p53 in Human Cancer

  • Jeffrey R. Marks
  • Andrew M. Davidoff
  • J. Dirk Iglehart
Part of the Contemporary Biomedicine book series (CB, volume 12)


It has been a brief and dizzying trip for p53, from an obscure gene with marginal transforming activity in tissue-culture cells to the most ubiquitous genetic alteration in human cancer. p53 was not the first oncogene to be implicated in the etiology of human cancer. However, the emergent story has been in large part responsible for the current frenzy of activity and widespread enthusiasm for studying the genetics of human cancer. Important aspects of the p53 story remain unknown: the function of the gene product and its central role as a target for transformation in such a variety of systems are still challenging questions.


Breast Cancer Missense Mutation Cell BioI Inflammatory Breast Carcinoma Dominant Oncogene 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. Agoff, S. N., J. Hou, D. I. H. Linzer, and B. Wu (1993), Science 259, 84–87.PubMedGoogle Scholar
  2. Ahuja, H., M. Bar Eli, S. H. Advani, S. Benchimol, and M. J. Cline (1989), Proc. Natl. Acad. Sci. USA 86, 6783–6787.PubMedGoogle Scholar
  3. Akslen, L. A. and O. Morkve (1992), Int. J. Cancer 52, 13–16.PubMedGoogle Scholar
  4. Allred, D. C., G. M. Clark, R. Elledge, S. A. W. Fuqua, R. W. Brown, G. C. Chamness, C. K. Osborne, and W. L. McGuire (1993), J. Natl. Cancer Inst. 85, 200–206.PubMedGoogle Scholar
  5. Andreassen, A., T. Oyjord, E. Hovig, R. Holm, V. A. Florenes, J. M. Nesland, O. Myklebost, J. Hoie, O. S. Bruland, and A. L. Borresen (1993), Cancer Res. 53, 468–471.PubMedGoogle Scholar
  6. Baker, S. J., S. Markowitz, E. R. Fearon, J. K. Willson, and B. Vogelstein (1990a), Science 249, 912–915.PubMedGoogle Scholar
  7. Baker, S. J., A. C. Preisinger, J. M. Jessup, C. Paraskeva, S. Markowitz, J. K. Willson, S. Hamilton, and B. Vogelstein (1990b), Cancer Res. 50, 7717–7722.PubMedGoogle Scholar
  8. Baker, S. J., E. R. Fearon, J. M. Nigro, S. R. Hamilton, A. C. Preisinger, J. M. Jessup, P. vanTuinen, D. H. Ledbetter, D. F. Barker, Y. Nakamura, R. White, and B. Vogelstein (1989), Science 244, 217–221.PubMedGoogle Scholar
  9. Barbareschi, M., P. Iuzzolino, A. Pennella, A. Allegranza, G. Arrigoni, P. Dalla Palma, and C. Doglioni (1992), J. Clin. Pathol. 45, 583–586.PubMedGoogle Scholar
  10. Bargonetti, J., P. N. Friedman, S. E. Kern, B. Vogelstein, and C. Prives (1991), Cell 65, 1083–1091.PubMedGoogle Scholar
  11. Bartek, J., B. Vojtesek, and D. P. Lane (1992), Eur. J. Cancer 29A, 101–107.Google Scholar
  12. Bartek, J., J. Bartkova, B. Vojtesek, Z. Staskova, J. Lukas, A. Rejthar, J. Kovarik, C. A. Midgley, J. V. Gannon, and D. P. Lane (1991), Oncogene 6, 1699–1703.PubMedGoogle Scholar
  13. Bartkova, J., J. Bartek, J. Lukas, B. Vojtesek, Z. Staskova, A. Rejthar, J. Kovarik, C. A. Midgley, and D. P. Lane (1991), Int. J. Cancer 49, 196–202.PubMedGoogle Scholar
  14. Bell, S. M., N. Scott, D. Cross, P. Sagar, F. A. Lewis, G. E. Blair, G. R. Taylor, M. F. Dixon, and P. Quirke (1993), Gastroenterology 104, 57–64.PubMedGoogle Scholar
  15. Bischoff, J. R., P. N. Friedman, D. R. Marshak, C. Prives, and D. Beach (1990), Proc. Natl. Acad. Sci. USA 87, 4766–4770.PubMedGoogle Scholar
  16. Blount, P. L., S. Ramel, W. H. Raskind, R. C. Haggitt, C. A. Sanchez, P. J. Dean, P. S. Rabinovitch, and B. J. Reid (1991), Cancer Res. 51, 5482–5486.PubMedGoogle Scholar
  17. Borresen, A-L., E. Hovig, B. Smith-Sorensen, D. Malkin, S. Lystad, T. I. Andersen, J. M. Nesland, K. J. Isselbacher, and S. H. Friend (1991), Proc. Natl. Acad. Sci. USA 88, 8405–8409.PubMedGoogle Scholar
  18. Bosari, S., A. K. Lee, G. Viale, G. J. Heatley, and G. Coggi (1992), Virchows. Arch. A. Pathol. Anat. Histopathol. 421, 291–295.PubMedGoogle Scholar
  19. Brachman, D. G., D. Graves, E. Yokes, M. Beckett, D. Haraf, A. Montag, E. Dunphy, R. Mick, D. Yandell, and R. R. Weichselbaum (1992), Cancer Res. 52, 4832–4836.PubMedGoogle Scholar
  20. Braithwaite, A. W., H. W. Sturzbecher, C. Addison, C. Palmer, K. Rudge, and J. R. Jenkins (1987), Nature 329, 458–460.PubMedGoogle Scholar
  21. Brash, D. E., J. A. Rudolph, J. A. Simon, A. Lin, G. J. McKenna, H. P. Baden, A. J. Halperin, and J. Ponten (1991), Proc. Natl. Acad. Sci. USA 88, 10,124–10,128.Google Scholar
  22. Bressac, B., M. Kew, J. Wands, and M. Ozturk (1991), Nature 350, 429–431.PubMedGoogle Scholar
  23. Campo, E., O. Calle-Martin, R. Miguel, A. Palacin, M. Romero, V. Fabregat, J. Vives, A. Cardesa, and J. Yague (1991), Cancer Res. 51, 4436–4442.PubMedGoogle Scholar
  24. Caron de Fromentel, C., and T. Soussi (1992), Genes Chrom. Cancer 4, 1–15.Google Scholar
  25. Caron de Fromentel, C., F. May Levin, H. Mouriesse, J. Lemerle, K. Chandrasekaran, and P. May (1987), Int. J. Cancer 39, 185–189.Google Scholar
  26. Casey, G., M. Lo-Hsueh, M. E. Lopez, B. Vogelstein, and E. J. Stanbridge (1991), Oncogene 6, 1791–1797.PubMedGoogle Scholar
  27. Casson, A. G., T. Mukhopadhyay, K. R. Cleary, J. Y. Ro, B. Levin, and J. A. Roth (1991), Cancer Res. 51, 4495–4499.PubMedGoogle Scholar
  28. Cattoretti, G., F. Rilke, S. Andreola, L. DAmato, and D. Delia (1988), Int. J. Cancer 41, 178–183.PubMedGoogle Scholar
  29. Cesarman, E., A. Chadburn, G. Inghirami, G. Gaidano, and D. M. Knowles (1992), Blood 80, 3205–3216.PubMedGoogle Scholar
  30. Challen, C., J. Lunec, W. Warren, J. Collier, and M. F. Bassendine (1992), Hepatology 16, 1362–1366.PubMedGoogle Scholar
  31. Chen, P. L., Y. M. Chen, R. Bookstein, and W. H. Lee (1990), Science 250, 1576–1580.PubMedGoogle Scholar
  32. Chen, Y., P. L. Chen, N. Arnaiz, D. Goodrich, and W. H. Lee (1991), Oncogene 6, 1799–1805.PubMedGoogle Scholar
  33. Cheng, J., J.-K. Yee, J. Yeargin, T. Friedmann, and M. Haas (1992), Cancer Res. 52, 222–226.PubMedGoogle Scholar
  34. Chiba, I., T. Takahashi, M. M. Nau, D. DAmico, D. T. Curiel, T. Mitsudomi, D. L. Buchhagen, D. Carbone, S. Piantadosi, and H. Koga (1990), Oncogene 5, 1603–1610.PubMedGoogle Scholar
  35. Chin, K-V., K. Ueda, I. Pastan, and M. M. Gottesman (1992), Science 255, 459–462.PubMedGoogle Scholar
  36. Coles, C., A. M. Thompson, P. A. Elder, B. B. Cohen, I. M. Mackenzie, G. Cranston, U. Chetty, J. Mackay, M. Macdonald, and Y. Nakamura (1990), Lancet 336, 761–763.PubMedGoogle Scholar
  37. Crawford, L. V., D. C. Pim, and R. D. Bulbrook (1982), Int. J. Cancer 30, 403–408.PubMedGoogle Scholar
  38. Crook, T. and K. H. Vousden (1992), EMBO J. 11, 3935–3940.PubMedGoogle Scholar
  39. Crook, T., D. Wrede, J. A. Tidy, W. P. Mason, D. J. Evans, and K. H. Vousden (1992), Lancet 339, 1070–1073.PubMedGoogle Scholar
  40. Crook, T., D. Wrede, J. Tidy, J. Scholefield, L. Crawford, and K. H. Vousden (1991), Oncogene 6, 1251–1257.PubMedGoogle Scholar
  41. Cunningham, J., J. A. Lust, D. J. Schaid, G. D. Bren, H. A. Carpenter, E. Rizza, J. S. Kovach, and S. N. Thibodeau (1992), Cancer Res. 52, 1974–1980.PubMedGoogle Scholar
  42. D’Amico, D., D. Carbone, T. Mitsudomi, M. Nau, J. Fedorko, E. Russell, B. Johnson, D. Buchhagen, S. Bodner, R. Phelps, A. Gazdar, and J. D. Minna (1992), Oncogene 7, 339–346.PubMedGoogle Scholar
  43. Davidoff, A. M., J. D. Iglehart, and J. R. Marks (1992), Proc. Natl. Acad. Sci. USA 89, 3439–3442.PubMedGoogle Scholar
  44. Davidoff, A. M., J. E. Herndon, B. J. Kerns, J. C. Pence, J. D. Iglehart, and J. R. Marks (1991a), Surgery 110, 259–264.PubMedGoogle Scholar
  45. Davidoff, A. M., P. A. Humphrey, J. D. Iglehart, and J. R. Marks (1991b), Proc. Natl. Acad. Sci. USA 88, 5006–5010.PubMedGoogle Scholar
  46. Davidoff, A. M., B. J. Kerns, J. D. Iglehart, and J. R. Marks (1991c), Cancer Res. 51, 2605–2610.PubMedGoogle Scholar
  47. Deppert, W., G. Buschhausen Denker, T. Patschinsky, and K. Steinmeyer (1990), Oncogene 5, 1701–1706.PubMedGoogle Scholar
  48. Dolcetti, R., C. Doglioni, R. Maestro, D. Gasparotto, L. Barzan, A. Pastore, M. Romanelli, and M. Boiocchi (1992), Int. J. Cancer 52, 178–182.PubMedGoogle Scholar
  49. Donehower, L. A., M. Harvey, B. L. Slagle, M. J. McArthur, C. A. Jr. Montgomery, J. S. Butel, and A. Bradley (1992), Nature 356, 215–221.PubMedGoogle Scholar
  50. Dony, C., M. Kessel, and P. Gruss (1985), Nature 317, 636–639.PubMedGoogle Scholar
  51. Dyson, N., P. M. Howley, K. Munger, and E. Harlow (1989), Science 243, 934–937.PubMedGoogle Scholar
  52. Eisenstadt, E., A. J. Warren, J. Porter, D. Atkins, and J. H. Miller (1982), Proc. Natl. Acad. Sci. USA 79, 1945–1949.PubMedGoogle Scholar
  53. El-Deiry, W. S., S. E. Kern, J. A. Pietenpol, K. W. Kinzler, and B. Vogelstein (1992), Nature Genet. 1, 45–49.PubMedGoogle Scholar
  54. El-Deiry, W. S., T. Tokino, V. E. Velculescu, D. B. Levy, R. Parsons, J. M. Trent, D. Lin, W. E. Mercer, K. W. Kinzler„ and B. Vogelstein (1993), Cell 75, 817–825.PubMedGoogle Scholar
  55. El-Deiry, W. S., J. W. Harper, P. M. O’Connor, V. E. Velculescu, C. E. Canman, J. Jackman, J. A. Pietenpol, M. Burrel, D. E. Hill, Y. Wang, K. G. Wiman, W. E. Mercer, M. B. Kastan, K. W. Kohn, S. J. Elledge, K. W. Kinzler„ and B. Vogelstein (1994), Cancer Res. 54, 1169–1174.PubMedGoogle Scholar
  56. Eliyahu, D., A. Raz, P. Gruss, D. Givol, and M. Oren (1984), Nature 312, 646–649. Eliyahu, D., D. Michalovitz, S. Eliyahu, O. Pinhasi-Kimhi, and M. Oren (1989), Proc. Natl. Acad. Sci. USA 86, 8763–8767.Google Scholar
  57. Ellison, D. W., K. C. Gatter, P. V. Steart, D. P. Lane, and R. O. Weller (1992), J. Pathol. 168, 383–386.PubMedGoogle Scholar
  58. Fakharzadeh, S. S., S. P. Trusko, and D. L. George (1991), EMBO J. 10, 1565–1569.PubMedGoogle Scholar
  59. Fearon, E. R. and B. Vogelstein (1990), Cell 61, 759–767.PubMedGoogle Scholar
  60. Felix, C. A., C. C. Kappel, T. Mitsudomi, M. M. Nau, M. Tsokos, G. D. Crouch, P. D. Nisen, N. J. Winick, and L. J. Helman (1992a), Cancer Res. 52, 2243–2247.PubMedGoogle Scholar
  61. Felix, C. A., M. M. Nau, T. Takahashi, T. Mitsudomi, I. Chiba, D. G. Poplack, G. H. Reaman, D. E. Cole, J. J. Letterio, and J. Whang Peng (1992b), J. Clin. Invest. 89, 640–647.PubMedGoogle Scholar
  62. Fenaux, P., P. Jonveaux, I. Quiquandon, C. Preudhomme, J. L. Lai, M. Vanrumbeke, M. H. Loucheux Lefebvre, F. Bauters, R. Berger, and J. P. Kerckaert (1992a), Leukemia 6, 42–46.PubMedGoogle Scholar
  63. Fenaux, P., C. Preudhomme, J. L. Lai, I. Quiquandon, P. Jonveaux, M. Vanrumbeke, C. Sartiaux, P. Morel, M. H. Loucheux Lefebvre, and F. Bauters (1992b), Leukemia 6, 246–250.PubMedGoogle Scholar
  64. Fenaux, P., C. Preudhomme, I. Quiquandon, P. Jonveaux, J. L. Lai, M. Vanrumbeke, M. H. Loucheux Lefebvre, F. Bauters, R. Berger, and J. P. Kerckaert (1992c), Br. J. Haematol. 80, 178–183.PubMedGoogle Scholar
  65. Field, J. K., D. A. Spandidos, A. Malliri, J. R. Gosney, M. Yiagnisis, and P. M. Stell (1991), Br. J. Cancer 64, 573–577.PubMedGoogle Scholar
  66. Fields, S. and S. K. Jang (1990), Science 249, 1046–1049.PubMedGoogle Scholar
  67. Finlay, C. A., P. W. Hinds, and A. J. Levine (1989), Cell 57, 1083–1093.PubMedGoogle Scholar
  68. Finlay, C. A., P. W. Hinds, T. H. Tan, D. Eliyahu, M. Oren, and A. J. Levine (1988), Mol. Cell Biol. 8, 531–539.PubMedGoogle Scholar
  69. Fontoura, B. M. A., E. A. Sorokina, E. David, and R. B. Carroll (1992), Mol. Cell Biol. 12, 5145–5151.PubMedGoogle Scholar
  70. Frankel, R. H., W. Bayona, M. Koslow, and E. W. Newcomb (1992), Cancer Res. 52, 1427–1433.PubMedGoogle Scholar
  71. Freed, M. I., I. Lubin, and D. T. Simmons (1983), J. Virol. 46, 1061–1065.PubMedGoogle Scholar
  72. Friedman, P. N., S. E. Kern, B. Vogelstein, and C. Prives (1990), Proc. Natl. Acad. Sci. USA 87, 9275–9279.PubMedGoogle Scholar
  73. Fujimoto, K., Y. Yamada, E. Okajima, T. Kakizoe, H. Sasaki, T. Sugimura, and M. Terada (1992), Cancer Res. 52, 1393–1398.PubMedGoogle Scholar
  74. Fujita, M., M. Inoue, O. Tanizawa, S. Iwamoto, and T. Enomoto (1992), Cancer Res. 52, 5323–5328.PubMedGoogle Scholar
  75. Fults, D., D. Brockmeyer, M. W. Tullous, C. A. Pedone, and R. M. Cawthon (1992), Cancer Res. 52, 674–679.PubMedGoogle Scholar
  76. Gannon, J. V. and D. P. Lane (1987), Nature 329, 456–458.PubMedGoogle Scholar
  77. Gannon, J. V., R. Greaves, R. Iggo, and D. P. Lane (1990), EMBO J. 9, 1595–1602.PubMedGoogle Scholar
  78. Ginsberg, D., F. Mechta, M. Yaniv, and M. Oren (1991), Proc. Natl. Acad. Sci. USA 88, 9979–9983.PubMedGoogle Scholar
  79. Halevy, O., D. Michalovitz, and M. Oren (1990), Science 250, 113–116.PubMedGoogle Scholar
  80. Harper, J. W., G. R. Adami, N. Wei, K. Keyomarsi, and S. J. Elledge (1993), Cell 75, 805–816.PubMedGoogle Scholar
  81. Hinds, P., C. Finlay, and A. J. Levine (1989), J. Virol. 63, 739–746.PubMedGoogle Scholar
  82. Hinds, P. W., C. A. Finlay, A. B. Frey, and A. J. Levine (1987), Mol. Cell Biol. 7, 2863–2869.PubMedGoogle Scholar
  83. Hinds, P. W., C. A. Finlay, R. S. Quartin, S. J. Baker, E. R. Fearon, B. Vogelstein, and A. J. Levine (1990), Cell Growth Differ. 1, 571–580.PubMedGoogle Scholar
  84. Hollstein, M., D. Sidransky, B. Vogelstein, and C. C. Harris (1991), Science 253, 49–53. Hollstein, M. C., R. A. Metcalf, J. A. Welsh, R. Montesano, and C. C. Harris (1990), Proc. Natl. Acad. Sci. USA 87, 9958–9961.Google Scholar
  85. Horak, E., K. Smith, L. Bromley, S. LeJeune, M. Greenall, D. Lane, and A. L. Harris (1991), Oncogene 6, 2277–2284.PubMedGoogle Scholar
  86. Horio, Y., T. Takahashi, T. Kuroishi, K. Hibi, M. Suyama, T. Niimi, K. Shimokata, K. Yamakawa, Y. Nakamura, and R. Ueda (1993), Cancer Res. 53, 1–4.PubMedGoogle Scholar
  87. Hosono, S., M. J. Chou, C. S. Lee, and C. Shih (1993), Oncogene 8, 491–496.PubMedGoogle Scholar
  88. Hsia, C. C., D. E. Kleiner, Jr., C. A. Axiotis, A. Di Bisceglie, A. M. Nomura, G. N. Stemmermann, and E. Tabor (1992), J. Natl. Cancer Inst. 84, 1638–1641.PubMedGoogle Scholar
  89. Hsu, I. C., R. A. Metcalf, T. Sun, J. A. Welsh, N. J. Wang, and C. C. Harris (1991), Nature 350, 427, 428.Google Scholar
  90. Hu, G., W. Zhang, and A. B. Deisseroth (1992), Br. J. Haematol. 81, 489–494.PubMedGoogle Scholar
  91. Humphrey, P. A., D. W. Franquemont, W. A. Geary, B.-J. M. Kerns, J. D. Iglehart, and J. R. Marks (1994), App. Immunohist. 2, 22–28.Google Scholar
  92. Iggo, R., K. Gatter, J. Bartek, D. Lane, and A. L. Harris (1990), Lancet 335, 675–679.PubMedGoogle Scholar
  93. Isaacs, W. B., B. S. Carter, and C. M. Ewing (1991), Cancer Res. 51, 4716–4720.PubMedGoogle Scholar
  94. Isola, J., T. Visakorpi, K. Holli, and O. P. Kallioniemi (1992), J. Natl. Cancer Inst. 84, 1109–1114.PubMedGoogle Scholar
  95. Jaros, E., R. H. Perry, L. Adam, P. J. Kelly, P. J. Crawford, R. M. Kalbag, A. D. Mendelow, R. P. Sengupta, and A. D. Pearson (1992), Br. J. Cancer 66, 373–385.PubMedGoogle Scholar
  96. Johnson, P., D. Gray, M. Mowat, and S. Benchimol (1991), Mol. Cell Biol. 11, 1–11.PubMedGoogle Scholar
  97. Jonveaux, P. and R. Berger (1991), Leukemia 5, 839, 840.Google Scholar
  98. Kelman, Z., M. Prokocimer, S. Peller, Y. Kahn, G. Rechavi, Y. Manor, A. Cohen, and V. Rotter (1989), Blood 74, 2318–2324.PubMedGoogle Scholar
  99. Kern, S. E., J. A. Pietenpol, S. Thiagalingam, A. Seymour, K. W. Kinzler, and B. Vogelstein (1992), Science 256, 827–830.PubMedGoogle Scholar
  100. Kern, S. E., K. W. Kinzler, A. Bruskin, D. Jarosz, P. Friedman, C. Prives, and B. Vogelstein (1991), Science 252, 1708–1711.PubMedGoogle Scholar
  101. Kern, S. E., E. R. Fearon, K. W. Tersmette, J. P. Enterline, M. Leppert, Y. Nakamura, R. White, B. Vogelstein, and S. R. Hamilton (1989), JAMA 261, 3099–3103.PubMedGoogle Scholar
  102. Kohler, M. F., A. Berchuck, A. M. Davidoff, P. A. Humphrey, R. K. Dodge, J. D. Iglehart, J. T. Soper, D. L. Clarke-Pearson, R. C. Bast, and J. R. Marks (1992), Cancer Res. 52, 1622–1627.PubMedGoogle Scholar
  103. Kraiss, S., A. Quaiser, M. Oren, and M. Montenarh (1988), J. Virol. 62, 4737–4744.PubMedGoogle Scholar
  104. Kuerbitz, S. J., B. S. Plunkett, W. V. Walsh, and M. B. Kastan (1992), Proc. Natl. Acad. Sci. USA 89, 7491–7495.PubMedGoogle Scholar
  105. Ladanyi, M., C. Cha, R. Lewis, S. C. Jhanwar, A. G. Huvos, and J. H. Healey (1993), Cancer Res. 53, 16–18.PubMedGoogle Scholar
  106. Lam, K. T., and S. K. Calderwood (1992), Biochem. Biophys. Res. Commun. 184, 167–174.PubMedGoogle Scholar
  107. Lane, D. P. and L. V. Crawford (1979), Nature 278, 261–263.PubMedGoogle Scholar
  108. Ledinko, N. and R. L. Costantino (1990), Anticancer Res. 10, 1335–1339.PubMedGoogle Scholar
  109. Lehman, T. A., W. P. Bennett, R. A. Metcalf, J. A. Welsh, J. Ecker, R. V. Modali, S. Ullrich, J. W. Romano, E. Appella, J. R. Testa, B. I. Gerwin, and C. C. Harris (1991), Cancer Res. 51, 4090–4096.PubMedGoogle Scholar
  110. Lemoine, N. R., C. M. Hughes, and J. K. Cowell (1992), J. Pathol. 168, 237–242.PubMedGoogle Scholar
  111. Li, F. P. and J. F. Fraumeni (1969), Ann. Int. Med. 71, 747–752.PubMedGoogle Scholar
  112. Li, F. P., J. F. Fraumeni, J. J. Mulvhill, W. A. Blattner, M. G. Dreyfuss, M. A. Tucker, and R. W. Miller (1988), Cancer Res. 48, 5358–5362.PubMedGoogle Scholar
  113. Lin, D., M. T. Shields, S. J. Ullrich, E. Appella, and W. E. Mercer (1992), Proc. Natl. Acad. Sci. USA 89, 9210–9214.PubMedGoogle Scholar
  114. Linzer, D. I. and A. J. Levine (1979), Cell 17, 43–52.PubMedGoogle Scholar
  115. Liu, F.-S., M. F. Kohler, J. R. Marks, R. C. Bast, J. Boyd, and A. Berchuck (1994), Obstet. Gynecol. 83, 118–124.PubMedGoogle Scholar
  116. Mackay, J., C. M. Steel, P. A. Elder, A. P. M. Forrest, and H. J. Evans (1988), Lancet 325, 1384–1385.Google Scholar
  117. Malkin, D., K. W. Jolly, N. Barbier, A. T. Look, S. H. Friend, M. C. Gebhardt, T. I. Andersen, A-L. Borresen, F. P. Li, J. Garber, and L. C. Strong (1992), N. Engl. J. Med. 326, 1309–1315.PubMedGoogle Scholar
  118. Malkin, D., F. P. Li, L. C. Strong, J. F. Fraumeni, Jr., C. E. Nelson, D. H. Kim, J. Kassel, M. A. Gryka, F. Z. Bischoff, and M. A. Tainsky (1990), Science 250, 1233–1238.PubMedGoogle Scholar
  119. Marks, J. R., A. M. Davidoff, B. J. Kerns, P. A. Humphrey, J. C. Pence, R. K. Dodge, D. L. Clarke-Pearson, R. C. Bast, and A. Berchuck (1991), Cancer Res. 51, 2979 2984.Google Scholar
  120. Marks, J. R., P. A. Humphrey, K. Wu, D. Beary, B.-J. M. Kerns, and J. D. Iglehart (1994), Ann. Surg. 219, 332–341.PubMedGoogle Scholar
  121. Martin, H. M., M. I. Filipe, R. W. Morris, D. P. Lane, and F. Silvestre (1992), Int. J. Cancer 50, 859–862.PubMedGoogle Scholar
  122. Mashal, R., M. Shtalrid, M. Talpaz, H. Kantarjian, L. Smith, M. Beran, A. Cork, J. Trujillo, J. Gutterman, and A. Deisseroth (1990), Blood 75, 180–183.PubMedGoogle Scholar
  123. Mashiyama, S., Y. Murakami, T. Yoshimoto, T. Sekiya, and K. Hayashi (1991), Oncogene 6, 1313–1318.PubMedGoogle Scholar
  124. May, E., J. R. Jenkins, and P. May (1991), Oncogene 6, 1363–1365.PubMedGoogle Scholar
  125. Mayall, F. G., H. Goddard, and A. R. Gibbs (1992), J. Pathol. 168, 377–381.PubMedGoogle Scholar
  126. Meek, D. W., S. Simon, U. Kikkawa, and W. Eckhart (1990), EMBO J. 9, 3253–3260.PubMedGoogle Scholar
  127. Mercer, W. E. and R. Baserga (1985), Exp. Cell Res. 160, 31–46.PubMedGoogle Scholar
  128. Mercer, W. E., M. T. Shields, D. Lin, E. Appella, and S. J. Ullrich (1991), Proc. Natl. Acad. Sci. USA 88, 1958–1962.PubMedGoogle Scholar
  129. Mercer, W. E., M. T. Shields, M. Amin, G. J. Sauve, E. Appella, J. W. Romano, and S. J. Ullrich (1990), Proc. Natl. Acad. Sci. USA 87, 6166–6170.PubMedGoogle Scholar
  130. Michalovitz, D., D. Eliyahu, and M. Oren (1986), Mol. Cell Biol. 6, 3531–3536.PubMedGoogle Scholar
  131. Miller, C. W., K. Simon, A. Aslo, K. Kok, J. Yokota, C. H. Buys, M. Terada, and H. P. Koeffler (1992), Cancer Res. 52, 1695–1698.PubMedGoogle Scholar
  132. Milner, J., and E. A. Medcalf (1991), Cell 65, 765–774.PubMedGoogle Scholar
  133. Milner, J., A. Cook, and J. Mason (1990), EMBO J. 9, 2885–2889.PubMedGoogle Scholar
  134. Milner, J., E. A. Medcalf, and A. C. Cook (1991), Mol. Cell Biol. 11, 12–19.PubMedGoogle Scholar
  135. Moll, U. M., G. Riou, and A. J. Levine (1992), Proc. Natl. Acad. Sci. USA 89, 7262–7266.PubMedGoogle Scholar
  136. Momand, J., G. P. Zambetti, D. C. Olson, D. George, and A. J. Levine (1992), Cell 69, 1237–1245.PubMedGoogle Scholar
  137. Montenarh, M., M. Kohler, and R. Henning (1986), J. Virol. 60, 761–764.PubMedGoogle Scholar
  138. Mulligan, L. M., G. J. Matlashewski, H. J. Scrable, and W. K. Cavenee (1990), Proc. Natl. Acad. Sci. USA 87, 5863–5867.PubMedGoogle Scholar
  139. Murakami, Y., K. Hayashi, and T. Sekiya (1991), Cancer Res. 51, 3356–3361.PubMedGoogle Scholar
  140. Nelson, W. G. and M. B. Kastan (1994), Mol. Cell Biol. 14, 1815–1823.PubMedGoogle Scholar
  141. Nigro, J. M., S. J. Baker, A. C. Preisinger, J. M. Jessup, R. Hostetter, K. Cleary, S. H. Bigner, N. Davidson, S. Baylin, P. Devilee, T. Glover, F. S. Collins, A. Weston, R. Modali, C. C. Harris, and B. Vogelstein (1989), Nature 342, 705–708.PubMedGoogle Scholar
  142. Nishida, N., Y. Fukuda, H. Kokuryu, J. Toguchida, D. W. Yandell, M. Ikenega, H. Imura, and K. Ishizaki (1993), Cancer Res. 53, 368–372.PubMedGoogle Scholar
  143. Oda, T., H. Tsuda, A. Scarpa, M. Sakamoto, and S. Hirohashi (1992a), Cancer Res. 52, 3674–3678.PubMedGoogle Scholar
  144. Oda, T., H. Tsuda, A. Scarpa, M. Sakamoto, and S. Hirohashi (1992b), Cancer Res. 52, 6358–6364.PubMedGoogle Scholar
  145. Oka, K., J. Ishikawa, J. M. Bruner, R. Takahashi, and H. Saya (1991), Mol. Carcinog. 4, 10–13.PubMedGoogle Scholar
  146. Okamoto, A., Y. Sameshima, Y. Yamada, S. Teshima, Y. Terashima, M. Terada, and J. Yokota (1991a), Cancer Res. 51, 5632–5636.PubMedGoogle Scholar
  147. Okamoto, A., Y. Sameshima, S. Yokoyama, Y. Terashima, T. Sugimura, M. Terada, and J. Yokota (1991b), Cancer Res. 51, 5171–5176.PubMedGoogle Scholar
  148. Oliner, J. D., K. W. Kinzler, P. S. Meltzer, D. L. George, and B. Vogelstein (1992), Nature 358, 80–83.PubMedGoogle Scholar
  149. Ozturk, M. (1991), Lancet 338, 1356–1359.PubMedGoogle Scholar
  150. Parada, L. F., H. Land, R. A. Weinberg, D. Wolf, and V. Rotter (1984), Nature 312, 649–651.PubMedGoogle Scholar
  151. Perutz, M. F. (1990), J. Mol. Biol. 213, 203–206.PubMedGoogle Scholar
  152. Pinhasi-Kimhi, O., D. Michalovitz, A. Ben Zeev, and M. Oren (1986), Nature 320, 182–184.PubMedGoogle Scholar
  153. Quinlan, D. C., A. G. Davidson, C. L. Summers, H. E. Warden, and H. M. Doshi (1992), Cancer Res. 52, 4828–4831.PubMedGoogle Scholar
  154. Raycroft, L., H. Y. Wu, and G. Lozano (1990), Science 249, 1049–1051.PubMedGoogle Scholar
  155. Reich, N. C. and A. J. Levine (1984), Nature 308, 199–201.PubMedGoogle Scholar
  156. Reich, N. C., M. Oren, and A. J. Levine (1983), Mol. Cell Biol. 3, 2143–2150.PubMedGoogle Scholar
  157. Reihsaus, E., M. Kohler, S. Kraiss, M. Oren, and M. Montenarh (1990), Oncogene 5, 137–145.PubMedGoogle Scholar
  158. Rodrigues, N. R., A. Rowan, M. E. Smith, I. B. Kerr, W. F. Bodmer, J. V. Gannon, and D. P. Lane (1990), Proc. Natl. Acad. Sci. USA 87, 7555–7559.PubMedGoogle Scholar
  159. Rogel, A., M. Popliker, C. G. Webb, and M. Oren (1985), Mol. Cell Biol. 5, 2851–2855.PubMedGoogle Scholar
  160. Ruggeri, B., S. Y. Zhang, J. Caamano, M. DiRado, S. D. Flynn, and A. J. Klein Szanto (1992), Oncogene7,1503–1511.PubMedGoogle Scholar
  161. Said, J. W., R. Barrera, I. P. Shintaku, H. Nakamura, and H. P. Koeffler (1992), Am. J. Pathol. 141, 1343–1348.Google Scholar
  162. Sakashita, A., T. Hattori, C. W. Miller, H. Suzushima, N. Asou, K. Takatsuki, and H. P. Koeffler (1992), Blood 79, 477–480.PubMedGoogle Scholar
  163. Sameshima, Y., T. Akiyama, N. Mori, H. Mizoguchi, K. Toyoshima, T. Sugimura, M. Terada, and J. Yokota (1990), Biochem. Biophys. Res. Commun. 173, 697–703.PubMedGoogle Scholar
  164. Sameshima, Y., Y. Matsuno, S. Hirohashi, Y. Shimosato, H. Mizoguchi, T. Sugimura, M. Terada, and J. Yokota (1992), Oncogene 7, 451–457.PubMedGoogle Scholar
  165. Santhanam, U., A. Ray, and P. B. Sehgal (1991), Proc. Natl. Acad. Sci. USA 88, 7605–7605.PubMedGoogle Scholar
  166. Sarkis, A. S., G. Dalbagni, C. Cordon Cardo, Z. F. Zhang, J. Sheinfeld, W. R. Fair, H. W. Herr, and V. E. Reuter (1993), J. Natl. Cancer Inst. 85, 53–59.PubMedGoogle Scholar
  167. Sarnow, P., Y. S. Ho, J. Williams, and A. J. Levine (1982), Cell 28, 387–394.PubMedGoogle Scholar
  168. Sato, T., A. Tanigami, K. Yamakawa, F. Akiyama, F. Kasumi, G. Sakamoto, and Y. Nakamura (1990), Cancer Res. 50, 7184–7189.PubMedGoogle Scholar
  169. Scheffner, M., B. A. Werness, J. M. Huibregtse, A. J. Levine, and P. M. Howley (1990), Cell 63, 1129–1136.PubMedGoogle Scholar
  170. Schlichtholz, B., Y. Legros, D. Gillet, C. Gaillard, M. Marty, D. Lane, F. Calvo, and T. Soussi (1992), Cancer Res. 52, 6380–6384.PubMedGoogle Scholar
  171. Schmieg, F. I. and D. T. Simmons (1984), J. Virol. 52, 350–355.PubMedGoogle Scholar
  172. Scorsone, K. A., Y-Z. Zhou, J. S. Butel, and B. L. Slagle (1992), Cancer Res. 52, 1635–1638.PubMedGoogle Scholar
  173. Scott, N., P. Sagar, J. Stewart, G. E. Blair, M. F. Dixon, and P. Quirke (1991), Br. J. Cancer 63, 317–319.PubMedGoogle Scholar
  174. Seto, E., A. Usheva, G. P. Zambetti, J. Momand, N. Horikoshi, R. Weinmann, A. J. Levine, and T. Shenk (1992), Proc. Natl. Acad. Sci. USA 89, 12,028–12,032.Google Scholar
  175. Shaulsky, G., A. Ben Zeev, and V. Rotter (1990a), Oncogene 5, 1707–1711.PubMedGoogle Scholar
  176. Shaulsky, G., N. Goldfinger, A. Ben Zeev, and V. Rotter (1990b), Mol. Cell Biol. 10, 6565–6579.PubMedGoogle Scholar
  177. Shaulsky, G., N. Goldfinger, and V. Rotter (1991), Cancer Res. 51, 5232–5237.PubMedGoogle Scholar
  178. Shea, C. R., N. S. McNutt, M. Volkenandt, J. Lugo, P. G. Prioleau, and A. P. Albino (1992), Am. J. Pathol. 141, 25–29.Google Scholar
  179. Sheu, J. C., G. T. Huang, P. H. Lee, J. C. Chung, H. C. Chou, M. Y. Lai, J. T. Wang, H. S. Lee, L. N. Shih, and P. M. Yang (1992), Cancer Res. 52, 6098–6100.PubMedGoogle Scholar
  180. Shiio, Y., T. Yamamoto, and N. Yamaguchi (1992), Proc. Natl. Acad. Sci. USA 89, 5206–5210.PubMedGoogle Scholar
  181. Sidransky, D., A. von Eschenbach, Y. C. Tsai, P. Jones, I. Summerhayes, F. Marshall, M. Paul, P. Green, S. R. Hamilton, and P. Frost (1991), Science 252, 706–709.PubMedGoogle Scholar
  182. Slagle, B. L., Y. Z. Zhou, and J. S. Butel (1991), Cancer Res. 51, 49–54.PubMedGoogle Scholar
  183. Slingerland, J. M., J. R. Jenkins, and S. Benchimol (1993), EMBO J. 12, 1029–1037.PubMedGoogle Scholar
  184. Soini, Y., P. Paakko, M. Alavaikko, and K. Vahakangas (1992a), J. Clin. Pathol. 45, 1011–1014.PubMedGoogle Scholar
  185. Soini, Y., K. Vahakangas, K. Nuorva, D. Kamel, D. P. Lane, and P. Paakko (1992b), J. Pathol. 168, 29–33.PubMedGoogle Scholar
  186. Sommer, S. S., J. Cunningham, S. Saitoh, J. J. Schroeder, L. E. Wold, and J. S. Kovach (1992), J. Natl. Cancer Inst. 84, 246–252.PubMedGoogle Scholar
  187. Sompayrac, L. M., E. G. Gurney, and K. J. Danna (1983), Mol. Cell Biol. 3, 290–296.PubMedGoogle Scholar
  188. Soussi, T., C. Caron de Fromentel, M. Mechali, P. May, and M. Kress (1987), Oncogene 1, 71–78.PubMedGoogle Scholar
  189. Srivastava, S., Z. Q. Zou, K. Pirollo, W. Blattner, and E. H. Chang (1990), Nature 348, 747–749.PubMedGoogle Scholar
  190. Steinmeyer, K., H. Maacke, and W. Deppert (1990), Oncogene 5, 1691–1699.PubMedGoogle Scholar
  191. Stephenson, T. J., J. Royds, P. B. Silcocks, and S. S. Bleehen (1992), Br. l. Dermatol. 127, 566–570.Google Scholar
  192. Stratton, M. R., S. Moss, W. Warren, H. Patterson, J. Clark, C. Fisher, C. D. Fletcher, A. Ball, M. Thomas, and B. A. Gusterson (1990), Oncogene 5, 1297–1301.PubMedGoogle Scholar
  193. Stretch, J. R., K. C. Gatter, E. Ralfkiaer, D. P. Lane, and A. L. Harris (1991), Cancer Res. 51, 5976–5979.PubMedGoogle Scholar
  194. Strong, L. C. (1977), Cancer 40, 438–444.PubMedGoogle Scholar
  195. Suzuki, H., T. Takahashi, T. Kuroishi, M. Suyama, Y. Ariyoshi, and R. Ueda (1992), Cancer Res. 52, 734–736.PubMedGoogle Scholar
  196. Suzuki, Y., G. Tamura, R. Satodate, and T. Fujioka (1992), Jpn. J. Cancer Res. 83, 233–235.PubMedGoogle Scholar
  197. Sved, J. and A. Bird (1990), Proc. Natl. Acad. Sci. USA 87, 4692–4698.PubMedGoogle Scholar
  198. Takahashi, T., D. DAmico, I. Chiba, D. L. Buchhagen, and J. D. Minna (1990), J. Clin. Invest. 86, 363–369.PubMedGoogle Scholar
  199. Takahashi, T., M. M. Nau, I. Chiba, M. J. Birrer, R. K. Rosenberg, M. Vinocour, M. Levitt, H. Pass, A. F. Gazdar, and J. D. Minna (1989), Science 246, 491–494.PubMedGoogle Scholar
  200. Takahashi, T., H. Suzuki, T. Hida, Y. Sekido, Y. Ariyoshi, and R. Ueda (1991), Oncogene 6, 1775–1778.PubMedGoogle Scholar
  201. Tamura, G., C. Maesawa, Y. Suzuki, R. Satodate, K. Ishida, and K. Saito (1992), Jpn. J. Cancer Res. 83, 559–562.PubMedGoogle Scholar
  202. Thompson, A. M., T. J. Anderson, A. Condie, J. Prosser, U. Chetty, D. C. Carter, H. J. Evans, and C. M. Steel (1992), Int. l. Cancer 50, 528–532.Google Scholar
  203. Thompson, A. M., C. M. Steel, U. Chetty, R. A. Hawkins, W. R. Miller, D. C. Carter, A. P. Forrest, and H. J. Evans (1990), Br. J. Cancer 61, 74–78.PubMedGoogle Scholar
  204. Thor, A. D., D. H. Moore, S. M. Edgerton, E. S. Kawasaki, E. Reishaus, H. T. Lynch, J. N. Marcus, L. Schwartz, L-C. Chen, B. H. Mayall, and H. S. Smith (1992), J. Natl. Cancer Inst. 84, 845–855.PubMedGoogle Scholar
  205. Toguchida, J., T. Yamaguchi, S. H. Dayton, R. L. Beauchamp, G. E. Herrera, K. Ichizaki, T. Yamamuro, P. A. Meyers, J. B. Little, M. S. Sasaki, R. R. Weichselbaum, and D. W. Yandell (1992a), N. Engl. J. Med. 326, 1301–1308.PubMedGoogle Scholar
  206. Toguchida, J., T. Yamaguchi, B. Ritchie, R. L. Beauchamp, S. H. Dayton, G. E. Herrera, T. Yamamuro, Y. Kotoura, M. S. Sasaki, and J. B. Little (1992b), Cancer Res. 52, 6194–6199.PubMedGoogle Scholar
  207. Uchino, S., M. Noguchi, T. Hirota, M. Itabashi, T. Saito, M. Kobayashi, and S. Hirohashi (1992), Jpn. J. Clin. Oncol. 22, 225–231.PubMedGoogle Scholar
  208. Ueda, Y., B. Dockhorn Dworniczak, S. Blasius, W. Mellin, P. Wuisman, W. Bocker, and A. Roessner (1993), J. Cancer Res. Clin. Oncol. 119, 172–178.PubMedGoogle Scholar
  209. Urano, Y., H. Oura, A. Sakaki, H. Nagae, K. Matsumoto, K. Fukuhara, T. Nagae, S. Arase, Y. Ninomiya, and H. Nakanishi (1992), J. Dermatol. Sci. 4, 69–75.PubMedGoogle Scholar
  210. van den Berg, F. M., A. J. Tigges, M. E. Schipper, F. C. den Hartog Jager, W. G. Kroes, and J. M. Walboomers (1989), J. Pathol. 157, 193–199.PubMedGoogle Scholar
  211. Varley, J. M., W. J. Brammar, D. P. Lane, J. E. Swallow, C. Dolan, and R. A. Walker (1991), Oncogene 6, 413–421.PubMedGoogle Scholar
  212. Villuendas, R., M. A. Piris, J. L. Orradre, M. Mollejo, P. Algara, L. Sanchez, J. C. Martinez, and P. Martinez (1992), J. Pathol. 166, 235–241.PubMedGoogle Scholar
  213. Visakorpi, T., O. P. Kallioniemi, A. Heikkinen, T. Koivula, and J. Isola (1992), J. Natl. Cancer Inst. 84, 883–887.PubMedGoogle Scholar
  214. Vogelstein, B., E. R. Fearon, S. R. Hamilton, S. E. Kern, A. C. Preisinger, M. Leppert, Y. Nakamura, R. White, A. M. Smits, and J. L. Bos (1988), N. Engl. J. Med. 319, 525–532.PubMedGoogle Scholar
  215. Wang, E. H., P. N. Friedman, and C. Prives (1989), Cell 57, 379–392.PubMedGoogle Scholar
  216. Wang, N. P., H. To, W. H. Lee, and E. Y.-H. P. Lee (1993), Oncogene 8, 279–288.PubMedGoogle Scholar
  217. Watling, D. L., A. M. Gown, and M. D. Coltrera (1992), Head Neck 14, 437–444.PubMedGoogle Scholar
  218. Weintraub, H., S. Hauschka, and S. J. Tapscott (1991), Proc. Natl. Acad. Sci. USA 88, 4570–4571.PubMedGoogle Scholar
  219. Werness, B. A., A. J. Levine, and P. M. Howley (1990), Science 248, 76–79.PubMedGoogle Scholar
  220. Winter, S. F., J. D. Minna, B. E. Johnson, T. Takahashi, A. F. Gazdar, and D. P. Carbone (1992), Cancer Res. 52, 4168–4171.PubMedGoogle Scholar
  221. Xiong, Y., H. Zhang, and D. D. Beach (1992), Cell 71, 505–514.PubMedGoogle Scholar
  222. Yamaguchi, A., Y. Kurosaka, S. Fushida, M. Kanno, Y. Yonemura, K. Miwa, and I. Miyazaki (1992), Cancer 70, 2778–2784.PubMedGoogle Scholar
  223. Yew, P. R., and A. J. Berk (1992), Nature 357, 82–85.PubMedGoogle Scholar
  224. Yewdell, J. W., J. V. Gannon, and D. P. Lane (1986), J. Virol. 59, 444–452.PubMedGoogle Scholar
  225. Yin, Y., M. A. Tainsky, F. Z. Bischoff, L. C. Strong, and G. M. Wahl (1992), Cell 70, 937–948.PubMedGoogle Scholar
  226. Yoshimoto, K., H. Iwahana, A. Fukuda, T. Sano, S. Saito, and M. Itakura (1992), Cancer Res. 52, 5061–5064.PubMedGoogle Scholar
  227. Zhan, Q., F. Carrier, and A. J. Fornace, Jr. (1993) Mol. Cell Biol. 13, 4242–4250.PubMedGoogle Scholar

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© Springer Science+Business Media New York 1995

Authors and Affiliations

  • Jeffrey R. Marks
  • Andrew M. Davidoff
  • J. Dirk Iglehart

There are no affiliations available

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