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Anatomical Distribution of Metabotropic Glutamate Receptors in Mammalian Brain

  • Claudia M. Testa
  • Maria Vincenza Catania
  • Anne B. Young
Chapter
Part of the The Receptors book series (REC)

Abstract

Metabotropic glutamate receptors (mGluRs) are linked to second messengers through G-proteins and play an important role in normal neuronal functions, as well as plasticity and response to injury. Until recently, it has not been possible to examine the detailed localization of mGluRs in mammalian brain because of the lack of specific agonists and antagonists amenable to ligand binding studies and the lack of cloned cDNA sequences for the development of specific in situ hybridization probes or antibodies for immunocytochemistry. In the past few years, many of these reagents have become available, yielding data from several avenues that have indicated marked regional heterogeneity in the distributions of mGluR subtypes. In this chapter, we will review the regional expression of the five mGluR genes that have been most thoroughly characterized, the second-messenger systems associated with these receptors, and the autoradiographic binding studies of pharmacological subtypes.

Keywords

Entorhinal Cortex Metabotropic Glutamate Receptor Subthalamic Nucleus Anatomical Distribution Metabotropic Receptor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© Springer Science+Business Media New York 1994

Authors and Affiliations

  • Claudia M. Testa
  • Maria Vincenza Catania
  • Anne B. Young

There are no affiliations available

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