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Molecular Cloning, Expression, and Characterization of Metabotropic Glutamate Receptor Subtypes

  • Chapter
The Metabotropic Glutamate Receptors

Part of the book series: The Receptors ((REC))

Abstract

The excitatory amino acid, l-glutamate, is a primary neurotransmitter in excitatory synaptic pathways in the central nervous system (for a review, see Monaghan et al., 1989; Headley and Grillner, 1990; Mayer and Miller 1990; Nakanishi, 1992). l-Glutamate-mediated neurotransmission is involved in numerous neuronal functions, and excess glutamatergic stimulation may also be involved in the etiology of stroke, epilepsy, and neurodegenerative disorders (Monaghan et al., 1989; Meldrum and Garthwaite, 1990). Receptors for l-glutamate can be classified into two distinct groups based on their signal transduction pathways: (1) ionotropic glutamate receptors, which when activated are directly coupled to the opening of cationic channels (MacDermott et al., 1986; Murphy et al., 1987)—ionotropic glutamate receptors have been further defined by pharmacological and electrophysiological selectivity for N-methyl-d-aspartate (NMDA), α-amino-3-hydroxyl-5-methyl-1-isoxazole-4-propionic acid (AMPA), and kainic acid—and (2) metabotropic glutamate receptors (mGluRs), which are G-protein-coupled receptors (Monaghan et al., 1989; Nahorski and Potter, 1989; Mayer and Miller, 1990; Schoepp and Conn, 1993).

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Authors
  1. Peter D. Suzdak
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  2. Christian Thomsen
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  3. Eileen Mulvihill
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  4. Peter Kristensen
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Editors and Affiliations

  1. Department of Pharmacology, Emory University, Atlanta, GA, USA

    P. Jeffrey Conn

  2. Zeneca Pharmaceuticals Group, Wilmington, DE, USA

    Jitendra Patel

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Suzdak, P.D., Thomsen, C., Mulvihill, E., Kristensen, P. (1994). Molecular Cloning, Expression, and Characterization of Metabotropic Glutamate Receptor Subtypes. In: Conn, P.J., Patel, J. (eds) The Metabotropic Glutamate Receptors. The Receptors. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-4757-2298-7_1

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  • DOI: https://doi.org/10.1007/978-1-4757-2298-7_1

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