Two Kinds of Spatially Separated Caffeine-Sensitive Calcium Stores in Smooth Muscle Cells from Guinea-Pig Mesenteric Artery
Ca2+ stores are known to play an important role in the regulation of cellular Ca2+ and vascular contractility. However, their physiological significance in vascular smooth muscle cells (SMC) is still a subject of much discussion (for references see 17, 18). In contrast to its classical role of releasing Ca2+ to initiate contraction it was proposed that superficially located sarcoplasmic reticulum (SR) can exert a protective Ca2+ buffering action, sequestering Ca2+ ions that enter the cell from extracellular space (7, 19, 20).
KeywordsSarcoplasmic Reticulum Outward Current Free Solution Calcium Store Intestinal Smooth Muscle
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