P-Glycoproteins in Tumors

  • William T. Bellamy
  • Thomas M. Grogan
  • Ronald S. Weinstein
Part of the Contemporary Biomedicine book series (CB, volume 12)


Chemotherapy, in specific clinical settings, is an effective modality of cancer therapy. For example, progress has been made in the treatment of Hodgkin’s disease, large-cell lymphoma, acute lymphocytic leukemia, and testicular cancer to the point that these entities are now considered to be “curable.” In addition, with the development of combination chemotherapy, other malignancies, such as ovarian cancer, small-cell lung cancer, and advanced breast cancer, although not yet curable, demonstrate meaningful clinical responses to therapy in many patients (Chabner et al., 1984). Unfortunately, when a relapse occurs, it is often associated with the development of drug-resistant tumors. This limits additional response to chemotherapy.


Acute Lymphocytic Leukemia Testicular Cancer Vinca Alkaloid RNase Protection Assay Murine Leukemia Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Arceci, R. J., J. M. Croop, S. B. Horwitz, and D. Housman (1988), Proc. Natl. Acad. Sci. USA 85, 4350–4354.PubMedCrossRefGoogle Scholar
  2. Arceci, R. J., K. Stieglitz, J. Bras, A. Schinkel, F. Baas, and J. Croop (1993), Cancer Res. 53, 310–317.PubMedGoogle Scholar
  3. Arias, I. M. (1990) Hepatology 12, 159–165.PubMedCrossRefGoogle Scholar
  4. Beck, W. and M. Cirtain (1982), Cancer Res. 42, 184–186.PubMedGoogle Scholar
  5. Bellamy, W. T., W. S. Dalton, and R. T. Dorr (1990), Cancer Invest. 8, 545–560.CrossRefGoogle Scholar
  6. Bellamy, W. T., A. Odeleye, P. Finley, E. Huizenga, W. S. Dalton, R. S. Weinstein, and T. M. Grogan (1993), Am. J. Pathol. 142, 691–698.PubMedGoogle Scholar
  7. Bonadonna, G., P. Valagussa and A. Santoro (1986), Ann. Inter. Med. 104, 739–746.Google Scholar
  8. Boscoboinik, D., M. Debane, A. Stafford, C. Jung, R. Gupta, and R. Epand (1990), Biochemica et Biophysica Acta 1027, 225–228.CrossRefGoogle Scholar
  9. Callen, D. F., E. Baker, R. N. Simmers, R. Seshadri, and I. B. Roninson (1987), Human Genet. 77, 142–144.CrossRefGoogle Scholar
  10. Chabner, B. A. and A. Fojo (1989), J. Natl. Cancer Inst. 81, 910–913.PubMedCrossRefGoogle Scholar
  11. Chabner, B. A., R. Fine, C. Allegra, G. Yeh, and G. Curt (1984), Cancer 54, 2599–2608.PubMedCrossRefGoogle Scholar
  12. Chan, H. S. L., P. Thonier, G. Haddad, and V. Ling (1990), J. Clin. Oncol. 8, 689–704.PubMedGoogle Scholar
  13. Chaudhary, P. M. and I. B. Roninson (1991), Cell 66, 85–94.PubMedCrossRefGoogle Scholar
  14. Chaudhary, P. M., E. B. Mechetner, and I. B. Roninson (1992), Blood 80, 2735–2739.PubMedGoogle Scholar
  15. Chin, J. E., R. Soffir, K. E. Noonan, K. Choi, and I. B. Roninson (1989), Mol. Cell. Biol. 9, 3808–3820.PubMedGoogle Scholar
  16. Chin, K.-V., I. Pastan, and M. M. Gottesman (1993), Adv. Cancer Res. 60, 157–180.PubMedCrossRefGoogle Scholar
  17. Choi, K., C.-J. Chen, M. Kriegler, and I. B. Roninson (1988), Cell 53, 519–529.PubMedCrossRefGoogle Scholar
  18. Cole, S., G. Bhardwaj, J. H. Gerlach, J. Mackie, C. Grant, K. Almquist, A. Stewart, A. Duncan, and R. Deeley (1992), Science 258, 1650–1654.PubMedCrossRefGoogle Scholar
  19. Cordon-Cardo, C., J. P. O’Brien, J. Boccia, D. Casals, J. R. Bertino, and M. R. Melamed (1990) J. Histochem. Cytochem. 38, 1277–1287.PubMedCrossRefGoogle Scholar
  20. Cordon-Cardo, C., J. P. O’Brien, D. Casals, L. Rittman-Grauer, J. Biedler, M. Melamed, and J. Bertino (1989), Proc. Natl. Acad. Sci. USA 86, 695–698.PubMedCrossRefGoogle Scholar
  21. Dalton, W. S., T. M. Grogan, P. S. Meltzer, R. Scheper, B. G. M. Dune, C. Taylor, T. Miller, and S. Salmon (1989), J. Clin. Oncol. 7, 415–424.PubMedGoogle Scholar
  22. Decker, D. A., L. W. Morris, A. J. Levine, J. E. Pettinga, J. L. Grudzien, and D. H. Farkas (1993) Laboratory Med. 24, 574–578.Google Scholar
  23. DeVita, V., A. Serpick, and P. Carbone (1970), Ann. Inter. Med. 73, 881–895.Google Scholar
  24. Endicott, J. A. and V. Ling (1989) Annu. Rev. Biochem. 58, 137–171.PubMedCrossRefGoogle Scholar
  25. Fitzgerald, D., M. Willingham, C. Carderelli, H. Hamada, T. Tsuruo, M. M. Gottesman, and I. Pastan (1987), Proc. Natl. Acad. Sci. USA 84, 4288–4297.PubMedCrossRefGoogle Scholar
  26. Fojo, A. T., K. Ueda, and W. Slaman (1987), Proc. Natl. Acad. Sci. USA 84, 265–269.PubMedCrossRefGoogle Scholar
  27. Fojo, A. T., C. H. Herzog, L. Mickley, E. D. Murphy, G.-M. Lai, and S. E. Bates (1992) in Drug Resistance as a Biochemical Target of Chemotherapy (Tsuruo, T. and M. Ogawa, eds.), Academic, San Diego, pp. 179–192.Google Scholar
  28. Foote, S. J., J. K. Thompson, A. F. Cowman, and D. Kemp (1989), Cell 57, 921–930.PubMedCrossRefGoogle Scholar
  29. Futscher, B., L. L. Blake, J. H. Gerlach, T. M. Grogan, and W. S. Dalton (1993), Anal. Biochem. 213, 414–421.PubMedCrossRefGoogle Scholar
  30. Gerlach, J. H., N. Kartner, D. R. Bell, and V. Ling (1986a), Cancer Surv. 5, 25–46.PubMedGoogle Scholar
  31. Gerlach, J. H., J. A. Endicott, P. F. Juranka, G. Henderson, F. Sarang, K. Deuchars, and V. Ling (1986b), Nature 324, 485–489.PubMedCrossRefGoogle Scholar
  32. Gerlach, H. H., D. R. Bell, C. Karakousis, H. Slocum, N. Kartner, Y. Rustum, V. Ling, and R. Baker (1987), J. Clin. Oncol. 5, 1452–1460.PubMedGoogle Scholar
  33. Goldie, J. and A. Coldman (1984), Cancer Res. 44, 3643–3653.PubMedGoogle Scholar
  34. Goldstein, L. J., H. Galski, A. Fojo, M. Willingham, S. Lai, A. Gazdar, R. Pirker, A. Green, W. Cist, G. Brodeur, M. Lieber, J. Cossman, M. M. Gottesman, and I. Pastan (1989), J. Natl. Cancer Inst. 81, 116–124.PubMedCrossRefGoogle Scholar
  35. Gottesman, M. M. (1993), Cancer Res. 53, 747–754.PubMedGoogle Scholar
  36. Gottesman, M. M., L. J. Goldstein, E. Bruggemann, S. Currier, H. Galski, C. Cardarelli, F. Thiebaut, M. Willingham, and I. Pastan (1989), in Cancer Cells, vol. 7 (Furth M. and M. Greaves, eds.), Cold Spring Harbor, New York, pp. 75–80.Google Scholar
  37. Greenberger, L. M., S. S. Williams, and S. B. Horwitz (1987), J. Biol. Chem. 262, 13685–13689.PubMedGoogle Scholar
  38. Grogan, T. M., C. M. Spier, S. Salmon, M. Matzner, J. Rybski, R. S. Weinstein, R. Scheper, and W. S. Dalton (1993), Blood 81, 490–495.PubMedGoogle Scholar
  39. Grogan, T. M., W. S. Dalton, J. Rybski, C. M. Spier, P. Meltzer, L. Richter, M. Gleason, J. Pindur, A. Cline, R. Scheper, T. Tsuruo, and S. Salmon (1990), Lab. Invest. 63, 815–824.PubMedGoogle Scholar
  40. Gros, P. and E. Buschman (1993), Int. Rev. Cytology 137c, 169–197.CrossRefGoogle Scholar
  41. Gros, P., J. Croop, and D. Housman (1986), Cell 46, 371–380.CrossRefGoogle Scholar
  42. Guild, B., R. Mulligan, P. Gros, and D. Housman (1988), Proc. Natl. Acad. Sci. USA 85, 1595–1599.PubMedCrossRefGoogle Scholar
  43. Holmes, J., A. Jacobs, G. Carter, A. Janoswska-Wieczorek, and R. Padua (1989), Br. J. Haematol. 72, 40–44.PubMedCrossRefGoogle Scholar
  44. Horton, J., K. Thimmaiah, J. Houghton, M. Horowitz, and P. Houghton (1989), Biochem. Pharmacol. 38, 1727–1736.PubMedCrossRefGoogle Scholar
  45. Hu, X., T. Martin, D. Bell, M. Luise, and J. Zalcberg (1990), Cancer Res. 50, 2953–2957.PubMedGoogle Scholar
  46. Ito, Y., M. Tanimoto, T. Kumazawa, M. Okumura, Y. Morishima, R. Ohno, and S. Hidehiko (1989), Cancer 63, 1534–1538.PubMedCrossRefGoogle Scholar
  47. Juliano, R. L. and V. Ling (1976), Biochim. Biophys. Acta 455, 152–162.PubMedCrossRefGoogle Scholar
  48. Juranka, P. F., R. L. Zastawny, and V. Ling (1989), FASEB J. 3, 2583–2592.PubMedGoogle Scholar
  49. Kakehi, Y., H. Kanamaru, O. Yoshida, H. Ohkubo, S. Nakanishi, M. M. Gottesman, and I. Pastan (1988), J. Urol. 139, 862–865.PubMedGoogle Scholar
  50. Kanamaru, H. H., Y. Kakehi, O. Yoshida, S. Nakanishi, I. Pastan, and M. M. Gottesman (1989), J. Natl. Cancer Inst. 81, 844–849.PubMedCrossRefGoogle Scholar
  51. Kane, S. E. and M. M. Gottesman (1989), Cancer Cells 1, 33–36.PubMedGoogle Scholar
  52. Kaye, S. B. (1993), Br. J. Cancer 67, 641–643.PubMedCrossRefGoogle Scholar
  53. Kessel, D., V. Botterill, and I. Wodinsky (1968), Cancer Res. 28, 938–941.PubMedGoogle Scholar
  54. Lum, B. L., S. Kaubisch, A. M. Yahanda, K. M. Adler, L. Jew, M. N. Ehsan, N. A. Brophy, J. Halsey, M. P. Gosland, and B. I. Sikic (1992), J. Clin. Oncol. 10, 1635–1642.PubMedGoogle Scholar
  55. Ma, D., R. Davey, D. Harman, J. Isbister, R. Schurr, S. Mackertich, C. Dowden, and D. Bell (1987), Lancet 1, 135–137.PubMedCrossRefGoogle Scholar
  56. Marie, J., R. Zittoun, and B. Sikic (1991), Blood 78, 586–592.PubMedGoogle Scholar
  57. Marie, J., N. Brophy, M. Ehsan, Y. Aihara, N. Mohamed, J. Cornbleet, N. Chao, and B. Sikic (1992), Br. J. Haematol. 81, 145–152.PubMedCrossRefGoogle Scholar
  58. McLachlin, J., M. Eglitis, K. Ueda, P. Kantoff, I. Pastan, W. F. Anderson, and M. M. Gottesman (1990), J. Natl. Cancer Inst. 82, 1260–1263.PubMedCrossRefGoogle Scholar
  59. Mechetner, E. B. and I. B. Roninson (1992), Proc. Natl. Acad. Sci. USA 89, 5824–5828.Google Scholar
  60. Mickisch, G., G. Merlino, H. Galski, M. M. Gottesman, and I. Pastan (1991), Proc. Natl. Acad. Sci. USA 88, 547–551.PubMedCrossRefGoogle Scholar
  61. Miller, T. P., T. M. Grogan, W. S. Dalton, C. Spier, R. Scheper, and S. Salmon (1991), J. Clin. Oncol. 9, 17–24.PubMedGoogle Scholar
  62. Murphy, L. D., C. E. Herzog, J. B. Rudick, A. Fojo, and S. Bates (1990), Biochemistry 29, 10, 351–10, 356.Google Scholar
  63. Nielsen, D. and T. Skovsgaard (1992), Biochim. Biophys. Acta 1139, 169–183.PubMedCrossRefGoogle Scholar
  64. Noonan, K. E., C. Beck, T. A. Holzmayer, J. Chin, J. Wunder, I. Andrulis, A. Gazdar, C. Willma, B. Griffith, D. Von Hoff, and I. B. Roninson (1990), Proc. Natl. Acad. Sci. USA 87, 7160–7164.PubMedCrossRefGoogle Scholar
  65. Pastan, I. and M. M. Gottesman (1987), N. Engl. J. Med. 316, 1388–1393.PubMedCrossRefGoogle Scholar
  66. Pirker, R., L. Goldstein, H. Ludwig, W. Linkesch, C. Lechner, M. M. Gottesman, and I. Pastan (1989), Cancer Commun. 1, 141–144.PubMedGoogle Scholar
  67. Qian, X.-D. and W. T. Beck (1990), J. Biol. Chem. 265 18,753–18,756.Google Scholar
  68. Roninson, I. B., I. Pastan, and M. M. Gottesman (1991), in Molecular and Cellular Biology of Multidrug Resistance in Tumor Cells (Roninson, I. B., ed.), Plenum, New York, pp. 91–106.CrossRefGoogle Scholar
  69. Roninson, I. B., K. E. Noonan, K. Choi, B. S. Morse, C.-J. Chen, J. Chin, R. Kaplan-Stern, and A. R. Safa (1992), in Drug Resistance as a Biochemical Target in Cancer Chemotherapy (Tsuruo, T. and M. Ogawa, eds.), Academic, San Diego, pp. 27–44.Google Scholar
  70. Roninson, I. B., M. Patel, I. Lee, K. Noonan, C. Chen, K. Choi, J. Chin, R. Kaplan, and T. Tsuruo (1989), in Cancer Cells, vol. 7 (Furth M. and M. Greaves, eds.), Cold Spring Harbor, NY, pp. 81–86.Google Scholar
  71. Rothenberg, M. and V. Ling (1989), J. Natl. Cancer Inst. 81, 907–910.PubMedCrossRefGoogle Scholar
  72. Salmon, S. E., T. M. Grogan, T. Miller, R. Scheper, and W. S. Dalton (1989), J. Natl. Cancer Inst. 81, 679–701.CrossRefGoogle Scholar
  73. Shen, D.-W., I. Pastan, and M. M. Gottesman (1988), Cancer Res. 48, 4334–4339.PubMedGoogle Scholar
  74. Sonneveld, P., B. G. M. Dude, H. Lokhorst, J.-P Marie, G. Solbu, S. Suciu, R. Zittoun, R. Lowenberg, and K. Nooter (1992), Lancet 340, 255–259.PubMedCrossRefGoogle Scholar
  75. Sugawara, I., M. Nakahama, H. Hamada, T. Tsuruo, S. Itoyama, and S. Mori (1988), Cancer Res. 48, 1926–1929.PubMedGoogle Scholar
  76. Tatsuta, T., M. Naito, T. Ohara, I. Sugawara, and T. Tsuruo (1992), J. Biol. Chem. 267 20,383–20,391.Google Scholar
  77. Thiebaut, F., T. Tsuruo, H. Hamada, M. M. Gottesman, I. Pastan, and M. Willingham (1989), J. Histochem. Cytochem. 37, 159–164.PubMedCrossRefGoogle Scholar
  78. Tsuji, A., T. Terasaki, Y. Takabatalke, Y. Tenda, I. Tamai, T. Yamashima, S. Moritani, T. Tsuruo, and J. Yamashita (1992), Life Sci. 51, 1427–1437.PubMedCrossRefGoogle Scholar
  79. Tsuruo, T., H. Iida, S. Tsukagoshi, and Y. Sakuri (1981), Cancer Res. 41, 1967–1972.PubMedGoogle Scholar
  80. Tsuruo, T., H. Iida, S. Tsukagoshi, and Y. Sakuri (1982), Cancer Res. 42, 4730–4733.PubMedGoogle Scholar
  81. Tsuruo, T., H. Hamada, S. Sato, and Y. Heike (1989), Jpn. J. Cancer Res. 80, 627–631.PubMedCrossRefGoogle Scholar
  82. Ueda, K., C. Carderelli, M. M. Gottesman, and I. Pastan (1987), Proc. Natl. Acad. Sci. USA 84, 3004–3008.PubMedCrossRefGoogle Scholar
  83. Ueda, K., N. Okamura, M. Hirai, Y. Tanigawara, T. Saeki, N. Kioka, T. Komano, R. Hori (1992), J. Biol. Chem. 267, 24248–24252.PubMedGoogle Scholar
  84. Valverde, M. A., M. Diaz, F. V. Sepulveda, D. R. Gill, E. C. Hyde, and C. F. Higgins (1992), Nature 355, 830–833.Google Scholar
  85. Van der Bliek, A. M., P. M. Kooiman, C. Schneider, and P. Borst (1988), Gene 71, 404–411.Google Scholar
  86. Van der Bliek, A. M., F. Baas, T. Ten Houte de Lange, P. Kooiman, T. Van der VeldeKoerts, and P. Borst (1987), Eur. Mol. Biol. J. 6, 3325–3331.Google Scholar
  87. Weinstein, R. S., J. R. Kuszak, L. F. Kluskens, and J. S. Coon (1990), Human Pathol. 21, 34–48.CrossRefGoogle Scholar
  88. Weinstein, R. S., S. M. Jakate, J. M. Dominguez, M. D. Lebovitz, G. K. Koukoulis, J. R. Kuszak, L. F. Kluskens, T. M. Grogan, T. J. Saclarides, and I. B. Roninson (1991a), Cancer Res. 51, 2720–2726.PubMedGoogle Scholar
  89. Weinstein, R. S., T. M. Grogan, J. R. Kuszak, S. M. Jakate, L. F. Kluskens, and J. F. Coon (199lb), Adv. Path. Lab. Med. 4, 207–234.Google Scholar
  90. Yang, C., S. G. DePinho, L. M. Greenberger, R. Arceci, and S. B. Horwitz (1989), J. Biol. Chem. 264, 782–788.PubMedGoogle Scholar
  91. Yang, C., D. Cohen, L. M. Greenberger, S. Hsu, and S. B. Horwitz (1990), J. Biol. Chem. 265, 10,282–10,288.PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • William T. Bellamy
  • Thomas M. Grogan
  • Ronald S. Weinstein

There are no affiliations available

Personalised recommendations