. Okada, H. Nakagawa, and H. Hanafusa (1994), Proc. Natl. Acad. Sci. USA 913984–3988.Google Scholar
  292. Sanz, L., E. Berra, M M. Municio, I. Dominguez, J. Lozano, T. Johansen, J. Moscat, and M T. Diaz-Meco (1994), J. Biol. Chem 269 10,044–10,049.Google Scholar
  293. Sato, H., T. Takino, Y. Okada, J. Cao, A. Shinagawa, E. Yamamoto, and M. Seiki (1994), Nature 370, 61–65.PubMedCrossRefGoogle Scholar
  294. Saxena, A., W. C. Clark, J. T. Robertson, B. Ikejiri, E. H. Oldfield, and I. U. Ali (1992), Cancer Res. 52, 6716–6721.PubMedGoogle Scholar
  295. Schaller, M. D., J. D. Hildebrand, J. D. Shannon, J. W. Fox, R. R. Vines, and J. T. Parsons (1994), Mol. Cell Biol 14, 1680–1688.PubMedGoogle Scholar
  296. Schmid, M., T. Haaf, and D. Grunert (1984), Hum. Genet 67, 257–263.PubMedCrossRefGoogle Scholar
  297. Seizinger, B. R., S. de la Monte, L. Atkins, J. F. Gusella, and R. L. Martuza (1987), Proc. Natl. Acad. Sci. USA 84, 5419–5423.PubMedCrossRefGoogle Scholar
  298. Sharrard, R. M., J. A. Royds, S. Rogers, and A. J. Shorthouse (1992), Br. J. Cancer 65, 667–672.PubMedCrossRefGoogle Scholar
  299. Shaulian, E., A. Zauberman, D. Ginsberg, and M. Oren (1992), Mol. Cell. Biol. 12, 5548–5592. Shaulsky, G., A. Ben-Zeev, and V. Rotter (1990a), Oncogene 5, 1707–1711.Google Scholar
  300. Shaulsky, G., N. Goldfinger, A. Ben-Zeev, and V. Rotter (1990b), Mol. Cell. Biol 10, 6565–6577.PubMedGoogle Scholar
  301. Shaulsky, G., N. Goldfinger, A. Peled, and V. Rotter V (1991a), Proc. Natl. Acad. Sci. USA 88, 8982–8986.PubMedCrossRefGoogle Scholar
  302. Shaulsky, G., N. Goldfinger, and V. Rotter (199 lb), Cancer Res 51 5232–5237.Google Scholar
  303. Shaw, P., R. Bovey, S. Tardy, R. Sahli, B. Sordat, and J. Costa (1992), Proc. Natl. Acad. Sci. USA 89, 4495–4499.PubMedCrossRefGoogle Scholar
  304. Shirasawa, S., K. Urabe, Y. Yanagawa, K. Toshitani, T. Iwama, and Saszuki (1991), Cancer Res. 51, 2874–2878.PubMedGoogle Scholar
  305. Shirota, K., L. LeDuy, S. Y. Yuan, and S. Jothy (1990), Virchows Arch B Cell Pathol. 58, 303–308.Google Scholar
  306. Shivapurkar, N., Z. Tang, A. Ferreira, S. Nasim, C. T. Garrett, and O. Alabaster (1994), Carcinogenesis 15, 775–778PubMedCrossRefGoogle Scholar
  307. Shou, C., C. L. Farnsworth, B. G. Neel, and L. A. Feig (1992), Nature (Lond.) 358, 351–354.CrossRefGoogle Scholar
  308. Shrivastava, A., S. Saleque, G. V. Kalpana, S. Artandi, S. P. Goff, and K Calame (1993), Science 262, 1889–1892.PubMedCrossRefGoogle Scholar
  309. Sidransky, D., T. Tokino, S. R. Hamilton, K. W. Kinzler, B. Levin, P. Frost, and B. Vogelstein (1992), Science 256, 102–105.PubMedCrossRefGoogle Scholar
  310. Sikora, K., S. Chan, G. Evan, H. Gabra, N. Markham, J. Stewart, and J. Watson (1987), Cancer 59 (7), 1289–1295.PubMedCrossRefGoogle Scholar
  311. Silverman, A. L., J. G. Park, S. R. Hamilton, A. F. Gazdar, G. D. Luk, and S. B. Baylin (1989), Cancer Res. 49, 3648–3473.Google Scholar
  312. Singh, P., J. C. Reubi, G. Rajakumar, Y. S. Guo, H. Prioux, and L. Chicone (1993), J. Steroid Biochem. Mol. Biol 46, 49–60.PubMedCrossRefGoogle Scholar
  313. Slebos, R. J., G. G. Habets, S. G. Evers, W. J. Mooi, and S. Rodenhuis (1991), Int. J. Cancer 48, 51–56.PubMedCrossRefGoogle Scholar
  314. Slebos, R. J., R. E. Kibbelaar O. Dalesio, A. Kooistra, J. Stam, C. J. Meijer, and S. S. Wagenaar (1990), N. Engl. J. Med 323, 561–565.PubMedCrossRefGoogle Scholar
  315. Smith, D. R., T. Myint, and H. S. Goh (1993), Br. J. Cancer 68, 407–413.PubMedCrossRefGoogle Scholar
  316. Solomon, E., R. Voss, V. Hall, W. F. Bodmer, J. R. Jass, A. J. Jeffrey, F. C. Lucibello, I. Patel, and S. H. Rider (1987), Nature 328, 616–619.PubMedCrossRefGoogle Scholar
  317. Spandidos, D. A., and I. B. Kerr (1984a), Br. J. Cancer 49, 681–688.PubMedCrossRefGoogle Scholar
  318. Spandldos, D. A. and N. M. Wilkie (1984b), Nature 310, 469–475.CrossRefGoogle Scholar
  319. Stahl, J. A., A. Leone, A. M. Rosengard, L. Porter, C. R. King, and P. S. Steeg (1991), Cancer Res. 51, 445–449.PubMedGoogle Scholar
  320. Stanbridge, E. J. (1988), Cancer Surv. 7, 317–324.PubMedGoogle Scholar
  321. Steeg, P. S., G. Bevilacqua, L. Kopper, U. P. Thorgeirsson, J. E. Talmadge, L. A. Liotta, and M. E. Sobel (1988a), J. Natl. Cancer Inst 80, 200–204.PubMedCrossRefGoogle Scholar
  322. Steeg, P. S., G. Bevilacqua, R. Pozzati, L. A. Liotta, and M. E. Sobel (1988b), Cancer Res. 48, 6550–6554.PubMedGoogle Scholar
  323. Steinbach, G., J. Lupton, B. S. Reddy, J. G. Kral, and P. R. Holt (1994), Gastroenterology 106, 1162–1167.PubMedGoogle Scholar
  324. Stetler-Stevenson, W. G., L. A. Liotta, and D. E. Kleiner, Jr. (1993), FASEB 7, 1434–1441. Stewart, J., G. Evan, J. Watson, and K. Sikora (1986), Br. J. Cancer 53, 1–6.Google Scholar
  325. Stoke, D., S. G. Macdonald, K. Cadwallader, M. Symons, J. F. Hancock (1994), Science 264, 1463–1467.CrossRefGoogle Scholar
  326. Strange, R., F. Li, S. Saurer, A. Burkhardt, and R. R. Friis (1992), Development 115, 49–58. Strassmann, G., M. Fong, C. E. Freter, S. Windsor, F. D’Alessandro, and R. P. Nordan (1993), J. Clin. Invest 92, 2152–2159.Google Scholar
  327. Stryer, L. G. (1986), Annu. Rev. Cell Biol 2, 391–419.PubMedCrossRefGoogle Scholar
  328. Su, L.-K., B. Vogelstein, and K. W. Kinzler (1993a), Science 262, 1734–1737.PubMedCrossRefGoogle Scholar
  329. Su, L.-K., K. A. Johnson, K. J. Smith, D. E. Hill, B. Vogelstein, and K. W. Kinzler (1993), Cancer Res. 53, 2728–2731.PubMedGoogle Scholar
  330. Suzuki, K., T. Ono, and K. Takahashi (1992), Biochem. Biophys. Res. Commun 183, 1175–1183.PubMedCrossRefGoogle Scholar
  331. Sweet, R. W., S. Yokoyama, T. Kamata, J. R. Feramisco, M. Rosenberg, and M. Gross (1984), Nature 311, 273–275.PubMedCrossRefGoogle Scholar
  332. Tanaka, K., M. Oshimura, R. Kikuchi, M. Seki, T. Hayashi, and M. Miyaki (1991), Nature 349, 340–342.PubMedCrossRefGoogle Scholar
  333. Taylor, C. W., Y. S. Kim, K. E. Childress-Fields, and L. C. Yeoman (1992), Cancer Lett. 62, 95–105.PubMedCrossRefGoogle Scholar
  334. Testa, J. E., R. L. Medcalf, J. F. Cajot, W. D. Schleuning, and B. Sordat (1989), Int. J. Cancer 43, 816–822.PubMedCrossRefGoogle Scholar
  335. Thibodeau, S. N., G. Bren, and D. Schaid (1993), Science 260, 816–819.PubMedCrossRefGoogle Scholar
  336. Thor, A., P. H. Hand, D. Wunderlich, A. Caruso, R. Muraro, and J. Schlom (1984), Nature (Lond.) 311, 562–564.CrossRefGoogle Scholar
  337. Toyoshima, H. and T. Hunter (1994), Cell 78, 67–74.PubMedCrossRefGoogle Scholar
  338. Tsioulias, G. J., T. Muto, Y. Morioka, T. Yamamoto, and S. Mori (1990), Jpn. J. Exp. Med 60, 343–349.PubMedGoogle Scholar
  339. Tulchin, N., L. Ornstein, N. Harpaz, J. Guillem, C. Borner, and K. O’Toole (1992), Am. J. Pathol 140, 719–729.PubMedGoogle Scholar
  340. Uchino, S., H. Tsuda, M. Noguchi, J. Yokota, M. Terada, T. Saito, M. Kobayashj, T. Sugimura, and S. Hirohashi (1992), Cancer Res. 30, 99–102.Google Scholar
  341. Untawale, S. and M. A. Blick (1988), Anticancer Res. 8, 1–7.PubMedGoogle Scholar
  342. Vachtenheim, J., I. Horakova, and H. Novotna (1994), Cancer Res. 54, 1145–1148. Varesco, L., J. Groden, L. Spirio, M. Robertson, R. Weiss, V. Gismondi, G. B. Ferrara, and R. White (1993), Cancer Res 53, 5581–5584.Google Scholar
  343. Varesco, L., M. A. Caligon, P. Simi, D. M. Black, V. Nardini, L. Casarino, M. Rochi, G.Ferrara, E. Solomon, and G. Bevilacqua (1992), Genes Chromo. Cancer 4, 84–88.CrossRefGoogle Scholar
  344. Vasen, H. F. A., J.-P. Mecklin, P. Meera Khan, and H. T. Lynch (1991), Dis. Colon Rectum 34, 424, 425.Google Scholar
  345. Vassalli, J.-D., A. P. Sappino, and D. Belin. (1991), J. Clin. Invest. 88, 1067–1072. Viel, A., R. Maestro, G. Toffoli, G. Grion, and M. J. Boiocchi (1990), Cancer Res. Clin. Oncol 116 (3), 288–294.Google Scholar
  346. Vivona, A. A., B. Shpitz, A. Medline, W. R. Bruce, K. Hay, M. A. Ward, H. S. Stern, and S. Gallinger (1993), Carcinogenesis 14, 1777–1781.PubMedCrossRefGoogle Scholar
  347. Vogelstein, B., E. R. Fearon, S. E. Kern, S. R. Hamilton, A. C. Preisinger, Y. Nakamura, and R. White (1989), Science 244, 207–211.PubMedCrossRefGoogle Scholar
  348. Vogelstein, B., E. R. Fearon, S. R. Hamilton, S. E. Kern, A. C. Preisinger, M. Leppert, Y. Nakumura, R. White, A. M. M. Smits, and J. L. Bos (1988), N. Engl. J. Med 319, 525–532.PubMedCrossRefGoogle Scholar
  349. Waga, S., G. J. Hannon, D. Beach, and B. Stillman (1994), Nature 369, 574–578.PubMedCrossRefGoogle Scholar
  350. Wang, L., U. Patel, L. Ghosh, H.-C. Chen, and S. Banerjee (1993), Cancer Res. 53, 717–720. Wang, Y. and W. Eckhart (1992), Proc. Natl. Acad. Sci. USA 89, 4231–4235Google Scholar
  351. Wei, W., R. D. Masteller, P. Sanyal, E. Gonzales, McKinney, C. Dasgupta, P. Li, B X. Liu, and D. Brock (1992), Proc. Natl. Acad. Sci. USA 89 1700–1704.Google Scholar
  352. Weith, A., T. Martinsson, C. Cziepluch, S. Bruderlein, L. C. Amler, F. Berthold, and M. Schwab (1989), Genes Chromosomes Cancer 1, 159–166.PubMedCrossRefGoogle Scholar
  353. Weyman, C. M., E. Taparowsky, M. Wolfson, and C. L. Ashendel (1988), Cancer Res. 48, 6536–6541.Google Scholar
  354. Willingham, M. C., S. B. Banks-Schlegel, and I. H. Pastan (1983), Exp. Cell Res 149, 141–149.PubMedCrossRefGoogle Scholar
  355. Wolf, C., N. Rouyer, Y. Lutz, C. M. Adida, J. Loriot, P. Bellocq, P. Chambon, and P. Basset (1993), Proc. Natl. Acad. Sci. USA 90, 1843–1847.PubMedCrossRefGoogle Scholar
  356. Wolf, D., N. Harris, and V. Rotter (1984), Cell 38, 119–126.PubMedCrossRefGoogle Scholar
  357. Wolfman, A. and I. G. Macara (1987), Nature (Lond.) 325, 359–361.CrossRefGoogle Scholar
  358. Wolfman, A., T. G. Wingrove, P. J. Blackshear, and I. G. Macara (1987), J. Biol. Chem 262 16,546–16,552.Google Scholar
  359. Working Report from the Division of Research Grants, NIH (1992) Cancer Res. 52, 6129–6133.Google Scholar
  360. Wyllie, F. S., T. Dawson, J. A. Bond, P. Goretzki, S. Game, S. Prime, and D. WynfordThomas (1991), Mol. Cell Endocrinol 76 (1–3), 13–21.PubMedCrossRefGoogle Scholar
  361. Xie, B., C. D. Bucana, and I. J. Fidler (1994), Am. J. Pathol 144, 1058–1067.Google Scholar
  362. Yamagata, S., Y. Ito, R. Tanaka, S. Shimizu (1988), Biochem. Biophys. Res. Commun 151, 158–162.PubMedCrossRefGoogle Scholar
  363. Yan, Z., S. Hsu, S. Winawer, and E. Friedman (1992), Oncogene 7 (4), 801–805.PubMedGoogle Scholar
  364. Yanagi, H., Y. Sasguri, K. Sugama, M. Morinmatsu, H. Nagase, E. Yonish-Rouach, D. Resnitzky, J. Lotem, L. Sachs, A. Kimchi, and M. Oren (1991), Nature (Lond.) 352, 345–347.CrossRefGoogle Scholar
  365. Yonish-Rouach, E., D. Grunwald, S. Wilder, A. Kimchi, E. May, J.-J. Lawrence, P. May, and M. Oren (1993), Mol. Cell. Biol 13, 1415–1423.PubMedGoogle Scholar
  366. Yonish-Rouach, E., D. Resnitzky, J. Lotem, L. Sachs, A. Kimchi, and M. Oren (1991), Nature 352, 345–347.PubMedCrossRefGoogle Scholar
  367. Yoshimoto, M., F. Itoh, H. Yamamoto, Y. Hinoda, K. Imai, and A. Yachi (1993), Int. J. Cancer 54, 614–618.PubMedCrossRefGoogle Scholar
  368. Zhang, W., G. Hu, E. Estey, J. Hester, and A. Deisseroth (1992), Oncogene 7, 1645–1647.PubMedGoogle Scholar
  369. Zhang, X.-F., J. Settleman, J. M. Kyriakis, E. Takeuchi-Suzuki, S. J. Elledge, M. S. Marshall, J. T. Bruder, U. R. Rapp, and J. Avruch (1993), Nature 364, 308–313.PubMedCrossRefGoogle Scholar
  370. Zipfel, P A. B. L. Ziober, S. L. Morris, and K. M. Mulder (1993), Cell Growth Differ. 4, 637–645.PubMedGoogle Scholar
  371. Zucker, S., R. M. Lysik, M. H. Zarrabi, and U. Moll (1993), Cancer Res. 53, 140–146.PubMedGoogle Scholar
  372. Zucker, S., R. M. Lysik, M. H. Zarrabi, W. Stetler-Stevenson, L. A. Liotta, H. Birkedal- Hansen, W. Mann, and M. Furie (1992), Cancer Edpidermol. Biomarkers Prey 1, 475–479.Google Scholar

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© Springer Science+Business Media New York 1995

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  • Suhail Nasim
  • Carleton T. Garrett

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